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CRKL and CK2 <i>β</i>over Expression Are Independent Predictors of Patients Survival in Endometrioid Endometrial Carcinoma

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Open Journal of Obstetrics and Gynecology 2019年第4期9卷 479-493页

作者： Randa Mohamed Kaf Wafaa El-Beshbishi Ahmed A. Obaya Rham Z. Ahmed khaled fathy helal Mohamed SH. Ramadan Abdelwahab S. Almoregy Ibrahim A. Heggy Ola A. Harb Department of Pathology Faculty of Medicine Zagazig University Zagazig Egypt Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Mansoura University Mansoura Egypt Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Zagazig University Zagazig Egypt Department of Medical Oncology Faculty of Medicine Zagazig University Zagazig Egypt Department of Gynecology & Obstetrics Faculty of Medicine Zagazig University Zagazig Egypt Department of General Surgery Faculty of Medicine Zagazig University Zagazig Egypt

Context: The prognostic significance of expression of V-Crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) and Protein kinase CK2 β in endometroid carcinoma is not fully clarified. Aim: To assess the prognostic values and clinicopathological roles of CRKL and CK2 β expression in endometroid carcinoma by correlation their expression levels with clinicopathological parameters, response to therapy, and recurrence of the tumor and patients survival. Settings: Faculty of Medicine, Zagazig University, and Mansoura University. Methods: CRKL and CK2 β expressions were evaluated in 50 paraffin blocks EC patients that were followed up for 5 years. The relationship between their level of expressions, clinicopathological criteria and prognosis of patients was analyzed. Statistical analysis used: SPSS 22.0 for windows (SPSS Inc., Chicago, IL, USA) and MedCalc windows (Software bvba 13, Ostend, Belgium). Results: High expression of CRKL and CK was positively correlated with higher grade of the tumor (p = 0.004 and 0.006 respectively), presence of L.N metastases (p = 0.009 and 0.003 respectively), presence of distant metastases (p = 0.029 and 0.003 respectively) and advanced FIGO stage (p 0.001), poor response to therapy (p = 0.046 and 0.005 respectively), higher incidence of recurrence of the tumor after therapy (p = 0.004 and 0.048 respectively), higher incidence of cancer progression p = 0.018 and 0.044 respectively), poor PFS (p = 0.008 and 0.013 respectively), and OS rates

关键词： CRKL CK2 β Endometroid Carcinoma Immunohistochemistry Prognosis

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Numerical Analysis of Laterally Loaded Long Piles in Cohesionless Soil

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Computers, Materials & Continua 2022年第5期71卷 2175-2190页

作者： Ayman Abd-Elhamed Mohamed fathy khaled M.Abdelgaber Physics and Engineering Mathematics Department Faculty of Engineering-MattariaHelwan UniversityCairo11718Egypt Faculty of Engineering King Salman International UniversitySouth SinaiRas SedrEgypt Basic and Applied Science Department College of Engineering and TechnologyArab Academy for ScienceTechnology and Maritime TransportCairo11799Egypt

The capability of piles to withstand horizontal loads is a major design *** current research work aims to investigate numerically the responses of laterally loaded piles at working load employing the concept of a beam-on-Winkler-foundation *** governing differential equation for a laterally loaded pile on elastic subgrade is *** on LegendreGalerkin method and Runge-Kutta formulas of order four and five,the flexural equation of long piles embedded in homogeneous sandy soils with modulus of subgrade reaction linearly variable with depth is solved for both free-and fixed-headed ***,as one of the world’s leading computational software,was employed for the implementation of *** proposed numerical techniques provide the responses for the entire pile length under the applied lateral *** utilized numerical approaches are validated against experimental and analytical results of previously published works showing a more accurate estimation of the response of laterally loaded ***,the proposed approaches can maintain both mathematical simplicity and comparable accuracy with the experimental results.

关键词： Numerical solution laterally loaded pile cohesionless soil Legendre-Galerkin Runge-Kutta

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Dissolved gas analysis and dissipation factor measurement of mineral oil-based nanofluids under thermal and electrical faults

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High Voltage 2023年第3期8卷 455-465页

作者： Ahmed Maher Diaa-Eldin A.Mansour khaled helal Ramadan A.A.Abd El Aal Department of Electrical Engineering Faculty of EngineeringPort-Said UniversityPort-SaidEgypt Department of Electrical Power Engineering Faculty of EngineeringEgypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityAlexandriaEgypt Department of Electrical Power and Machines Engineering Faculty of EngineeringTanta UniversityTantaEgypt

Mineral oil is the most frequent insulating liquid used in oil-immersed transformers for electrical insulation and heat ***,oil-based nanofluids are becoming more popular in scientific research as they have proved to have better dielectric and thermal *** applying these nanofluids into actual transformers,they would be exposed to thermal and electrical ***,The aim of the authors is to investigate the generation pattern of dissolved gases in nanofluids under thermal and electrical faults and to assess the applicability of traditional Dissolved Gas Analysis(DGA)techniques if oil-based nanofluids are used in ***-based nanofluid samples were prepared using a magnetic stirrer and an ultrasonic homogeniser and then subjected to simulated thermal and electrical faults in the laboratory using properly sealed test *** types of metal oxides,Silicon dioxide,Titanium dioxide,and Aluminium oxide nanoparticles,have been used to prepare nanofluids with 0.02 g/L and 0.04 g/L *** gases released and dissolved into oil due to the simulated faults were analysed and compared to traditional mineral oil as a *** dielectric dissipation factor was obtained and analysed for all *** to the findings,the presence and concentration of nanoparticles were shown to influence the amount of gases *** a result,this research is crucial in guaranteeing that traditional DGA techniques can be employed in transformers that use oil-based nanofluids.

关键词： electrical thermal dioxide

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Gut virome:New key players in the pathogenesis of inflammatory bowel disease

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World Journal of Methodology 2025年第2期15卷 27-43页

作者： helal F Hetta Rehab Ahmed Yasmin N Ramadan Hayam fathy Mohammed Khorshid Mohamed M Mabrouk Mai Hashem Department of Medical Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of Microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of Microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Internal Medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Department of Internal Medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Department of Tropical Medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

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A Novel Meta-Heuristic Optimization Algorithm in White Blood Cells Classification

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Computers, Materials & Continua 2023年第4期75卷 1527-1545页

作者： khaled A.fathy Humam K.Yaseen Mohammad T.Abou-Kreisha Kamal A.ElDahshan Mathematics Department Faculty of ScienceAl-Azhar UniversityCairo11884Egypt

Some human diseases are recognized through of each type of White Blood Cell(WBC)count,so detecting and classifying each type is important for human *** main aim of this paper is to propose a computer-aided WBCs utility analysis tool designed,developed,and evaluated to classify WBCs into five types namely neutrophils,eosinophils,lymphocytes,monocytes,and *** a computer-artificial model reduces resource and time *** pre-trained deep learning models have been used to extract features,including AlexNet,Visual Geometry Group(VGG),Residual Network(ResNet),which belong to different taxonomy types of deep learning ***,Binary Border Collie Optimization(BBCO)is introduced as an updated version of Border Collie Optimization(BCO)for feature reduction based on maximizing classification *** proposed computer aid diagnosis tool merges transfer deep learning ResNet101,BBCO feature reduction,and Support Vector Machine(SVM)classifier to forma hybridmodelResNet101-BBCO-SVM an accurate and fast model for classifying *** a result,the ResNet101-BBCO-SVM scores the best accuracy at 99.21%,compared to recent studies in the *** model showed that the addition of the BBCO algorithm increased the detection accuracy,and at the same time,decreased the classification time *** effectiveness of the ResNet101-BBCO-SVM model has been demonstrated and beaten in reasonable ratios in recent literary studies and end-to-end transfer learning of pre-trained models.

关键词： White blood cells deep learning machine learning data mining optimization border collie optimization

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Origin and Petrogenetic Implications of Spessartine Garnet in Highly-Fractionated Granite from the Central Eastern Desert of Egypt

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Acta Geologica Sinica(English Edition) 2020年第3期94卷 763-776页

作者： Mabrouk SAMI Theodoros NTAFLOS Haroun A.MOHAMED Esam S.FARAHAT Christoph HAUZENBERGER Nasser M.MAHDY khaled M.ABDELFADIL Douaa fathy Geology Department Faculty of ScienceMinia UniversityEl-Minia 61519Egypt Department of Lithospheric Research University of ViennaAlthanstrasse 14A-1090 ViennaAustria Institute of Mineralogy and Petrology Karl-Franzens UniversityGrazAustria Nuclear Materials Authority P.O.530El-MaadiCairoEgypt Geology Department Faculty of ScienceSohag UniversityEgypt

A highly-fractionated garnet-bearing muscovite granite represents the marginal granitic facies of the Abu-Diab multiphase pluton in the Central Eastern Desert of Egypt. New electron microprobe analyses(EMPA) and laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) data from garnets are reported, in order to constrain their origin and genesis. Garnet in the Abu-Diab host granite is euhedral to subhedral, generally homogeneous and, in rare cases, it shows weak zonation. The garnet contains appreciable amounts of MnO and FeO, with lesser amounts of MgO and CaO, yielding an end-member formula of Sps61–72Alm25–35Prp1–4Adr0–1. Moreover, it is depleted in large ion lithophile elements(LILE) with lower values of Ba, Nb and Sr relative to the primitive mantle. Additionally, it contains high concentrations of HREE and Y and their REE pattern shows strong negative Eu anomalies. The garnet was crystallized under relatively low temperature(646°C–591°C) and pressure(< 3 kbar) conditions. The textural and chemical features indicate that the garnet is magmatic in origin and is chemically similar to that from highly-fractionated A-type granite. It was probably formed at the expense of biotite in a highly-evolved MnO-rich magma and/or by hydroxyl complexing of Mn during the ascending fluid phases.

关键词： spessartine garnet LA-ICP-MS A-type granite Abu-Diab Egypt

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Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection

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World Journal of Pediatrics 2017年第4期13卷 346-352页

作者： Ahmed Megahed Nanees Salem Abeer fathy Tarik Barakat Mona Abd El Latif Alsayed Suzy Abd El Mabood khaled R Zalata Ahmed F Abdalla Pediatric Gastroenterology and Hepatology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Endocrinology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Hematology&Oncology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pathology Department Faculty of MedicineMansoura UniversityEgypt

Background:The impact of chronic hepatitis C (CHC) on bone mineral density (BMD) has been well studied in adults with a relative paucity of data in children,especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RV).In the current work,we assessed prospectively changes in BMD in children with CHC before,during,and after ***:Forty-six consecutive children with noncirrhotic genotype 4 CHC were subjected to dual-energy X-ray absorptiometry at baseline,24 weeks,48 weeks of therapy and 24 weeks after ***,bone mineral content (BMC),and Z score of lumbar spine (L2-L4) were *** pubertal stage,viral load,liver function tests,serum calcium,phosphorus,alkaline phosphatase,parathyroid hormone,and liver histopathology were assessed in all included ***:Thirty (65.2%) patients had normal BMD,10 (21.7%) were at risk for low BMD,and 6 (13.1%) had low BMD for chronological *** with low BMD were significantly older (P=0.001),with higher frequency of delayed puberty than other groups (P=0.002).Baseline densitometric parameters (BMD & BMC) were significantly positively correlated with patients' age,weight,height,body mass index and hemoglobin level;while they were insignificantly correlated with basal viral load,histopathology activity index and fibrosis *** parameters improved significantly on PEG-IFN plus RV treatment,this improvement was found to be sustainable 24 weeks after ***:Low BMD is detectable in a proportion of CHC *** therapy leads to a sustainable increase in BMD.

关键词： bone mineral density chronic hepatitis C pegylated interferon ribavirin

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Letrozole versus Gonadotropin in Unexplained Infertile Couples Failed to Conceive with Clomiphene Citrate

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Open Journal of Obstetrics and Gynecology 2014年第10期4卷 636-641页

作者： Moustafa Abbas Ibrahaiem Sherin A. Shazly khaled F. helal Hala Mowafy Manal M. El Behery Obstetrics and Gynecology Department Faculty of Medicine Zagazig University Ash Sharqiyah Egypt

Background:?Unexplained infertility represents about 15% - 20% of infertile couples. Usually, these cases need assistance. Clomiphene citrate is the most used drug for this problem but sometimes pregnancy failed to achieve it, so other options for assistance are gonadotrophin or letrezole. The objective of our study was to compare the pregnancy rate for letrezole and gonadotropin inunexplained infertile women’s who failed to conceive with clomiphene citrate. Methods: This prospective quasi-randomized trial was carried out in cytogenetic unite at obstetrics and gynecology department, Zagazig University Hospital. 140 infertile females were included, induction of ovulation by letrozole for half of them and by gonadotrophin for the other half. Results: There was statistically highly significant decrease in duration of stimulation, E2 levels and endometrial thickness at day of HCG in letrezole group, no significant difference between two groups as regard number of follicles and pregnancy rate per cycle, while the cumulative pregnancy rate and the cost of stimulation are significantly higher in gonadotrophin group. Conclusion: In patient with unexplained infertility who failed to conceive with clomiphene citrate, gonadotrophins have a higher pregnancy rate than letrezole. However, pregnancy rate was high enough with lower cost with letrezole to be acceptable and justified its use in this group of patients.

关键词： Letrozole Gonadotropin Infertility Clomiphene Citrate

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The safety,efficacy and pharmaceutical quality of male enhancement nutraceuticals bought online:Truth versus claim

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Journal of Integrative Medicine 2021年第3期19卷 232-242页

作者： Mohamed Ismail Nounou Heba AEassa Nada Ahelal khaled Aboul Fotouh Ihab Mansoor Isabel KLatz Cindy Zheng Hadeer AEassa Dina Mohamed Diana MHuynh Abigail RWiss Jessica Sweeney Monica TOakes Mark MMikhail Nadine Amine Harshvir Kaur Natalia Echeverry Kamila Orzechowski Doreen Szollosi Department of Pharmaceutical Sciences School of Pharmacy&Physician Assistant Studies(SOPPAS)University of Saint Joseph(USJ)HartfordConnecticut 06103USA Department of Pharmaceutics and Industrial Pharmacy Faculty of PharmacyAL-Azhar UniversityCairo 11651Egypt Pharmaceutical Sciences Department Irma Lerma Rangel College of PharmacyTexas A&M Health Science CenterTexas A&M UniversityCollege StationTexas 77843USA Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinTexas 78712USA Department of Pharmaceutics Faculty of PharmacyAssiut UniversityAssiut 71526Egypt Department of Pharmaceutics Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt Department of Public Health Sciences College of Health SciencesThe University of Texas at El PasoTX 79968USA Genetic Engineering and Biotechnology Research Institute University of Sadat CitySadat 32897Egypt Department of Industrial Pharmacy Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Objective:Nutraceutical products are widely used for their claimed therapeutic ***,falsified or adulterated nutraceuticals present a major health threat to *** study investigates the pharmaceutical quality,safety and anti-inflammatory effects of six male enhancement nutraceuticals that claim to be 100%***:Three batches of six male enhancement products were tested to detect the presence and levels of adulterants via high-performance liquid chromatography(HPLC).The pharmaceutical quality of the selected nutraceuticals was tested with near infrared spectroscopy(NIR)and Se De *** cytotoxic effects of these products on HepG2 cells were determined through cell proliferation(XTT)and lactate dehydrogenase(LDH)cytotoxicity ***,the in vitro inflammatory effects of these products were investigated using murine J774 macrophages through cytokine release ***:HPLC analysis detected the presence of sildenafil citrate,a vasodilator,and the active ingredient in Viagra and Revatio,in all batches of the products we *** of sildenafil citrate ranged from 0.45 mg to 51.85 mg among different *** assessment showed inter-and intra-batch heterogeneity in product *** of the XTT and LDH assays showed significant cytotoxic effects of the analyzed *** analysis revealed that the viability of HepG2 treated with tested products varied from 27.57%to 41.43%.Interestingly,the male enhancement products also showed anti-inflammatory ***:Despite their labeling as 100%natural,all products tested in this study contained levels of sildenafil citrate,which was not reported on the *** was a lack of pharmaceutical uniformity among products of the same batch and across different ***,the products we tested had cytotoxic *** study findings highlight the adulteration,poor quality and hazard of these ***,strict regulation of these product

关键词： Nutraceuticals Adulteration Erectile dysfunction Sildenafil citrate Online market

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