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Elucidating the molecular basis of ATP-induced cell death in breast cancer: Construction of a robust prognostic model

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World Journal of Clinical Oncology 2024年第2期15卷 208-242页

作者： Hao-Ling Zhang Sandai Doblin Zhong-Wen Zhang Zhi-Jing Song Babu Dinesh Yasser Tabana DahhamSabbar Saad Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang Hao-Long Zhang Sen Wu Rui Zhao Barakat khaled Department of Biomedical Sciences Advanced Medical and Dental InstituteUniversiti Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Department of Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Universiti Sains Malaysia Advanced Medical and Dental InstitutePenang 13200Malaysia Department of Biomedical Science Universiti Sains MalaysiaPenang 13200Malaysia

BACKGROUND Breast cancer is a multifaceted and formidable disease with profound public health *** demise mechanisms play a pivotal role in breast cancer pathogenesis,with ATP-triggered cell death attracting mounting interest for its unique specificity and potential therapeutic *** To investigate the impact of ATP-induced cell death(AICD)on breast cancer,enhancing our understanding of its *** The foundational genes orchestrating AICD mechanisms were extracted from the literature,underpinning the establishment of a prognostic ***,a microRNA(miRNA)prognostic model was constructed that mirrored the gene-based prognostic *** between high-and low-risk cohorts within mRNA and miRNA characteristic models were scrutinized,with the aim of delineating common influence mechanisms,substantiated through enrichment analysis and immune infiltration *** The mRNA prognostic model in this study encompassed four specific mRNAs:P2X purinoceptor 4,pannexin 1,caspase 7,and cyclin *** miRNA prognostic model integrated four pivotal miRNAs:hsa-miR-615-3p,hsa-miR-519b-3p,hsa-miR-342-3p,and hsa-miR-324-3p.B cells,CD4+T cells,CD8+T cells,endothelial cells,and macrophages exhibited inverse correlations with risk scores across all breast cancer ***,Kyoto Encyclopedia of Genes and Genomes analysis revealed that genes differentially expressed in response to mRNA risk scores significantly enriched 25 signaling pathways,while miRNA risk scores significantly enriched 29 signaling pathways,with 16 pathways being jointly *** Of paramount significance,distinct mRNA and miRNA signature models were devised tailored to AICD,both potentially autonomous prognostic *** study's elucidation of the molecular underpinnings of AICD in breast cancer enhances the arsenal of potential therapeutic tools,offering an unparalleled window for innovative ***,this paper revea

关键词： ATP-induced cell death mRNA miRNA Prognostic model Breast cancer

Artificially Generated Facial Images for Gender Classification Using Deep Learning

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Computer Systems Science & Engineering 2023年第2期44卷 1341-1355页

作者： Valliappan Raman khaled ELKarazle Patrick Then Coimbatore Institute of Technology Coimbatore641014India Swinburne University of Technology Kuching95530Malaysia

Given the current expansion of the computer visionﬁeld,several appli-cations that rely on extracting biometric information like facial gender for access control,security or marketing purposes are becoming more common.A typical gender classiﬁer requires many training samples to learn as many distinguishable features as ***,collecting facial images from individuals is usually a sensitive task,and it might violate either an individual's privacy or a speciﬁc data privacy *** order to bridge the gap between privacy and the need for many facial images for deep learning training,an artiﬁcially generated dataset of facial images is *** acquire a pre-trained Style-Generative Adversar-ial Networks(StyleGAN)generator and use it to create a dataset of facial *** label the images according to the observed gender using a set of criteria that differentiate the facial features of males and females *** use this manually-labelled dataset to train three facial gender classiﬁers,a custom-designed network,and two pre-trained networks based on the Visual Geometry Group designs(VGG16)and(VGG19).We cross-validate these three classiﬁers on two separate datasets containing labelled images of actual *** testing,we use the UTKFace and the Kaggle gender *** experimental results suggest that using a set of artiﬁcial images for training produces a comparable performance with accuracies similar to existing state-of-the-art methods,which uses actual images of *** average classiﬁcation accuracy of each classiﬁer is between 94%and 95%,which is similar to existing proposed methods.

关键词： Facial recognition data collection facial images generative adversarial networks facial gender estimation

Evaluating the impact of traffic violations on crash injury severity on Wyoming interstates:An investigation with a random parameters model with heterogeneity in means approach

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第4期9卷 654-665页

作者： Anas Alrejjal Milhan Moomen khaled Ksaibati Department of Civil and Architectural Engineering University of WyomingLaramieWY 82070USA South Carolina Department of Transportation ColumbiaSC 29202USA

This study investigated the impact of traffic violations on crash injury severity on Wyoming’s interstate highways.A random parameters multinomial logit(MNL)model with heterogeneity in means was estimated as an alternative to the mixed logit *** was done to better account for unobserved heterogeneity in the crash *** per the results,the random parameters model with heterogeneity in means not only exhibited a better fit but also uncovered more insights regarding the factors influencing crash injury *** advanced model showed that traffic violations,crash characteristics and environmental characteristics among other factors impact crash injury severity on Wyoming’s interstate *** regards to traffic violations,driving too fast for prevailing conditions and driving under the influence of alcohol and drugs were identified as the main violations that significantly influenced crash *** other useful insights,the heterogeneity in mean specification indicated that the likelihood of severe injury crashes is increased by the interactive effect between non-trucks(vehicles not classified as trucks)and driving too fast for *** is a significant implication that high speed behavior by non-truck drivers in adverse weather conditions is ranked as one of the hazardous traffic violations on Wyoming’s *** study provided for the first time important information on the impact of traffic violations on crash severity of crashes that occurred on challenging roadways that characterized by mountainous terrain and severe weather *** from the study will help enforcement agencies in the state to better identify appropriate countermeasures to mitigate the impact of violations on crash severity.

关键词： Random parameters Heterogeneity in means Injury severity Interstate safety

A remote sensing-based agricultural drought indicator and its implementation over a semi-arid region, Jordan

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Journal of Arid Land 2017年第3期9卷 319-330页

作者： khaled HAZAYMEH Quazi K HASSAN Department of Geomatics Engineering Schulich School of Engineering University of Calgary Department of Geography Faculty of Arts Yarmouk University

The objective of the study was to develop a remote sensing （i.e., Landsat-8 and MODIS）-based agricultural drought indicator （ADI） at 30-m spatial resolution and 8-day temporal resolution and also to evaluate its performance over a heterogeneous agriculture dominant semi-arid region in Jordan. Firstly, we used principal component analysis （PCA） to evaluate the correlations among six commonly used remote sensing-derived agricultural drought related variables. The variables included normalized difference water index （NDWI）, normalized difference vegetation index （NDVI）, visible and shortwave drought index （VSDI）, normalized multiband drought index （NMDI）, moisture stress index （MSI）, and land surface temperature （LST）. Secondly, we integrated the relatively less correlated variables （that were found to be NDWI, VSDI, and LST） to generate four agricultural drought categories/conditions （i.e., wet, mild drought, moderate drought, and severe drought）. Finally, we evaluated the ADI maps against a set of 8-day ground-based standardized precipitation index values （i.e., SPI-I, SPI-2, ..., SPLS） by use of confusion matrices and observed the best results for SPI-4 （i.e., overall accuracy and Kappa-values were 83% and 76%, respectively） and SPI-5 （i.e., overall accuracy and Kappa-values were 85% and 78%, respectively）. The results demonstrated that the method would be valuable for monitoring agricultural drought conditions in semi-arid regions at both a reasonably high spatial resolution （i.e., 30-m） and a short time period （i.e., 8-day）.

关键词： spatio-temporal image fusion model (STI-FM) land surface temperature (LST) surface reflectance standardizedprecipitation index (SPI) Landsat-8 MODIS

A practical application of photogrammetry to performing rib characterization measurements in an underground coal mine using a DSLR camera

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International Journal of Mining Science and Technology 2017年第1期27卷 83-90页

作者： Brent A.Slaker khaled M.Mohamed Mining Engineer Ground Control Branch NIOSH Office of Mine Safety and Health ResearchPittsburghPAUSA

Understanding coal mine rib behavior is important for inferring pillar loading conditions as well as ensuring the safety of miners who are regularly exposed to ribs. Due to the variability in the geometry of underground openings and ground behavior, point measurements often fail to capture the true movement of mine workings. Photogrammetry is a potentially fast, cheap, and precise supplemental measurement tool in comparison to extensometers, tape measures, or laser range meters, but its application in underground coal has been limited. The practical use of photogrammetry was tested at the Safety Research Coal Mine, National Institute for Occupational Safety and Health(NIOSH). A commercially available, digital single-lens reflex(DSLR) camera was used to perform the photogrammetric surveys for the experiment. Several experiments were performed using different lighting conditions, distances to subject,camera settings, and photograph overlaps, with results summarized as follows: the lighting method was found to be insignificant if the scene was appropriately illuminated. It was found that the distance to the subject has a minimal impact on result accuracy, and that camera settings have a significant impact on the photogrammetric quality of images. An increasing photograph resolution was preferable when measuring plane orientations; otherwise a high point cloud density would likely be excessive. Focal ratio(F-stop) changes affect the depth of field and image quality in situations where multiple angles are necessary to survey cleat orientations. Photograph overlap is very important to proper three-dimensional reconstruction, and at least 60% overlap between photograph pairs is ideal to avoid unnecessary post-processing. The suggestions and guidelines proposed are designed to increase the quality of photogrammetry inputs and outputs as well as minimize processing time, and serve as a starting point for an underground coal photogrammetry study.

关键词： Photogrammetry Coal mining Underground Rib characterization

Proteomic approach in human health and disease: Preventive and cure studies

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Asian Pacific Journal of Tropical Biomedicine 2018年第4期8卷 226-236页

作者： khaled MM.Koriem Department of Medical Physiology Medical Research Division National Research Centre

Proteomic is a branch of science that deals with various numbers of proteins where proteins are essential human *** has a lot of functions inside the human and animal living *** review helps to make a thought on the importance of proteomic application in human health and disease with special reference to preventive and cure *** human health can be divided into physical and mental *** physical health relates to keeping human body state in a good health and to nutritional type and environmental *** mental health correlates to human psychological *** main factors that affect the status of human health are human diet,exercise and *** healthy diet is very important and needs to maintain the human *** training program exercise improves human fitness and overall health and *** sleep is a vital factor to sustain the human *** human disease indicates abnormal human condition which influences the specific human part or the whole human *** are external and internal factors which induce human *** external factors include pathogens while internal factors include allergies and *** are 4 principle types of human diseases:(1)infectious disease,(2)deficiency disease,(3)genetic disease and(4)physiological *** are many and various external microbes'factors that induce human infectious disease and these agents include viruses,bacteria,fungi and *** lack of necessary and vital dietary rudiments such as vitamins and minerals is the main cause of human deficiency *** genetic disease is initiated by hereditary disturbances that occur in the human genetic *** physiological disease occurs when the normal human function body is affected due to human organs become *** conclusion,proteomic plays a vital and significant role in human health and disease.

关键词： Proteomic Diet Exercise Sleep Disease

Determining driver perceptions about distractions and modeling their effects on driving behavior at different age groups

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第1期9卷 33-43页

作者： Uneb Gazder khaled J.Assi Civil Engineering Department University of BahrainIsa TownBahrain Civil and Environmental Engineering Department King Fahd University of Petroleum and MineralsDhahranSaudi Arabia

This study was aimed at determining the driving distractions which are perceived most hazardous and determining the effects of these distractions and age on speed and headway. A questionnaire survey was done to find out the opinion of drivers related to the most hazardous distraction. 639 responses were collected in the survey which were used to determine the top-rated distractions for drivers in Bahrain. Roadside observations were taken to observe the speed, headway, age and type of distraction for the driver. Speed was observed for 48 drivers while headway was observed for 36 drivers along with other parameters. The most hazardous distractions, according to the participants of the questionnaire, are using mobile phones, handling children, and accidents or incidents on the road. Further, the results of the two-way analysis of variance(ANOVA) test and regression analysis demonstrated that using mobile phones and age have a significant effect on both speed and headway. Speed tends to decrease with distraction for all age groups while decreasing the headway for young and middle-aged drivers. The effect of distraction is higher than the effect of age on speed, as well as headway. Texting has the most significant effect among distractions on headway. It is hereby recommended that policymakers should focus on increasing awareness and stringent law enforcement related to handling mobile phones and children, especially for young and middle-aged drivers.

关键词： Traffic engineering Traffic safety Driving behavior Speed Driving distraction Mobile phone

Magnetic resonance imaging in patients with transient ischemic attack

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Neural Regeneration Research 2014年第3期9卷 234-235页

作者： Mohamed Al-khaled Department of Neurology University of Lübeck

Transient ischemic attack （TIA） is a temporary event, which portends a higher risk of a disabling stroke following the TIA. However, the evaluation and management of TIA vary worldwide and is debated and controversial. With the development of brain imaging, particularly diffusion weighted imaging-magnetic resonance imaging （DWI-MRI）, the diagnosis of TIA changed from time-based definition to a tissue-based one. DWI-MRI be-came a mandatory tool in the TIA workup. The DWI-MRI provides not only the evidence to distinguish between TIA and acute ischemic stroke, fur-thermore it predicts TIA patients who are at higher risk of disabling stroke, which can be prevented by an immediate evaluation and treatment of TLA.

关键词： TIA Magnetic resonance imaging in patients with transient ischemic attack DWI MRI

Do statins reduce the mortality rate in stroke patients treated with systemic thrombolysis in a 5-year single-center study?

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Neural Regeneration Research 2021年第9期16卷 1807-1812页

作者： Toralf Brüning Mohamed Al-khaled Department of Neurology University Medical Center Schleswig-HolsteinCampus LübeckLübeckGermany

The present study investigated the association between pre-treatment with a cholesterol-lowering drug(statin) or new setting hereon and the effect on the mortality rate in patients with acute ischemic stroke who received intravenous systemic thrombolysis. During a 5-year period(starting in October 2008), 542 consecutive stroke patients who received intravenous systemic thrombolysis with recombinant tissue plasminogen activator(rt-PA) at the Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Germany, were included. Patients were characterized according to statins. The primary endpoint was mortality;it was assessed twice: in hospital and 3 months after discharge. The secondary outcome was the rate of symptomatic intracerebral hemorrhage. Of the 542 stroke patients examined(mean age 72 ± 13 years;51% women, mean National Institutes of Health Stroke Scale(NIHSS) score 11), 138 patients(25.5%) had been pretreated with statin, while in 190 patients(35.1%) statin therapy was initiated during their stay in hospital, whereas 193(35.6%) never received statins. Patients pre-treated with statin were older and more frequently had previous illnesses(arterial hypertension, diabetes mellitus and previous cerebral infarctions), but were comparably similarly affected by the stroke(NIHSS 11 vs. 11;P = 0.76) compared to patients who were not on statin treatment at the time of cerebral infarction. Patients pretreated with statin did not differ in 3-month mortality from those newly treated to a statin(7.6% vs. 8%;P = 0.9). Interestingly, the group of patients pretreated with statin showed a lower rate of in hospital mortality(6.6% vs. 17.0;P = 0.005) and 3-month mortality(10.7% vs. 23.7%;P = 0.005) than the group of patients who had no statin treatment at all. The same effect was seen for patients newly adjusted to a statin during the hospital stay compared to patients who did not receive statins(3-month mortality: 7.1% vs. 23.7%;P < 0.001). With a good funct

关键词： acute ischemic stroke hemorrhage mortality outcome secondary prophylaxis statins stroke systemic thrombolysis