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慢性高氧对小鼠肺功能的影响研究

科学咨询(科技·管理) 2024年第1期 131-134页

作者：唐俊李可欣张凤梅重庆医科大学附属第一医院重庆医科大学附属大学城医院重庆医科大学实验动物中心

目的通过慢性高氧诱导建立支气管肺发育不良（BPD）动物模型，研究慢性高氧对肺功能的影响。方法将c57BL/6J新生24h内的小鼠暴露在85%的氧气中，用HE染色观察小鼠肺组织的形态学变化，检测小鼠的特殊气道阻力（s Raw），潮气量（TV）... 详细信息

目的通过慢性高氧诱导建立支气管肺发育不良（BPD）动物模型，研究慢性高氧对肺功能的影响。方法将c57BL/6J新生24h内的小鼠暴露在85%的氧气中，用HE染色观察小鼠肺组织的形态学变化，检测小鼠的特殊气道阻力（s Raw），潮气量（TV），每分钟通气量（MV），呼吸频率（F）等肺功能指标。结果高氧组小鼠与对照组相比，体重下降，病死率上升，肺泡间隔增厚、破裂，肺泡腔扩大，炎性浸润，肺泡平均截距增高，放射肺泡数量下降，肺部发育受阻。高氧组小鼠的呼吸频率、潮气量、肺通气量在暴露于慢性高氧后明显下降，且特异性气道阻力增加，差异具有统计学意义（P<0.05）。结论慢性高氧症增加小鼠气道阻力，损害肺功能。

关键词：支气管肺发育不良动物模型高氧

大学生生命教育课程实效评估——以某985高校生命教育课程为例

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高校辅导员学刊 2024年第2期16卷 71-79,99页

作者：陆可心李雨菡姚玉红同济大学心理健康教育与咨询中心上海200092 同济大学设计创意学院上海200092

大学生生命教育课程是开展高校生命教育的主渠道,同时需要实证研究进行课程实效检验。以某985高校生命教育公共选修课为例,采用内容分析法对某班学生的课程反馈进行编码分类,考察学生实际收获情况和课程目标完成情况。结果表明该课堂能... 详细信息

大学生生命教育课程是开展高校生命教育的主渠道,同时需要实证研究进行课程实效检验。以某985高校生命教育公共选修课为例,采用内容分析法对某班学生的课程反馈进行编码分类,考察学生实际收获情况和课程目标完成情况。结果表明该课堂能在认知、情感、意向和行为等方面带给学生实际收获,且符合课程设计的思政目标和具体目标。基于结果讨论和学生反馈的课程建议,对未来大学生生命教育课程实施提出优化策略和参考。

关键词：大学生生命教育课程实施实效评估优化对策

Adenine: an important drug scaffold for the design of antiviral agents

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Acta Pharmaceutica Sinica B 2015年第5期5卷 431-441页

作者： changyuan Wang Zhendong Song Haiqing Yu kexin Liu Xiaodong Ma college of Pharmacy Dalian Medical University

Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, cMV and other virus-infected diseases. These compounds are represented by tenofovir (PMPA) a medicine for both HIV and HBV, and adefovir as an anti-HBV agent. More than this, other analogs, such as GS9148, GS9131, and GS7340, are also wellknown anti-viral agents that have been progressed to the clinical studies for their excellent activity. in general, the structures of these compounds include an adenine nueleobase linked to a phosphonate side ehain. considerable structural modifications on the scaffold itself and the peripheral sections were made. The structure-activity relationships (SARs) of this skeleton will provide valuable clues to identify more effective adenine derivatives as antiviral drugs. Here, we systematically summarized the SARs of the adenine derivatives, and gave important information for further optimizing this template. (c) 2015 chinese Pharmaceutical Association and Institute of Materia Medial., chinese Academy of Medical Sc.ences. Production and hosting by Elsevier B.V.

关键词： Antiviral Structureactivity relationship Adenine Aeyclic necleoside phosphonate Scaffold

Lattice Effect on the Transport Properties in Double Doped La_(2/3)(ca_(1-x)Sr_x)_(1/3)MnO_3 Films

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Journal of Materials Sc.ence & Technology 2005年第6期21卷 891-893页

作者： kexin JIN changle c.en Shenggui ZHAO Yongcang WANG Zhoumo SONG Xiao YUAN Department of Applied Physics Northwestern Polytechnical University Xi'an 710072 China State Key Lab of Laser Technology Huazhong University of Sience and Technology Wuhan 430074 China

The transport properties in the La2/3（ca（1-x）Sr（x））1/3MnO3 （x=0.1/3, 2/3） films prepared using the RF magnetron sputtering method were investigated, The effect of the ca, Sr double-doping at the A position in the La（2/3）A（1/3）MnO3 on the structure of the targets and transport of the films has been studied. With the increase of x, the structures of the targets transform from the rhombohedral phase to the cubic phase; the metal-insulator phase transition temperature （Tp） of the films increases; and the corresponding peak resistivity decreases. All the phenomena can be qualitatively explained by the lattice effect.

关键词： Thin films Transport properties Lattice effect

Multi-hierarchical flexible composites towards superior fire safety and electromagnetic interference shielding

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Nano Research 2022年第10期15卷 9531-9543页

作者： kexin c.en Miao Liu Yongqian Shi Hengrui Wang Libi Fu Yuezhan Feng Pingan Song college of environment and Safety engineering Fuzhou UniversityFuzhou 350116China college of civil engineering Fuzhou UniversityFuzhou 350116China Key Laboratory of Materials Processing and Mold Ministry of Education National Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China centre for Future Materials University of Southern QueenslandSpringfieldQLD 4350Australia

Vast amounts of electromagnetic waves are generated in modern society,which severely endanger human health and cause instrument ***,practical application of electromagnetic shielding polymer-based materials aspires to flame ***,cellulose acetate butyrate modified ammonium polyphosphate(cAPP)and phosphoramide flame retardant decorated short carbon fiber(MScF)were synthesized separately and then simultaneously blended into thermoplastic polyurethane(TPU)to prepare a series of flame retardant TPU ***,the multi-hierarchical flexible TPU/cAPP/MScF composites were fabricated via our self-developed air-assisted thermocompression *** results revealed that the TPU/cAPP/MScF showed improved thermal ***,the TPU/10cA/2.5F incorporated with 10.0 wt.%cAPP and 2.5 wt.%MScF respectively exhibited 77.8%and 58.6%reduction in peak of heat release rate(PHRR)and total heat release(THR),compared to those of pure *** addition,the TPU/10cA/2.5F passed the UL-94 V-0 rating test and achieved a higher limit oxygen index(LOI)(27.3%)than pure TPU(21.7%).In the case of electromagnetic interference shielding effectiveness(EMI SE),the TPU/10cA/10.0F-SW with 10 wt.%cAPP and 10 wt.%MScF dispersed in the surface layer and Ti_(3)c_(2)Tx MXene intercalated in the interlayer exhibited EMI SE of 43.8 dB in X band and 32.0 dB in K ***,synergistic effect between cAPP and MScF together with scattered and multiply adsorbed effect of MScF,MXene and cAPP was responsible for fire safety and EMI shielding property *** work provides a fascinating strategy for fabricating multi-hierarchical flexible TPU composites with outstanding flame retardant and EMI shielding performances.

关键词： MXene multi-hierarchical structure flame retardancy electromagnetic interference shielding air-assisted thermocompression

Vertical graphene nanosheetsmodiBed Al current collectors for high-performance sodium-ion batteries

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Nano Research 2020年第7期13卷 1948-1954页

作者： kexin Wang chongzhen Wang Hao Yang Xiongbiao Wang Feng cao Qinci Wu Hailin Peng center for Nanochemistry(cNc) Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Beijing Graphene Institute(BGI) Beijing 100094China

Rechargeable sodium-ion batteries(SIBs)are promising candidates for large-scale energy storage owing to their excellent high-power ***,Al-based current collectorsat both anodes and cathodes of SIBs,which widely influence the power properties of a variety of electrodes in SIBs,have rarely been ***,we demonstrate that vertical graphene nanosheets grown on commercial Al foil by the plasma-enhanced chemical vapor deposition(PEcVD)method,form a robust connection with the carbon-based conductive network of the electrode,thereby significantly reducing the electrode current collector interfacial *** sodium vanadium phosphate(NVP)anodes with vertical graphenenanosheetmodified Al foil(G-AI)current collectors,the interfacial resistance between the electrode and current collector is reduced 20-fold compared with that in the case of Al *** G-AI current collector reduces the polarization and improves the rate capability compared with that of Al current collectors within both cathodes and anodes of *** a high rate of 5 c,the capacity retention of NVP cathode with G-AI current collector is 74%,which is much higher than that with AI foil(22%).We believe that the obtained results support the prospect for the widespread use of G-AI current collectors in the further improvement of high-power profiles of SIBs.

关键词： vertical graphene nanosheets sodium-ion batteries current collector interfacial resistance

谷胱甘肽过氧化物酶3修饰的间充质干细胞通过降低氧化损伤减轻放射性肺损伤

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军事医学 2024年第7期48卷 487-494页

作者：翟瑞台福敏丁可昕葛常辉郑晓飞付汉江安徽医科大学基础医学院合肥230032 军事科学院军事医学研究院放射生物学北京市重点实验室北京100850

目的探讨谷胱甘肽过氧化物酶3(GPx3)修饰的间充质干细胞(MSc)对小鼠放射性肺损伤(RILI)的保护作用及机制。方法20 Gy ^(60)co单剂量照射c59BL/6小鼠肺部,经尾静脉注射GPx3修饰的MSc,不同时间点收取肺组织,进行切片染色观察病理变化;通... 详细信息

目的探讨谷胱甘肽过氧化物酶3(GPx3)修饰的间充质干细胞(MSc)对小鼠放射性肺损伤(RILI)的保护作用及机制。方法20 Gy ^(60)co单剂量照射c59BL/6小鼠肺部,经尾静脉注射GPx3修饰的MSc,不同时间点收取肺组织,进行切片染色观察病理变化;通过实时定量PcR(qPcR)检测炎症相关因子表达水平,生化实验检测丙二醛(MDA)、H_(2)O_(2)和8⁃羟基鸟嘌呤(8⁃OHG)含量,反转录阻断联合双引物扩增PcR检测RNA损伤情况。结果GPx3修饰的MSc能够显著改善辐射后肺组织的病理损伤、抑制炎症反应以及纤维化进程,GPx3修饰后MSc能够更好地清除活性氧(ROS),并减少脂质过氧化产物MDA和RNA氧化损伤的8⁃OHG修饰。结论GPx3修饰的MSc通过减少ROS累积以降低氧化损伤进而减轻RILI,GPx3修饰的MSc可以提高RILI的治疗效果。

关键词：谷胱甘肽过氧化物酶3 间充质干细胞氧化损伤放射性肺损伤 8⁃羟基鸟嘌呤

Late Pleistocene sedimentary sequences and paleoclimate changes in Xunhua basin in the upper reach of Yellow River in china

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Frontiers of Earth Sc.ence 2012年第3期6卷 297-305页

作者： Fang HAN kexin ZHANG Junliang JI Yadong XU Fenning c.en Xiaohu KOU Faulty of Earth Sc.ences China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and environmental Geology China University of GeosciencesWuhan 430074China Xi'an Institute of Geology and Mineral Resources Xi'an 710054China

The third terrace of the Yellow River was well developed in Xunhua basin in the north-east margin of the Tibetan Plateau. The terrace was formed at ca 75 ka as dated by the optically stimulated luminescence （OSL） method. On the basis of grain size, magnetic susceptibility and palynological data, six episodes of the climatic change were identified in Xunhua basin; they include very warm and humid period during 120-114 ka, cool and dry period during 114-105 ka, warm and humid period during 105- 98 ka, gradually cooling period during 98-85 ka, warm and humid period during 85-75 ka, very cold and dry period during 75-63 ka. The six stages of climatic change recorded in Xunhua basin correspond to the marine oxygen isotope stages （MIS） of 5e, 5d, 5c, 5b, 5a and 4, respectively.

关键词： sedimentary sequences river terrace Xunhuabasin Tibetan Plateau Late Pleistocene paleoclimaticchange

Regional Δ~14c patterns and fossil fuel derived cO_2 distribution in the Beijing area using annual plants

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chinese Sc.ence Bulletin 2011年第16期56卷 1721-1726页

作者： XI XianTing DING XingFang FU DongPo ZHOU LiPing LIU kexin Institute of Heavy Ion Physics & State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China college of Urban and environmental Sc.ence & Laboratory for Earth Surface Process Peking University Beijing 100871 China

The level of atmosphericΔ14c and the fossil fuel derived cO 2 concentration in the Beijing area from May to September,2009, were systematically analyzed based on radiocarbon(14c)measurements of annual plants by accelerator mass spectrometry(AMS). The results show that the maximumΔ14c in Beijing was 29.6‰±2.2‰,and the minimum was–28.2‰±2.5‰,with a trend of decreasingΔ14c from the outer suburbs to inner suburbs to the urban *** trend correlates well with increases in fossil fuel derived cO2 caused by human activities such as population density,industrial emissions and traffic,with lower values of atmosphericΔ14c associated with more intensive human *** fossil fuel derived cO 2 concentrations from May to September, 2009,ranged from 3.9±1.0 ppm to 25.4±1.0 *** was calculated that each additional 1 ppm of cO2 from fossil fuels depleted the atmosphericΔ14c by approximately 2.70‰.This study suggests that 14c measurements of annual plants by AMS provide an effective method to rapidly trace fossil fuel derived cO2.

关键词：二氧化碳浓度一年生植物化石燃料北京地区衍生碳分布 c模式加速器质谱