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针灸治疗慢性非特异性腰痛随机对照试验结局指标的现状研究

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中国全科医学 2023年第9期26卷 1053-1063页

作者：林蕙泽闫文茜张萍萍费静雯申江红柳兰萍王翔朱可欣杨涛于金娜中国中医科学院广安门医院针灸科北京市100053

背景针灸是治疗慢性非特异性腰痛(CNSLBP)的重要方法。随着研究的发展,大量针灸治疗CNSLBP的随机对照试验(RCT)已经发表,但由于在结局指标选择方面存在一定的问题,严重限制了高质量临床证据的产生。目的评价针灸治疗CNSLBP RCT选用的结... 详细信息

背景针灸是治疗慢性非特异性腰痛(CNSLBP)的重要方法。随着研究的发展,大量针灸治疗CNSLBP的随机对照试验(RCT)已经发表,但由于在结局指标选择方面存在一定的问题,严重限制了高质量临床证据的产生。目的评价针灸治疗CNSLBP RCT选用的结局指标情况,为针灸治疗CNSLBP相关研究提供参考依据。方法系统检索4个中文数据库(中国知网、维普网、万方数据知识服务平台、中国生物医学文献服务系统)、3个英文数据库(PubMed、Embase、Cochrane Library)2017-01-01至2022-03-15发布的针灸治疗CNSLBP的文献,以及自建库以来至2022-03-15发表的非特异性腰痛(NSLBP)的核心结局指标集(COS)。对纳入的针灸治疗CNSLBP的文献基本特征进行分析,对文献的临床结局指标进行归类,对文献中的结局指标及《中医病证诊断疗效标准》的应用现状进行分析。分析NSLBP研究的COS现状,比较其与现有针灸治疗CNSLBP文献结局指标的异同。结果本研究纳入的针灸治疗CNSLBP的49篇文献均为RCT,共包含4篇英文文献和45篇中文文献。共包含4272例患者,其中观察组2049例、对照组2223例,年龄为18~69岁。38篇文献报告了病程。纳入的文献共包含33个结局指标,分为疼痛类指标、功能障碍指标、复合指标、生活质量指标、日常生活能力指标、安全性指标、患者满意度指标、疾病认知指标、心理状态指标、其他指标。单篇文献的结局指标数量为1~8个。42篇文献的结局指标测量时点为治疗前和治疗后2个时点。仅有2篇文献报告了安全性指标。《中医病证诊断疗效标准》中“有效率”指标的使用率为77.55%(38/49)。11篇NSLBP研究的COS的指标域涵盖了疼痛类指标、功能障碍指标、生活质量指标、心理状态指标、社会功能指标和患者满意度指标等,其中3篇文献对指标域重要性进行了分级,4篇文献涵盖了患者满意度指标,5篇文献涵盖了心理状态指标,9篇文献针对不同的指标域选择了不同的测量工具;1篇文献为中医治疗NSLBP研究的COS。结论针灸治疗CNSLBP RCT的结局指标与NSLBP研究的COS均在不同程度上对疼痛、功能障碍、生活质量、心理状态和患者满意度的结局指标有所关注,但在指标域的选择上存在种类、关注方向和测量工具的差异。针灸治疗CNSLBP RCT的结局指标的现状存在主次结局指标、测量时点不明确,指标数量的选择异质性大,指标应用不规范,重视疗效指标、轻视安全性指标等问题,建议今后的针灸研究在设计结局指标时,参照目前已有的NSLBP研究的COS及常用的测量工具,同时结合研究本身的特点扩展相应的公认的结局指标。

关键词：针灸疗法腰痛慢性非特异性腰痛随机对照试验结局指标集结局指标

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云南省传统村落空间分布特征及保护管理研究

小城镇建设 2024年第5期42卷 76-84页

作者：黄书健撒莹朱可欣徐安民刘思雨云南大学建筑与规划学院云南大学建筑与规划学院建筑系

传统村落是中华文化的重要载体。本文采用最近邻指数、地理集中指数、不平衡指数和核密度等分析方法,结合ArcGIS10.8,对云南省777个国家级传统村落进行了空间分布特征分析。结果显示:1)云南省传统村落整体呈凝聚分布。2)市级尺度上,传... 详细信息

传统村落是中华文化的重要载体。本文采用最近邻指数、地理集中指数、不平衡指数和核密度等分析方法,结合ArcGIS10.8,对云南省777个国家级传统村落进行了空间分布特征分析。结果显示:1)云南省传统村落整体呈凝聚分布。2)市级尺度上,传统村落呈分散分布,县级尺度上则呈集中分布;不论在县域还是市域范围内,传统村落都存在不均衡分布。3)共有3个主要的高密度聚集区,分别位于滇西北、滇西及滇南地区。通过地理探测器研究方法,发现自然地理环境和社会经济环境因素交替影响传统村落的空间分异,其中自然地理环境因素具有较大影响力,特别是地形因素。在社会经济环境方面,到最近市中心距离和路网密度也有显著影响。最后,提出了以下保护管理策略:1)结合当地民族特色,打造区域传统村落名片;2)因地制宜,集中连片保护利用;3)重视地形与交通的影响作用;4)保护与发展相结合;5)构建利益共享机制。

关键词：传统村落空间分布特征地理探测器村落保护管理云南省

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谢圣芳教授辨治慢性肾衰竭并发胃肠功能紊乱经验

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基层中医药 2024年第1期3卷 1-5页

作者：朱可芯吴敏卞芝琳韩世亮谢圣芳南京中医药大学附属中西医结合医院江苏南京210028 江苏省中医药研究院江苏南京210028

胃肠功能紊乱是慢性肾衰竭常见的并发症,临床上表现为恶心、呕吐、腹痛、便秘和腹泻,严重影响患者生活质量,且目前尚无明确的有效治疗措施。谢圣芳教授(以下简称谢师)认为本病病机可归结为本虚标实,以脾肾虚衰、邪实潴留为主要病理状态... 详细信息

胃肠功能紊乱是慢性肾衰竭常见的并发症,临床上表现为恶心、呕吐、腹痛、便秘和腹泻,严重影响患者生活质量,且目前尚无明确的有效治疗措施。谢圣芳教授(以下简称谢师)认为本病病机可归结为本虚标实,以脾肾虚衰、邪实潴留为主要病理状态。治疗上以注重维护肾气、顾护脾胃为原则,遣方用药偏于和缓,攻补兼施,以缓解患者临床症状,提高生活质量和延缓生存期,对慢性肾衰竭并发胃肠功能紊乱患者疗效显著。笔者师从谢圣芳教授,长期跟诊于谢师左右,记录其临床治疗肾脏相关疾病的临证思考与见解,并举医案一则,为中医药治疗慢性肾衰竭并发胃肠功能紊乱提供新的治疗思路。

关键词：慢性肾衰竭胃肠功能紊乱医案特色经验

Near-infrared six-band polarization-independent wide-angle absorber based on metal cavity arrays filled with GaAs

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Science China(Information Sciences) 2019年第6期62卷 189-191页

作者： Dan HU Hongyan WANG Xiwei ZHANG kexin WANG Qiaofen zhu School of Physics and Electrical Engineering Anyang Normal University School of Education Information Technology and Communication Anyang Normal University School of Science Hebei University of Engineering

Dear editor,Since the first microwave metamaterial perfect absorber (MPA) was reported by Landy et al.[1],the study of metamaterial perfect absorbers has attracted attention because of their broad application prospect... 详细信息

关键词： Near-infrared six-band polarization-independent wide-angle absorber based on metal cavity arrays filled with GaAs ab Figure

Tailoring d-band center over electron traversing effect of Ni M@C-CoP(M=Zn,Mo,Ni,Co)for high-performance electrocatalysis hydrogen evolution

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Journal of Materials Science & Technology 2023年第35期166卷 164-172页

作者： Hao Luo Xudong Zhang Hui zhu kexin Zhang Fan Yang Kewei Xu Sen Yu Dagang Guo State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an710049China Center for High Performance Computing Network Information CenterXi’an Jiaotong UniversityXi’an710049China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an710049China Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an710016China

Attaining a highly efficient and inexpensive electrocatalyst is significant for the hydrogen evolution reaction(HER)but still challenging *** transition-metal phosphides(TMPs)catalysts with platinum-like electronic structures are a potential candidate for the HER,but those are prone to be strongly bound with hydrogen intermediates(H∗),resulting in sluggish HER *** we report a unique hybrid structure of CoP anchored on graphene nanoscrolls@carbon nano tubes(CNTs)scaffold(Ni M@C-CoP)encapsulating various Ni M(M=Zn,Mo,Ni,Co)bimetal nanoalloy via chemical vapor deposi-tion(CVD)growth of CNT on graphene nanoscrolls followed by the impregnation of cobalt precursors and phosphorization for efficiently electrocatalytic hydrogen *** nanoparticles mainly scattered at the tip of CNT branches which exhibited the analogical“Three-layer core-shell”*** and density functional theory(DFT)calculations consistently disclose that the encapsulated various NiMs can offer different numbers of electrons to weaken the interactions of outmost CoP with H∗and push the downshift of the d-band center to different degrees as well as stabilize the outmost CoP nanopar-ticles to gain catalytic stability via the electron traversing *** electrocatalytic HER activity can be maximumly enhanced with low overpotentials of 78 mV(alkaline)and 89 mV(acidic)at a current density of 10 mA/cm^(2) and sustained at least 24 h especially for NiZn@C-CoP *** novel system is distinct from conventional three-layer heterostructure,providing a specially thought of d-band center control engineering strategy for the design of heterogeneous catalysts and expanding to other electrocat-alysts,energy storage,sensing,and other applications.

关键词： Electron traversing effect 3D graphene/CNT CoP nanoparticle d-band center Hydrogen evolution

MOF-derived Co-MOF,O-doped carbon as trifunctional electrocatalysts to enable highly efficient Zn-air batteries and water-splitting

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Journal of Energy Chemistry 2021年第5期30卷 290-298页

作者： Xinde Duan Na Pan Can Sun kexin Zhang Xukun zhu Mingdao Zhang Li Song Hegen Zheng School of Environmental Science and Engineering Nanjing University of Information Science&TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlCollaborative Innovation Center of Atmospheric Environment and Equipment TechnologyNanjing 210044JiangsuChina State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023JiangsuChina

Development of high-efficiency non-noble electrocatalysts for oxygen reduction reaction(ORR),oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is urgently needed for high-performance Zn-air batteries and overall water ***,a facile strategy to synthesize novel Co-MOF,O-doped carbon(Co-MOF-T)based on Zn,Co-doped glucosamine and ZIF-8 by pyrolysis at temperature T was *** prepared Co-MOF-800 showed a superior oxygen reduction reaction(ORR)activity comparable to that of commercial Pt/C *** addition,this catalyst shows great potential in the overall water splitting due to the excellent oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)*** on the trifunctional activity,the primary Zn-air batteries using a Co-MOF-800 air electrode achieved a high open-circuit voltage of 1.38 V,a specific capacity of 671.6 mAh g^(-1) Zn,and a prominent peak power density of 144 mW cm^(-2).Also,the rechargeable Zn-air batteries based on CoMOF-800 air electrode could be smoothly run for 510 cycles with a low voltage gap of 0.58 ***,the trifunctional Co-MOF-800 catalyst was applied to boost the electrochemical water splitting,demonstrating its promising potential as a green energy material for practical applications.

关键词： Metal-organic frameworks Carbon catalysts Trifunctional electrocatalyst Metal-air batteries Water splitting

Effect of spinal manipulation on degenerative scoliosis

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Journal of Traditional Chinese Medicine 2020年第6期40卷 1033-1040页

作者： Sun Wu Gao Jinghua zhu Liguo Wang Baojian Xiao Wei Wang Zhenzhong Yang kexin Spine Department 2 Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing 100102China State Key Laboratory of Pharmaceutical New-Tech for Chinese Medicine Jiangsu Kanion Pharmaceutical Co.Ltdv Lianyungang 222001Jiangsu ProvinceChina

OBJECTIVE:To investigate the effect of spinal manipulation(SM)on degenerative scoliosis by evaluating patients’visual analog scale(VAS)scores,Cobb angles,sagittal vertical axis(SVA),and apical vertebral rotation(AVR)and to explore factors that influence treatment ***:A total of 55 patients with degenerative scoliosis received 4 weeks of *** treatment,patients were divided into two groups:the remission group(VAS score<40 mm)and the non-remission group(VAS score≥40 mm).Pre-versus post-treatment VAS scores,Cobb angles,SVA,and AVR were compared in each group and in the total *** data(sex,age,symptom characteristics,duration of symptoms,VAS score,Cobb angle,SVA,and AVR)were compared between *** influencing the post-treatment VAS score were explored with multiple linear regression ***:No changes were found in the Cobb angle(P=0.722)or AVR(P=0.424)after intervention in the overall ***,the SVA(P<0.001)and VAS score(P=0.000)changed significantly after *** changes were observed in the remission group(n=29).Multiple linear regression revealed that the only factors influencing treatment effect were symptom characteristics,SVA,and VAS ***:SM relieved pain and improved sagittal imbalance in patients with degenerative *** did not lessen the severity of coronal curvature or vertebral *** influencing the effect of SM included symptom characteristics,VAS score,and SVA.A larger randomized trial is needed to further confirm our results.

关键词： Manipulation spinal Scoliosis Cobb angle Sagittal vertical axis Apical vertebral rotation

SD-265法用于改善新冠相关被隔离者睡眠的探讨和思考

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世界睡眠医学杂志 2021年第7期8卷 1279-1281页

作者：李红岩段莹陈铁光朱可欣叶永铭孙书臣中国中医科学院广安门医院(南区)睡眠医学中心北京102618 空军特色医学中心睡眠医学中心北京100142 中国中医科学院广安门医院针灸科北京100053

新型冠状病毒肺炎自报道以来已经在世界范围广泛流行,集中隔离或居家隔离是疫情防控中十分重要的组成部分,现有研究表明大量被隔离者睡眠质量下降。SD-265法是一种中医与现代睡眠医学结合的灵活有效的方法,是在“天人合一、阴平阳秘”... 详细信息

新型冠状病毒肺炎自报道以来已经在世界范围广泛流行,集中隔离或居家隔离是疫情防控中十分重要的组成部分,现有研究表明大量被隔离者睡眠质量下降。SD-265法是一种中医与现代睡眠医学结合的灵活有效的方法,是在“天人合一、阴平阳秘”的思想指导下,充分考虑环境和人体的昼夜特点。结合中药药物剂型合理转换应用、传统功法和现代睡眠医学的认知行为治疗形成的一套以中医整体观为指导,突出医患互动治疗为特点的睡眠紊乱干预方法。将此方法应用于改善被隔离者睡眠获得较好的疗效,值得进一步研究完善和推广应用。

关键词：失眠新型冠状病毒肺炎隔离中医新方法

A closer look at the belief propagation algorithm in side-channel attack on CCA-secure PQC KEM

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Science China(Information Sciences) 2024年第11期67卷 317-334页

作者： kexin QIAO Zhaoyang WANG Heng CHANG Siwei SUN Zehan WU Junjie CHENG Changhai OU An WANG Liehuang zhu School of Cyberspace Science and Technology Beijing Institute of Technology State Key Laboratory of Cryptology School of Cryptology University of Chinese Academy of Sciences School of Cyber Science and Engineering Wuhan University

The implementation security of post-quantum cryptography(PQC) algorithms has emerged as a critical concern with the PQC standardization process reaching its end. In a side-channel-assisted chosen-ciphertext attack, the attacker builds linear inequalities on secret key components and uses the belief propagation(BP) algorithm to solve. The number of inequalities leverages the query complexity of the attack, so the fewer the better. In this paper, we use the PQC standard algorithm CRYSTALS-KYBER as a study case to construct bilateral inequalities on key variables with substantially narrower intervals using a side-channel-assisted oracle. For KYBER512, KYBER768, and KYBER1024, the average Shannon entropy carried by such inequality is improved from the previous 0.6094, 0.4734, and 0.8544 to 0.6418, 0.4777, and 1.2007. The number of such inequalities required to recover the key utilizing the BP algorithm for KYBER512 and KYBER1024 is reduced by 5.32% and 40.53% in theory and experimentally the reduction is even *** query complexity is reduced by 43%, 37%, and 48% for KYBER512, 768, and 1024 assuming reasonably perfect reliability. Furthermore, we introduce a strategy aimed at further refining the interval of *** into the BP algorithm, we discover a measure metric named JSD(Jensen-Shannon distance)-metric that can gauge the tightness of an inequality. We then develop a machine learning-based strategy to utilize the JSD-metrics to contract boundaries of inequalities even with fewer inequalities given, thus improving the entropy carried by the system of linear inequalities. This contraction strategy is at the algorithmic level and has the potential to be employed in all attacks endeavoring to establish a system of inequalities concerning key variables.

关键词： Kyber chosen-ciphertext attack side-channel belief propagation contraction strategy machine learning