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Understanding the mechanistic regulation of ferroptosis in cancer:the gene matters

Journal of Genetics and Genomics 2022年第10期49卷 913-926页

作者： Min gao kexin Fan Yuhan Chen Guangjian Zhang Jing Chen Yilei Zhang The Institute of Molecular and Translational Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesXi'an Jiaotong University Health Science CenterXi'anShaanxi 710061China Department of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Department of Obstetrics Xi'an New Chang'an Maternity HospitalXi'anShaanxi 710001China Shaanxi Stem Cell Engineering Application Research Center Shaanxi Jiuzhou Biomedical Science and Technology GroupXi'anShaanxi 710065China

Ferroptosis has emerged as a crucial regulated cell death involved in a variety of physiological processes or pathological diseases,such as tumor suppression.Though initially being found from anticancer drug screening and considered not essential as apoptosis for growth and development,numerous studies have demonstrated that ferroptosis is tightly regulated by key genetic pathways and/or genes,including several tumor suppressors and oncogenes.In this review,we introduce the basic concepts of ferroptosis,characterized by the features of non-apoptotic,iron-dependent,and overwhelmed accumulation of lipid peroxides,and the underlying regulated circuits are considered to be pro-ferroptotic pathways.Then,we discuss several established lipid peroxidation defending systems within cells,including SLC7A11/GPX4,FSP1/CoQ,GCH1/BH4,and mitochondria DHODH/CoQ,all of which serve as anti-ferroptotic pathways to prevent ferroptosis.Moreover,we provide a comprehensive summary of the genetic regulation of ferroptosis via targeting the above-mentioned pro-ferroptotic or anti-ferroptotic pathways.The regulation of proand anti-ferroptotic pathways gives rise to more specific responses to the tumor cells in a contextdependent manner,highlighting the unceasing study and deeper understanding of mechanistic regulation of ferroptosis for the purpose of applying ferroptosis induction in cancer therapy.

关键词： Ferroptosis Ferroptotic pathways Genetic regulation Tumor suppression Cancer therapy

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CRISPR/Cas:a potential gene-editing tool in the nervous system

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Cell Regeneration 2020年第1期9卷 122-129页

作者： Yanxia gao Kexin Gao Hui Yang Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Research Center for Brain Science and Brain-Inspired IntelligenceShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

The rapidly developmental RNA-guided CRISPR/Cas system is a powerful tool for RNA and DNA editing in a variety of cells from different species and makes a great contribution to gene function research,disease model generation and gene therapy development in the past few years.The ease of use,low cost and high efficiency of CRISPR/Cas make it commonly used in various conditions.In this review,we introduce the CRISPR/Cas system and its diverse applications in nervous system briefly,which provides a better understanding for its potential application values.

关键词： CRISPR/Cas system potential

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Effect of Microstructural Characteristics on Fracture Toughness in Direct Energy Deposited Novel Ti-6Al-4V-1Mo Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 119-131页

作者： Chao Xia kexin Zhao Xin Zhou Yuqi He Panpan gao Hengxin Zhang Guangrui gao Fengying Zhang Hua Tan School of Material Science and Engineering Chang’an UniversityXi’an710064China Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi’an710038China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China Surface Material Protection Co. LtdXi’an710018China

Meeting the damage tolerance requirements for engineering-grade titanium alloys pose a significant challenge in achieving high fracture toughness in direct energy deposition(DED)titanium alloys.This work primarily investigated the relationship between the microstructure and the fracture toughness of DED new Ti-6Al-4V-1Mo alloy.Two types of microstructures were designed via two process strategies:high-line energy density(HE)and low-line energy density(LE).Relative to LE samples,HE samples possess larger-sized microstructural characteristics(coarser grain boundaryα(α_(GB)),largerαcolonies,and coarserαlaths).Lessα/βphase boundaries were formed by coarserαlaths in the HE samples,increasing the movement of dislocations,resulting in tensile strength decreasing from 1007.1 MPa(LE)to 930.8 MPa(HE)and elongation increasing from 10.8%(LE)to 15.7%(HE).Also,HE samples exhibited an excellent fracture toughness of 114.0 MPa m^(1/2),significantly higher than that of LE samples(76.8 MPa m^(1/2)).An analysis of crack propagation paths was conducted to investigate the factors contributing to toughening.The primary factor enhancing toughness is the frequent obstruction of cracks by coarseαGB and largeαcolonies in HE samples.Particularly,the pretty large-angle deflections induced by the superposition effect of coarseαGB and largeαcolonies play a vital of significant role.These factors induced the long and tortuous high-energy pathways,which resulted in ultimately improved fracture toughness.The discovered microstructural toughening mechanisms can serve as a reference for future studies involving titanium alloys,offering insights on how to enhance fracture toughness by achieving similar characteristics.

关键词： Direct energy deposition Ti-6Al-4V-1Mo Tensile properties Fracture toughness Crack propagation

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Preparation of vapreotide-templated silver nanocages and their photothermal therapy efficacy

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Chinese Journal of Chemical Engineering 2018年第7期26卷 1586-1590页

作者： Ruiyan Zhu Yanji Li kexin Bian Zhengrong gao Dawei gao Applied Chemistry Key Lab of Hebei Province Department of BioengineeringYanshan UniversityQinhuangdao 066004China Hebei Province Asparagus Industry Technology Research Institute Qinhuangdao 066004China Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China

Vapreotide acetate(Vap) was used as a biotemplate to synthesize silver nanocages through direct co-incubation of a AgNO_3 solution, following by reduction using fresh NaBH_4. The characterized vapreotide-templated silver nanocages(Vap-Ag ) presented a wide and red shifted absorption band with a maximum between 480 nm and 800 nm and possessed a uniform structure with a face-centered cubic crystal structure. The biocompatibility of Vap-AgN Cs was assessed using the MTT method, indicating Vap-AgN Cs had better biocompatibility when its concentration was lower than 2.5 × 10^(-4) mmol·L^(-1). The photothermal characteristics of Vap-Ag NCs were analyzed with laser irradiation(808 nm, 1.5 W·cm^(-2)) and the results showed that the temperature of the VapAg NCs solution reached 45 °C starting from 25 °C within 5 min. Additionally, Vap-Ag NCs with a laser led to HeL a cell death. Therefore, the prepared Vap-AgN Cs is expected to be an effective photothermal therapy agent.

关键词：治疗功效模板银 AgNO3 NaBH4 一致结构水晶结构 HeLa

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重庆与欧盟合作项目进展良好未来发展可期

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重庆与世界 2023年第6期 18-19页

作者： gao Xiang Niu kexin 重庆市政府外办重庆日报

欧盟国家是重庆十分重要的对外交往合作对象，双方在经贸、科技、教育、文化等领域开展了全面且富有成果的交流与合作。记者5月25日从市政府外办了解到，重庆与欧盟合作项目进展良好，未来发展可期。据介绍，中欧班列（重庆）与欧盟国...

欧盟国家是重庆十分重要的对外交往合作对象，双方在经贸、科技、教育、文化等领域开展了全面且富有成果的交流与合作。记者5月25日从市政府外办了解到，重庆与欧盟合作项目进展良好，未来发展可期。据介绍，中欧班列（重庆）与欧盟国家物流交往势头良好。自2011年以来，中欧班列（重庆）已发运超1.2万列，其中直达欧盟国家的班列已累计开行近6500列。目前，中欧班列（重庆）已开行直达欧盟国家铁路线路近20条，已在欧盟15个国家45个城市建立集结分拨点，运输辐射范围可覆盖欧盟全境。

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Research on the Theory of Governmental Environmental Regulatory Responsibility

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环境科学前沿（中英文版） 2023年第1期10卷 1-3页

作者： Kexin Gao Beijing Zhongyin(Shenzhen)Law Firm

In recent years,the environmental pollution caused by the rapid development of tourist attractions has increasingly become the focus of society,which has triggered scholars to think about the government's responsibility for environmental regulation,and has generated a variety of theories in the academic world.For example,the stakeholder theory extends corporate governance to the regulation of tourism scenic spots,and achieves the purpose of perfecting the environmental regulation of tourism scenic spots by continuously enriching the scope of stakeholders'subjects;the property rights theory analyzes the transaction costs generated by various economic activities in the regulation of tourism scenic spots from macro and micro perspectives,and the public goods theory clarifies the concept,types and characteristics of tourism scenic spots as public goods.Therefore,based on stakeholder theory,property rights theory and public goods theory,this paper explores and clarifies the content of the government's responsibility in the environmental regulation of tourism scenic spots,and tries to further enrich the theoretical results of the government's environmental regulation responsibility,in order to provide new ideas for the sustainable development of tourism scenic spots from the theoretical point of view.

关键词： Tourist Attractions Stakeholders Environmental Regulation Model

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CMIP6和CMIP5模式对中国极端温度的模拟能力的评估

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Atmospheric and Oceanic Science Letters 2020年第6期13卷 589-597页

作者： LUO Neng GUO Yan gao Zhibo CHEN kexin CHOU Jieming State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijingChina Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) GuangzhouChina Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

本文评估了CMIP5和CMIP6模式对中国在1979-2005年期间的极端温度的模拟性能。结果表明:CMIP6模式可以很好地再现年最大日最高气温,年最小日最低气温和霜冻日数的空间分布特征。对于年最大日最高气温,持续暖日日数和暖昼,CMIP6模式间的... 详细信息

本文评估了CMIP5和CMIP6模式对中国在1979-2005年期间的极端温度的模拟性能。结果表明:CMIP6模式可以很好地再现年最大日最高气温,年最小日最低气温和霜冻日数的空间分布特征。对于年最大日最高气温,持续暖日日数和暖昼,CMIP6模式间的不确定性相对于CMIP5模式有所降低。并且,CMIP6模式也能表现出观测到的极端温度的趋势。然而,CMIP6模式再现暖昼和冷夜的能力仍然不足,特别是在青藏高原上存在明显的冷偏差或者暖偏差对于某些指数。单个CMIP6或CMIP5模式的模拟能力就不同的指数而有所不同,某些模式的模拟能力较为突出。对于一些来自同一机构不同版本的模式,改进的CMIP6模式与CMIP5模式的模拟结果没有明显差异。多模式中位数平均的模拟效果优于大多数单个模式。

关键词：极端温度中国 CMIP6 CMIP5 模式评估

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2023“一带一路”陆海联动发展论坛在重庆开幕共享“一带一路”发展新机遇共创陆海联动发展新未来袁家军出席开幕式并致辞顺通·赛雅佳阿贡·拉克索诺郭业洲致辞戴夫·拉克索诺坎葆·恩塔万出席胡衡华主持唐方裕出席

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重庆与世界 2023年第6期 20-24页

作者： gao Xiang Yang Zeyun Niu kexin 重庆市政府外办重庆日报

5月17日，2023“一带一路”陆海联动发展论坛在重庆开幕。论坛由“一带一路”智库合作联盟和重庆市人民政府主办，中共中央对外联络部当代世界研究中心和重庆市人民政府外事办公室承办。来自“一带一路”合作伙伴国家的政党政要、智库...

5月17日，2023“一带一路”陆海联动发展论坛在重庆开幕。论坛由“一带一路”智库合作联盟和重庆市人民政府主办，中共中央对外联络部当代世界研究中心和重庆市人民政府外事办公室承办。来自“一带一路”合作伙伴国家的政党政要、智库学者、工商界人士，汇聚山城重庆，共谋发展大计、共享发展机遇，共创陆海联动发展新未来。

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Effect of riboflavin deficiency on intestinal morphology,jejunum mucosa proteomics,and cecal microbiota of Pekin ducks

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Animal Nutrition 2023年第1期12卷 215-226页

作者： Yaxi Xu Bo Zhang Rui Zhao Kexin Gao Suyun Liang Yongbao Wu Yongsheng Hao Dapeng Liu Zhanbao Guo Jian Hu Zhengkui Zhou Ming Xie Jing Tang State Key Laboratory of Animal Nutrition Key Laboratory of Animal(Poultry)Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

This study was to determine the effects of riboflavin deficiency(RD)on intestinal development,jejunum mucosa proteome,cecal short-chain fatty acids(SCFA)profiling,and cecal microbial diversity and community of starter Pekin ducks.Male white Pekin ducks(1 d old,n=240)were allocated into 2 groups,with 12 replicates and 10 birds per replicate in each group.For 21 d,all ducks had ad libitum access to either an RD or a riboflavin adequate(control,CON)diet,formulated by supplementing a basal diet with 0 or 10 mg riboflavin per kg of diet,respectively.Compared to the CON group,growth retardation,high mortality,and poor riboflavin status were observed in the RD group.Furthermore,RD reduced the villus height and the ratio of villus height to crypt depth of jejunum and ileum(P<0.05),indicating morphological alterations of the small intestine.In addition,dietary RD enhanced relative cecum weight and decreased cecal SCFA concentrations(P<0.05),including propionate,isobutyrate,butyrate,and isovalerate.The jejunum mucosa proteomics showed that 208 proteins were upregulated and 229 proteins were downregulated in the RD group compared to those in the CON group.Among these,RD mainly suppressed intestinal absorption and energy generation processes such as glycolysis and gluconeogenesis,fatty acid beta oxidation,tricarboxylic acid cycle,and oxidative phosphorylation,leading to impaired ATP generation.In addition,RD decreased the community richness and diversity of the bacterial community in the cecum of ducks.Specifically,RD reduced the abundance of butyrate-producing bacteria in the cecum(P<0.05),such as Eubacterium coprostanoligenes,Prevotella and Faecalibacterium.Dietary RD resulted in growth depression and intestinal hypofunction of Pekin ducks,which could be associated with impaired intestinal absorption and energy generation processes in intestinal mucosa,as well as gut microbiota dysbiosis.These findings contribute to our understanding of the mechanisms of intestinal hypofunction due to RD.

关键词： Riboflavin Deficiency Intestinal morphology Proteomics Cecal microbiota Short-chain fatty acids

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Research progress on space charge layer effect in lithium-ion solid-state battery

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Science China(Technological Sciences) 2022年第10期65卷 2246-2258页

作者： ZHANG Qian KONG YaQi gao kexin WEN YaJing ZHANG Qi FANG HuaYi MA ChunJie DU YaPing Department of Applied Chemistry Xi’an University of TechnologyXi’an 710048China Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional MaterialsSchool of Materials Science and Engineering&National Institute for Advanced MaterialsNankai UniversityTianjin 300350China Shaanxi Lanwan Jinping New Energy Co. Ltd.Weinan 714000China

The development of lithium-ion solid electrolyte provides new ideas for solving the safety problems of secondary lithium-ion batteries(LIB) and, at the same time, the improvement of energy density. However, the consequent solid-solid interfacial problems have become a typical bottleneck to the performance. It has been considered that the space charge layer(SCL) formed at the interface to balance the sharp electrochemical inherent difference of properties is one of the most important factors that affect the ion transportation along and across the interface. Its existence may hinder ion transportation and increase the interfacial impedance but may also help to provide a new percolation path for lithium ion and so to enhance the ion migration. However the mechanism of SPL formation and its regulation on ion transport is not very clear, so it has raised a lot of attention and interest from LIB researchers. The purpose of this article is to try to gain some knowledge of SCL and, at the same time to browse through the related research in recent years. Hopefully, it may help those interested in solid electrolyte development for all-solidstate lithium-ion batteries(ASSB) in the future.

关键词： space charge layer interface solid electrolyte lithium-ion battery

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