Understanding the mechanistic regulation of ferroptosis in cancer:the gene matters

作     者：Min Gao Kexin Fan Yuhan Chen Guangjian Zhang Jing Chen Yilei Zhang Min Gao;Kexin Fan;Yuhan Chen;Guangjian Zhang;Jing Chen;Yilei Zhang

作者机构：The Institute of Molecular and Translational MedicineDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesXi'an Jiaotong University Health Science CenterXi'anShaanxi 710061China Department of Thoracic SurgeryThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Department of ObstetricsXi'an New Chang'an Maternity HospitalXi'anShaanxi 710001China Shaanxi Stem Cell Engineering Application Research CenterShaanxi Jiuzhou Biomedical Science and Technology GroupXi'anShaanxi 710065China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2022年第49卷第10期

页      面：913-926页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the funding support from National Natural Science Foundation of China(82103272 to Y.Zhang) Xi’an Jiaotong University(xtr042021011 to Y.Zhang) Department of Science and Technology of Shaanxi Province(2022KW-48 to J Chen) supported by Top Young Talents Programme at Xi’an Jiaotong University 

主　　题：Ferroptosis Ferroptotic pathways Genetic regulation Tumor suppression Cancer therapy 

摘      要：Ferroptosis has emerged as a crucial regulated cell death involved in a variety of physiological processes or pathological diseases,such as tumor *** initially being found from anticancer drug screening and considered not essential as apoptosis for growth and development,numerous studies have demonstrated that ferroptosis is tightly regulated by key genetic pathways and/or genes,including several tumor suppressors and *** this review,we introduce the basic concepts of ferroptosis,characterized by the features of non-apoptotic,iron-dependent,and overwhelmed accumulation of lipid peroxides,and the underlying regulated circuits are considered to be pro-ferroptotic ***,we discuss several established lipid peroxidation defending systems within cells,including SLC7A11/GPX4,FSP1/CoQ,GCH1/BH4,and mitochondria DHODH/CoQ,all of which serve as anti-ferroptotic pathways to prevent ***,we provide a comprehensive summary of the genetic regulation of ferroptosis via targeting the above-mentioned pro-ferroptotic or anti-ferroptotic *** regulation of proand anti-ferroptotic pathways gives rise to more specific responses to the tumor cells in a contextdependent manner,highlighting the unceasing study and deeper understanding of mechanistic regulation of ferroptosis for the purpose of applying ferroptosis induction in cancer therapy.