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Isolated left ventricular apical hypoplasia:Systematic review and analysis of the 37 cases reported so far

世界临床病例杂志 2023年第23期11卷 5494-5503页

作者： pier paolo Bassareo Sophie Duignan Adam James Esme Dunne Colin J McMahon kevin p walsh University College of Dublin School of Medicine and Department of Cardiology at Mater Misericordiae University HospitalDublin D07 R2WYIreland Department of Cardiology Children's Health CrumlinDublin D12 N512Ireland University College of Dublin School of Medicine and Department of CardiologyChildren's Health IrelandDublin D12 N512Ireland

BACKGROUND Isolated left ventricular apical hypoplasia(ILVAH),also known as truncated left ventricle(LV),is a very unusual *** is characterised by a truncated,spherical,and non-apex forming *** true apex is occupied by the right *** to the rarity of the disease,just a few case reports and limited case series have been published in the *** To analysing the so far 37 reported ILVAH cases *** The electronic databases pubMed and Scopus were investigated from their establishment up to December 13,*** The majority of cases reported occurred in males(52.7%).Mean age at diagnosis was 26.1±19.6 *** than a third of the patients were asymptomatic(35.1%).The most usual clinical presentation was breathlessness(40.5%).The most commonly detected electrocardiogram changes were T wave abnormalities(29.7%)and right axis deviation with poor R wave progression(24.3%).Atrial fibrillation/flutter was detected in 24.3%.Echocardiography was performed in 97.3%of cases and cardiac MRI in 91.9%of *** fraction was reduced in more than a half of patients(56.7%).An associated congenital heart disease was found in 16.2%.Heart failure therapy was administered in 35.1%of *** outcome was favorable in the vast majority of patients,with just one *** ILVAH is a multifaceted entity with a so far unpredictable course,ranging from benign until the elderly to sudden death during adolescence.

关键词： Isolated left ventricular apical hypoplasia Truncated left ventricle Electrocardiography Echocardiography Cardiac magnetic resonance imaging Heart failure

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Use of the GORE^(®) DrySeal Flex Introducer Sheath to Facilitate Implantation of the Transcatheter Venus p-valve

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Congenital Heart Disease 2021年第3期16卷 197-203页

作者： Matthew I.Jones Matthew Murphy Eric Rosenthal kevin p.walsh Damien Kenny Shakeel A.Qureshi Gianfranco Butera Department of Congenital Cardiology Evelina London Children’s HospitalGuy’s&St Thomas’NHS Foundation TrustLondonUK Department of Cardiology Mater Misericordiae University HospitalDublinIreland Department of pediatric Cardiology Our Lady’s Children’s HospitalDublinIreland School of Biomedical Engineering and Imaging Sciences Kings CollegeLondonUK

Objectives:We report our experience of using the 65 cm large diameter GORE^(®) DrySeal Flex Introducer sheath to facilitate transcatheter implantation of the Venus p-valve in the pulmonary ***:Transcatheter implantation of pulmonary valves can be difficult due to rigidity of the valve delivery system or the anatomy of the RVOT and pulmonary artery bifurcation and the risk of iatrogenic damage to the tricuspid valve support *** long sheaths to pass and protect the tricuspid valve may facilitate the ***:Multi-centre registry of patients who underwent transcatheter pulmonary valve implantation of the Venus p-valve using the GORE^(®) DrySeal Flex introducer sheath to facilitate passage of the valve to the right ventricular outflow *** success,time to valve implantation and radiation safety parameters were *** data were compared to a control group of subjects treated between July 2014 and May 2016 with the same valve but without the use of GORE^(®) ***:Between December 2016 and September 2018,the Venus p-valve was successfully deployed through the GORE^(®) DrySeal in 12 *** were no procedure-related *** a control group,10 subjects treated between July 2014 and May 2016 were *** procedure time was significantly shorter in the GORE^(®) DrySeal group compared to the control group 96±27 min vs.164±12 min(pp(24±11 min)when compared with the control group(32±14 min,ppreviously described techniques of implanting the Venus p-valve in the pulmonary position after surgical repair of congenital heart *** our experience,the GORE^(®) DrySeal sheath has considerably facilitated the procedure and reduced the potential risks.

关键词： Congenital heart disease percutaneous pulmonary valve

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A thermodynamic perspective on electrode poisoning in solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1449-1455页

作者： kevin Huang Department of Mechanical Engineering University of South CarolinaColumbiaUSA

A critical challenge to the commercialization of clean and high-efficiency solid oxide fuel cell(SOFC)technology is the insuf-ficient stack lifespan caused by a variety of degradation mechanisms,which are associated with cell components and chemical *** components related degradation refers to thermal/chemical/electrochemical deterioration of cell materials under operating conditions,whereas the latter regards impurities in feedstocks of oxidant(air)and reductant(fuel).This article provides a thermodynamic perspective on the understanding of the impurities-induced degradation mechanisms in *** discussion focuses on using thermodynamic ana-lysis to elucidate poisoning mechanisms in cathodes by impurity species such as Cr,CO_(2),H_(2)O,and SO_(2) and in the anode by species such as S(or H_(2)S),SiO_(2),and p_(2)(or pH_(3)).The author hopes the presented fundamental insights can provide a theoretical foundation for search-ing for better technical solutions to address the critical degradation challenges.

关键词： impurities air fuel reaction activity

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Integrated photonic fractional convolution accelerator

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photonics Research 2024年第8期12卷 1828-1839页

作者： kevin ZELAYA MOHAMMED-ALI MIRI Department of physics Queens College of the City University of New YorkQueensNew York 11367USA physics program The Graduate Center of the City University of New YorkNew YorkNew York 10016USA

An integrated photonic circuit architecture to perform a modified-convolution operation based on the discrete fractional Fourier transform(DFrFT) is introduced. This is accomplished by utilizing two nonuniformly coupled waveguide lattices with equally spaced eigenmode spectra, the lengths of which are chosen so that the DFrFT and its inverse operations are achieved. A programmable modulator array is interlaced so that the required fractional convolution operation is performed. Numerical simulations demonstrate that the proposed architecture can effectively perform smoothing and edge detection tasks even for noisy input signals, which is further verified by electromagnetic wave simulations. Notably, mild lattice defects do not jeopardize the architecture performance, showing its resilience to manufacturing errors.

关键词： fractional convolution utilizing

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Neurolithography:Lithography as an enabling technology in neurology and neuroscience

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Medicine in Novel Technology and Devices 2024年第2期22卷 15-18页

作者： kevin Zhai Department of Medical Education Weill Cornell Medicine-QatarP.O.Box 24144DohaQatar

Modern lithography,which enables the fabrication of complex structures in biomedical devices with exceptional precision,is a potentially transformative force in the neural *** such as photolithography,electron beam lithography,and soft lithography have been utilized to produce devices that guide neuronal growth and differentiation and measure electrophysiological signals at the single-cell *** the clinical sphere,lithography plays a role in the manufacturing of devices for deep brain stimulation,brain-computer interface,and ***,we briefly review the applications of lithography in basic and translational neuroscience and clinical neurology,with an eye toward future advancement.

关键词： Lithography Neurolithography Semiconductors Microfluidics Neural devices

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An Efficient Smoothing and Thresholding Image Segmentation Framework with Weighted Anisotropic-Isotropic Total Variation

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1369-1405页

作者： kevin Bui Yifei Lou Fredrick park Jack Xin Department of Mathematics University of CaliforniaIrvineIrvineCA 92697-3875USA Department of Mathematics University of North CarolinaChapel HillChapel HillNC 27599.USA Department of Mathematics and Computer Science Whittier CollegeWhittierCA 90602USA

In this paper,we design an efficient,multi-stage image segmentation framework that incorporates a weighted difference of anisotropic and isotropic total variation(AITV).The segmentation framework generally consists of two stages:smoothing and thresholding,thus referred to as smoothing-and-thresholding(SaT).In the first stage,a smoothed image is obtained by an AITV-regularized Mumford-Shah(MS)model,which can be solved efficiently by the alternating direction method of multipliers(ADMMs)with a closed-form solution of a proximal operator of the l_(1)-αl_(2) *** convergence of the ADMM algorithm is *** the second stage,we threshold the smoothed image by K-means clustering to obtain the final segmentation *** experiments demonstrate that the proposed segmentation framework is versatile for both grayscale and color images,effcient in producing high-quality segmentation results within a few seconds,and robust to input images that are corrupted with noise,blur,or *** compare the AITV method with its original convex TV and nonconvex TVp(Opparts,showcasing the qualitative and quantitative advantages of our proposed method.

关键词： Image segmentation Non-convex optimization Mumford-Shah(MS)model Alternating direction method of multipliers(ADMMs) proximal operator

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Creation and validation of a novel low-cost dry lab for early resident training and assessment of robotic prostatectomy technical proficiency

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Current Urology 2024年第2期18卷 133-138页

作者： kevin Kunitsky Abhishek Venkataramana Katherine E.Fero Jorge Ballon Jacob Komberg Robert Reiter Wayne Brisbane Institute of Urologic Oncology Department of UrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFLUSA

purpose:To evaluate the preliminary validity and acceptability of a low-cost low-fidelity robotic surgery dry lab for training and assessing residents’technical proficiency with key robotic radical prostatectomy *** and methods:Three standardized inanimate tasks were created to simulate the radical prostatectomy steps of posterior dissection,neurovascular bundle release,and urethrovesical *** trainees and faculty at a single institution completed and evaluated each dry lab *** validity was evaluated by comparing task completion times and Global Evaluative Assessment of Robotic Skills scores across four participant cohorts:medical students(n=5),junior residents(n=5),senior residents(n=5),and attending surgeons(n=7).Content validity,face validity,and acceptabilitywere evaluated through a posttask survey using a 5-point Likert ***:There was a significant difference in the individual and composite task completion times and Global Evaluative Assessment of Robotic Skills scores across all participant cohorts(all pptability for use in residency ***,model realism,compared with human tissue,was poorly *** dry lab production cost was less than US$***:This low-cost procedure-specific dry lab demonstrated evidence of content validity,construct validity,and acceptability for simulating key robotic prostatectomy technical steps and can be used to augment robot-assisted laparoscopic prostatectomy surgical training.

关键词： Robotic surgery education Radical prostatectomy Simulation Dry laboratory Validation

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Knowledge, attitudes, and practices regarding Covid-19 and their relationship with Covid-19 booster vaccination status among women with infertility

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Asian pacific Journal of Reproduction 2024年第2期13卷 68-75页

作者： Gita pratama Mila Maidarti Kanadi Sumapradja Achmad Kemal Harzif Natasha Talya kevin Ezekia Irfan Arieqal Hatta Ampri Reproductive Immunoendocrinology Division Department of Obstetrics and GynecologyFaculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia Yasmin IVF Clinic dr.Cipto Mangunkusumo General Hospital JakartaIndonesia Human Reproduction Infertilityand Family Planning ClusterIndonesia Reproductive Medicine Research and Training CenterFaculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia

Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with ***:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,*** assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic ***:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 *** the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,p=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,p=0.56).participants’knowledge about vaccines and infertility was correlated with booster vaccination status(p=0.04).Academic background(p=0.01)and attitudes(p=0.01)were also correlated with booster vaccination *** significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding *** participants had poor knowledge about the relationship between infertility and the Covid-19 *** general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.

关键词： Covid-19 Booster vaccine Infertility Knowledge Attitude practice Human reproduction pandemic

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen kevin Li Arka Majumdar pJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of physics University of WashingtonSeattleWA98195USA Department of physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied physics program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIps)are capable of forming hybrid light-matter states known as exciton-polaritons(E–ps)when the excitonic medium is confined in an optical *** the case of 2D HOIps,they can self-hybridize into E–ps at specific thicknesses of the HOIp crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–ps in 2D HOIps,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIp crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–p *** E–ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–ps to lower energy E–***,we also demonstrate that E–ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Interfacial engineering through lead binding using crown ethers in perovskite solar cells

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Journal of Energy Chemistry 2024年第5期92卷 263-270页

作者： Sun-Ju Kim YeonJu Kim Ramesh Kumar Chitumalla Gayoung Ham Thanh-Danh Nguyen Joonkyung Jang Hyojung Cha Jovana Milić Jun-Ho Yum kevin Sivula Ji-Youn Seo Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Laboratory for Molecular Engineering of Optoelectronic Nanomaterials Institute of Chemical Sciences and EngineeringÉcole Polytechnique Fédérale de Lausanne(EPFL)1015 LausanneSwitzerland Department of Energy Convergence and Climate Change Kyungpook National UniversityDaegu 41566Republic of Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea Adolphe Merkle Institute University of FribourgCH-1700 FribourgSwitzerland

In the domain of perovskite solar cells(pSCs),the imperative to reconcile impressive photovoltaic performance with lead-related issue and environmental stability has driven innovative *** study pioneers an approach that not only rectifies lead leakage but also places paramount importance on the attainment of rigorous interfacial *** ethers,notably benzo-18-crown-6-ether(B18C6),were strategically integrated at the perovskite-hole transport material *** ethers exhibit a dual role:efficiently sequestering and immobilizing pb^(2+)ions through host-guest complexation and simultaneously establishing a robust interfacial passivation *** crown ether candidates,guided by density functional theory(DFT)calculations,demonstrated proficiency in binding pb2+ions and optimizing interfacial *** devices incorporating these materials achieved exceptional power conversion efficiency(pCE),notably 21.7%for B18C6,underscoring their efficacy in lead binding and interfacial *** techniques,including time-of-flight secondary ion mass spectrometry(ToF-SIMS),ultraviolet photoelectron spectroscopy(UpS),time-resolved photoluminescence(TRpL),and transient absorption spectroscopy(TAS),unequivocally affirmed pb^(2+)ion capture and suppression of non-radiative ***,these pSCs maintained efficiency even after enduring 300 h of exposure to 85%relative *** research underscores the transformative potential of crown ethers,simultaneously addressing lead binding and stringent interfacial passivation for sustainable pSCs poised to commercialize and advance renewable energy applications.

关键词： perovskite solar cells Interfacial passivation Crown ether materials Stability

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