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Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases

World Journal of Gastroenterology 2013年第1期19卷 115-121页

作者： Ana paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner kevin p high Caryn G Morse Section of Infectious Diseases Department of MedicineWake Forest School of MedicineWinston-SalemNC 27109-7205United States Liver Diseases Branch National Institute of DiabetesDigestive and Kidney DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Laboratory of Immunoregulation National Institute of Allergy and Infectious DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Division of Infectious Diseases and Immunology Department of MedicineNew York University School of MedicineNew YorkNY 10016United States Laboratory of pathology Wake Forest School of MedicineWinston-SalemNC 27109-7205United States Laboratory of pathology National Cancer InstituteNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Department of Critical Care Medicine National Institutes of Health Clinical CenterBethesdaMD 20892-1403United States

Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to *** in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not *** date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected *** report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated *** includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis *** HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral *** was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other *** HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes.

关键词： Human immunodeficiency virus Antiretroviral therapy Vanishing bile duct syndrome Ductopenia Liver biopsy

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pRESSURE－INDUCED 4p→4s ELECTRON TRANSFER AND ITS EFFECT ON ELECTRICAL TRANSpORT OF COppER

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中国有色金属学会会刊：英文版 1994年第2期4卷 82-85页

作者： pu,Fengnian(Institute of high-Temperature and high-pressure physics,Chengdu University of Science and Technology,Chengdu 610065) Chengdu Univ of Science and Technology Chengdu China

ＰＲＥＳＳＵＲＥ－ＩＮＤＵＣＥＤ４ｐ→４ｓＥＬＥＣＴＲＯＮＴＲＡＮＳＦＥＲＡＮＤＩＴＳＥＦＦＥＣＴＯＮＥＬＥＣＴＲＩＣＡＬＴＲＡＮＳＰＯＲＴＯＦＣＯＰＰＥＲＰＲＥＳＳＵＲＥ－ＩＮＤＵＣＥＤ４ｐ→４ｓＥＬＥＣＴＲＯＮＴ... 详细信息

ＰＲＥＳＳＵＲＥ－ＩＮＤＵＣＥＤ４ｐ→４ｓＥＬＥＣＴＲＯＮＴＲＡＮＳＦＥＲＡＮＤＩＴＳＥＦＦＥＣＴＯＮＥＬＥＣＴＲＩＣＡＬＴＲＡＮＳＰＯＲＴＯＦＣＯＰＰＥＲＰＲＥＳＳＵＲＥ－ＩＮＤＵＣＥＤ４ｐ→４ｓＥＬＥＣＴＲＯＮＴＲＡＮＳＦＥＲＡＮＤＩＴＳＥＦＦＥ...

关键词： high pressure copper electron transfer electrical resistance

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Discrete element modelling of the quasi-static uniaxial compression of individual infant formula agglomerates

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particuology 2012年第5期10卷 523-531页

作者： kevin J.Hanley Catherine O'Sullivan Edmond p.Byrne kevin Cronin Department of process and Chemical Engineering University College CorkCorkIreland Department of Civil and Environmental Engineering Skempton BuildingImperial College LondonLondon SW7 2AZ United Kingdom

Infant formula is usually produced in an agglomerated powder form. These agglomerates are subjected to many transient forces following their manufacture. These can be difficult to quantify experimentally because of their small magnitudes and short durations, Numerical models have the potential to address this gap in the experimental data. The objective of the research described here was to calibrate a discrete element model for these agglomerates using experimental data obtained for quasi-static loading, and to use this model to study the mechanics of the particle response in detail. The Taguchi method was previously proposed as a viable calibration approach for discrete element models. In this work, the method was assessed for calibration of the model parameters （e.g., bond stiffnesses and strengths） considering three responses： the force at failure, strain at failure and agglomerate stiffness. The Weibull moduli for the simulation results and the experimental data were almost identical following calibration and the 37% characteristic stresses were similar. An analysis of the energy terms in the model provided useful insight into the model response. The bond energy and the normal force exerted on the platens were strongly correlated, and bond breakage events coincided with the highest energy dissipation rates.

关键词： Discrete element modellingUniaxial compressionQuasi-static crushingSimulationGranular materialsTaguchi methods

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Freeform spectrometer enabling increased compactness

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Light(Science & Applications) 2017年第1期6卷 646-655页

作者： Jacob Reimers Aaron Bauer kevin p Thompson Jannick p Rolland The Institute of Optics University of RochesterRochesterNY 14627USA Synopsys Inc.3 Graywood LanePittsfordNY 14534USA

We present optical designs with freeform optics in the context of hyperspectral *** show designs that are 5×more compact in volume than similar designs using conventional spherical or aspherical *** will show how combining the concepts of spatial and spectral-band broadening,which will be introduced in this paper,led to the improvement in compactness that is uniquely enabled by freeform optics.

关键词： aberrations freeform optics imaging spectrometer

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Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

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Cellular & Molecular Immunology 2023年第6期20卷 626-650页

作者： Grffn Copp kevin p.Robb Sowmya Viswanathan Osteoarthritis Research program Division of Orthopedic SurgerySchroeder Arthritis InstituteUniversity Health NetworkTorontoONCanada Krembil Research Institute University Health NetworkTorontoONCanada institute of Biomedical Engineering University of TorontoTorontoONCanada Department of Medicine Division of HematologyUniversity of TorontoTorontoONCanada

Osteoarthritis(OA)is a degenerative multifactorial disease with concomitant structural,inflammatory,and metabolic changes that fluctuate in a temporal and patient-specific *** complexity has contributed to refractory responses to various *** have shown promise as multimodal therapeutics in mitigating OA symptoms and disease ***,we evaluated 15 randomized controlled clinical trials(RCTs)and 11 nonrandomized RCTs using culture-expanded MSCs in the treatment of knee OA,and we found net positive effects of MSCs on mitigating pain and symptoms(improving function in 12/15 RCTs relative to baseline and in 11/15 RCTs relative to control groups at study endpoints)and on cartilage protection and/or repair(18/21 clinical studies).We examined MsC dose,tissue of origin,and autologous *** origins as well as patient clinical phenotype,endotype,age,sex and level of OA severity as key parameters in parsing MSC clinical *** relatively small sample size of 610 patients limited the drawing of definitive ***,we noted trends toward moderate to higher doses of MsCs in select OA patient clinical phenotypes mitigating pain and leading to structural improvements or cartilage *** from preclinical studies is supportive of MsC anti-inflammatory and immunomodulatory effects,but additional investigations on immunomodulatory,chondroprotective and other clinical mechanisms of action are *** hypothesize that MsC basal immunomodulatory"fitness"correlates with OA treatment efficacy,but this hypothesis needs to be validated in future *** conclude with a roadmap articulating the need to match an OA patient subset defined by molecular endotype and clinical phenotype with basally immunomodulatory"ft"or engineered-to-be-fit-for-OA MsCs in well-designed,data-intensive clinical trials to advance the field.

关键词： MSC Osteoarthritis Cell therapy mesenchymal stromal cell RCT

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Digestive retention times for Allen’s swamp monkey and L’Hoest’s monkey: data with implications for the evolution of cercopithecine digestive strategy

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Integrative Zoology 2012年第2期7卷 183-191页

作者： kevin p.BLAINE Joanna E.LAMBERT Department of Anesthesia Stanford University Medical CenterStanfordCaliforniaUSA Department of Ecological Anthropology University of Texas at San AntonioSan AntonioTexasUSA

primates access energy from plant fiber via bacterial fermentation in either a modified forestomach(‘foregut’),a caecocolic(‘hindgut’)chamber of the large intestine,or *** digestive retention times allow for more complete fermentation;as such,primates that consume an herbivorous diet high in fiber are expected to have both relatively and absolutely longer retention times than those mammals that rely on more readily digestible plant foods,such as *** used particulate markers to measure the digestive retention times of captive Allen’s swamp monkeys[Allenopithecus nigroviridis(pocock,1907)](n=3)and L’Hoest’s monkey(Cercopithecus lhoesti ***,1899)(n=2).Results indicate mean retention times of 23.2-29.4 h and 23.2-24.0 h for *** and ***,*** from this study,in combination with previously published data on digestive retention times in other primate species,indicate that cercopithecines differ from other primate taxa by having lengthier retention times that can be predicted by body mass *** data are consistent with the hypothesis that relatively lengthy retention times are a primitive trait for Cercopithecinae.

关键词： Cercopithecinae digestive retention time evolution of diet fermentation plant fiber

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A thermodynamic perspective on electrode poisoning in solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1449-1455页

作者： kevin Huang Department of Mechanical Engineering University of South CarolinaColumbiaUSA

A critical challenge to the commercialization of clean and high-efficiency solid oxide fuel cell(SOFC)technology is the insuf-ficient stack lifespan caused by a variety of degradation mechanisms,which are associated with cell components and chemical *** components related degradation refers to thermal/chemical/electrochemical deterioration of cell materials under operating conditions,whereas the latter regards impurities in feedstocks of oxidant(air)and reductant(fuel).This article provides a thermodynamic perspective on the understanding of the impurities-induced degradation mechanisms in *** discussion focuses on using thermodynamic ana-lysis to elucidate poisoning mechanisms in cathodes by impurity species such as Cr,CO_(2),H_(2)O,and SO_(2) and in the anode by species such as S(or H_(2)S),SiO_(2),and p_(2)(or pH_(3)).The author hopes the presented fundamental insights can provide a theoretical foundation for search-ing for better technical solutions to address the critical degradation challenges.

关键词： impurities air fuel reaction activity

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Build Axial Gradient Field by Using Axial Magnetized permanent Rings

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Journal of Materials Science & Technology 2002年第6期18卷 483-484页

作者： Quanling pENGInstitute of high Energy physics, Chinese Academy of Sciences p.O. Box 918-9, Beijing 100039, China Institute of high Energy physics Chinese Academy of Sciences P.O. Box 918-9 Beijing 100039 China

Axial magnetic field produced by an axial magnetized permanent ring was studied. For two permanent rings, if they are magnetized in the same directions, a nearly uniform axial field can be produced. If they are magnetized in opposite direction, an axial gradient magnetic field can be generated, with the field range changing from-Bo to Bo- A permanent magnet with a high axial gradient field was fabricated, the measured results agree with the pANDIRA calculation very well. For wider usage, it is desirable for the field gradient to be changed. Some methods to produce the variable gradient field are presented. These kinds of axial gradient magnetic field can also be used as a beam focusing for linear accelerator if the periodic field can be produced along the beam trajectory. The axial magnetic field is something like a solenoid, large stray field will leak to the outside environment if no method is taken to control them. In this paper, one method is illustrated to shield off the outside leakage field.

关键词： Axial magnetized permanent ring Electron beam Leakage

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An approach to viscoelastic c haracterization of dispersive media by inversion of a general wave propagation model

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 73-88页

作者： Fernando Zvietcovich Jannick p.Rolland kevin J.parker Department of Electrical and Computer Engineering University of Rochester Rochester New York 14627USA The Institute of Optics University of Rochester Rochester New York 14627USA

In the characterization of elastic properties of tissue using dynarmic optical coherence elasto-graphy,shear/surface waves are propagated and tracked in order to estimate speed and Y oung's ***,for dispersive tssues,the displacement pulse is highly damped and distorted during propagation,diminishing the ffectiveness of peak tracking approaches,and leading to biased cstimates of wave ***,plane wave propagation is sometimes assumed,which contributes to estimation ***,we invert a wave propagation model that incorpo-rates propagation,decay,and distortion of pulses in a dispersive media in order to accurately estimate its elastic and viscous *** model uses a general first-order approximation of dispersion,avoiding the use of any particular rheological model of *** are conducted in elastic and viscoelastic tissue mimicking phantoms by producing a Gaussian push using acoustic radiation force excitation and measuring the wave propagation using a Fourier domain optical coherence tomography *** confirmed the ffectiveness of the inversion method in est imat ing viscoelastic parameters in both the viscoelastic and elastic phantoms when compared to mechanical ***,the viscoelastic characterization of a fresh porcine comea was *** results validate this approach when compared to other methods.

关键词： Elastography viscoelasticity cylindrical waves optical coherence tomography shear waves surface acoustic waves viscoelastic pha ntoms

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Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation

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Journal of pharmaceutical Analysis 2018年第5期8卷 302-306页

作者： kevin p.Kent Chad E.Schroeder Chandana Sharma Upstream R&D MilliporeSigma

Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation strategies are used to mitigate the amount of aggregation that occurs upon putting a protein solution through a freeze-thaw cycle. Additionally, low pH solutions cause native antibodies to unfold, which are prone to aggregate upon pH neutralization, There is great interest in the mechanism that causes therapeutic proteins to aggregate since aggregate species can cause unwanted immunogenicity in patients, Herein, an increase in aggregation is reported when the pH is adjusted from pH 3 up to a pH ranging from pH 4 to pH 7 during the thaw process of a frozen antibody solution, Raising the pH during the thaw process caused a significant increase in the percent aggregation observed. Two antibodies and one Fc-fusion protein were evaluated during the pH jump thaw process and similar effects were observed. The results provide a new tool to study the kinetics of therapeutic protein ag- gregation upon pH increase,

关键词： Monoclonal antibodies Freeze-thaw protein aggregation protein stability

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