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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong lily Song William Wagstaff Rex C.Haydon Hue H.luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He lewis l.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and lRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason lynch Christopher E.Stevens Christopher Munley Chentao li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen kevin li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Effect of Ultraviolet Radiation on Hsp70 Protein Expression in HaCaT Cells

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World Journal of Nuclear Science and Technology 2024年第1期14卷 59-71页

作者： Sergio Hugo Sánchez Rodríguez Jesús Rodríguez Vergil Manuel Venancio Muñoz Juárez kevin Said Ramírez Dávila luis Martín García Ortiz Germán Flores Cortés luz Elena Vidales Rodríguez Jesús Adrián lópez David Alejandro García lópez laboratorio de Biología Celular y Neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México laboatorio de Bacterias y Hongos Filamentosos Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México laboratorio de MicroRNAs Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México

Ultraviolet radiation by its wavelength is divided into: UVA, UVB and UVC. Only UVA and UVB manage to penetrate the ozone layer, but due to anthropological activities, all of them are capable of interacting with humans to a greater or lesser extent, and can generate adverse effects such as cellular stress when interacting with intra-and extracellular biomolecules. The skin is the first organ in contact with UV radiation, and the stress it generates can be analyzed by the expression of a bioindicator of cellular damage such as Hsp70. Therefore, the objective of the project was: to determine the effect of UVA, UVB and UVC radiation on HaCaT epithelial cells, by analyzing the expression of Hsp70. Materials and methods: HaCaT cells were cultured in vitro, which were irradiated with UVA, UVB and UVC light at different doses, to subsequently determine the degree of Hsp70 expression by Immunodetection by PAGE-SDS and Western Blot. Results: Basal expression of Hsp70 was observed in no irradiated HaCaT cells. When HaCaT cells were irradiated with UVA, UVB, UVC, an increase in this Hsp70 protein was observed. With UVA, a higher degree of expression was observed at a time of 30 minutes of irradiation. With UVB the highest expression shifted to a time of 20 minutes. With UVC, overexpression was observed after 10 minutes. Conclusion: UV radiation generates cellular stress on HaCaT cells, evaluated by the stress bioindicator Hsp70. According to the wavelength of UV radiation, those that have a shorter wavelength have a greater potential for cellular damage, such as UVC.

关键词： Ultraviolet A light (UVA) Ultraviolet B light (UVB) Ultraviolet C light (UVC) Heat Shock Protein 70 (Hsp70) HaCaT

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Surgical outcomes and quality of life following exercise-based prehabilitation for hepato-pancreatico-biliary surgery:A systematic review and meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 207-217页

作者： Andy Deprato kevin Verhoeff Kieran Purich Janice Y Kung David l Bigam Khaled Z Dajani University of Alberta 116 St&85 AveEdmontonAlberta T6G 2R3Canada Department of Surgery University of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada John W.Scott Health Sciences library University of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada Department of Surgery Division of General SurgeryHPB Transplant and OncologyUniversity of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada

Background:Hepato-pancreatico-biliary(HPB)patients experience significant risk of preoperative *** assessing preventative prehabilitation in HPB populations are *** systematic review and meta-analysis evaluates outcomes for HPB patients treated with exercise *** sources:A comprehensive search of MEDlINE(via Ovid),Embase(Ovid),Scopus,Web of Science Core Collection,Cochrane library(Wiley),Pro Quest Dissertations,Theses Global,and Google Scholar was conducted with review and extraction following PRISMA *** studies evaluated more than 5 adult HPB patients undergoing≥7-day exercise *** primary outcome was postoperative length of stay(lOS);secondary outcomes included complications,mortality,physical performance,and quality of ***:We evaluated 1778 titles and abstracts and selected 6(randomized controlled trial,n=3;prospective cohort,n=1;retrospective cohort,n=2)that included 957 *** those,536 patients(56.0%)underwent exercise prehabilitation and 421(44.0%)received standard *** in both groups were similar with regards to important demographic *** was associated with a 5.20-day lOS reduction(P=0.03);when outliers were removed,lOS reduction decreased to 1.85 days and was non-statistically significant(P=0.34).Postoperative complications(OR=0.70;95%CI:0.39 to 1.26;P=0.23),major complications(OR=0.83;95%CI:0.60 to 1.14;P=0.24),and mortality(OR=0.67;95%CI:0.17 to 2.70;P=0.57)were *** was associated with improved strength,cardiopulmonary function,quality of life,and alleviated ***:Exercise prehabilitation may reduce lOS and morbidity following HPB *** with well-defined exercise regimens are needed to optimize exercise prehabilitation outcomes.

关键词： Exercise-based prehabilitation Preoperative exercise Hepatobiliary Pancreaticoduodenectomy Hepatic resection Pancreatectomy

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Climate change and surgical implications

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Emergency and Critical Care Medicine 2023年第1期3卷 4-5页

作者： Clifton Ewbank kevin Gianaris Adam l.Kushner Department of Surgery University of California San Francisco–East BayOaklandCAUSA Indiana University College of Medicine IndianapolisINUSA Bloomberg School of Public Health Johns Hopkins UniversityBaltimoreMDUSA

The healthcare sector contributes nearly 5%of the total global carbon emissions,and much of this is attributable to the delivery of surgical *** this article,we reviewthe impact of surgery on climate change and propos... 详细信息

关键词： Climate change Global surgery Surgery

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Morphological Characterization of Arbuscular Mycorrhizal Fungi Associated with the Rhizosphere According to the Age of Xanthosoma sagittifolium l. Schott Plants in the Field

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American Journal of Plant Sciences 2024年第3期15卷 161-179页

作者： Audrey Maguy Bengono Nyimiebolo Astride Carole Djeuani Hermann Désiré Mbouobda Antoine Marie kevin Tiki Theresa Akinimbom Moma Diobe Motassy Manuela Samuel Brice Adounga Christophe Fendju Pangueko Jones Nshanji Issofa Nguetrapouna Rose Theophine Derricka Djem Moutamal A. Ziem Amang Amang Nicolas Niemenak laboratory of Plant Physiology Department of Biological Sciences Higher Teacher Training College (HTTC) University of Yaoundé I Yaoundé Cameroon Department of Plant Biology Faculty of Sciences University of Yaoundé I Yaoundé Cameroon Department of Biology Higher Teacher Training College Bambili (HTTC) The University of Bamenda Bamenda Cameroon Departments of Microbiology Faculty of Science University of Yaoundé 1 Yaoundé Cameroon

The objective of this work was to carry out a morphological characterization of arbuscular mycorrhizal fungi in the rhizosphere of Xanthosoma sagittifolium l. Schott plants. The plant material used was the white and red cultivars of X. sagittifolium, belonging to age intervals of 3 - 6, 6 - 9, and 9 - 12 months. Three harvest sites were chosen in the Central Region of Cameroon. In each site, soil from the rhizosphere and plant roots was collected in a randomized manner. In the field, the agronomic parameters were evaluated. The physicochemical characteristics of the soils, the mycorrhization index, and the morphological characterization of the mycorrhizal types of each site were carried out. The results obtained show that the agronomic growth parameters varied significantly using the Student Newman and Keuls Test depending on the harvest sites. The soils’ pH in all sites was acidic and ranged between 4.6 and 5.8. The Nkometou site has a loamy texture while the Olembe and Soa sites have loam-clay-sandy and loam-clay textures respectively. The highest mycorrhization frequencies appeared at the Nkometou site, with 75 and 87.33% of the white and red cultivars plant roots at 6 - 9 and 3 - 6 months. The relative abundance of AMF arbuscular mycorrhizal fungal spores in the rhizosphere of X. sagittifolium plants varied with age and cultivar. There were 673 spores between 9 - 12 months in Nkometou in the red cultivar. Six AMF genera were identified in all the different soils collected: Acaulospora sp., Funneliformis sp., Gigaspora sp., Glomus sp., Scutellospora sp., and Septoglomus sp. The genus Glomus sp. was the most present at all age intervals in both cultivars.

关键词： Xanthosoma sagittifolium l. Schott Rhizosphere Harvest Site Arbuscular Mycorrhizal Fungi Diversity

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EASE-DGGS:a hybrid discrete global grid system for Earth sciences

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Big Earth Data 2022年第3期6卷 340-357页

作者： Jeffery A.Thompson Mary J.Brodzik kevin A.T.Silverstein Mason A.Hurley Nathan l.Carlson Minnesota Supercomputing Institute University of MinnesotaMinneapolisMNUSA GEMS Informatics Initiative University of MinnesotaMinneapolisMNUSA National Snow and Ice Data Center Cooperative Institute for Research in Environmental SciencesUniversity of ColoradoBoulderCOUSA

Although we live in an era of unprecedented quantities and access to data,deriving actionable information from raw data is a hard *** observation systems(EOS)have experienced rapid growth and uptake in recent decades,and the rate at which we obtain remotely sensed images is *** significant effort and attention has been devoted to designing systems that deliver analytics ready imagery faster,less attention has been devoted to developing analytical frameworks that enable EOS to be seamlessly integrated with other data for quantitative *** global grid systems(DGGS)have been proposed as one potential solution that addresses the challenge of geospatial data integration and ***,we propose the systematic extension of EASE-Grid in order to provide DGGS-like characteristics for EOS data *** describe the extensions as well as present implementation as an application programming interface(API),which forms part of the University of Minnesota’s GEMS(Genetic x Environment x Management x Socioeconomic)Informatics Center’s API portfolio.

关键词： Discrete global grid systems DGGS EASE Grid coordinate reference systems

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Small duct primary sclerosing cholangitis: A discrete variant or a bridge to large duct disease, a practical review

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World Journal of Hepatology 2022年第3期14卷 495-503页

作者： Christopher M Nguyen kevin T Kline Heather l Stevenson Kashif Khan Sreeram Parupudi Department of Internal Medicine The University of Texas Medical BranchGalvestonTX 77555United States Department of Gastroenterology and Hepatology The University of Texas Medical BranchGalvestonTX 77555United States Department of Pathology University of Texas Medical BranchGalvestonTX 77555United States

The natural history,associations with inflammatory bowel disease(IBD),and long-term outcomes of large duct primary sclerosing cholangitis(ldPSC)have been well *** duct primary sclerosing cholangitis(sdPSC)is a much less common and relatively more benign *** natural history of sdPSC has been difficult to characterize given the limited number of studies in the literature especially with regards to the subset of patients who progress to large duct *** has been unclear whether sdPSC represented a subset of ldPSC,an earlier staging of ldPSC,or a completely separate and distinct entity of its *** associations between sdPSC and IBD have been established with suspicion that concurrent sdPSC-IBD may be a key prognostic factor in determining which patients are at risk of progression to *** is known regarding the discrete circumstances that predisposes some patients with sdPSC to progress to *** has been suspected that progression to large biliary duct involvement subjects this subset of patients to potentially developing lifethreatening *** the authors conducted a thorough review of the published sdPSC literature using Pubmed searches and cross-referencing to compile all accessible studies regarding cohorts of sdPSC patients in order better characterize the subset of sdPSC patients who progress to ldPSC and the associated outcomes.

关键词： Small duct primary sclerosing cholangitis Inflammatory bowel disease Progression Primary sclerosing cholangitis Outcomes

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Strawberry (Fragaria spp.): Cultivation, Production, Consumption, and Marketing in Cameroon

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Agricultural Sciences 2024年第4期15卷 449-471页

作者： Djeuani Astride Carole Moutamal Djem Rose Theophine Derricka Mbouobda Hermann Désiré Abdoulaye Souaibou Meliga Essimi Célestine Bouopda Nono Joël Anafack Donasson Dioril Messouang Bernard Didier Ndongo III Boris Charlen Kaffo Emmanuel Kamga Fossouo Anselme Xavier Tiki Antoine Marie kevin Nyimiebolo Bengono Audrey Maguy Manuela Diobe Motassy Adounga Samuel Brice Amama Amama Benjamin Nshanji Jones Panguepko Fendju Christophe Nzie Oussena Nguetrapouna Issofa Mpon Ikoyin linda NKouéya Christelle ladone Amang Amang A. Ziem Niemenak Nicolas laboratory of Plant Physiology and Biochemistry Department of Biological Sciences Higher Teachers&#8217 Training College University of Yaound&#233 1 Yaound&#233 Cameroon Department of Plant Biology Faculty of Science University of Yaound&#233 1 Yaound&#233 Cameroon Department of Biology Higher Teachers&#8217 Training College Bambili University of Bamenda Bamenda Cameroon Mbidjoro Sustainable living Environment Ngaound&#233r&#233 Cameroon Cé r&#232s Agricole Yaound&#233 Cameroon KAFFO Farm Baham Cameroon Agro Ankh Dschang Cameroon Bio Farm of lolodorf Lolodorf Cameroon Or Rouge d’ Afrique Obala Cameroon Bafoussam Farm Bafoussam Cameroon King Farms Baham Cameroon Department of Microbiology Faculty of Science University of Yaound&#233 1 Yaound&#233 Cameroon

Strawberry (Fragaria spp.) is one of the most important fruits classified as exotic fruits imported into Cameroon. To have an inventory of its cultivation in Cameroon, a survey study was carried out among eight farms of Fragaria spp. from January 2021 to February 2022. The plant was introduced in Cameroon in 2018. There are 13 varieties of Fragaria spp. currently cultivated. Among these 13 varieties, eleven are hybrids of Fragaria x ananassa (“Amiga”, “Amine”, “Camarosa”, “Chandler”, “Charlotte”, “Elsanta”, “Gariguette”, “Madame Moutot”, “Ostara”, “Ruby gem” and “San Andreas”), and two of the hybrids of Fragaria vesca (“Maestro” and “Mara des bois”). The cropping system, irrigation system, and type of fertilizers applied differ from one strawberry farm to another. Biofertilizers (such as mycorrhizal), inorganic and organic fertilizers are actually used to improve production. The potential annual production of strawberries from January 2021 to February 2022, estimated based on the survey data, was 21.216 tons for all growers. Among these eight production farms, the lolodorf BIO Farm presents 6000 kg (six tons) of strawberries and 100,000 stolons (seedlings) produced, from seven varieties of Fragaria spp. cultivated, with 6 varieties which are hybrids variety Fragaria x ananassa (“Amiga”, “Amine”, “Chandler”, “Gariguette”, “Madame Moutot”, and “Ruby gem”), and one which is a hybrid of Fragaria vesca (“Mara des bois”). Certain diseases were also observed and recorded depending on the growing areas.

关键词： Fragaria spp. Cultivation Technique Attack of Pathogens Annual Production Cameroon

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The complexity of providing humanitarian surgical care in armed conflict: a framework to help categorize needs

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Emergency and Critical Care Medicine 2022年第2期2卷 41-44页

作者： kevin Gianaris Barclay T.Stewart Sherry M.Wren Adam l.Kushner Indiana University School of Medicine IndianapolisINUSA Department of Surgery University of WashingtonSeattleWAUSA Harborview Injury Prevention and Research Center University of WashingtonSeattleWAUSA Department of Surgery Stanford UniversityPalo AltoCAUSA Surgeons OverSeas New York CityNYUSA Department of International Health Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMDUSA

Armed conflicts are increasing globally due to political unrest and the broader effects of climate *** resources to provide quality surgical care,it becomes nearly impossible to provide quality emergency surgery and trauma care similar to that in high-income *** understand and help aid organizations provide resources and address the surgical needs of populations facing armed conflict,a matrix to identify variables and help with interventions was *** published global surgery matrix based on the PIPES(Personnel,Infrastructure,Procedures,Equipment and Supplies)surgical capacity tool was adapted to this *** novel matrix incorporates 108 *** variables are grossly divided into local and international agency components to address the issue of who is providing *** a time continuum of pre-conflict,conflict,and post-conflict allows organizations to concentrate on when during the conflict to target their *** addition to the previously used personnel,infrastructure,procedures,equipment,and supplies categories,a sixth category called standards was included that addresses the issues such as information technology,data systems,quality improvement programs,and patient *** testing of this matrix to obtain feedback from end users is the next step in ***,peri-conflict preparedness should increase and improve surgical outcomes and reduce in death and disabilities around the world.

关键词： Armed conflict Emergency care Global surgery Humanitarian assistance Trauma care

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