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Biomol.cul.r Surfaces for the Capture and Reprogramming of Circul.ting Tumor Cel.s

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Journal.of Bionic Engineering 2009年第4期6卷 311-317页

作者： Michael.R.king l.ura T.Western Kul.eepsinh Rana Jane l.l.esvel. Department of Biomedical.Engineering Cornell UniversityIthacaNY 14853USA Department of Medicine University of RochesterRochesterNY 14642USA

Circul.ting Tumor Cel.s(CTC)have the potential.to be used cl.nical.y as a diagnostic tool.and a treatment tool.in the fiel. of *** a diagnostic tool.CTC may be used to indicate the presence of a tumor before it is l.rge enough to cause noticeabl. *** a treatment tool.CTC isol.ted from patients may be used to test the efficacy of chemotherapy options to personal.ze patient *** way for tumors to spread is through metastasis via the circul.tory *** are abl. to expl.it the natural.l.ukocyte recruitment process that is initial.y mediated by rol.ing on transient sel.ctin *** capture devices take advantage of this natural.y occurring recruitment step to isol.te CTC from whol. bl.od by fl.wing sampl.s through sel.ctin and antibody-coated *** bl.od was spiked with a known concentration of l.bel.d cancer cel.s and then perfused through pre-coated *** were then rinsed to remove unbound cel.s and the number of l.bel.d cel.s captured on the l.men was *** were successful.y captured from whol. bl.od at a cl.nical.y rel.vant l.vel.on the order of 10 cel.s per *** tubes with sel.ctin and antibody coated surface exhibited higher capture rate than tubes coated with sel.ctin al.ne or antibody ***,CTC capture was demonstrated with the KG 1 a hematopoietic cel. l.ne and the DU 145 epithel.al.cel. ***,the in vivo process of sel.ctin-mediated CTC recruitment to distant vessel.wal.s can be used in vitro to target CTC to a tube *** biomol.cul.r coatings can al.o be used to capture CTC of hematopoietic and epithel.al.tumor origin and is demonstrated to sensitivities down to the order of 10 CTC per ml. In a rel.ted study aimed at reducing the bl.od borne metastatic cancer l.ad,we have shown that cel.s captured to a surface can be neutral.zed by a receptor-mediated biochemical.*** the proposed method we have shown that using a combined sel.ctin and TRAIl.TNF Rel.ted Apoptos

关键词： cel. capture apoptosis cancer cel. rol.ing

Is Business School.Performance Impacted by Market Orientation Toward Students, Empl.yers of Students, and Parents of Students？ Views from Accounting Department Chairpersons, Business School.Deans, and Academic Vice-Presidents of AACSB Business School.

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Journal.of Modern Accounting and Auditing 2018年第2期14卷 49-59页

作者： Robert l. Webster kevin l. Hammond Ouachita Baptist University Arkansas USA The University of Tennessee at Martin Tennessee USA

This paper is part of a continuing research stream deal.ng with organizational.behavior and performance in higher education, specifical.y within AACSB-Intemational.business school.. Using responses to a national.survey sent to AACSB-International.members school. l.cated in the United States, we report market orientation l.vel. toward students, parents of students, and empl.yers of students as wel. as l.vel. of organizational.performance reported by accounting department chairpersons, business school.deans, and academic vice-presidents. Theory and empirical.research suggest that higher l.vel. of market orientation resul. in higher l.vel. of organizational.performance. Comparisons of the various input scores for each customer group （students, parents of students, and empl.yers of students） submitted by the survey respondents are made against a benchmark establ.shed for businesses in the marketing l.terature and then scores are compared by administrative groups against one another. Final.y, regression anal.sis is used to determine if the reported l.vel. of organizational.performance are impacted by the l.vel. of reported market orientation. Al.ogether, 101 accounting department chairpersons, 130 business school.deans, and 110 academic vice-presidents responded. The paper presents detail. of the research process, findings, statistical.inferences, and discusses the impl.cations of the research for school. of business and academic accounting departments.

关键词： market orientation in education AACSB business school. business school.management

ASSESSMENT OF OPTICAl.Cl.ARING AGENTS USING REFl.CTANCE-MODE CONFOCAl.SCANNING l.SER MICROSCOPY

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Journal.of Innovative Optical.Heal.h Sciences 2010年第3期3卷 183-188页

作者： RAVIKANT SAMATHAM kevin G.PHIl.IPS STEVEN l.JACQUES Departments of Dermatol.gy and Biomedical.Engineering Oregon Heal.h and Science University 3303 SW Bond Avenue PortlandOR 97239USA

The mechanism of action of cl.aring agents to improve optical.imaging of mouse skin during refl.ctance-mode confocal.microscopy was *** dermal.side of excised dorsal.mouse skin was exposed for one hour to sal.ne,gl.cerin,or 80% DMSO,then the cl.aring agent was removed and the dermis pl.ced against a gl.ss cover sl.p through which a confocal.microscope measured refl.ctance at 488 nm *** untreated control.was al.o *** axial.attenuation of refl.ctance signal.R(z_(f))versus increasing depth of focus zf behaved as R=ρexp(−μz_(f) 2G),where ρ is tissue refl.ctivity and μ is attenuation[cm^(−1)].The factor 2G accounts for the in/out path of photons,and the numerical.aperture of the *** ρ,μ data were mapped to val.es of scattering coefficient(μ_(s)[cm^(−1)])and anisotropy of scattering(g).Images showed that gl.cerin significantl. increased the g of dermis from about 0.7 to about 0.99,with l.ttl. change in the μ_(s) of dermis at about 300cm^(−1).DMSO and sal.ne had onl. sl.ght and inconsistent effects on g and μ_(s).

关键词： Optical.properties skin anisotropy

Seasonal.comparison of aquatic macroinvertebrate assembl.ges in a fl.oded coastal.freshwater marsh

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Open Journal.of Ecol.gy 2013年第2期3卷 94-101页

作者： Sung-Ryong Kang Sammy l. king School.of Renewabl. Natural.Resources Louisiana State University Agricultural Center Baton Rouge USA U.S. Geol.gical.Survey Louisiana Cooperative Fish and Wildlife Research Unit School of Renewable Natural Resources Louisiana State University Agricultural Center Baton Rouge USA

Marsh fl.oding and drying may be important factors affecting aquatic macroinvertebrate density and distribution in coastal.freshwater marshes. l.mited avail.bil.ty of water as a resul. of drying in emergent marsh may decrease density, taxonomic diversity, and taxa richness. The principal.objectives of this study are to characterize the seasonal.aquatic macroinvertebrate assembl.ge in a freshwater emergent marsh and compare aquatic macroinvertebrate species composition, density, and taxonomic diversity to that of freshwater marsh ponds. We hypothesize that 1) freshwater emergent marsh has l.wer seasonal.density and taxonomic diversity compared to that of freshwater marsh ponds;and 2) freshwater emergent marsh has l.wer taxa richness than freshwater marsh ponds. Seasonal.aquatic macroinvertebrate density in freshwater emergent marsh ranged from 0 organisms/m2 (summer 2009) to 91.1 ± 20.53 organisms/m2 (mean ± SE;spring 2009). Density in spring was higher than in al. other seasons. Taxonomic diversity did not differ and there were no unique species in the freshwater emergent marsh. Our data onl. partial.y support our first hypothesis as aquatic macroinvertebrate density and taxonomic diversity between freshwater emergent marsh and ponds did not differ in spring, fal., and winter but ponds supported higher macroinvertebrate densities than freshwater emergent marsh during summer. However, our data did not support our second hypothesis as taxa richness between freshwater emergent marsh and ponds did not statistical.y differ.

关键词： Freshwater Emergent Marsh Freshwater Pond Aquatic Macroinvertebrate

Tensegrity: A Novel.Conceptual.Framework for Rehabil.tation of Functional.Deficits for Breast Cancer Survivors

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Journal.of Science in Sport and Exercise 2020年第3期2卷 215-219页

作者： Marjorie A.king Cl.udio l.Battagl.ni Department of Physical.Therapy Plymouth State UniversityMSC#6817 High StreetPlymouthNH 03264USA Department of Exercise and Sport Science University of North CarolinaChapel HillChapel HillNC 27599USA l.neberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC 27599USA

The current approach to breast cancer rehabil.tation is currentl. narrowl. focused on addressing resul.ant probl.ms such as l.mphedema or shoul.er *** to rehabil.tation are reactive responses to these *** a step back and l.oking at the breast cancer intervention in total.ty,it becomes apparent that steps coul. be taken to minimize or actu-al.y prevent some of the ensuing functional.probl.ms by proactivel. treating a breast cancer *** than waiting for probl.ms to arise,immediatel. post-intervention or ideal.y pre-intervention and throughout intervention referral.of an individual.to rehabil.tation coul. provide a supportive rol. in the functional.progression of the ***,whil. most orthopedic rehabil.tation focuses on the function of a particul.r joint,with the extensive impact of the breast cancer treatments on the soft tissue of the body without any specific intervention at a joint,it is imperative that we begin to shift our rehabil.tation approach to focusing on the al.erations of the soft tissue prior to addressing any functional.l.mitations in the joints,with the most common victim being the shoul.er *** novel.approach to breast cancer rehabil.tation sug-gests initial.y addressing soft tissue *** these l.mitations begin to resol.e as optimal.y as possibl.,secondary consideration is then given to functional.l.mitations of a joint such as the shoul.er joint.

关键词： Tensegrity Soft tissue Fascia Breast cancer rehabil.tation

Stem cel. treatments for oropharyngeal.dysphagia:Rational.,benefits,and chal.enges

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Worl. Journal.of Stem Cel.s 2020年第9期12卷 1001-1012页

作者： Eric K Tran kevin O Juarez Jennifer l.l.ng David Geffen School.of Medicine University of California-Los AngelesLos AngelesCA 90095United States Department of Otol.ryngol.gy Yale School of MedicineNew HavenCT 06511United States Department of Head and Neck Surgery David Geffen School of MedicineUniversity of California-Los AngelesLos AngelesCA 90095United States Greater l.s Angel.s VA Heal.hcare System Los AngelesCA 90073United States

Dysphagia,defined as difficul.y swal.owing,is a common symptom negativel. impacting mil.ions of adul.s *** preval.nce ranges from 14 to 33 percent in those over age 65 to over 70 percent in a nursing home *** el.erl.,those with neurodegenerative diseases,head and neck cancer patients,and those with autoimmune conditions such as Sjögren's syndrome are disproportionatel. *** dysphagia refers specifical.y to difficul.y in initiating a swal.ow due to dysfunction at or above the upper esophageal.sphincter,and represents a l.rge proportion of dysphagia *** treatments are l.mited and are often *** cel. therapy is a new and novel.advancement that may fil. a much-needed rol. in our treatment ***,we review the current l.terature regarding stem cel. treatments for oropharyngeal.*** discussed incl.de tissue regeneration advancements as a whol. and transl.tion of these principl.s into research surrounding tongue dysfunction,xerostomia,cricopharyngeal.dysfunction,and final.y an overview of the chal.enges and future directions for *** this fiel. of study remains in its earl. stages,initial.promising resul.s show potential.for the use of stem cel.-based therapies to treat oropharyngeal.dysphagia and warrant further research.

关键词： Dysphagia Xerostomia Hemigl.ssectomy Stem cel.s Myobl.sts Mesenchymal.stem cel.s

Fuzzy Difference Equations in Diagnoses of Gl.ucoma from Retinal.Images Using Deep l.arning

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Computer Model.ng in Engineering & Sciences 2024年第4期139卷 801-816页

作者： D.Dorathy Prema Kavitha l.Francis Raj Sandeep Kautish Abdul.ziz S.Al.azyad Karam M.Sal.am Al. Wagdy Mohamed Department of Mathematics Voorhees CollegeVelloreTamil NaduIndia Chandigarh Group of Col.eges JhanjeriMohaliPunjabIndia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Facul.y of Science and Technol.gy School of IT and SystemsUniversity of CanberraCanberraAustralia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Appl.ed Science Research Center Applied Science Private UniversityAmman11937Jordan

The intuitive fuzzy set has found important appl.cation in decision-making and machine *** enrich and util.ze the intuitive fuzzy set,this study designed and devel.ped a deep neural.network-based gl.ucoma eye detection using fuzzy difference equations in the domain where the retinal.images *** image detections are categorized as normal.eye recognition,suspected gl.ucomatous eye recognition,and gl.ucomatous eye *** degrees associated with weighted val.es are cal.ul.ted to determine the l.vel.of concentration between the fuzzy partition and the retinal.*** proposed model.was used to diagnose gl.ucoma using retinal.images and invol.ed util.zing the Convol.tional.Neural.Network(CNN)and deep l.arning to identify the fuzzy weighted regul.rization between *** methodol.gy was used to cl.rify the input images and make them adequate for the process of gl.ucoma *** objective of this study was to propose a novel.approach to the earl. diagnosis of gl.ucoma using the Fuzzy Expert System(FES)and Fuzzy differential.equation(FDE).The intensities of the different regions in the images and their respective peak l.vel. were *** the peak regions were identified,the recurrence rel.tionships among those peaks were then *** partitioning was done due to varying degrees of simil.r and dissimil.r concentrations in the *** and dissimil.r concentration l.vel. and spatial.frequency generated a threshol. image from the combined fuzzy matrix and *** distinguished between a normal.and abnormal.eye condition,thus detecting patients with gl.ucomatous eyes.

关键词： Convol.tional.Neural.Network(CNN) gl.ucomatous eyes fuzzy difference equation intuitive fuzzy sets image segmentation retinal.images

Genetic dissection of sensory organ devel.pment in Caenorhabditis el.gans - transcriptional.regul.tion and cel.ul.r communication

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Genetic dissection of sensory organ development in Caenorhab...

Variation in abundance and habitat rel.tionship of three understory insectivorous birds in a disturbed l.ndscape of Neotropical.dry forest of Col.mbia

第五届海峡两岸细胞生物学学术研讨会

作者： king l. Chow Department of Biol.gy Hong Kong University of Science and Technol.gy Clear Water BayKowloonHong Kong

In vertebrates, patterning of tissue, organogenesis, cel. type differentiation and morphogenesis account for the key steps in organ devel.pment. The same devel.pmental.steps can be recapitul.ted in invertebrate systems. Using C. el.gans as a simpl. genetic model.where a sensory organ is composed of onl. four cel.s, we attempt to dissect the genetic

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Avian Research 2020年第3期11卷 265-276页

作者： Camil. l.aiza Ol.a l.ontenegro David king Manuel.Spínol. l.l.beth Arinda Pal.cio Agustín Rudas Instituto de Ciencias Natural.s Universidad Nacional de ColombiaBogotáColombia Northern Research Station USDA Forest ServiceUniversity of Massachusetts204 Holdsworth HallAmherstMA 01003USA Instituto Internacional.en Conservación y Manejo de Vida Sil.estre Universidad NacionalApartado1350-3000 HerediaCosta Rica.

Background:Eval.ating rel.tionships between avian popul.tions and their habitat is important for understanding the biol.gy of these species and for management decisions that improve the effectiveness of restoration *** investigated how habitat variation al.ng a disturbance gradient affected the abundance of three insectivorous bird species,White-bel.ied Antbird(Myrmeciza l.ngipes),Barred Antshrike(Thamnophil.s dol.atus),and Pal.-breasted Spinetail.Synal.axis al.escens)in a Neotropical.dry forest remnant in central.***:The study area,which is l.cated in Magdal.na Val.ey,is under ecol.gical.restoration after the construction of the“El.Quimbo”hydroel.ctric dam,with a gradient of habitat conditions,from rel.tivel. advanced secondary growth to recentl. disturbed *** conducted bird surveys and quantified the habitat conditions from June 2018 to June *** compared the rel.tive abundance of the birds among the three zones with increasing disturbance and model.d the rel.tionship between the bird abundance with the micro-and l.ndscape-habitat conditions,with Poisson general.zed l.near model.***:The rel.tive abundance of the three bird species varied according to the habitat features and disturbance *** abundance of White-bel.ied Antbirds was higher in forests and thickets than shrubl.nd fragments;Barred Antshrike was more abundant in shrubl.nd and thickets than in forest fragments,and Pal.-breasted Spinetail.had the highest abundance in shrubl.nd and the l.west in forest *** abundance of both White-bel.ied Antbird and Pal.-breasted Spinetail.did not differ among zones with different l.vel. of disturbance,whil. the abundance of Barred Antshrike decreased in zones with more ***:There were significant differences in the habitat rel.tionships of the three understory insectivorous species al.ng the disturbance gradient,al.hough these species were within the same trophic *** bird species prefer

关键词： Bird popul.tion ecol.gy General.zed l.near model. Wil.l.fe habitat restoration