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Gene expression profiling improves prognostication by nomogram in patients with soft-tissue sarcomas

Cancer Communications 2022年第6期42卷 563-566页

作者： Amandine Crombé Mariella Spalato-Ceruso Audrey Michot Yech’an Laizet Carlo Lucchesi Maud Toulmonde kevin bourcier Francois Le Loarer Antoine Italiano Department of Imaging Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France Department of Medicine Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France Department of Surgery Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France Bioinformatics Unit BordeauxNouvelle-Aquitaine F-33076France Department of Pathology Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France University of Bordeaux BordeauxNouvelle-Aquitaine F-33000France

Dear Editor,Surgery remains the cornerstone of treatment for softtissue sarcomas(STS)[1].However,despite adequate locoregional treatment,30%-40%of the patients eventually develop metastases[2,3].Accurate risk assessment is crucial to tailor therapeutic strategies and to identify high-risk patients who may benefit from perioperative ***,several efforts have been made to develop prognostic nomograms that enable individual prognosis prediction;representing an important decision-making aid for oncologists and surgeons involved in sarcoma care[4-6].

关键词： patients sarcoma Surgery

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Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence

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World Journal of Gastroenterology 2021年第26期27卷 4088-4103页

作者： Simon bourcier Julian Klug Lee S Nguyen Department of Intensive Care Medicine University Hospital of GenevaGeneva 1201Switzerland Department of Internal Medicine Groupement Hospitalier de l’Ouest LémaniqueNyon 1260Switzerland Department of Intensive Care Medicine CMC Ambroise ParéNeuilly-sur-Seine 92200France

Acute mesenteric ischemia(AMI)is a severe condition associated with poor prognosis,ultimately leading to death due to multiorgan *** mechanisms may lead to AMI,and non-occlusive mesenteric ischemia(NOMI)represents a particular form of *** is prevalent in intensive care units in critically ill *** NOMI management,promptness and accuracy of diagnosis are paramount to achieve decisive treatment,but the last decades have been marked by failure to improve NOMI prognosis,due to lack of tools to detect this *** real-life diagnostic management relies on a combination of physical examination,several biomarkers,imaging,and endoscopy to detect the possibility of several grades of NOMI,research studies only focus on a few elements at a *** the era of artificial intelligence(AI),which can aggregate thousands of variables in complex longitudinal models,the prospect of achieving accurate diagnosis through machine-learning-based algorithms may be *** the following work,we bring you a state-of-the-art literature review regarding NOMI,its presentation,its mechanics,and the pitfalls of routine work-up diagnostic exams including biomarkers,imaging,and endoscopy,we raise the perspectives of new biomarker exams,and finally we discuss what AI may add to the field,after summarizing what this technique encompasses.

关键词： Mesenteric ischemia Biomarkers Critically ill Machine learning Artificial intelligence

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验证高估率(overR)和双层磁敏感血管征(TL-SVS)作为心源性栓塞性卒中的影像学生物标志及其与从发病到MRI检查时间的相关性

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国际医学放射学杂志 2019年第4期 497-498页

作者：吴越 R.bourcier L.Legrand S.Soize J.Labreuche M.Beaumont H.Desal Department of Diagnostic and Interventional Neuroradiology Guillaume et René Laennec University Hospital

摘要目的在"THRACE"试验中验证与双层磁敏感血管征(TL-SVS)和高估率(overR)相关的临床特征和MRI技术参数。方法分析病人治疗前的脑梯度回波(GRE)序列和

关键词： SVS 磁敏感血管征 MRI overR 检查时间栓塞性卒中影像学 TL-SVS 心源性生物标志

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穿透性角膜移植术后植片中心厚度的预后

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 50-50页

作者： Borderie V.M . Touzeau O. bourcier T. 张少娟 Service V Ctr. Hosp. Natl. d'O. 28 ruede Charenton 75012 Paris FranceDr.

Objective: To analyze the outcome of graft central thickness after penetrating keratoplasty. Design: Retrospective observational cohort study. Participants: E ight hundred fifty-six consecutive penetrating keratoplasties (772 patients) pe rformed between 1992 and 2001 were analyzed and 772 were included (1 graft per p atient was included). Methods: Slit-lamp examination and ultrasound pachymetry. Main Outcome Measures: Slit-lamp findings, intraocular pressure, and graft cen tral thickness were recorded. Results: Patients were observed for an average of 55 months. The 36-and 60-month graft survival estimates were, respectively, 77 .2%and 71.0%. The average graft central thickness in successful transplants wa s 655 μm at 1 week, 558 μm at 1 month, 533 μm at 6 months, 538 μm at 12 mont hs, 558 μm at 24 months, 561 μm at 36 months, and 568 μm at 5 years. At each postoperative time point, the percentage of eyes with decreased, normal, and inc reased graft central thickness was significantly different according to slit-la mp findings. Of the patients with increased graft thickness, 46.2%had a simple outcome (normal intraocular pressure and normal slit-lamp findings), 28.6%expe rienced rejection, 15.8%experienced a graft nonimmunological event, and 9.4%ex perienced increased intraocular pressure. At each postoperative follow-up, subs equent graft survival was significantly lower in patients with increased graft t hickness as compared with patients with normal or decreased graft thickness. Whe n analyzing only patients with simple outcome, the relative risk of graft failur e was 3.3 if graft thickness was increased at 1 month (P < 0.0001). Conclusions: In conclusion, graft central thickness assessed by ultrasound pachymetry is a u seful method for observing patients who have undergone penetrating keratoplasty. Evenwhen slit-lamp examination reveals no complications, patients with an incr ease in graft thickness above the upper limit of normal for the postoperative ti me poi

关键词：植片角膜移植超声测厚仪队列研究观察性相对风险免疫反应

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胶质母细胞瘤患者低钠血症与患者生存率预测并无相关性（英文）

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中华神经外科疾病研究杂志 2018年第1期17卷 38-38页

作者： Mrowczynski OD bourcier AJ Liao J Langan ST Specht CS Rizk EB Department of Neurosurgery Penn State Milton S.Hershey Medical Center Department of Public Health Sciences Penn State Milton S.Hershey Medical Center Department of Pathology Penn State Milton S.Hershey Medical Center

Glioblastoma is a devastating malignancy with a dismal survival ***,there are limited prognostic markers of glioblastoma including IDH1,ATRX,MGMT,PTEN,EGFRv Ⅲ,and *** these biomarkers for tumor prognosis are available,a surgical biopsy must be performed for these analyses,which has morbidity involved.A non-invasive and readily available biomarker is sought after which provides clinicians prognostic *** is an electrolyte that is easily and quickly obtained through analysis of a patient's *** has been shown to have a predictive and negative prognostic indication in multiple cancer types,but the role of glioblastoma patients' serum sodium at the time of diagnosis in predicting glioblastoma patient survival has not been *** assessed whether hyponatremia at the time of glioblastoma diagnosis correlates to patient survival and show that in our cohort of 200 glioblastoma patients,sodium,at any level,did not significantly correlate to glioblastoma survival,unlike what is seen in multiple other cancer *** further demonstrate that inducing hyponatremia in an orthotopic murine model of glioblastoma has no effects on tumor progression and survival.

关键词：《中华神经外科疾病研究杂志》英文摘要期刊编辑工作

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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