胶质母细胞瘤患者低钠血症与患者生存率预测并无相关性（英文）

作     者：Mrowczynski OD Bourcier AJ Liao J Langan ST Specht CS Rizk EB 

作者机构：Department of NeurosurgeryPenn State Milton S.Hershey Medical Center Department of Public Health SciencesPenn State Milton S.Hershey Medical Center Department of PathologyPenn State Milton S.Hershey Medical Center 

出 版 物：《中华神经外科疾病研究杂志》 (Chinese Journal of Neurosurgical Disease Research)

年 卷 期：2018年第17卷第1期

页      面：38-38页

学科分类：1205[管理学-图书情报与档案管理] 12[管理学] 120502[管理学-情报学] 

主　　题：《中华神经外科疾病研究杂志》 英文摘要 期刊 编辑工作 

摘      要：Glioblastoma is a devastating malignancy with a dismal survival ***,there are limited prognostic markers of glioblastoma including IDH1,ATRX,MGMT,PTEN,EGFRv Ⅲ,and *** these biomarkers for tumor prognosis are available,a surgical biopsy must be performed for these analyses,which has morbidity involved.A non-invasive and readily available biomarker is sought after which provides clinicians prognostic *** is an electrolyte that is easily and quickly obtained through analysis of a patient s *** has been shown to have a predictive and negative prognostic indication in multiple cancer types,but the role of glioblastoma patients serum sodium at the time of diagnosis in predicting glioblastoma patient survival has not been *** assessed whether hyponatremia at the time of glioblastoma diagnosis correlates to patient survival and show that in our cohort of 200 glioblastoma patients,sodium,at any level,did not significantly correlate to glioblastoma survival,unlike what is seen in multiple other cancer *** further demonstrate that inducing hyponatremia in an orthotopic murine model of glioblastoma has no effects on tumor progression and survival.