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Oral microbiome: possible harbinger for children’s health

International Journal of Oral Science 2020年第2期12卷 89-101页

作者： Jin Xiao kevin a.fiscella Steven R.Gill Eastman Institute for Oral Health University of Rochester Medical CenterRochesterNYUSA Department of Family Medicine University of Rochester Medical CenterRochesterNYUSA Department of Microbiology and Immunology University of Rochester Medical CenterRochesterNYUSA Genomics Research Center University of Rochester Medical CenterRochesterNYUSA

The human microbiome functions as an intricate and coordinated microbial network,residing throughout the mucosal surfaces of the skin,oral cavity,gastrointestinal tract,respiratory tract,and reproductive *** oral microbiome encompasses a highly diverse microbiota,consisting of over 700 microorganisms,including bacteria,fungi,and *** our understanding of the relationship between the oral microbiome and human health has evolved,we have identified a diverse array of oral and systemic diseases associated with this microbial community,including but not limited to caries,periodontal diseases,oral cancer,colorectal cancer,pancreatic cancer,and inflammatory bowel *** potential predictive relationship between the oral microbiota and these human diseases suggests that the oral cavity is an ideal site for disease diagnosis and development of rapid point-of-care *** oral cavity is easily accessible with a non-invasive collection of biological *** can envision a future where early life salivary diagnostic tools will be used to predict and prevent future disease via analyzing and shaping the infant’s oral *** this review,we present evidence for the establishment of the oral microbiome during early childhood,the capability of using childhood oral microbiome to predict future oral and systemic diseases,and the limitations of the current evidence.

关键词： diagnosis salivary biome

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阴道菌群能否解释阴道pH值的种族差异

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 9-9页

作者： fiscella K. Klebanoff M.A. 王刚 Dept.Fam.Med.Comm.and Prev.Med. Univ.Rochester Sch.Med.and Dent.RochesterNYD iv.Epidemiol.S.BethesdaMDUnited States Dr.

Objectives The study assessed racia l differences in vaginal pH among women without bacterial vag *** design Data from the Vaginal Infections and Prematurity(VIP)Study were *** 1984to 1989,13,917largely low -income women were enrolled during routine prenatal visits from 23to 26weeks’*** cultures,Gram stains,and pH levels were colle *** of pH by race were made among women with G ram stain scores<7and without trichomoniasis before and after ad-justment for actual Gram stain *** Amongwomen with Gram stain scores<7,there was a modest but statis-tically significant racial differe nce in vaginal pH ***,after controlling for diff erence in Gram stain score,age,and study site,there was no longer a signifi-cant difference in vaginal *** There is no sig-nificant difference in vaginal pH le vel between black and white women after controlling for di fferences in confounding factors,particularly vaginal flora.

关键词：阴道菌群 pH值种族差异革兰染色中阴道常规产前检查毛滴虫病感染性疾病有显著性差异黑人妇女

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维普期刊数据库

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低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系

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中华高血压杂志 2020年第7期28卷 699-699页

作者： Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) 不详

低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险... 详细信息

低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。

关键词：社会经济地位冠状动脉粥样硬化性心脏病 CHD 成年人

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维普期刊数据库

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利用药房给出的数据测量青光眼患者用药物降眼压治疗的持续性和忠诚度

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 16-16页

作者： Wilensky J. fiscella R.G. Carlson A.M. 王海燕 Dr.University of Ilinois at Chicago 1855West Taylor Chicago IL 60612 United States

PURPOSE: Determine persistence and adherence of glaucoma patients to therapeutic regimens of prostaglandin/-prostamide-class IOP-lowering medications. DESIGN: Retrospective, population-based study. METHODS: Glaucoma patients in the IMS Health LifeLink database with a pharmacy claimfor latanoprost (n = 1567), travoprost (n = 381), or bimatoprost (n = 476) between September, 2001 and March, 2002 who had no claims for IOP-lowering medication in the previous 180 days, and who were persistent during the first 90 days of therapy. Values reported in the quantity dispensed and days supply fields of the database were used in an algorithmthat corrected anomalous data and adjusted days supply to calculate the main outcome measures, persistence, and adherence to therapy. RESULTS: The percentage of patients persistent for the 12-month observation period was 69.4%(1087/1567) for those prescribed latanoprost, 70.6%(269/381) for those prescribed travoprost, and 68.1%(324/467) for those prescribed bimatoprost. Mean adherence for patients prescribed latanoprost was 75.4%of the year, for those prescribed travoprost, 77.1%of the year, and for those prescribed bimatoprost, 78.2%of the year. The mean number of days adherent for bimatoprost-treated patients (291.2 days)was significantly greater than for latanoprost-treated patients (281.0 days), and not remarkably different from travoprost-treated patients (287.0 days). CONCLUSIONS: Overall, patients in this study who were taking IOP-lowering prostaglandin/prostamide medications had a mean adherence rate of 76%on average, suggesting that opportunities remain for improvement of adherence to therapeutic regimens for glaucoma treatment with prostamides and prostaglandins.

关键词：降眼压曲伏前列素拉坦前列素拉坦前列腺素青光眼忠诚度患者持续性药物

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