Oral microbiome: possible harbinger for children’s health

作     者：Jin Xiao Kevin A.Fiscella Steven R.Gill Jin Xiao;Kevin A. Fiscella;Steven R. Gill

作者机构：Eastman Institute for Oral HealthUniversity of Rochester Medical CenterRochesterNYUSA Department of Family MedicineUniversity of Rochester Medical CenterRochesterNYUSA Department of Microbiology and ImmunologyUniversity of Rochester Medical CenterRochesterNYUSA Genomics Research CenterUniversity of Rochester Medical CenterRochesterNYUSA 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2020年第12卷第2期

页      面：89-101页

核心收录：

学科分类：1003[医学-口腔医学] 100301[医学-口腔基础医学] 10[医学] 

基　　金：supported by the National Institute for Dental and Craniofacial Research K23 DE027412 

主　　题：diagnosis salivary biome 

摘      要：The human microbiome functions as an intricate and coordinated microbial network,residing throughout the mucosal surfaces of the skin,oral cavity,gastrointestinal tract,respiratory tract,and reproductive *** oral microbiome encompasses a highly diverse microbiota,consisting of over 700 microorganisms,including bacteria,fungi,and *** our understanding of the relationship between the oral microbiome and human health has evolved,we have identified a diverse array of oral and systemic diseases associated with this microbial community,including but not limited to caries,periodontal diseases,oral cancer,colorectal cancer,pancreatic cancer,and inflammatory bowel *** potential predictive relationship between the oral microbiota and these human diseases suggests that the oral cavity is an ideal site for disease diagnosis and development of rapid point-of-care *** oral cavity is easily accessible with a non-invasive collection of biological *** can envision a future where early life salivary diagnostic tools will be used to predict and prevent future disease via analyzing and shaping the infant’s oral *** this review,we present evidence for the establishment of the oral microbiome during early childhood,the capability of using childhood oral microbiome to predict future oral and systemic diseases,and the limitations of the current evidence.