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Protective effects of rice bran hydrolysates on heart rate variability,cardiac oxidative stress,and cardiac remodeling in high fat and high fructose diet-fed rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 183-193页

作者： ketmanee senaphan Upa Kukongviriyapan Pisit Suwannachot Geerasak Thiratanaboon Weerapon Sangartit Supawan Thawornchinsombut Akkasit Jongjareonrak Division of Physiology Faculty of Veterinary MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Cardiovascular Research Group Khon Kaen UniversityKhon Kaen 40002Thailand Department of Physiology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Food Technology Faculty of TechnologyKhon Kaen UniversityKhon Kaen 40002Thailand Faculty of Agro-Industry Chiang Mai UniversityChiang Mai 50100Thailand

Objective:To examine the ameliorative effect of rice bran hydrolysates(RBH)on metabolic disorders,cardiac oxidative stress,heart rate variability(HRV),and cardiac structural changes in high fat and high fructose(HFHF)-fed ***:Male Sprague-Dawley rats were daily fed either standard chow diet with tap water or an HFHF diet with 10%fructose in drinking water over 16 ***(500 and 1000 mg/kg/day)was orally administered to the HFHF-diet-fed rats during the last 6 weeks of the study *** the end of the treatment,metabolic parameters,oxidative stress,HRV,and cardiac structural changes were ***:RBH administration significantly ameliorated metabolic disorders by improving lipid profiles,insulin sensitivity,and hemodynamic ***,RBH restored HRV,as evidenced by decreasing the ratio of low-frequency to highfrequency power of HRV,a marker of autonomic *** oxidative stress was also mitigated after RBH supplementation by decreasing cardiac malondialdehyde and protein carbonyl,upregulating eNOS expression,and increasing catalase activity in the ***,RBH mitigated cardiac structural changes by reducing cardiac hypertrophy and myocardial fibrosis in HFHFdiet-fed ***:The present findings suggest that consumption of RBH may exert cardioprotective effects against autonomic imbalances,cardiac oxidative stress,and structural changes in metabolic syndrome.

关键词： Rice bran hydrolysates Heart rate variability Cardiac remodeling Metabolic syndrome Oxidative stress

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Sang-Yod rice bran hydrolysates alleviate hypertension, endothelial dysfunction, vascular remodeling, and oxidative stress in nitric oxide deficient hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第1期11卷 10-19页

作者： Gulladawan Jan-On Akarachai Tubsakul Weerapon Sangartit Poungrat Pakdeechote Veerapol Kukongviriyapan ketmanee senaphan Chakree Thongraung Upa Kukongviriyapan Department of Physiology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand School of Medicine Walailak UniversityNakhon Si ThammaratThailand Department of Pharmacology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand Division of Physiology Faculty of Veterinary MedicineKhon Kaen UniversityKhon KaenThailand Department of Food Technology Faculty of Agro-IndustryPrince of Songkla UniversitySongklaThailand

Objective:To evaluate the potential therapeutic effect of Sang-Yod rice bran hydrolysates(SRH)and in combination with lisinopril against hypertension,endothelial dysfunction,vascular remodeling,and oxidative stress in rats with nitric oxide deficiency-induced ***:Hypertension was induced in male Sprague-Dawley rats by administration of a nitric oxide synthase inhibitor,Nω-nitro-L-arginine methyl ester(L-NAME)in drinking water for 6 *** rats were administered daily with SRH(500 mg/kg/day),lisinopril(1 mg/kg/day),or the combination of SRH and lisinopril by gastric lavage for the last 3 weeks of L-NAME *** status,vascular reactivity to vasoactive agents,and vascular remodeling were *** and aortic tissues were collected for measurements of oxidative stress markers,plasma angiotensin-converting enzyme(ACE)activity,plasma angiotensinⅡ,and protein ***:L-NAME induced remarkable hypertension and severe oxidative stress,and altered contents of smooth muscle cells,elastin,and collagen of the aortic *** or lisinopril alone reduced blood pressure,restored endothelial function,decreased plasma ACEs and angiotensinⅡlevels,alleviated oxidant markers and glutathione redox status,and restored the vascular *** effects were associated with increased expression of endothelial nitric oxide synthase and decreased expression of gp91phox and AT1R *** combination of SRH and lisinopril was more effective than ***:SRH alone or in combination with lisinopril exert an antihypertensive effect and improve endothelial function and vascular remodeling through reducing oxidative stress and suppressing elevated renin-angiotensin system.

关键词： Sang-Yod rice bran hydrolysates Hypertension Endothelial dysfunction Oxidative stress Vascular remodeling

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