检索结果-南通市图书馆

Chinese Medical Journal 2005年第18期118卷 1577-1581页

作者： Hiroko Kurioka kentaro takahashi Nobuyuki Kita Yoichi Noda Department of General Medicine Shimane Prefectural Central Hospital Izumo JapanDepartment of Obstetrics and Gynecology Shiga University of Medical Science Ohtsu Japan Department of Obstetrics and Gynecology Shiga University of Medical Science Ohtsu Japan Department of Obstetrics and Gynecology Shiga University of Medical Science Ohtsu Japan

Gynecologic and obstetric disorders presenting with abdominal pain are ectopic pregnancy,rupture of endometrial cysts, mature cystic teratoma and torsion of the adnexae. Hemorrhagic ovarian cysts, which included among... 详细信息

关键词： hemorrhagic ovarian cyst·ovarian hyperstimulation syndrome·human menopausal gonadotropin·human chorionic gonadotropin

维普期刊数据库

Clinical efficacy and safety of second line and salvage aflibercept for advanced colorectal cancer in Akita prefecture

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第4期13卷 295-304页

作者： Taichi Yoshida kentaro takahashi Kengo Shibuya Osamu Muto Yuko Yoshida Daiki Taguchi Kazuhiro Shimazu Koji Fukuda Fuminori Ono Kyoko Nomura Hiroyuki Shibata Department of Clinical Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Gastroenterological Surgery Nakadori General HospitalAkita 010-8577Japan Department of Gastroenterology Akita Kousei MedicalAkita 010-0948Japan Department of Medical Oncology Akita Red Cross HospitalAkita 010-1495Japan Department of Surgery Omagari Kousei Medical CenterAkita 014-0027Japan Department of Environmental Health Science and Public Health Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Angiogenesis inhibitors(AIs)combination with cytotoxic chemotherapy is a promising treatment for patients with colorectal cancer(CRC).Aflibercept(AFL)is an option for second-line treatment of CRC,according to the‘VELOUR’***,we can choose from three AIs,including bevacizumab,ramucirumab,and *** AIs can be used in subsequent treatment because of their distinctive mechanisms of *** addressed the uncertainty regarding AFL efficacy and safety in heavily-treated patients by comparing outcomes of survival treatment with second-line *** To determine and compare the efficacy and safety profiles of AFL in the secondline and salvage therapy *** Clinical data of 41 patients with advanced CRC who received intravenous AFL combined with the folinic acid-fluorouracil-irinotecan(FOLFIRI)regimen were collected retrospectively from six institutions in Japan,for the period from May 2017 to March *** characteristics collected included age,sex,tumor location,RAS and RAF status,metastatic sites,number of previous treatment cycles,therapeutic response,adverse events,duration of previous AI treatment,and survival *** end points were time to AFL treatment failure(aTTF)and median survival time post-AFL(aMST).Statistical analyses were performed to compare the efficacy and safety in the second-line setting with those of the salvage therapy setting,which was defined as the days since the end of secondline *** All 41 patients who received AFL+FOLFIRI for advanced CRC had metastatic or unresectable ***-two patients received AFL in the second-line setting and nineteen in the salvage therapy *** patient characteristics were similar in the two groups,except for two *** median duration of the previous AI administration was shorter in the second-line patients compared with that in the salvage therapy patients(144 d vs 323 d,P=0.006).In the second-line and salvage therapy groups,the objectiv

关键词： Colorectal cancer Aflibercept Second-line chemotherapy Folinic acidfluorouracil-irinotecan Palliative chemotherapy Observational cohort study

SERUM CA 125 LEVELS IN PATIENTS WITH ENDOMETRIOSIS FOLLOWING SURGERY AND/OR DANAiZOL TREATMENT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 1988年第9期101卷 702-702页

作者： kentaro takahashi Hiroko Nagata Satoshi Kijima Yoshie Date Kazuo Yoshino Toshihiko Shibukawa Manabu Kitao Department of Obstetrics and Gynecology Shimane Medical University Izumo 693 Japan

To determine the value of serum CA 125 in assessing the effect of chemotherapy for patients with endometriosis, we measured continuously serum CA 125 levels in 9 cases of external endometriosis treated with danazol alone, and 12 cases of external endometriosis treated by operation and with danazol, and 20 cases of adenomyosis treated by operation during the 4 weeks after treatment. Analyzing the results following treatment, we found that the percentage of decrease differed in serum CA 125 among the 3 groups as compared with their respective pretreatment level. Therefore, we consider that serum CA 125 may serve as an identification marker for assessing the effect of these treatments.

关键词：

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

多囊卵巢综合征的三维和彩色多普勒超声诊断

中国超声医学杂志 2000年第8期16卷 62-64页

作者：谢红宁,秦幸吉,高桥健太郎,宫崎康二中山医科大学附属一院超声科日本岛根医科大学妇产科日本岛根医科大学妇产科日本岛根医科大学妇产科

目的 :测量多囊卵巢综合征 ( PCOS)的卵巢三维容积 ,观察其血流特征 ,探讨三维超声和彩色多普勒超声对 PCOS的诊断价值。方法 :检测 10例 PCOS和 2 0例正常已婚妇女的卵巢三维容积、血流动力学指标 ;仪器采用 Voluson 5 30 D经阴道三维 ... 详细信息

目的 :测量多囊卵巢综合征 ( PCOS)的卵巢三维容积 ,观察其血流特征 ,探讨三维超声和彩色多普勒超声对 PCOS的诊断价值。方法 :检测 10例 PCOS和 2 0例正常已婚妇女的卵巢三维容积、血流动力学指标 ;仪器采用 Voluson 5 30 D经阴道三维 /彩色多普勒超声诊断仪。结果 :PCOS组的卵巢容积 ( 9.41± 3.0 8) ml、基质容积 ( 8.31± 3.0 7) ml和卵泡数量 ( 11.2 5± 4.33) ml显著大于对照组 ( 5 .6 6± 2 .30 ) ml、 ( 4.5 4± 1.83) ml和 ( 3.5 5± 1.5 7)ml;PCOS组卵巢髓质内血流 PI ( 0 .95± 0 .15 )和 RI ( 0 .5 9± 0 .0 5 ) ,显著低于对照组 ( 1.2 2± 0 .2 9和 0 .6 2± 0 .0 6 ) ,PSV ( 12 .6 6± 3.35 ) cm/s则显著高于对照组 ( 8.42± 1.91) cm/s。结论 :三维和彩色多普勒超声增加了鉴别 PCOS的客观定量指标

关键词：多囊卵巢综合征三维超声彩色多普勒超声

The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2011年第9期2卷 755-763页

作者： kentaro Ito Akinori takahashi Masahiro Morita Toru Suzuki Tadashi Yamamoto Division of Oncology Department of Cancer BiologyInstitute of Medical ScienceUniversity of TokyoTokyo 108-8639Japan Cell Signal Unit Okinawa Institute of Science and Technology1919-1Okinawa 904-0412Japan

The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic *** evidence suggests that the non-enzymatic subunits are involved in the regulation of mRNA deadenylation,although their precise roles remain to be *** this study,we addressed the function of the CNOT1 subunit by depleting its expression in HeLa *** cytometric analysis revealed that the sub G1 fraction was increased in CNOT1-depleted ***,the same level of the sub G1 fraction was seen when cells were treated with a mixture of siRNAs targeted against all enzymatic subunits,suggesting that CNOT1 depletion induces apoptosis by destroying the CCR4-NOT-associated deadenylase *** analysis revealed that CNOT1 depletion leads to a reduction in the amount of other CCR4-NOT ***,the specific activity of the CNOT6L immunoprecipitates-associated deadenylase from CNOT1-depleted cells was less than that from control *** formation of P-bodies,where mRNA decay is reported to take place,was largely suppressed in CNOT1-depleted ***,CNOT1 has an important role in exhibiting enzymatic activity of the CCR4-NOT complex,and thus is critical in control of mRNA deadenylation and mRNA *** further showed that CNOT1 depletion enhanced CHOP mRNA levels and activated caspase-4,which is associated with endoplasmic reticulum ER stress-induced *** together,CNOT1 depletion structurally and functionally deteriorates the CCR4-NOTcomplex and induces stabilization of mRNAs,which results in the increment of translation causing ER stress-mediated *** conclude that CNOT1 contributes to cell viability by securing the activity of the CCR4-NOT deadenylase.

关键词： deadenylation CCR4-NOT small interfering RNA P-bodies apoptosis

维普期刊数据库

Drastic transitions of excited state and coupling regime in all-inorganic perovskite microcavities characterized by exciton/plasmon hybrid natures

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第1期11卷 79-86页

作者： Shuki Enomoto Tomoya Tagami Yusuke Ueda Yuta Moriyama kentaro Fujiwara Shun takahashi Kenichi Yamashita Faculty of Electrical Engineering and Electronics Kyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan

Lead-halide perovskites are highly promising for various optoelectronic applications,including laser ***,fundamental photophysics explaining the coherent-light emission from this material system is so intricate and often the subject of ***,we systematically investigate photoluminescence properties of all-inorganic perovskite microcavity at room temperature and discuss the excited state and the light–matter coupling regime depending on excitation ***-resolved photoluminescence clearly exhibits that the microcavity system shows a transition from weak coupling regime to strong coupling regime,revealing the increase in correlated electron–hole *** pumping fluence above the threshold,the photoluminescence signal shows a lasing behavior with bosonic condensation characteristics,accompanied by long-range phase *** excitation density required for the lasing behavior,however,is found to exceed the Mott density,excluding the exciton as the excited *** results demonstrate that the polaritonic Bardeen–Cooper–Schrieffer state originates the strong coupling formation and the lasing behavior.

关键词： pumping coupling regime

Diversion colitis and pouchitis: A mini-review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第16期24卷 1734-1747页

作者： kentaro Tominaga Kenya Kamimura Kazuya takahashi Junji Yokoyama Satoshi Yamagiwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an inflammatory disorder occurring in the ileal pouch, resulting from the exclusion of the fecal stream and a subsequent lack of nutrients from luminal bacteria. Although the vast majority of patients with surgically-diverted gastrointestinal tracts remain asymptomatic, it has been reported that diversion colitis and pouchitis might occur in almost all patients with diversion. Surgical closure of the stoma, with reestablishment of gut continuity, is the only curative intervention available for patients with diversion disease. Pharmacologic treatments using short-chain fatty acids, mesalamine, or corticosteroids are reportedly effective for those who are not candidates for surgical reestablishment; however, there are no established assessment criteria for determining the severity of diversion colitis, and no management strategies to date. Therefore, in this mini-review, we summarize and review various recently-reported treatments for diversion disease. We are hopeful that the information summarized here will assist physicians who treat patients with diversion colitis and pouchitis, leading to better case management.

关键词： Diversion colitis Diversion pouchitis Ileitis Inflammatory bowel disease

Voltammetric response of ferroceneboronic acid to diol and phenolic compounds as possible pollutants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2011年第6期23卷 1027-1032页

作者： Shigehiro takahashi Naoyuki Abiko Nobuhiro Haraguchi Hiroyuki Fujita Eriko Seki Tetsuya Ono kentaro Yoshida Jun-ichi Anzai Graduate School of Pharmaceutical Sciences Tohoku UniversityAramakiAoba-kuSendai 980-8578Japan School of Pharmaceutical Sciences Ohu University31-1 MisumidoTomita-machiKoriyamaFukushima 963-8611Japan

A voltammetric determination of possible organic pollutants such as diol and phenolic compounds in water was studied using ferroceneboronic acid（FBA） as a redox-active marker.A cyclic voltammogram of FBA exhibited a pair of oxidation and reduction peaks at 230 and 170 mV at pH 7.0,respectively,while another pair of redox peaks was observed in the presence of diol or phenolic compounds *** results were rationalized based on the formation of boronate esters of FBA with the added *** changes in the redox peak currents were dependent on the concentration of the additives,suggesting a usefulness of FBA in the electrochemical determination of these compounds in water.

关键词： ferroceneboronic acid sugar phenolic compound cyclic voltammetry pollutants in water electrochemical determination

维普期刊数据库

NAD＋ Accumulation during Pollen Maturation in Arabidopsis Regulating Onset of Germination

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2013年第1期6卷 216-225页

作者： Shin-nosuke Hashida Hideyuki takahashi kentaro Takahara Maki Kawai-Yamada Kazuyoshi Kitazaki Kazuhiro Shoji Fumiyuki Goto Toshihiro Yoshihara Hirofumi Uchimiya Institute of Molecular and Cellular Biosciences (IMCB) University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-0032 Japan Environmental Science Research Laboratory Central Research Institute of Electric Power Industry (CRIEPI) 1646 Abiko Chiba 270-1194 Japan Iwate Biotechnology Research Center (IBRC) Kitakami Iwate 024-0003 Japan Department of Environmental Science and Human Engineering Saitama University Sakura-ku Saitama 338-0825 Japan Institute for Environmental Science and Technology Saitama University 255 Shimo-Okubo Sakura-ku Saitama 338-8570 Japan

Although the nicotinamide nucleotides NAD（H） and NADP（H） are essential for various metabolic reactions that play major roles in maintenance of cellular homeostasis, the significance of NAD biosynthesis is not well under- stood. Here, we investigated the dynamics of pollen nicotinamide nucleotides in response to imbibition, a representative germination cue. Metabolic analysis with capillary electrophoresis electrospray ionization mass spectrometry revealed that excess amount of NAD＊ is accumulated in freshly harvested dry pollen, whereas it dramatically decreased immedi- ately after contact with water, importantly, excess of NAD~ impaired pollen tube growth. Moreover, NAD~ accumulation was retained after pollen was imbibed in the presence of NAD^-consuming reaction inhibitors and pollen germination was greatly retarded. Pollen deficient in the nicotinate/nicotinamide mononucleotide adenyltransferase （NMNAT） gene, encoding a key enzyme in NAD biosynthesis, and a lack of NAD＊ accumulation in the gametophyte, showed precocious pollen tube germination inside the anther Iocule and vigorous tube growth under high-humidity conditions. Hence, the accumulation of excess NAD＊ is not essential for pollen germination, but instead participates in regulating the timing of germination onset. These results indicate that NAD＋ accumulation acts to negatively regulate germination and a decrease in NAD＋ plays an important role in metabolic state transition.

关键词： Arabidopsis nicotinamide adenine dinucleotide (NAD) NAD biosynthesis NAD consumption NMNAT pollengermination pollen longevity.

Septic Arthritis of the Hand during Treatment of Complex Regional Pain Syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Orthopedics 2018年第8期8卷 317-321页

作者： kentaro Tsuji Hiroshi takahashi Ryoichi Fukano Masayuki Sekiguchi Department of Orthopedic Surgery Toho University School of Medicine Tokyo Japan

Complex regional pain syndrome (CRPS) complicated with septic arthritis of the hand has not previously been described. We treated a patient in whom swelling of the wrist recurred during treatment of CRPS and septic arthritis of the hand was induced by group G hemolytic streptococcus. There are case reports of tuberculous arthritis of the hand during treatment of CRPS;however, the causal relationship of wrist joint inflammation with CRPS is unclear. Careful follow-up is necessary for wrist joint inflammation if a patient with CRPS relapses with swelling of the wrist.

关键词： Septic Arthritis Complex Regional Pain Syndrome (CRPS) Hand