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A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i>Infection in Children

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Advances in Microbiology 2017年第4期7卷 253-264页

作者： Tamaki Ikuse Takahiro Kudo Naho Obayashi Keisuke Jimbo Yo aoyagi Yoshikazu Ohtsuka Thomas G. Blanchard Steven J. Czinn Toshiaki Shimizu Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan Department of Pediatrics University of Maryland School of Medicine Baltimore USA

Proper diagnosis in the pediatric population is required to eradicate Helicobacter pylori (H. pylori) and prevent gastric cancer. Our aim was to assess the performance of non-invasive tests to diagnose H. pylori infection in pediatric patients. A retrospective analysis was performed on 141 pediatric patients requiring endoscopic evaluation and diagnostic tests for H. pylori infection to define the cause of abdominal symptoms. Non-invasive tests included the 13C-urea breath test (UBT), a monoclonal stool antigen test using enzyme-linked immuno-sorbent assay (mSAT), and a serum immunoglobulin G antibody test using antigens derived from Japanese individuals (S-Ab). This study investigated sensitivity, specificity, likelihood ratios for a positive and a negative test (LR+ and LR-), and accuracy of non-invasive tests, in comparison with invasive tests. Eighty two of 141 patients (58%) were recognized as H. pylori positive by invasive methods. When UBT, mSAT or S-Ab were analyzed, all were found to be effective over 94% accurate. Specificity ranged between 86.7% and 95.8%, and sensitivity ranged between 93.8% and 97.1%. When subjects were stratified into three distinct age groups, the best performance was achieved for 1-6 years old with mSAT at 100% for sensitivity, specificity, and accuracy. S-Ab yielded the best results for children 7-12 years old and the UBT test performed best for 13-18 years old. These results demonstrate the utility of UBT, mSAT, and S-Ab non-invasive tests in diagnosing H. pylori but suggest that certain tests may be optimal for children of distinct ages. Three non-invasive tests, UBT, mSAT and S-Ab showed sufficient sensitivity, specificity and accuracy for the initial diagnosis of H. pylori infection among pediatric patients. Non-invasive tests may contribute to achieving minimum invasive diagnosis with combining with a histological test and a culture test in children.

关键词： Accuracy Non-Invasive Tests Urea Breath Test Stool Antigen Test Serum Antibody Test

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Antibiotic Resistance of <i>Helicobacter pylori</i>and Eradication Rate in Japanese Pediatric Patients

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Advances in Microbiology 2017年第4期7卷 241-252页

作者： Tamaki Ikuse Yo aoyagi Naho Obayashi Keisuke Jimbo Takahiro Kudo Yoshikazu Ohtsuka Thomas G. Blanchard Steven J. Czinn Toshiaki Shimizu Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan Department of Pediatrics University of Maryland School of Medicine Baltimore USA

Helicobacter pylori (H. pylori) eradication rates achieved with a proton pump inhibitor (PPI), amoxicillin and clarithromycin have recently decreased to about 75% because of the increase in clarithromycin resistance in Japan. In the present study, H. pylori resistance rates against clarithromycin, amoxicillin and metronidazole were investigated in pediatric patients and eradication rates were evaluated when tailored antibiotics regimens based on antibiotic sensitivity data were used. We isolated H. pylori endoscopically from 77 pediatric patients suffering from abdominal symptoms. The susceptibility tests of H. pylori strains to clarithromycin, amoxicillin and metronidazole were examined and eradication therapy was tailored using the appropriate antibiotics. Seventy-seven patients were treated with a mean age of 12.16 ± 3.34 years (range, 4.92-19.75) consisting of 40 males and 37 females. The average resistance rates between 1998 and 2016 to clarithromycin, amoxicillin and metronidazole were 54.5% (42 of 77), 6.5% (5 of 77) and 5.2% (4 of 77) respectively. The prevalence of clarithromycin resistance increased significantly over time to reach 88.9% by 2013-2016. Successful eradication rates using tailored antibiotic treatment was 93.8% (61 of 65). Clarithromycin-based eradication therapy rate reached 92.6% against clarithromycin-sensitive strains. Metronidazole-based initial eradication therapy also had a high successful rate (97.0%) to clarithromycin-resistant strains. Although high rates of clarithromycin resistant H. pylori reaching about 90% were observed in Japanese children, tailored eradication therapy using the appropriate antibiotic agents were highly successful. H. pylori sensitivity testing and eradication therapy with appropriate antibacterial agents may contribute to accomplishment of high initial eradication rates and consequently reducing the incidence of developing gastric cancer.

关键词： Resistance Eradication Rate Susceptibility Test Clarithromycin Metronidazole

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W350计划日本东京

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世界建筑导报 2023年第S2期38卷 76-79页

作者：青柳创无不详 Sumitomo Forestry Co. Ltd. Nikken Sekkei

打造森林城市,还原绿色生活的木结构超高层建筑构想W350计划不仅仅是未来技术的发展蓝图。在人工林覆盖率约30%的日本,由于现代化导致木材需求下降、山林荒废和国内林业衰退,该项目也对濒临崩溃的森林循环提出了问题和解决思路。开启该... 详细信息

打造森林城市,还原绿色生活的木结构超高层建筑构想W350计划不仅仅是未来技术的发展蓝图。在人工林覆盖率约30%的日本,由于现代化导致木材需求下降、山林荒废和国内林业衰退,该项目也对濒临崩溃的森林循环提出了问题和解决思路。开启该项目是为了研究在日本城市中用木结构建造一座350米高超高层建筑能否成为恢复原有森林循环(植树育林、砍伐后用于建筑等产品、待到腐朽后再回归土壤重新培育树木的循环)、复活山林和激活城市环境的有效方法。为实现该目标而进行的每一次技术验证和讨论都凸显了木材、山林以及木材这种材料所具有的现代意义,以及用木结构建造摩天大楼这一行为的社会意义。

关键词：超高层建筑木结构摩天大楼木材需求技术验证日本东京覆盖率山林

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Association of ITPA polymorphism with outcomes of peginterferon-α plus ribavirin combination therapy

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2013年第3期4卷 54-60页

作者： Tatsuya Fujino Yoko aoyagi Mariko Takahashi Ryoko Yada Naoko Yamamoto Yuki Ohishi Akihiko Nishiura Motoyuki Kohjima Tsuyoshi Yoshimoto Kunitaka Fukuizumi Manabu Nakashima Masaki Kato Kazuhiro Kotoh Makoto Nakamuta Munechika Enjoji Laboratory for Clinical Investigation National Hospital Organization Nagasaki Medical CenterOhmuraNagasaki 856-8562Japan Clinical Research Institute National Hospital Organization Kyushu Medical CenterFukuoka 814-0180Japan Faculty of Pharmaceutical Sciences Fukuoka UniversityFukuoka 814-0180Japan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 814-0180Japan

AIM:To analyzed the association between inosine triphosphatase(ITPA)(rs1127354) genotypes and sustained virological response(SVR) rates in peginterferon(Peg-IFN)α + ribavirin(RBV) ***:Patients who underwent Peg-IFNα + RBV combination therapy were enrolled(n = 120) and they had no history of other IFN-based *** in hemoglobin levels during therapy,cumulative reduction of RBV dose,frequency of treatment withdrawal,and SVR rates were investigated in each ITPA ***:In patients with ITPA CC genotype,hemoglobin decline was significantly greater and the percentage of patients in whom total RBV dose was < 60% of standard and/or treatment was withdrawn was significantly higher compared with CA/AA ***,SVR rates were equivalent between CC and CA/AA genotypes,and within a subset of patients with Interleukin 28B(IL28B)(rs8099917) TT genotype,SVR rates tended to be higher in patients with ITPA CC genotype,although the difference was not ***:ITPA CC genotype was a disadvantageous factor for Peg-IFNα + RBV treatment in relation to completion rates and RBV ***,CC genotype was not inferior to CA/AA genotype for SVR *** full-length treatment is accomplished,it is plausible that more SVR is achieved in patients with ITPA CC variant,especially in a background of IL28B TT genotype.

关键词： Chronic hepatitis C Interleukin 28B Inosine triphosphatase Peginterferon Ribavirin

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家长对幼儿教育的期望:中、日、韩三国之比较

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学前教育研究 2006年第4期 60-62页

作者：周爱保马小凤青柳肇西北师范大学心理系兰州730070 早稻田大学人类科学部

本研究采用自编量表调查了来自中、日、韩三国的727名家长对其孩子受教育的期望。结果显示:三国家长对其孩子的成长都持积极期望的态度;在“主体积极发展”“关注饮食”“意志力培养”“道德判断”“与成人情感交流”等因子上,国别差异... 详细信息

本研究采用自编量表调查了来自中、日、韩三国的727名家长对其孩子受教育的期望。结果显示:三国家长对其孩子的成长都持积极期望的态度;在“主体积极发展”“关注饮食”“意志力培养”“道德判断”“与成人情感交流”等因子上,国别差异显著;国别与性别,国别与年龄,性别与年龄,国别、性别与年龄交互作用均不显著。

关键词：家长期望国别性别跨文化比较

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肠内营养法作为肠淋巴管扩张症的主要疗法:与完全肠外营养相比要素饮食与多聚合剂的价值

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 8-9页

作者： aoyagi K. Iida M. Matsumoto T. Sakisaka S. 刘丽娜 Third Department of Medicine School of Medicine Fukuoka University 7- 45- 1 Nanakuma Jonan-ku Fukuoka 814- 0180 Japan Dr.

Intestinal lymphangiectasia (IL) is a rare disease requiring oral fat restriction. The aim of this study was to evaluate the efficacy of enteral nutrition compared to that of total parenteral nutrition (TPN).We retrospectively reviewed nine patients with IL presenting with protein- losing enteropathy. Of these, seven patients not responding to a low- fat diet were treated with elemental diet (ED), polymeric diet (PD) containing medium- chain triglycerides, or TPN. Improvement in serum total protein was observed in two of three on ED and in one of two on PD, compared with three of three on TPN. Enteric protein loss was improved in two of two on ED, one of two on PD, and two of two on TPN. Outpatients who continued to receive enteral nutrition maintained a total protein level. Enteral nutirition appears to be as effective as TPN for patients with IL, and it may provide a valid and safe alternative therapy.

关键词：肠淋巴管扩张症完全肠外营养主要疗法要素饮食聚合剂蛋白丢失性肠病血清总蛋白低脂饮食完全

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日本长崎县中老年妇女跌倒相关疾病与髋部骨折的病例对照研究

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中国骨质疏松杂志 2014年第7期20卷 839-843页

作者：黄海蓉叶兆嘉青柳潔田添英明深圳市麒麟山疗养院深圳518055 深圳市疾病预防控制中心深圳518055 长崎大学大学院公共卫生研究室长崎8518523 长崎县国民健康保险团体连合会长崎8500025

目的探讨中老年妇女跌倒相关疾病和髋部骨折的关系。方法研究对象为日本长崎县国民健康保险的参保者。收集45岁以上妇女髋部骨折住院患者1109例,按年龄配比随机抽取1109名其他患者,进行病例对照研究。髋部骨折和跌到相关疾病根据国际疾... 详细信息

目的探讨中老年妇女跌倒相关疾病和髋部骨折的关系。方法研究对象为日本长崎县国民健康保险的参保者。收集45岁以上妇女髋部骨折住院患者1109例,按年龄配比随机抽取1109名其他患者,进行病例对照研究。髋部骨折和跌到相关疾病根据国际疾病分类标准编码第十版(ICD-10)进行判定。卡方检验用于比较两组患者跌倒相关疾病的患病率差,条件Logistic回帰分析用于分析跌倒相关疾病与髋部骨折的关联性。结果 75%以上的髋部骨折患者的年龄大于80岁。髋部骨折患者的视力障碍(14.25%vs.8.66%,P<0.001),脑卒中(14.07%vs.9.92%,P=0.002),肌肉骨骼疾病(43.91%vs.38.77%,P<0.001),帕金森氏病(5.86%vs.1.53%,P<0.001),认知障碍(11.45%vs.4.33%,P<0.001)和抑郁症(13.89%vs.5.86%,P<0.001)的患病率显著高于对照组。这些疾病的髋部骨折相对危险度分别为:视力障碍1.49(95%CI:1.13,1.98)、脑卒中1.29(95%CI:0.98,1.69)、肌肉骨骼疾病1.29(95%CI:1.08,1.54)、帕金森氏病3.33(95%CI:1.87,5.92)、认知障碍2.46(95%CI:1.72,3.52)和抑郁症2.09(95%CI:1.54,2.85)。合并的跌倒相关疾病越多,髋部骨折风险越大。结论在中老年妇女,跌倒相关疾病与髋部骨折有显著的关联性。积极预防和治疗跌倒相关疾病可能有益于降低髋部骨折的发生危险。

关键词：跌倒相关疾病髋部骨折病例对照研究

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Immunohistochemical analysis of histone H3 modification in newt tail tissue cells follow ing amputation

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解剖学杂志 2021年第S1期44卷 213-213页

作者： Wu Jiwen Zhang Xu Reiko Sekiya aoyagi Kiyoshi Li Tao-Sheng Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesFujian Medical University Department of Public Health Nagasaki University Graduate School of Biomedical Sciences

Newts have impressive regenerative capabilities,but it remains unclear about the role of epigenetic regulation in regeneration *** herein investigated histone modifications in newt tail tissue cells following *** ribbed newts(6-8 months old)were suffered to about 1.5 cm length of amputation of their tails for initiating regeneration process,and the residual stump of tail tissues were collected for immunohistochemical analysis 3 days *** to the tissue cells of intact tails,c Kit positive stem cells and PCNA positive proliferating cells were significantly higher in tails suffered to *** also significantly induced the acetylation of H3K9,H3K14 and H3K27 in cells of the tails with amputation,but did not significantly change the methylation of *** results suggest that epigenetic regulation likely involves in newt tail regeneration following amputation.

关键词： amputation analysis likely

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幼儿做事能力的发展与家长的教育期望——中日韩跨文化比较研究

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幼儿教育（教育科学） 2007年第5期 49-52页

作者：周爱保陈斌青柳肇西北师范大学教育学院兰州730070 日本早稻田大学人类科学部

幼儿做事能力反映了幼儿的动作发展水平,而动作的发展与个体早期心理发展密切相关。本研究采用量表,对中国、日本和韩国的722名幼儿家长进行了问卷调查。考察了中日韩三国幼儿做事能力的现有水平和家长对幼儿做事能力的期望。研究结果显... 详细信息

幼儿做事能力反映了幼儿的动作发展水平,而动作的发展与个体早期心理发展密切相关。本研究采用量表,对中国、日本和韩国的722名幼儿家长进行了问卷调查。考察了中日韩三国幼儿做事能力的现有水平和家长对幼儿做事能力的期望。研究结果显示:(1)中国与日本之间、日本与韩国之间幼儿做事能力差异显著,而中国与韩国差异不显著。(2)中国家长与日本家长之间、日本家长与韩国家长之间对幼儿做事能力的期望存在显著差异,而中国家长与韩国家长差异不显著。(3)幼儿的做事能力与家长对幼儿做事能力的期望显著相关。不同的经济发展水平、文化传统和家庭教育观念是影响幼儿动作发展的重要因素。

关键词：做事能力家长幼儿期望中日韩

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市民社会的社会福利事业与资金筹措政策的新动向——日本市川市的市民活动团体资助制度

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社会保障研究 2008年第2期 144-156页

作者：于洋青柳龙司日本城西大学现代政策学院早稻田大学日本流通科学大学商学院

在居民对社会福利等公共服务的需求日益增大的今天,社会保障及社会福利服务的资金筹措问题备受关注。拙稿通过介绍在日本市川市实施的,由纳税人将个人居民税的1%指定交付给自己选择的公益性市民团体的'1%资助制度',向广大读者介绍最新... 详细信息

在居民对社会福利等公共服务的需求日益增大的今天,社会保障及社会福利服务的资金筹措问题备受关注。拙稿通过介绍在日本市川市实施的,由纳税人将个人居民税的1%指定交付给自己选择的公益性市民团体的'1%资助制度',向广大读者介绍最新的社会福利事业的筹资形式。'1%资助制度'的效果优于直接发放政府补助金的方式,是资助非营利团体开展公益活动的一种新尝试。通过对该制度的详细分析与探讨我们力图回答'1%资助制度'是否会带来挤出效应。经过分析,拙稿得出的结论是,'1%资助制度'的经济效果显著,对提高地区福利水平,培养居民的纳税意识,减缓政府财政紧张都有积极作用。不过必须指出的是,如今制度参与率不够理想,只有当参与率不断上升,才会带来更大的经济效果。

关键词：纳税投票人 “percentage law” “1%资助制度” 居民税

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