Immunohistochemical analysis of histone H3 modification in newt tail tissue cells follow ing amputation
作者机构：Department of Stem Cell BiologyAtomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesFujian Medical University Department of Public HealthNagasaki University Graduate School of Biomedical Sciences
出 版 物：《解剖学杂志》 (Chinese Journal of Anatomy)
年 卷 期：2021年第44卷第S1期
页 面：213-213页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：amputation analysis likely
摘 要：Newts have impressive regenerative capabilities,but it remains unclear about the role of epigenetic regulation in regeneration *** herein investigated histone modifications in newt tail tissue cells following *** ribbed newts(6-8 months old)were suffered to about 1.5 cm length of amputation of their tails for initiating regeneration process,and the residual stump of tail tissues were collected for immunohistochemical analysis 3 days *** to the tissue cells of intact tails,c Kit positive stem cells and PCNA positive proliferating cells were significantly higher in tails suffered to *** also significantly induced the acetylation of H3K9,H3K14 and H3K27 in cells of the tails with amputation,but did not significantly change the methylation of *** results suggest that epigenetic regulation likely involves in newt tail regeneration following amputation.
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