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城市住宅 1995年第7期2卷 16-21页

作者： kenneth ng Pauline Yu 熟芹 Kenii Desian

火炉自白我很少照镜,但是,他们告诉我,我是黑色的,而且有美丽的图案,长方形,我不知自己叫什么名字,他们叫我火炉。那么,我就是火炉了。一个漂亮的火炉。

关键词：火炉电视剧设计师电视机沙发户主长方形黑色自白图案

在数据安全性和真实性方面符合21 CFR Part 11的要求

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毒理学杂志 2007年第4期21卷 284-284页

作者： kenneth ng Waters Asia Limited

在必须遵循法规要求的企业中,向政府机构(FDA)提供数据保证所生产的产品可以满足质量和一致性的要求是一项费时和昂贵的挑战。在FDA发布新的“基于风险评估”方法的背景下,你如何来应对这些挑战来符合21CFRPart11的要求呢?[第一段]

关键词：数据安全性 21 CFR Part 11 风险评估

Hemorrhagic pancreatitis from fenofibrate and metformin toxicity:a case report

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World Journal of Emergency Medicine 2023年第6期14卷 495-498页

作者： Marcus Aik Beng Lee Mingwei ng Paul Yugendra Yiju Yao R Ponampalam Boon Kiat kenneth Tan Department of Emergency Medicine Singapore General HospitalSingapore 169608Singapore Analytical Toxicology Laboratory Health Sciences AuthoritySingapore 169078Singapore

Fibrates have been used for over forty-odd years to manage dyslipidemia and are generally considered safe and well-tolerated.^([1])However,little is known about the toxicity offibrates in overdose,[2]and most of the knowledge about fibrate toxicity comes from extrapolated observations of adverse effects encountered at therapeutic doses instead.

关键词： doses pancreatitis

Resection of T4 hepatocellular carcinomas with adjacent structures, is it justified？

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 52-57页

作者： kenneth SH Chok Ka Kin ng Tan To Cheung Albert CY Chan See Ching Chan Chung Mau Lo Department of Surgery The University of Hong Kong

BACKGROUND： T4 hepatocellular carcinoma （HCC） with invasion to adjacent structure（s） may require resection of not only the tumor but also the invaded structure（s）. This study aims to assess whether such combined resection for T4 HCC is justifiable. METHODS： Adult patients with T4 HCC were divided into three groups. Group 1： tumors and invaded adjacent structures were resected together if histopathologically confirmed tumor invasion; group 2： same as group 1 but histopathologically confirmed tumor adhesion; group 3： tumor resection only. Group comparisons were made. RESULTS： Totally 144 patients were included in the study. There were 71, 14 and 59 patients in groups 1, 2 and 3, respec- tively. The groups were comparable in demographics, compli- cation and survival. Ten hospital deaths occurred （5, 0 and 5 in groups 1, 2 and 3, respectively; P=0.533）. The 5-year overall survival （hospital mortality excluded） was 17.8% in group 1, 14.3% in group 2, and 28.9% in group 3 （P=0.191）. The 5-year disease-free survival was 10.4% in group 1 and 14.5% in group 3 （no data for group 2 yet）（P=0.565）. On multivariate analysis, macrovascular invasion and poor differentiation were risk factors for survival whereas combined resection did not impact patients＇ survival. CONCLUSIONS： Combined resection achieved survival outcomes similar to tumor resection only. Patients with tumor invasion and those with tumor adhesion had comparable survival after combined resection. At centers with the required expertise, combined resection should be attempted to treat T4 HCCs with clinically suspected invasion of adjacent structures.

关键词： desmosplastic reaction en-bloc resection hepatocellular carcinoma invasion recurrence

A case of persistent refractory hypoglycemia from polysubstance recreational drug use

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World Journal of Emergency Medicine 2023年第1期14卷 75-77页

作者： Jie Er Janice Soo Mingwei ng Terence Kee Liem Chong Boon Kiat kenneth Tan R Ponampalam Department of Emergency Medicine Singapore General Hospital169608Singapore

Dear editor,Studies have revealed a significant prevalence of mixed substance abuse,[1-3]and a focused approach towards polysubstance use has been emphasized.[4]Among recreational drugs,cases of hypoglycemia from ecstasy,[5]amphetamine,[6]eutylone,[7]and cannabinoid[8]use have been reported,but none of these cases have had persistent refractory hypoglycemia.

关键词： drugs cases prevalence

Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes

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World Journal of Gastroenterology 2010年第24期16卷 3056-3062页

作者： Tan To Cheung Kelvin K ng kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan Department of Surgery The University of Hong Kong 102 Pok Fu Lam Road Queen Mary Hospital

AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical ***: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were ***: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had few

关键词： Hepatocellular carcinoma Radiofrequency ablation Combined resection Resection Cirrhosis

The Implications of the Timing of Diagnosis of Dementia on the Dementia Caregiver

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Advances in Alzheimer's Disease 2016年第4期5卷 143-154页

作者： kenneth K. W. ng Melinda Martin-Khan Maree Farrow Elizabeth Beattie Nancy A. Pachana Centre for Research in Geriatric Medicine Faculty of Medicine School of Medicine The University of Queensland Brisbane Australia Queensland Health Sunshine Coast Hospital & Health Service Nambour Australia Centre for Online Health Faculty of Medicine School of Medicine The University of Queensland Brisbane Australia Wicking Dementia Research and Education Centre University of Tasmania Hobart Australia Faculty of Health School of Nursing Queensland University of Technology Brisbane Australia School of Psychology The University of Queensland Brisbane Australia

This is a consumer-reference feedback and feasibility testing of a protocol to obtain qualitative responses of co-residing caregivers to questions regarding the timing of dementia diagnosis and their experience of the disclosure of a diagnosis of dementia. Data collection involved focus group discussions and individual phone interviews of a convenience sample (N = 5) of an Alzheimer’s Australia state based Consumer Advisory Committee. Thematic analysis utilised the Leximancer software. Consumer feedback suggested a reordering of the interview questions and reversing the data collection sequence to reduce the emotional impact on participants. Suggestions were offered to limit the number of participants in the focus group to shorten the duration of the focus group session to prevent fatigue and to provide a support person to improve participant focus group comfort. Responses to the interview questions indicated caregivers retrospectively considered a timely diagnosis would have provided useful dementia-focused planning, reduced the difficulties of living with uncertainty and would have provided more time to obtain information and support. There were strong expectations for medical practitioners to be sensitive to the possibility of dementia and to be cognisant of the diagnostic concerns of caregivers. The diagnosis of dementia and its timing is important to the dementia caregiver in providing an explanation of the problems experienced and allowing earlier organisation of care, future planning and caregiver education to reduce the difficulties of living with undiagnosed and unrecognised dementia.

关键词： Caregiver Timing Diagnosis Dementia Co-Residing

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第二家居室

城市住宅 1997年第10期4卷 79-81页

作者： Louie ng kenneth Choi L/C Design

全屋无论是木围身、饰柜、门口、门框,都利用木的深浅色作对比,期望在有限的预算中,利用普通的材料也能增添特色。

关键词：居室室内装饰室内设计色彩对比

Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells

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Cellular & Molecular Immunology 2016年第1期13卷 119-131页

作者： Rhonda L Taylor Mark N Cruickshank Mahdad Karimi Han Leng ng Elizabeth Quail kenneth M Kaufman John B Harley Lawrence J Abraham Betty P Tsao Susan A Boackle Daniela Ulgiati School of Pathology and Laboratory Medicine Centre for Genetic Origins of Health and Disease The University of Western Australia Crawley WA Australia Biochemistry and Molecular Biology School of Chemistry and Biochemistry The University of Western Australia Crawley WA Australia Telethon Kids Institute The University of Western Australia Crawley WA Australia Cincinnati Children's Hospital Medical Center Cincinnati OH USA US Department of Veterans Affairs Medical Center Cincinnati OH USA Division of Rheumatology Department of Medicine University of California at Los Angeles Los Angeles CA USA Division of Rheumatology University of Colorado School of Medicine Aurora CO USA

Complement receptor 2 （CR2/CD21） is predominantly expressed on the surface of mature B cells where it forms part of a coreceptor complex that functions, in part, to modulate B-cell receptor signal strength. CR2/CD21 expression is tightly regulated throughout B-cell development such that CR2/CD21 cannot be detected on pre-B or terminally differentiated plasma cells. CR2/CD21 expression is upregulated at B-cell maturation and can be induced by IL-4 and CD40 signaling pathways. We have previously characterized elements in the proximal promoter and first intron of CR2/CD21 that are involved in regulating basal and tissue-specific expression. We now extend these analyses to the CR2/CD21 core promoter. We show that in mature B cells, CR2/~D21 transcription proceeds from a focused TSS regulated by a non-consensus TATA box, an initiator element and a downstream promoter element. Furthermore, occupancy of the general transcriptional machinery in pre-B versus mature B-cell lines correlate with CR2/CD21 expression level and indicate that promoter accessibility must switch from inactive to active during the transitional B-cell window.

关键词： B cells core promoter CR2/CD21 molecular biology transcription factor