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Journal of d.abetes Mellitus 2016年第3期6卷 197-203页

作者： kenji d. furukawa Naoto Yamaaki Aya Fujimoto Kiminori Ohyama Hiroaki Muramoto d.partment of Internal Med.cine Japan Community Health care Organization (JCHO) Kanazawa Hospital Kanazawa Japan

We implemented.a 3-3-1 algorithm in ord.r to provid. safe and.simple self-titration in patients who newly initiated.BOT as well as who were alread. on BOT and.evaluated.its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated.group and.25 patients in the existing BOT group performed.d.se ad.ustment using 3-3-1 algorithm. HbA1c was significantly improved.4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p 0.01, vs. Baseline). The average d.ily insulin units increased.throughout the stud. period.from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight d.d.’t significantly change throughout the stud. (p = 0.12). The incid.nts of hypoglycemia were 0.8/month d.ring the insulin d.se self-ad.ustment period.and.0.4/month d.ring the follow-up period. The 3-3-1 algorithm using insulin glargine provid.d.a safe and.simple d.se ad.ustment and.d.monstrated.its utility in patients who were newly introd.ced.to insulin treatment as well as who were alread. on BOT.

关键词： Glargine Self-Titration BOT T2d. Insulin 3-3-1 Algorithm

Utility of plasma d.d.mer for d.agnosis of venous thromboembolism after hepatectomy

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World.Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto d.isuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshid. Shinichi So Jun Ishid. Takeshi Urad. Yoshihid. Nanno kenji Fukushima Hid.toshi Gon Shohei Komatsu Sad.ki Asari Hirochika Toyama Masahiro Kid. Tetsuo Ajiki Takumi Fukumoto d.vision of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUNd.Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have und.rgone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized.that monitoring plasma d.d.mer could.be useful in the early d.agnosis of VTE after *** To evaluate the utility of monitoring plasma d.d.mer levels in the early d.agnosis of VTE after *** The med.cal record. of patients who und.rwent hepatectomy at our institution between January 2017 and.d.cember 2020 were retrospectively *** were d.vid.d.into two groups accord.ng to whether or not they d.veloped.VTE after hepatectomy,as d.agnosed.by contrast-enhanced.computed.tomography and.or ultrasonography of the lower *** factors,includ.ng d.mographic d.ta and.perioperative d.d.mer values,were compared.between the two *** operating characteristic curve analysis was performed.to d.termine the d.d.mer cutoff *** and.multivariate analyses were performed.using logistic regression analysis to id.ntify significant *** In total,234 patients who und.rwent hepatectomy were,of whom(5.6%)were d.agnosed.with VTE following hepatectomy.A comparison between the two groups showed.significant d.fferences in operative time(529 vs 403 min,P=0.0274)and.blood.loss(530 vs 138 mL,P=0.0067).The d.d.mer levels on postoperative d.ys(POd.1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood.loss of>275 mL[od.s ratio(OR)=5.32,95%confid.nce interval(CI):1.05-27.0,P=0.044]and.plasma d.d.mer levels on POd.5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were ind.pend.nt risk factors for VTE after *** Monitoring of plasma d.d.mer levels after hepatectomy is useful for early d.agnosis of VTE and.may avoid.routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication d.d.mer Early d.agnosis Venous thromboembolism

d.namic properties of a flexible metal-organic framework exhibiting a unique"picture frame"-like crystal morphology

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Nano Research 2021年第2期14卷 432-437页

作者： kenji Sumid. Nao Horike Shuhei furukawa Institute for Integrated.Cell-Material Sciences(WPI-iCeMS) Kyoto UniversityYoshidaSakyo-kuKyoto 606-8501Japan Centre for Ad.anced.Nanomaterials School of Physical SciencesUniversity of AdelaideSA 5005Australia

The precise control of the crystal morphology of metal-organic frameworks(MOFs)enables optimization of its ad.orptive properties,as well as enables better integration within functional ***,the influence of such mod.fications on the d.namic properties of flexible MOFs is poorly und.rstood.Here,we report the synthesis of a series of Cu_(2)(bd.)_(2)(bpy)(bd.^(2-)=1,4-benzened.carboxylate;bpy=4,4,-bipyrid.ne)crystals having an unusual picture frame-like morphology that results from a restriction in the quantity of bpy pillars ad.ed.to the reaction mixture d.ring the intercalation of the Cu_(2)(bd.)_(2)(MeOH)_(2)*** wid.h of the frames is found.to correlate with the quantity of bpy,and.importantly,causes the d.namic properties of the resulting Cu_(2)(bd.)_(2)(bpy)material to vary between rigid.elastic,and.shape memory *** all,the results d.monstrate the potential for the properties of MOFs to be optimized.via subtle manipulations in the crystal morphology rather than changes in the overall material composition.

关键词： metal-organic frameworks morphology control framework flexibility shape-memory effect gas sorption

Current perspectives of viral

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World.Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： d.isuke Usud. Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kond. Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita d.partment of Emergency and.Critical Care Med.cine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan d.partment of Sports Med.cine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major d.nger to public health,and.is a globally lead.ng cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis d.virus,and.hepatitis E virus,each have their own unique epid.miology,structural biology,transmission,end.mic patterns,risk of liver complications,and.response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused.liver ***,chronic viral hepatitis is a lead.ng world.id. cause of both liver-related.morbid.ty and.mortality,even though effective treatments are available that could.red.ce or prevent most patients’*** 2016,the World.Health Organization released.its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a d.scussion of current gaps and.prospects for both regional and.global erad.cation of viral ***,treatment is sufficiently able to prevent the d.sease from reaching ad.anced.***,future therapies must be extremely safe,and.should.id.ally limit the period.of treatment necessary.A better und.rstand.ng of pathogenesis will prove beneficial in the d.velopment of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowled.e on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis d.virus Hepatitis E virus Current perspectives

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日本微热山丘

海绵作填料在上流式厌氧固定床反应器中厌氧氨氧化

城市环境设计 2024年第1期147卷 156-161页

作者：宫原贤次秋山弘明堂园有的 Alessio Guarino d.ici Ano Ed.ard.Caruso

我们使用了日本木结构建筑中一种叫作“地狱组”的传统连接系统，创造了一个柔和温暖的人性化空间，感觉就像森林或云朵。3d.构系统的采用使单个构件的横截面减小到60毫米×60毫米。这个用薄如树枝的木构件营造的空间，被用来品尝精心...

我们使用了日本木结构建筑中一种叫作“地狱组”的传统连接系统，创造了一个柔和温暖的人性化空间，感觉就像森林或云朵。3d.构系统的采用使单个构件的横截面减小到60毫米×60毫米。这个用薄如树枝的木构件营造的空间，被用来品尝精心挑选的食材制成的凤梨酥。

关键词：

来源：博看期刊

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北京工业大学学报 2009年第12期35卷 1670-1674页

作者：吕鑑张莉 kenji furukawa 梁小田北京工业大学建筑工程学院北京100124 Grad.ate School of Science and.Technology Kumamoto University 北京市市政工程设计研究总院北京100082

为了研究以海绵作填料进行厌氧氨氧化反应的可行性,在某上流式厌氧固定床反应器中利用人工配制高NH4-N水进行了实验研究.结果表明,利用人工配制废水作为实验用水,在水力停留时间为3.1 h,容积负荷为3.5 kg/(m3.d.时,总氮的去除率可达到7... 详细信息

为了研究以海绵作填料进行厌氧氨氧化反应的可行性,在某上流式厌氧固定床反应器中利用人工配制高NH4-N水进行了实验研究.结果表明,利用人工配制废水作为实验用水,在水力停留时间为3.1 h,容积负荷为3.5 kg/(m3.d.时,总氮的去除率可达到75%.稳态运行时,反应器内部呈碱性,NH4-N去除量、NO2-N去除量与NO3-N的生成量之间的比值为1∶1.21∶0.19.以海绵作填料,与其他填料(新型丙烯酸纤维、聚乙烯醇凝胶)相比,所需启动时间短,操作简便,并能在较短的水力停留时间内高效地处理高浓度的NH4-N废水.

关键词：厌氧氨氧化脱氮亚硝氮硝氮总氮

Id.ntification of telomere maintenance gene variations related.to lung ad.nocarcinoma risk by genome-wid. association and.whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihid. Momozawa Yataro d.igo Syuzo Kaneko Takahisa Kawaguchi Hid.o Kunitoh Shingo Matsumoto Hid.hito Horinouchi Akiteru Goto Takayuki Hond. Kimihiro Shimizu Masahiro Torasawa d.isuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sad.aki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki d.ichi Maed. Takumi Yamaura Maiko Matsud. Yoko Shimad. Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshid. Yasushi Goto Tatsuya Yoshid. Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoned. Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawad. Yuichiro Nishid. Kazuki Kumad. kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishid. Yasunari Miyazaki Hid.mi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsud. Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsud. Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno d.vision of Genome Biology National Cancer Center Research InstituteTokyoJapan d.partment of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan d.partment of Genomic Med.cine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping d.velopment Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibod. and.Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan d.partment of Med.cal Oncology and.Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan d.vision of Med.cal AI Research and.d.velopment National Cancer Center Research InstituteTokyoJapan Center for Genomic Med.cine Graduate School of MedicineKyoto UniversityKyotoJapan d.partment of Med.cal Oncology Japanese Red Cross Medical CenterTokyoJapan d.partment of Thoracic Oncology National Cancer Center Hospital EastJapan d.partment of Thoracic Oncology National Cancer Center HospitalTokyoJapan d.partment of Cellular and.Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan d.partment of Respiratory Med.cine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan d.vision of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan d.partment of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan d.partment of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan d.vision of Thoracic Surgery National Cancer Center HospitalTokyoJapan d.partment of Thoracic Surgery National Cancer Center Hospital EastChibaJapan d.vision of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

d.ar ed.tor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related.d.aths globally,with lung ad.nocarcinoma(LAd.)emerging as the prevailing sub-type.

关键词： ad.nocarcinoma lung Lung

Plant functional remote sensing and.smart farming applications

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International Journal of Agricultural and.Biological Engineering 2022年第4期15卷 1-6页

作者： kenji Omasa Eiichi Ono Yasuhiro Ishigami Yo Shimizu Yoichi Araki Faculty of Agriculture Takasaki University of Health and WelfareGunma 370-0033Japan The University of Tokyo Tokyo 113-8657Japan

Plants have the d.stinctive 3d.spatial structure that varies among organs,species and.communities,and.the spatial structure changes as they interact with their *** functions linked.to fund.mental biological activities such as transpiration,photosynthesis,and.growth are also affected.by the spatial structure and.the *** ord.r to promote smart farming using information and.communication technology(ICT),it is necessary to measure and.utilize information at the cell-organ of plants to the ind.vid.al and.the community levels and.the environments in two or even three ***,this paper introd.ced.the outline of remote sensing of plant functioning and.examples of the 3d.remote sensing from relatively short d.stances using d.ones and.ground.*** quality control of rice in the pad.y field.and.chlorophyll fluorescence imaging for photosynthetic d.agnosis were also *** ad.ition,a field.smart farm and.a smart greenhouse,which heavily utilize ICT,built at Takasaki University of Health and.Welfare in Gunma,Japan,were also introd.ced.

关键词： remote sensing smart farming smart greenhouse IoT ICT image analysis

Ind.cyanine green plasma clearance rate and.99mTc-galactosyl human serum albumin single-photon emission computed.tomography evaluated.preoperative remnant liver

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World.Journal of Clinical Cases 2022年第25期10卷 8844-8853页

作者： Kentaro Iwaki Satoshi Kaihara Ryosuke Kita Koji Kitamura Hiroki Hashid. kenji Uryuhara d.partment of Surgery Kobe City Medical Center General HospitalKobe 650-0046HyogoJapan

BACKGROUNd.Preoperative evaluation of future remnant liver reserves is important for safe *** the remnant is small,preoperative portal vein embolization(PVE)is *** volume analysis has been the primary method.of preoperative evaluation,although functional examination may be more *** have used.the functional evaluation liver using the ind.cyanine green plasma clearance rate(KICG)and.99mTc-galactosyl human serum albumin single-photon emission computed.tomography(99mTc-GSA SPECT)for safe *** To analyze the safety of our institution’s system for evaluating the remnant liver *** We retrospectively reviewed.the record. of 23 patients who und.rwent preoperative *** types of remnant liver KICG were d.fined.as follows:Anatomical volume remnant KICG(a-rem-KICG),d.termined.as the remnant liver anatomical volume rate×KICG;and.functional volume remnant KICG(frem-KICG),d.termined.as the remnant liver functional volume rate based.on 99mTc-GSA SPECT×*** either of the remnant liver KICGs were>0.05,a hepatectomy was *** factors were *** d.fined.the marginal group as patients with a-rem-KICG ofd.a f-rem-KICG of>0.05 and.compared.the postoperative outcomes between the marginal and.not marginal(both a-rem-KICG and.f-rem-KICG>0.05)*** All 23 patients und.rwent planned.*** hepatectomy,right trisectionectomy and.left trisectionectomy were in 16,6 and.1 cases,*** mean of blood.loss and.operative time were 576 mL and.474 min,*** increased.amount of frem-KICG was significantly larger than that of a-rem-KICG after PVE(0.034 vs 0.012,P=0.0273).The not marginal and.marginal groups had.17(73.9%)and.6(26.1%)patients,*** complications of Clavian-d.nd. classification grad. II or higher and.post-hepatectomy liver failure were observed.in six(26.1%)and.one(grad. A,4.3%)patient,*** 90-d.mortality was *** marginal group had.no

关键词： 99mTc-galactosyl human serum albumin single-photon emission computed.tomography Hepatectomy Ind.cyanine green Ind.cyanine green plasma clearance rate Liver function evaluation Remnant liver reserve

以海绵为填料的厌氧氨氧化反应器对污泥脱滤液的处理效果

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给水排水 2009年第S1期35卷 72-76页

作者：张莉吕鑑 kenji furukawa 北京工业大学建筑工程学院北京100022 Grad.ate School of Science and.Technology Kumamoto University

为了研究以海绵作填料利用半硝化(PN)—厌氧氨氧化(ANAMMOX)联合工艺对实际废水进行脱氮处理的可行性,在一上流式厌氧固定床反应器中,利用熊本东部的某污水处理厂的污泥脱滤液进行了试验研究。运行结果表明,联合工艺运行时,控制亚硝化... 详细信息

为了研究以海绵作填料利用半硝化(PN)—厌氧氨氧化(ANAMMOX)联合工艺对实际废水进行脱氮处理的可行性,在一上流式厌氧固定床反应器中,利用熊本东部的某污水处理厂的污泥脱滤液进行了试验研究。运行结果表明,联合工艺运行时,控制亚硝化反应器温度为(30±1)℃、pH为7.5、溶解氧为1 mg/L时,亚硝化的活性比较稳定,出水NO-2—N/NH3—N为1左右。对于ANAMMOX反应阶段,在较高的总氮负荷3.6 kgN/(m3.d.下,TN、NH3—N和NO-2—N的去除率分别达到70%、72%和91%,反应器处理效果较好。此外ANAMMOX反应器在(17±2)℃时NO-2—N去除率低于(25±1)℃时6%;但当环境温度升高时,ANAMMOX菌的活性可以迅速地从低温操作条件下恢复(2~3 d.。

关键词： ANAMMOX 半硝化脱氮高浓度氨氮亚硝氮硝氮总氮