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Enzymatic remodeling of heparan sulfate:a therapeutic strategy for systemic and localized amyloidoses?

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Neural Regeneration Research 2016年第3期11卷 408-409页

作者： Kazuchika Nishitsuji Hiroyuki Saito kenji Uchimura Department of Molecular Pathology Institute of Biomedical SciencesTokushima University Graduate School Department of Molecular Physical Pharmaceutics Institute of Biomedical SciencesTokushima University Graduate School Department of Biochemistry Nagoya University Graduate School of Medicine

In 1854,Rudolf Virchow introduced the term＂amyloid＂to indicate white waxy deposits that stained positive for iodine and that were found in many organs of patients with chronic inflammatory *** observed that these deposits stained pale blue after treatment with iodine and became dark blue or black after subsequent addition of sulfuric acid,in a similar manner to that of cellulose or carbohydrate.

关键词： heparan amyloid remodeling carbohydrate stained subsequent Virchow organs iodine cellulose

Hemilaminectomy in dogs

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畜牧与兽医 2012年第S2期44卷 3-4页

作者： kenji Tani Department of Veterinary Surgery Joint Faculty of Veterinary MedicineYamaguchi University

1 Identification of the affected interspace:What site is disk material across the vertebral canal?Either myelography or advanced imaging should be performed for definitive *** is more accurate and usually much faster than myelography,especially in chondrodystrophoid *** is non-invasive as mineralized disk material shows clearly without need for contrast in most cases such as MiniaturedDucksfund which is very common breed in *** may be necessary if the extrude material is not *** images are superior to CT in a viewpoint to evaluate spinal cord.

关键词： vertebral viewpoint breed canal faster clearly articular removed exact facilitate

Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis

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World Journal of Gastroenterology 2005年第20期11卷 3085-3090页

作者： Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka kenji Kondo Kou Tanaka kenji Takai Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of Medicine HamamatsuJapan Department of Gastroenterology Fujieda Municipal General Hospital FujiedaJapan Department of Gastroenterology Hamamatsu Rosai Hospital Hamamatsu Japan Tanaka Clinic Shizuoka Japan SRL Inc. Tokyo Japan

AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients. METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP. RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytokine IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP. CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactive-oxygen-producing neutrophils fro

关键词： Ulcerative colitis Reactive-oxygen Leukocyta-pheresis Interleukin-10

Chemoradiotherapy for a patient with a giant esophageal fistula

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World Journal of Gastroenterology 2007年第15期13卷 2250-2254页

作者： Takuma Nomiya Kazuhide Teruyama Hitoshi Wada kenji Nemoto Department of Radiation Oncology Hiraka General Hospital Japan Department of Radiation Oncology Yamagata University Hospital Japan

We describe our experience of treatment for a giant esophageal malignant fistula, which has not been reported previously. A 36-year-old woman who was diagnosed as having massive esophageal small cell carcinoma with metastases was treated with chemoradiotherapy. However, a giant esophagomediastinal fistula appeared due to shrinkage of the massive tumor, and all anti-cancer treatment was suspended. However, chemoradiotherapy was restarted at the request of the patient despite the presence of the fistula. After restarting treatment, the giant esophageal fistula was naturally closed despite intensive chemoradiotherapy, and the patient became able to eat and drink. Although the patient finally died, her QOL and prognosis seemed to be improved by the chemoradiotherapy. Anti-cancer treatment could be safely performed despite the presence of a giant fistula. The giant fistula closed while intensive chemotherapy was administered to the patient. Therefore, the presence of a fistula may not be a contraindication for curative chemoradiotherapy. Completion of treatment with proper management and maintenance of patients would be of benefit to patients with fistula.

关键词： Esophageal malignancy Esophageal fistula Chemotherapy Radiation therapy Small cell carcinoma

Dedifferentiated liposarcoma of the rectum:A case report

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World Journal of Gastroenterology 2012年第41期18卷 5979-5981页

作者： Atsushi Tsuruta kenji Notohara Taebum Park Tadashi Itoh Department of Surgery Kurashiki Central HospitalOkayama 710-8602Japan Department of Pathology Kurashiki Central HospitalOkayama 710-8602Japan

Liposarcoma is one of the most common soft tissue sarcomas found in adults,and it usually occurs in the retroperitoneum and the ***,we describe a case of dedifferentiated liposarcoma originating from a well-differentiated liposarcoma of the mesorectum that presented as a protruding mass in the rectal ***'s operation with total mesorectal excision was performed and the tumor was removed *** management guidelines are currently available for liposarcoma of the *** propose that complete surgical resection be required for the treatment of rectal liposarcoma and that a long-term detailed follow up is necessary.

关键词： Dedifferentiated liposarcoma Soft tissuesarcoma Rectum Management Surgery

Geochemistry and sediment in the main stream of the Ca River basin, Vietnam: weathering process, solute-discharge relationships, and reservoir impact

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Acta Geochimica 2019年第5期38卷 627-641页

作者： Ho Thi Phuong kenji Okubo Md.Azhar Uddin School of Chemical Biological and Environmental TechnologiesVinh University182Le Duan StreetVinh CityNghe AnVietnam Graduate School of Environmental and Life Science Okayama University3-1-1Tsushima-NakaKita-kuOkayama 700-8530Japan

In this study,we investigated the chemical composition of dissolved solids in the Ca River basin,North-Central *** samples were collected from August 2017 to July 2018 at three hydrological stations located in the main stream of the Ca *** weathering was found as the dominant process controlling the water chemistry in that *** average concentrations of dissolved solids generally decreased from upstream to downstream,resulting in low concentrations of the major ions in the downstream *** in the concentrations of major chemical ions and suspended solids at discharge were also *** chemical weathering products were found to behave chemostatically with increasing discharges ***,dilution behaviors of solutes were shown in both midstream and *** evidence shows that water storage in reservoirs impacts a variety of suspended solids and dissolved solids in the Ca River.

关键词： Ca River Dissolved solids Geochemistry Carbonate weathering Suspended solids

Magnetic Behavior of Some Rare-Earth Transition-Metal Perovskite Oxide Systems

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Journal of Rare Earths 2004年第6期22卷 733-738页

作者： kenji Yoshii Akio Nakamura Masaichiro Mizumaki Naoshi Ikeda Jun'ichiro Mizuki Japan Atomic Energy Research Institute Mikazuki Hyogo 679-5148 JapanJapan Atomic Energy Research Institute Tokai-mura Ibaraki 305-1195 JapanJapan Synchrotron Radiation Research Institute Mikazuki Hyogo 679-5198 JapanJapan Synchrotron Radiation Research Institute Mikazuki Hyogo 679-5198 JapanJapan Atomic Energy Research Institute Mikazuki Hyogo 679-5148 Japan

Magnetic properties were investigated for the rare-earth 3d-transition metal oxides with the perovskite structure. Intriguing magnetic phenomena were reviewed for a few systems:magnetization peak effect in the titanates, magnetization reversal in the chromites and metallic ferromagnetism in the cobaltites. The results suggest an important role of the rare-earth ions for the magnetic properties of such complex oxides.

关键词： perovskite oxide magnetic properties rare earth transition metal

Subminiature Gain Flattening Filter using Micro Quartz-Rod-Lens Collimators

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光学学报 2003年第S1期23卷 197-198页

作者： kenji Nishiwaki kenji Oda Yoshikiyo Noguchi Kenichiro Asano Hideyuki Hosoya Optical Communication Technology Department Optics and Electronics Laboratory Fujikura Ltd. 1440 Mutsuzaki Sakura Chiba 285-8550 Japan

We have developed a subminiature gain flattening filter with the 90% volume reduced package compared with conventional ones. The excellent thermal stabilities for the transmission characteristics of 0.0002dB/℃and 0.6... 详细信息

关键词： transmission characteristics high power

Vortices within the Separation Region in a Decelerating Channel Flow (Effect of Inlet Velocity Gradient)

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Journal of Thermal Science 2005年第4期14卷 341-345页

作者： Yoichi KINOUE Toshiaki SETOGUCHI Mohammad MAMUN Norimasa SHIOMI kenji KANEKO Department of Mechanical Engineering Saga University1HonjoSaga840-8502Japan

An experimental investigation was made into three-dimensional separated flow and the vortices within the flow separation in a decelerating channel flow generated by the suction from a porous side wall. The flows along the side and bottom walls were visualized by the surface tuft method. The turbulent internal flow was measured by the split-film probe to investigate the turbulent flow including the reverse flow. In the flow visualization for the strong decelerating flow （the suction flow ratio：0.8）, two typical flow patterns appear alternatively. One is that the flow near the bottom wall separates more upstream than the flow near the top wall and a clockwise vortex can be seen in the separation region. Another is the reversal flow pattern with a counterclockwise vortex. By the turbulent flow measurement using the split-film probe, two peaks of turbulence level are observed for the strong decelerating flow case. These peaks can be related with two flow patterns mentioned above.

关键词： vortices within the separation decelerating channel flow turbulent flow split-film probe