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Study of Interaction between Supersonic Flow and Rods Surrounded by Porous Cavity

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Journal of Thermal Science 2006年第4期15卷 324-330页

作者： Minoru YAGA kenji yamamoto Piotr DOERFFER Kenyu OYAKAWA Dept.of Mech.Systems Eng. Univ.of the RyukyusSenbaru 1NishiharaOkinawa903-0213 Graduate student Faculty of Eng.Univ.of the RyukyusSenbaru 1NishiharaOkinawa903-0213 Institute of Fluid Flow Machinery Polish Academy of ScienceFiszera 14PL-80 952 GdanskPoland

In this paper, some preliminary calculations and the experiments were performed to figure out the flow field, in which some rods were normally inserted into the main flow surrounded by a porous cavity. As a result, it is found that the starting shock wave severely interacts with the rods, the bow shock wave, its reflections, and the porous wall, which are numerically well predicted at some conditions. Moreover, inserting the rods makes the pressure on the upper wall in the porous region increase when the main flow in the porous region is completely supersonic. The calculations also suggest that three rods cause the widest suction area.

关键词： shock wave compressible flow porous cavity bow shock wave rod

Glycosylation engineering of therapeutic IgG antibodies： challenges for the safety, functionality and efficacy

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Protein & Cell 2018年第1期9卷 47-62页

作者： Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami kenji yamamoto Tsuneo Matsumoto Pauline M. Rudd Department of Clinical Research NHO Yamaguchi-Ube Medical Center 685 Higashi-Kiwa Ube 755-0241 Japan Laboratory of Molecular Biology and Bioresponse Division of Integrated Life Science Graduate School of Biostudies KyotoUniversity Kitashirakawa Oiwake-Cho Sakyo-Ku Kyoto 606-8502 Japan NIBRT GlycoScience Group National Institute for Bioprocessing Research and Training Mount Merrion Blackrock Dublin 4Ireland Center for Regenerative Medicine Yamaguchi University Graduate School of Medicine 1-1-1 Minami Kogushi Ube 755-8505 Japan Center for Gene Research Yamaguchi University 1-1-1 Minami-Kogushi Ube 755-8505 Japan Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University 1-308 Suematsu Nonoichi Ishikawa 921-8836 Japan

Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary *** oligosaccharide attached to Asn297 of the Fc is essen- tial for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that gen- erate structural heterogeneity （glycoforms） exhibit unique biological activities. Hence, efficient and quan- titative glycan analysis techniques have been increas- ingly important for the development and quality control of therapeutic antibodies, and g｜ycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosy- lation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear magnetic resonance studies, which provides possibili- ties for the design of novel antibody therapeutics. Fur- thermore, the chemoenzymatic glycoengineering approach using endoglycosidase-based glycosyn- thases may facilitate the development of homogeneous IgG glycoforms with desirable functionality as next- generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the improvement of the safety,functionality, and efficacy of therapeutic IgG antibodies in the era of precision medicine.

关键词： chemoenzymatic glycoengineering crysta structure endoglycosidase fucose glycosylation,intravenous immunoglobulin sialic acid transglycosylation,ultra performance liquid chromatography

The second continent:Existence of granitic continental materials around the bottom of the mantle transition zone

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Geoscience Frontiers 2013年第1期4卷 1-6页

作者： kenji Kawai Shinji yamamoto Taku Tsuchiya Shigenori Maruyama Department of Earth Science University of CaliforniaSanta BarbaraCA 93106USA Department of Earth and Planetary Sciences Tokyo Institute of TechnologyOokayama 2-12-1MeguroTokyo 152-8551Japan Department of Earth and Planetary Sciences Tokyo Institute of TechnologyOokayama 2-12-1MeguroTokyo 152-8551.Japan Department of Earth Science and Astronomy Graduate School of Arts and SciencesThe University of TokyoKomaba 3-8-1MeguroTokyo 153-8902Japan Geodynamics Research Center Ehime University.Bunkyo-cho 2-5MatsuyamaEhime 790-8577Japan

It has been thought that granitic crust, having been formed on the surface, must have survived through the Earth＇s evolution because of its buoyancy. At subduction zones continental crust is predominantly created by arc magmatism and is returned to the mantle via sediment subduction, subduction erosion, and continental subduction. Granitic rocks, the major constituent of the continental crust, are lighter than the mantle at depths shallower than 270 km, but we show here, based on first principles calcu- lations, that beneath 270 km they have negative buoyancy compared to the surrounding material in the upper mantle and transition zone, and thus can be subducted in the depth range of 270-660 km. This suggests that there can be two reservoirs of granitic material in the Earth, one on the surface and the other at the base of the mantle transition zone （MTZ）. The accumulated volume of subducted granitic material at the base of the MTZ might amount to about six times the present volume of the continental crust. Our calculations also show that the seismic velocities of granitic material in the depth range from 270 to 660 km are faster than those of the surrounding mantle. This could explain the anomalous seismic-wave velocities observed around 660 km depth. The observed seismic scatterers and reported splitting of the 660 km discontinuity could be due to jadeite dissociation, chemical discontinuities between granitic material and the surrounding mantle, or a combination thereof.

关键词： Continental growthGraniteFirst principlesMantle transition zoneTectonicsGeodynamics

短双歧杆菌(Bifidobacterium breve203)α-D-半乳糖苷酶的诱导合成及部分酶性质研究

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山东大学学报（自然科学版） 2000年第1期35卷 108-116页

作者：肖敏刘树峰钱新民田中敬子山本宪二熊谷英彦山东大学微生物技术国家重点实验室山东济南250100 日本京都大学农学部微生物生产学京都6068502

研究发现 2 5株所试肠道细菌中只有 6株双歧杆菌可以利用棉子糖良好生长 ,并且在棉子糖的诱导下产生α D 半乳糖苷酶 .9种不同糖中 ,Bifidobacter iumbreve 2 0 3可以利用葡萄糖、半乳糖、果糖、麦芽糖、乳糖、蜜二糖、棉子糖良好生长 ... 详细信息

研究发现 2 5株所试肠道细菌中只有 6株双歧杆菌可以利用棉子糖良好生长 ,并且在棉子糖的诱导下产生α D 半乳糖苷酶 .9种不同糖中 ,Bifidobacter iumbreve 2 0 3可以利用葡萄糖、半乳糖、果糖、麦芽糖、乳糖、蜜二糖、棉子糖良好生长 ,但只有蜜二糖和棉子糖诱导α D 半乳糖苷酶的产生 .1 0mmol/L的棉子糖和蜜二糖对于α D 半乳糖苷酶的诱导合成是最佳浓度的 ,且此浓度下 ,棉子糖的诱导能力 (比活 7.1 3units/mg)是蜜二糖 (比活 3 .4 0units/mg)的 2倍以上 .B .breve 2 0 3菌株α D 半乳糖苷酶专一性水解α D 半乳糖苷键 ,不水解β D 半乳糖苷键 .酶反应的最适温度是 3 7℃ ,酶在 4 0℃以下稳定 ,60℃时剩余 80 %的酶活 ,65℃时剩余 2 0 %的酶活 ,70℃时失去所有的酶活 .酶在 pH5.5～ 9.5稳定 ,酶反应的最适pH是 5.5～ ***+、Cu2 +、Ag+和PCMB强烈抑制酶的活性 ,而Co2 +、Mg2 +、Ca2 +、Mn2 +、Zn2 +、EDTA和DTT对酶活性没有抑制 .

关键词：双歧杆菌 α-D-半乳糖苷酶诱导合成酶性质

Hydriding properties of uranium alloys for purposes of searching for new hydrogen storage materials

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Nuclear Science and Techniques 2015年第1期26卷 121-126页

作者： Michio Yamawaki Takuya yamamoto Yuji Arita Fumihiro Nakamori Kazuhito Ohsawa kenji Konashi Research Institute of Nuclear Engineering University of Fukui1-2-4 Kanawa-cho Tsuruga Fukui 914-0055 Japan Research Institute for Applied Mechanics Kyushu University6-1 Kasuga-koen Kasuga Fukuoka 816-8580 Japan Institute for Materials Research Tohoku University 2145-2 Narita-choOarai Higashi-Ibaragi-gun Ibaragi 311-1313 Japan

Hydriding properties of uranium alloys have been studied to search for new hydrogen storage materials to be applied to hydrogen energy systems. Application of uranium-base hydrogen storage materials can be expected to alleviate the risk, as well as to reduce the cost incurred by globally-stored large amounts of depleted uranium left after uranium enrichment. Various uranium alloys have been examined in terms of hydrogen absorptiondesorption properties, among which UNi Al intermetallic compound showed promising characteristics, such as lower absorption-desorption temperatures and better anti-powdering strength. First principle calculation has been carried out on UNi Al hydride to predict the change of crystal structure and the lattice constant with increasing hydrogen content, which showed this calculation to be promising in predicting candidates for good hydrogen absorbers.

关键词：氢化性能储氢材料铀合金第一原理计算金属间化合物能源系统解吸温度晶格常数

Effects of docosahexaenoic acid or arachidonic acid supplementation on the behavior of cardiomyocytes derived from human pluripotent stem cells

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BIOCELL 2023年第5期47卷 1095-1106页

作者： MIZUNA YANO KOTA HIROI TETSUYA YUASA kenji INOUE OSAMU yamamoto TAKAO NAKAMURA DAISUKE SATO ZHONGGANG FENG Graduate School of Science and Engineering Yamagata UniversityYonezawa9928510Japan Faculty of Health Sciences Japan Healthcare UniversitySapporo0620053Japan

Background:Human heart changes its energetic substrates from lactate and glucose to fatty acids during the neonatal *** the lack of fatty acids in media for the culture of cardiomyocytes derived from human pluripotent stem cells(hiPS-CM),researchers have supplemented mixtures of fatty acids to hiPS-CM and reported the enhancement in the maturation of *** our previous studies,we separately supplemented two polyunsaturated fatty acids(PUFAs),docosahexaenoic acid(DHA)or arachidonic acid(AA),to rat fetal cardiomyocytes and found that the supplementations upregulated the expressions of mRNAs for cardiomyocyte differentiation,fatty acid metabolism,and cellular *** enhancement in cellular contractility was attributed to the improvement in intercellular connection rather than a direct enhancement of the contractile ***:This study reports the successive results of the effects of DHA or AA supplementation on *** addition to the contractile force and mRNA measurements used in the previous study,we further investigated the effect of different cellular aggregations on the contractile force output by means of finite element analysis,measured glucose and fatty acids metabolites,and assessed cTNT and MLC2v expressions through immunofluorecsence ***:It showed that the sole supplementation of albumin-conjugated DHA or AA can be taken up by hiPS-CM without other uptake-enhancing factors,and the supplementations may activate the CD36_ERRγmetabolic *** or AA supplementation increased the cellular contractile ratio on collagen gels and AA supplementation stimulated hiPS-CM aggregation to form cellular *** enhancement effect on the hiPS-CM contractile force was modest since the increase in contractile force was not *** supplementation was more effective than DHA supplementation because it significantly upregulated mRNA expressions of P300 and ***,finite element analysis showed that the formati

关键词： Human iPS cells Cardiomyocytes Polyunsaturated fatty acid mRNA expression Contractility Fatty acid metabolism

Association of advanced glycation endproduct accumulation with overactive bladder in community-dwelling elderly: A cross-sectional Sukagawa study

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Asian Journal of Urology 2021年第2期8卷 189-196页

作者： kenji Omae Noriaki Kurita Sei Takahashi Shingo Fukuma Yosuke yamamoto Shunichi Fukuhara The Sukagawa Study Group Kyoto University School of Public Health in the Graduate School of MedicineDepartment of Healthcare EpidemiologyYoshida Konoe-choSakyo-kuKyotoJapan Fukushima Medical University Center for Innovative Research for Communities and Clinical Excellence1 HikarigaokaFukushima CityFukushimaJapan Fukushima Medical University Hospital Department of Innovative Research and Education for Clinicians and Trainees1 HikarigaokaFukushima CityFukushimaJapan Tokyo Women’s Medical University Department of Urology8-1 Kawada-choShinjuku-kuTokyoJapan Fukushima Medical University Graduate School of MedicineDepartment of Clinical Epidemiology1 HikarigaokaFukushima CityFukushimaJapan Kyoto University Graduate School of MedicineHuman Health SciencesYoshida Konoe-choSakyo-kuKyotoJapan 不详

Objective:This study aimed to evaluate the influence of advanced glycation end-product(AGE)accumulation on the prevalence and severity of overactive bladder(OAB)in community-dwelling elderly ***:We conducted a cross-sectional study involving 269 Japanese community dwellers aged≥75 years in *** accumulation was non-invasively measured via skin autofluorescence(SAF)values using AGE *** primary and secondary outcomes were the presence and severity of OAB evaluated using the Overactive Bladder Symptom Score(OABSS).Individuals with an urgency score of≥2 and sum score of≥3 were considered to have *** associations of SAF with the prevalence and severity of OAB were assessed using logistic and linear regression models,respectively,adjusted for clinically important ***:The median age of participants was 78 *** 269 participants,110(40.9%)were men and 75(27.9%)had *** median SAF was 2.2 arbitrary units(AUs).Increasing median SAF was observed with increasing *** analysis revealed that SAF was not associated with either the likelihood of having OAB(odds ratio per AU=0.77,95%confidence interval:0.37-1.62)or the natural log-transformed OABSS(0 per AU=-0.07,95%confidence interval:-0.26-0.12).Conclusions:In this study,AGE accumulation,as assessed by SAF,was not associated with the prevalence and severity of OAB in Japanese community-dwelling elderly people aged≥75 years.

关键词： Advanced glycation end-products Elderly Overactive bladder Skin autofluorescence Urinary incontinence

Long-term survival after resection of pancreatic cancer:A single-center retrospective analysis

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World Journal of Gastroenterology 2015年第1期21卷 262-268页

作者： Takehito yamamoto Shintaro Yagi Hiromitsu Kinoshita Yusuke Sakamoto Kazuyuki Okada kenji Uryuhara Takeshi Morimoto Satoshi Kaihara Ryo Hosotani Department of Surgery Kobe City Medical Center General HospitalHyogo 650-0047Japan Clinical Research Center Kobe City Medical Center General HospitalHyogo 650-0047JapanChief Statistician

AIM: To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic ***: From January 2000 to December 2011,195 patients underwent pancreatic resection in our *** prognostic factors after pancreatic resection were analyzed in all 195 *** excluding the censored cases within an observational period,the clinicopathological characteristics of 20 patients who survived ≥ 5(n = 20) and < 5(n = 76) years were *** this comparison,we analyzed the patients who underwent surgery before June 2008 and were observed for more than 5 *** statistical analyses,the log-rank test was used to compare the cumulative survival rates,and the χ2 and Mann-Whitney tests were used to compare the two *** CoxHazard model was used for a multivariate analysis,and P values less than 0.05 were considered significant.A multivariate analysis was conducted on the factors that were significant in the univariate ***: The median survival for all patients was 27.1 months,and the 5-year actuarial survival rate was 34.5%.The median observational period was 595 *** the univariate analysis,the UICC stage was significantly associated with survival time,and the CA19-9 ≤ 200 U/m L,DUPAN-2 ≤ 180 U/m L,t u m o r s i ze ≤ 2 0 m m,R 0 re s e c t i o n,a b s e n c e o f lymph node metastasis,absence of extrapancreatic neural invasion,and absence of portal invasion were favorable prognostic *** multivariate analysis showed that tumor size ≤ 20 mm(HR = 0.40; 95%CI: 0.17-0.83,P = 0.012) and negative surgical margins(R0 resection)(HR = 0.48; 95%CI: 0.30-0.77,P = 0.003) were independent favorable prognostic *** the 96 patients,20 patients survived for 5 years or more,and 76 patients died within 5 years after *** of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2(79.5 vs 312.5 U/mL,P = 0.032),tumor size ≤ 20 mm(

关键词： Pancreatic cancer Long-term survival Longterm surv

Nutritional supplement drink reduces inflammation and postoperative depression in patients after off-pump coronary artery bypass surgery

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World Journal of Cardiology 2021年第8期13卷 348-360页

作者： Satoshi Matsushita Akie Shimada Taira yamamoto Kazuo Minematsu Hirotaka Inaba kenji Kuwaki Atsushi Amano Department of Cardiovascular Surgery Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of School Health Graduate School of EducationNagasaki UniversityNagasaki 852-8521Japan Department of Cardiovascular Surgery Juntendo University Urayasu HospitalChiba 279-0021Japan Department of Cardiovascular Surgery Tokai University Hachioji HospitalTokyo 192-0032Japan

BACKGROUND Coronary artery bypass grafting is a surgical treatment for ischemic heart *** development in surgical technique and improvement of perioperative management reduced the postoperative complications,some patients still delayed in progress of postoperative *** this study,we aimed to investigate the effect of daily intake of an herbal medicine-containing drink for rehabilitation after surgery in patients with ischemic heart *** To investigate the effect of taking an herbal medicine-containing,commercially available drink for postoperative rehabilitation in those *** Patients who underwent isolated off-pump coronary artery bypass(OPCAB)surgery were divided into two groups depend on the timing of the admission to the hospital:the Yunker(YKR)group,that consumed one bottle of a caffeine-free nutritional supplement drink on a daily basis and the control group(CTL)that underwent regular *** A total of 229 patients(CTL=130,YKR=99)were *** significant differences were observed in the baseline characteristics between the two *** YKR group had a significantly increased number of daily steps postoperatively(P<0.05)and had significantly lower postoperative serum tumor necrosis factor-alpha levels(P<0.01),while no significant differences were observed in the levels of other inflammatory or stress-related cytokines(interleukin-6,adiponectin,superoxide dismutase,and urine 8-hydroxy-2′-deoxyguanosine)between the two ***,the YKR group showed a significant improvement in the Hospital Anxiety and Depression Score(P<0.05).Moreover,there were no differences in postoperative complications and the duration of postoperative hospital stay between the two *** Our results demonstrated that the daily intake of an herbal medicine-containing drink after OPCAB surgery may have beneficial effects on cardiac rehabilitation by reducing inflammation markers and depression.

关键词： Herbal medicine Inflammation Cardiac rehabilitation Moderate-to-vigorous intensity physical activity Off-pump coronary artery bypass