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Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis

World Journal of Gastroenterology 2009年第11期15卷 1394-1397页

作者： Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada kenichiro Kato Tadahiro Takada Junichi Fukushima Fukuo Kondo Hajime Takikawa Department of Surgery Teikyo UniversitySchool of MedicineTokyo173-8605Japan Department of Pathology Teikyo UniversitySchool of MedicineTokyo173-8605Japan Department of Medicine Teikyo University School of MedicineTokyo173-8605Japan

Eosinophilic cholangiopathy is a rare condition characterized by eosinophilic infiltration of the biliary tract and causes sclerosing cholangitis. We report a patient with secondary sclerosing cholangitis with eosinophilic cholecystitis. A 46-year-old Japanese man was admitted to our hospital with jaundice. Computed tomography revealed dilatation of both the intrahepatic and extrahepatic bile ducts, diffuse thickening of the wall of the extrahepatic bile duct, and thickening of the gallbladder wall. Under the diagnosis of lower bile duct carcinoma, he underwent pyloruspreserving pancreatoduodenectomy and liver biopsy. On histopathological examination, conspicuous fibrosis was seen in the lower bile duct wall. In the gallbladder wall, marked eosinophilic infiltration was seen. Liver biopsy revealed mild portal fibrosis. He was diagnosed as definite eosinophilic cholecystitis with sclerosing cholangitis with unknown etiology. The possible etiology of sderosing cholangitis was consequent fibrosis from previous eosinophilic infiltration in the bile duct. The clinicopathological findings of our case and a literature review indicated that eosinophilic cholangiopathy could cause a condition mimicking primary sclerosing cholangitis （PSC）. Bile duct wall thickening in patients with eosinophilic cholangitis might be due to fibrosis of the bile duct wall. Eosinophilic cholangiopathy might be confused as PSC with eosinophilia.

关键词： Eosinophilc cholangiopathy Primarysclerosing cholangitis Secondary sclerosing cholangitis Obstructive jaundice

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Bacterial Infection in the Limbs of Patients with Rheumatoid Arthritis during Biological Agent Therapy

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Open Journal of Rheumatology and Autoimmune Diseases 2012年第3期2卷 47-52页

作者： Hajime Yamanaka kenichiro Goto Munetaka Suzuki Department of Orthopaedic Surgery National Hospital Organization Shimoshizu Hospital Yotsukaido City Japan

Biological therapies in rheumatoid arthritis (RA) are known to increase the risk of serious infections. The present study was performed to evaluate the clinical features of bacterial infections occurring in the limbs during biological therapies in patients with RA. By March 2011, 11 RA patients (14 limbs) treated with biological agents at our institution required hospitalization due to bacterial infections occurring in the limbs. These patients had an average age of 53.7 years old. Infections occurred an average of 19 months after biological treatment. Two limbs in one patient were treated with infliximab, eight limbs in six patients were treated with etanercept, one limb in one patient was treated with adalimumab, and three limbs in three patients were treated with tocilizumab. Cellulitis occurred in 7 limbs, late infections after total knee arthroplasty occurred in two limbs, early infections after orthopedic surgery occurred in three limbs, and septic arthritis occurred in two limbs. Four cases had comorbidities—liver cirrhosis and diabetes mellitus in one and three cases, respectively. All patients were treated using corticosteroid with an average dose of 4.6 mg daily. Seven limbs required surgical treatment. All patients finally recovered. Ten limbs continued treatment with biological agents. Care must be taken regarding bacterial infection in the limbs of RA patients treated by using biological agents, particularly those with comorbidities. Further studies are required to confirm means of preventing such infections in daily practice.

关键词： Bacterial Infection Limbs Rheumatoid Arthritis Biological Agents

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Causative factors of discomfort in esophagogastroduodenoscopy: A large-scale cross-sectional study

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World Journal of Gastrointestinal Endoscopy 2020年第4期12卷 128-137页

作者： kenichiro Majima Takeshi Shimamoto Yosuke Muraki The Department of Health Management Kameda Medical CenterKamogawa City 296-8602Chiba PrefectureJapan The Department of Gastroenterology Graduate School of MedicineThe University of TokyoChiba City 261-7114Chiba PrefectureJapan

BACKGROUND It is important to reduce patient discomfort in *** measures can be taken to alleviate discomfort if the causative factors are determined;however,all the factors have not been elucidated *** To clearly determine the factors influencing discomfort in transoral esophagogastroduodenoscopy using a large-size cross-sectional study with readily available *** Consecutive patients who underwent screening transoral esophagogastroduodenoscopy consecutively between August 2017 and October 2017 at a health check-up center were *** was evaluated using a face scale between 0 and 10 with a 6-level *** and multiple regression analyses were performed to investigate the factors related to the discomfort in *** analysis was performed in both the unsedated and sedated study ***,sex,height,body mass index,smoking status,alcohol intake,hiatal hernia,history of gastrectomy,biopsy during examination,Lugol’s solution usage,administration of butylscopolamine with/without a sedative(pethidine,midazolam,or both),endoscope model,history of endoscopy,and endoscopists were considered as possible factors of *** Finally,1715 patients were enrolled in this ***,the median discomfort score was 2 and the interquartile range was *** discomfort(score≥6)was recorded in 18%of the *** to univariate analysis,in the unsedated group,young age(P<0.001),female sex(P<0.001),and no history of endoscopy(P<0.001)were factors associated with increased *** differences were also noted for height(P=0.007),smoking status(P=0.003),and endoscopists(P<0.001).In the sedation group,young age(P<0.001),female sex(P<0.001),and no history of endoscopy(P=0.004)were associated with increased discomfort;additionally,significant differences were found in smoking status(P<0.001),type of sedation(P<0.001),and endoscopists(P=0.027).There

关键词： Esophagogastroduodenoscopy Discomfort Smoking Alcohol Pethidine Endoscopy

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Compact Hybrid Subsystem of 16 Channel Optical Demultiplexer, 2x2 Switches, Optical Power Monitors and Control Circuit

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光学学报 2003年第S1期23卷 259-260页

作者： kenichiro Takahashi Toshihiko Kishimoto Shintaro Mouri Youichi Hata Hideaki Yusa Mitsuaki Tamura Kazuhito Saito Hisao Maki Sumitomo Electric Industries Ltd. 1 Taya Sakae Yokohama Japan

A compact hybrid subsystem of 16channel optical demultiplexer, 2x2 switches, optical power monitors and control circuit board is developed. The subsystem is able to add or drop arbitrary optical channels and monitor t... 详细信息

关键词： circuit board

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Lobulated inflammatory myoglandular polyp in the ascending colon observed by magnifying endoscopy and treated with endoscopic polypectomy

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World Journal of Gastroenterology 2008年第30期14卷 4838-4840页

作者： Hiromitsu Kanzaki Shoji Hirasaki Masato Okuda kenichiro Kudo Seiyuu Suzuki Department of Internal Medicine Sumitomo Besshi Hospital

The patient was a 33-year-old man with hematochezia. Colonoscopy revealed a Iobulated peduncular polyp with bleeding, about 40 mm in diameter, in the ascending colon. The polyp had both red and white components and a mosaic pattern. Magnifying observation revealed a red rugged surface component, and smooth white nodules with enlarged round or oval crypt openings. Endoscopic polypectomy was performed. Histological examination of the specimen revealed inflammatory granulation tissue in the lamina propria, proliferation of smooth muscle, and hyperplastic glands with cystic change. This polyp was diagnosed as inflammatory myoglandular polyp （IMGP）. Lobulated-type IMGP in the ascending colon is rare.

关键词： Inflammatory polyp Colonoscopy Magnifying endoscopy Endoscopic polypectomy Hematochezia

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Inflammatory myoglandular polyp causing hematochezia

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World Journal of Gastroenterology 2008年第34期14卷 5353-5355页

作者： Shoji Hirasaki Masato Okuda kenichiro Kudo Seiyuu Suzuki Atsuko Shirakawa Department of Internal Medicine Sumitomo Besshi Hospital Department of Pathology Sumitomo Besshi Hospital

A case of inflammatory myoglandular polyp (IMGP) causing hematochezia is reported. The patient was a 33-year-old man who visited our hospital for further evaluation of hematochezia. Colonoscopy revealed a red, hard, spherical peduncular polyp with erosion and mucous exudation, about 20 mm in diameter, in the descending colon. Excluding the polyp, there was no lesion in the colorectum. Endoscopic polypectomy was performed. Histological examination of the specimen revealed inflammatory granulation tissue in the lamina propria, proliferation of smooth muscle, and hyperplastic glands with variable cystic changes. This polyp was diagnosed as an IMGP. The symptom of hematochezia was resolved after endoscopic resection. Our case shows that treatment is necessary for IMGP if intestinal bleeding occurs and endoscopists should be aware of the endoscopic characteristics of IMGP.

关键词： Inflammatory myoglandular polyp Colonoscopy Endoscopic polypectomy Gastrointestinal bleeding

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Study on the production of IL-12, IL-10 in early stage after infection with Babesia microti and Babesia rodhaini in mice

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Journal of Northeast Agricultural University(English Edition) 2007年第1期14卷 17-21页

作者： LIU Yun Hachikuchi Rie kenichiro Ono College of Veterinary Medicine Northeast Agricultural University Harbin 150030 China Department of Clinical Pathobiology Veterinary Medical Science Graduate School of Agricultural Life Science University of Tokyo Tokyo 113 Japan

The serum levels of IL-12 and IL-10 in mice after infected with Babesia microti （B. microti） and Babesia rodhaini （B. rodhaini） were examined. Collected the mice serum and examined the concentration of IL-12 and IL-10 by using ELISA after infection with B. microti and B. rodhaini at 0, 3, 6, 9, 12, 18, 24, 36, 72, 96 h in mice. The results showed that B. microti infection resulted in IL-12 increasing, which peaked at 3 and 24 h after the infection, while same infection did not induce a significant change in IL-10 compared to uninfected mice. When mice were infected with B. rodhaini, any significant changes were not decteted both in IL-12 and IL-10 in comparison with uninfected animals during the period of 3-72 h after infection. Instead, a significant decline in IL-12 and IL-10 was found compared to uninfected mice 96 h after infection with B. rodhaini. It indicates that the mutagenetic cytokine is IL-12 in the serum of mice after infection with B. microti, and no any significant changes were detected in both IL-12 and IL-10 from 0 to 72 h after infected with B. rodhaini.

关键词： B. microti B. rodhaini mice IL-12 IL-10

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Control Device on Construction of Battery B,No.6 Coke Oven at WestJapan Works（Kurashiki）

Control Device on Construction of Battery B,No.6 Coke Oven a...

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Asia Steel International Conference 2012(Asia Steel 2012)

作者： SHOICHI Hirata kenichiro Tadokoro JFE Steel Corporation

＜正＞The battery named 6B of No.6 coke oven was newly constructed at West Japan Works（Kurashiki）,JFE *** constitutes 43 chambers and its production capacity is about 440 thousand ton per *** construction was started in September *** came into operation on December 15,2010,and it is in frill production *** most modern control technologies are adopted into this newly constructed coke oven *** control system constitutes a process computer,DCS（Distributed Control System） for instrumentation control and PLC（Program Logic controller） for electric *** process computer and DCS system controls the combustion of the coke oven automatically by using the thermometry results of each combustion chamber,and determines the distillation condition from the transition in the temperature of gas generated from the *** PLC system was introduced to carry out the factory automation control of the Pushing machine,the Charging car,the coke Guide car and the Quenching Electric Locomotive,which are equipped to the coke *** system achieves an efficient operation which brings about the result that only one operator on the Pushing machine can operate the other *** coke oven incidental facilities and CDQ（Coke Dry Quenching） are also controlled automatically according to the operating condition of these *** this report,the details of these controls are described.

关键词： Construction of Battery B control technologies Distributed Control System Program Logic controller

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Recent trends in the prevalence and distribution of colonic diverticula in Japan evaluated using computed tomography colonography

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World Journal of Gastroenterology 2021年第27期27卷 4441-4452页

作者： Noriyuki Isohata Koichi Nagata Kenichi Utano Ryoichi Nozaki Satoshi Nozu Takashi Kato Shigeyoshi Kijima Hiroshi Matsumoto kenichiro Majima Yasuji Ryu Michiaki Hirayama Shungo Endo Department of Coloproctology Fukushima Medical UniversityAizu Medical CenterAizuwakamatsu 969-3492FukushimaJapan Department of Gastroenterology Fukushima Medical UniversityFukushima 960-1295FukushimaJapan Department of Radiology Fukushima Medical UniversityAizu Medical CenterAizuwakamatsu 969-3492FukushimaJapan Department of Gastroenterology Takano HospitalColoproctology CenterKumamoto 862-0971KumamotoJapan Department of Radiology Saitama Cancer CenterIna 362-0806SaitamaJapan Department of Gastroenterology National Hospital Organization Hokkaido Medical CenterSapporo 063-0005HokkaidoJapan Department of Radiology Jichi Medical UniversityShimotsuke 329-0498TochigiJapan Division of Gastroenterology Kawasaki Medical School HospitalKurashiki 701-0192OkayamaJapan Department of Health Management Kameda Medical CenterKamogawa 296-8602ChibaJapan Department of Radiology Tonami General HospitalTonami 939-1395ToyamaJapan Department of Gastroenterology Tonan HospitalSapporo 060-0004HokkaidoJapan

BACKGROUND Computed tomography colonography(CTC)may be superior to colonoscopy and barium enema for detecting ***,few studies have used CTC to diagnose *** To evaluate the current prevalence and distribution of colonic diverticula in Japan using *** This study was conducted as part of the Japanese National Computed Tomographic Colonography Trial,which included 1181 participants from 14 hospitals in *** analyzed the prevalence and distribution of colonic diverticula and their relationships with age and *** relationship between the diverticula and the length of the large intestine was also *** Diverticulosis was present in 48.1%of the *** prevalence of diverticulosis was higher in the older participants(P<0.001 for trend).The diverticula seen in younger participants were predominantly located in the right-sided *** participants had a higher frequency of bilateral type(located in the rightand left-sided colon)diverticulosis(P<0.001 for trend).The length of the large intestine with multiple diverticula in the sigmoid colon was significantly shorter in those without diverticula(P<0.001).CONCLUSION The prevalence of colonic diverticulosis in Japan is higher than that previously *** prevalence was higher,and the distribution tended to be bilateral in older participants.

关键词： Computed tomography colonography Diverticulosis Diverticular disease Colon

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Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

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World Journal of Gastroenterology 2014年第43期20卷 16318-16322页

作者： Makoto Arai Tomoaki Matsumura kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka Department of Gastroenterology and Nephrology (K1) Graduate School of MedicineChiba UniversityChiba 260-8670Japan

AIM: To investigate the optimum period of treatment for post endoscopic submucosal dissection (ESD) ulcers.

关键词： Proton pump inhibitor Endoscopic submucosal dissection Esomeprazole Rebamipide Randomized control trial

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