Study on the production of IL-12, IL-10 in early stage after infection with Babesia microti and Babesia rodhaini in mice

作     者：LIU Yun Hachikuchi Rie Kenichiro Ono 

作者机构：College of Veterinary Medicine Northeast Agricultural University Harbin 150030 China Department of Clinical Pathobiology Veterinary Medical Science Graduate School of Agricultural Life Science University of Tokyo Tokyo 113 Japan 

出 版 物：《Journal of Northeast Agricultural University(English Edition)》 (东北农业大学学报（英文版）)

年 卷 期：2007年第14卷第1期

页      面：17-21页

学科分类：090601[农学-基础兽医学] 0907[农学-林学] 090705[农学-野生动植物保护与利用] 09[农学] 0906[农学-兽医学] 

主　　题：B. microti B. rodhaini mice IL-12 IL-10 

摘      要：The serum levels of IL-12 and IL-10 in mice after infected with Babesia microti （B. microti） and Babesia rodhaini （B. rodhaini） were examined. Collected the mice serum and examined the concentration of IL-12 and IL-10 by using ELISA after infection with B. microti and B. rodhaini at 0, 3, 6, 9, 12, 18, 24, 36, 72, 96 h in mice. The results showed that B. microti infection resulted in IL-12 increasing, which peaked at 3 and 24 h after the infection, while same infection did not induce a significant change in IL-10 compared to uninfected mice. When mice were infected with B. rodhaini, any significant changes were not decteted both in IL-12 and IL-10 in comparison with uninfected animals during the period of 3-72 h after infection. Instead, a significant decline in IL-12 and IL-10 was found compared to uninfected mice 96 h after infection with B. rodhaini. It indicates that the mutagenetic cytokine is IL-12 in the serum of mice after infection with B. microti, and no any significant changes were detected in both IL-12 and IL-10 from 0 to 72 h after infected with B. rodhaini.