检索结果-南通市图书馆

Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第47期29卷 6111-6121页

作者： Natsuki Ishida Tatsuhiro Ito kenichi takahashi Yusuke Asai Takahiro Miyazu Tomohiro Higuchi Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Ken Sugimoto Department of Endoscopic and Photodynamic Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan First Department of Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan

BACKGROUND Although the usefulness of endoscopic scores,such as the Mayo Endoscopic Subscore(MES),Ulcerative Colitis Endoscopic Index of Severity(UCEIS),and Ulcerative Colitis Colonoscopic Index of Severity(UCCIS),and biomarkers such as fecal calprotectin(FC)for predicting relapse in ulcerative colitis(UC)has been reported,few studies have included endoscopic scores for evaluating the entire *** To compare the usefulness of FC value and MES,UCEIS,and UCCIS for predicting relapse in patients with UC in clinical *** In total,75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were *** diagnosis of UC was confirmed based on the clinical presentation,endoscopic findings,and histology,according to the current established criteria for *** samples were collected the day before or after the colonoscopy for measurement of *** evaluations were performed using MES,UCEIS,and *** primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES,UCEIS,UCCIS,and *** secondary outcome was the comparison between endoscopic scores and biomarkers in en-rolled patients with UC with mucosal *** and UCCIS showed a significant correlation with UCEIS (r = 0.537, P < 0.001 and r = 0.957, P < 0.001, respectively).Receiver-operating characteristic analysis for predicting MES 0 showed that the area under the curve ofUCCIS was significantly higher than that of FC (P < 0.01). During the 1-year observation period, 18 (24%) patientsexperienced a relapse, and both the FC and UCCIS of the relapse group were significantly higher than that of theremission group. The cut-off values for predicting relapse were set at FC = 323 mg/kg and UCCIS = 10.2. The areaunder the curve of the receiver-operating characteristic analysis for predicting relapse did not show a significantdifference between FC and UCCIS. The accuracy of the

关键词： Ulcerative colitis Mayo Endoscopic Subscore Ulcerative Colitis Endoscopic Index of Severity Ulcerative Colitis Colonoscopic Index of Severity Fecal calprotectin Relapse

Is there diversity among UGT1A1 polymorphism in Japan?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2012年第7期4卷 170-175页

作者： Michiya Kobayashi Shoichi Hazama kenichi takahashi Koji Oba Naoko Okayama Mitsuaki Nishioka Yuji Hinoda Masaaki Oka Ken Okamoto Hiromichi Maeda Daisuke Nakamura Junichi Sakamoto Hideyuki Mishima Department of Human Health and Medical Sciences Kochi Medical School Nankoku 783-8505 Japan Department of Digestive Surgery and Surgical Oncology (Surgery Ⅱ) Yamaguchi University Graduate School of Medicine Ube Yamaguchi 755-8505 Japan Department of Surgery Aomori Prefectural Central Hospital Aomori 030-8553 Japan Translational Research and Clinical Trial Center Hok-kaido University Hospital Sapporo 060-8638 Japan Division of Laboratory Yamaguchi University Hospital Ube Yamaguchi 755-8505 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Ube Yama-guchi 755-8505 Japan Tokai University School of Medicine Is-ehara Kanagawa 259-1131 Japan Young Leaders Program in Healthcare Administration Nagoya University Graduate School of Medicine Nagoya 466-8550 Japan Department of Surgery Osaka National Hos-pital Osaka 565-0871 Japan

AIM: To investigate into the diversity of UGT1A1 polymorphism across three different districts in Japan and highlight genetic differences among the population in Japan. METHODS: We enrolled 50 healthy volunteers from each of the Yamaguchi (western part of Japan), Kochi(southern part of Japan) and Akita (northern part of Japan) prefectures. Blood samples (7 mL) were collected from each participant and stored in EDTA for subsequent genotyping by fragment size analysis, direct sequencing and TaqMan assay of UGT1A1*28, UGT1A7*3/UGT1A9*22 and UGT1A1*93/UGT1A1*6/ UGT1A1*27/UGT1A1*60/UGT1A7 (-57), respectively. RESULTS: The only statistically significant differences in allele polymorphisms among the group examined were for UGT1A1*6. The Akita population showed more UGT1A1*6 heterozygosity (P = 0.0496). CONCLUSION: Our study revealed no regional diversity among UGT1A1, UGT1A7 or UGT1A9 polymorphisms in Japan.

关键词： UGT1A1 gene Polymorphism Diversity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高原鼠兔生境选择的初步研究

四川大学学报（自然科学版） 2004年第5期41卷 1041-1045页

作者：王淯王小明王正寰 Patrick Giraudoux kenichi takahashi Graham Alastair 华东师范大学生命科学学院 DepartmentofBiologyandEcophysiology HokkaidoInstituteofPublicHealthDivisionofMedicalZoology TelfordInstituteforEnvironmentalSystems(Geography)

在石渠县西区的高山草甸和高山灌丛草甸分布区采用卫星照片(1∶100000)结合样线法,在草地(雅砻江及其支流两边)每隔150m设置一个样方,其他环境则每隔100m设置一个样方,样方面积为5×5m2,记录样方所在地的海拔高度、坡度、坡向、生境位... 详细信息

在石渠县西区的高山草甸和高山灌丛草甸分布区采用卫星照片(1∶100000)结合样线法,在草地(雅砻江及其支流两边)每隔150m设置一个样方,其他环境则每隔100m设置一个样方,样方面积为5×5m2,记录样方所在地的海拔高度、坡度、坡向、生境位置、样方内植被的盖度、阔叶植物盖度、阔叶植物高度、灌丛盖度、土壤质地、离水源的距离以及鼠兔洞数量.共设置样方312个,样方内的高原鼠兔洞数量最多为80个,最少为0,平均为13.7±15个.统计结果显示:影响高原鼠兔生境选择的主要因子依次是生境位置、土壤质地、离水源的距离、灌丛植物盖度和阔叶植物高度.分析表明,高原鼠兔选择的最优生境为下坡位、土质松软、离水源的距离小于50m、阔叶植物高度小于等于5cm,没有灌丛的环境.

关键词：高原鼠兔生境选择石渠县因子分析

Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第9期21卷 2700-2710页

作者： Reiko Kumagai kenichi Kohashi Shunsuke takahashi Hidetaka Yamamoto Minako Hirahashi kenichi Taguchi kenichi Nishiyama Yoshinao Oda Department of Anatomic Pathology Pathological SciencesGraduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Pathology National Hospital Organization Kyushu Cancer CenterFukuoka 811-1395Japan Division of Pathology Japanese Red Cross Fukuoka HospitalFukuoka 815-8555Japan

AIM:To clarify the correlation with phenotypic expression,clinicopathological features,genetic alteration and microsatellite-instability status in small intestinal adenocarcinoma(SIA).METHODS:The cases of 47 patients diagnosed with primary SIAs that were surgically resected at our institution in 1975-2005 were *** reviewed clinicopathological findings(age,gender,tumor size,gross appearance,histological morphologic type,invasion depth,lymphatic permeation,venous invasion,and lymph node metastasis),and the immunohistochemical expression of MUC5 AC,MUC6,MUC2,CD10,and mismatch-repair(MMR) proteins(MLH1 and MSH2).We analyzed KRAS and BRAF gene mutations,and the microsatellite instability(MSI) *** immunohistochemical staining of CD10,MUC2,MUC5 AC and MUC6 was considered positive when distinct staining in > 5% of the adenocarcinoma cells was *** evaluate of MMR protein expression,we used adjacent normal tissue including lymphoid follicles,inflammatory cells,and stromal cells as an internal positive *** without nuclear staining in the tumor cells were considered to have lost the expression of the respective MMR ***:There were 29 males and 18 females patients(mean age 59.9 years,range:23-87 years).Tumors were located in the duodenum in 14 cases(30%),the jejunum in 21 cases(45%),and the ileumin 12 cases(25%).A phenotypic expression analysis revealed 20 MUC2-positive tumors(42.6%),11 MUC5AC-positive(23.4%),4 MUC6-positive(8.5%),and 7 CD10-positive(14.9%).The tumor sizes of the MUC2(+) tumors were significantly larger than those of the MUC2(-) tumors(mean,5.7 ± 1.4 cm vs 4.7 ± 2.1 cm,P < 0.05).All three tumors with adenomatous component were positive for MUC2(P < 0.05).Polypoid appearance was seen significantly more frequently in the CD10(+) group than in the CD10(-) group(P < 0.05).The tumor size was significantly larger in the CD10(+) group than in the CD10(-) group(mean,5.9 ± 1.4 cm vs 5.0 ± 2.1 cm,P < 0.05).Of 34 SIAs with succ

关键词： Small intestine Adenocarcinoma Mucin CD10 Microsat

Drastic transitions of excited state and coupling regime in all-inorganic perovskite microcavities characterized by exciton/plasmon hybrid natures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第1期11卷 79-86页

作者： Shuki Enomoto Tomoya Tagami Yusuke Ueda Yuta Moriyama Kentaro Fujiwara Shun takahashi kenichi Yamashita Faculty of Electrical Engineering and Electronics Kyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan

Lead-halide perovskites are highly promising for various optoelectronic applications,including laser ***,fundamental photophysics explaining the coherent-light emission from this material system is so intricate and often the subject of ***,we systematically investigate photoluminescence properties of all-inorganic perovskite microcavity at room temperature and discuss the excited state and the light–matter coupling regime depending on excitation ***-resolved photoluminescence clearly exhibits that the microcavity system shows a transition from weak coupling regime to strong coupling regime,revealing the increase in correlated electron–hole *** pumping fluence above the threshold,the photoluminescence signal shows a lasing behavior with bosonic condensation characteristics,accompanied by long-range phase *** excitation density required for the lasing behavior,however,is found to exceed the Mott density,excluding the exciton as the excited *** results demonstrate that the polaritonic Bardeen–Cooper–Schrieffer state originates the strong coupling formation and the lasing behavior.

关键词： pumping coupling regime

Anillin actin-binding protein expression correlates with poor prognosis for prostate cancer patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第4期11卷 569-574页

作者： Shinichiro Yamamoto Daisuke Obinata kenichi Takayama Daigo Funakoshi Kyoko Fujiwara Makoto Hara Satoru takahashi Satoshi Inoue Department of Systems Aging Science and Medicine Tokyo Metropolitan Institute for Geriatrics and Gerontology35-2 Sakae-choItabashi-kuTokyoJapan Department of Urology Nihon University School of Medicine30-1OoyaguchikamichoItabashi-kuTokyoJapan Department of Anatomy Nihon University School of Dentistry1-8-13Kanda SurugadaiChiyoda-kuTokyoJapan Division of Neurology Department of MedicineNihon University School of Medicine30-1OoyaguchikamichoItabashi-kuTokyoJapan Research Center for Genomic Medicine Saitama Medical University1397-1 YamaneHidaka-shiSaitamaJapan

ObjectiveOctamer transcription factor 1(OCT1),a transcription factor that interacts with androgen receptor,is involved in prostate cancer(PCa)*** OCT1 target gene,Anillin actin-binding protein(ANLN),is highly expressed in castration-resistant PCa tissue;however,it remains unclear whether ANLN expression in hormone-sensitive PCa tissue could be used as a predictive biomarker for poor prognosis of *** aimed to investigate ANLN expression in PCa tissue obtained via radical prostatectomy and its correlation with clinical *** staining for ANLN was performed on 86 PCa specimens,followed by evaluation using immunoreactivity(IR)*** was analyzed by the log-rank test using the Kaplan–Meier method to generate a cancer-specific survival *** correlations between ANLN IR and clinical parameters as well as OCT1 IR were analyzed using the Chi-squared *** median IR score was 0 for ***,given the low median IR score,an IR score of≥3 was defined as *** were 17(19.8%)ANLN-positive cases,and these cases had a significantly poorer *** analysis revealed that the Gleason score,pathological tumor and lymph node stages,and positive ANLN expression were significant predictors of poor ***,patients with both positive ANLN and high OCT1 expression had a significantly decreased overall survival(p=0.001).ConclusionANLN,which is a OCT1 target gene especially in castration-resistant PCa,is expressed in a small number of hormone-sensitive PCa *** positive ANLN expression and high OCT1 expression are significantly correlated with poor prognosis for PCa patients.

关键词： Prostatecancer Androgenreceptor Octamer transcriptionfactor1 Anillin actin-binding protein

One Case of Suspected Angiostenosis Revealed by MRA Following Carotid Endarterectomy Due to a Rare Cause

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Modern Neurosurgery 2018年第3期8卷 276-281页

作者： Yuji Endo Naoki Sato Hidekazu takahashi Mamoru Ota Toshihito Ishikawa Katsuhiro Endo kenichi Ebihara Department of Neurosurgery Masu Memorial Hospital Fukushima Japan Department of Neurosurgery Ageo Central General Hospital Saitama Japan

We herein report on a case in which magnetic resonance angiography (MRA) following carotid endarterectomy revealed the appearance of angiostenosis due to an artifact of metallic powder, which was thought to have come from an old surgical instrument. The patient was a 77-year-old male. Carotid endarterectomy (CEA) was performed for stenosis in the internal carotid artery of his left neck (82%). Upon observing a decline in renal function following CEA surgery, a postoperative cervical MRA revealed the appearance of high-grade stenosis at the common carotid artery on which surgery was performed. No stenosis was revealed upon carotid ultrasonography and angiography. In the original MRA image, an orbicular low intensity area was observed in concordance with the narrow segment. 3D computed tomography (3D-CT) revealed a metallic finding, suggesting it was an artifact caused by metal powder. Close inspection of the metal surgical instruments used during surgery revealed slight damage to a suture snare which had been used for 30 years. Going forward, it is necessary to pay attention to old surgical instruments, introduce a system by which the number of years and the frequency of use of each surgical instrument can be learned, and replace them with new equipment as necessary.

关键词： Carotid Endarterectomy Operation Metal Artifact Surgical Instruments

Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2016年第19期8卷 716-722页

作者： Kazuya takahashi Yuichi Sato Junji Kohisa Jun Watanabe Hiroki Sato kenichi Mizuno Satoru Hashimoto Shuji Terai Department of Endoscopy Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Sado General Hospital Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital

AIM To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection(ESD).METHODS Data were obtained from a total of 26 *** patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole *** were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after *** images just after ESD,on day 8,and on day 28 were used for the evaluation of the shrinking rate of ESD *** shrinking rates and the incidence of delayed bleeding were compared between the 2 *** The shrinking rates of ESD ulcers on day 8 [vonoprazangroup: 61.8%(range: 24.0%-91.1%),lansoprazole group: 71.3%(range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3%(range: 76.2%-100%),lansoprazole group: 97.2%(range: 81.1%-99.8%)] were not statistically different between the 2 *** day 28,most of the ulcers in both groups healed to more than 90%,whereas 3 of 14(21.4%) in the vonoprazan group and 1 of 12(8.3%) in the lansoprazole group had delayed ulcer healing,which was not statistically different(P = 0.356).The frequency of delayed bleeding was 0 in the both *** together,there were no significant differences between the two drug *** Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective.

关键词： Lansoprazole Gastric cancer Endoscopic submucosal dissection Potassium-competitive acid blocker Proton pump inhibitor Vonoprazan

Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2017年第12期9卷 583-589页

作者： Kazunao Hayashi Kenya Kamimura Kazunori Hosaka Satoshi Ikarashi Junji Kohisa Kazuya takahashi Kentaro Tominaga kenichi Mizuno Satoru Hashimoto Junji Yokoyama Satoshi Yamagiwa Kazuyasu Takizawa Toshifumi Wakai Hajime Umezu Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Division of Digestive and General Surgery Graduate School of Medical and Dental Sciences Niigata University Department of Pathology Niigata University Medical and Dental Hospital

Duodenal gastrointestinal stromal tumors(GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography(EUS) and fine-needle aspiration(FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure.

关键词： Gastrointestinal stromal tumor Duodenum Extraluminal type Pancreatic head tumor Endoscopic ultrasonography Endoscopic ultrasound-guided fineneedle aspiration Partial resection