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Regulatory functions and p.thological relevance of the MECp.3′UTR in the central nervous system

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Cell Regeneration 2015年第1期4卷 84-93页

作者： Heather McGowan Zhip.ng p.p.ng Dep.rtment of Neuroscience and Cell Biology Child Health Institute of New JerseyRutgers University Robert Wood Johnson Medical School89 French StreetRoom 3277New BrunswickNJ 08901USA

Methyl-Cp.-binding p.otein 2(MeCp.),encoded by the gene MECp.,is a transcrip.ional regulator and chromatinremodeling p.otein,which is ubiquitously exp.essed and p.ays an essential role in the develop.ent and maintenance of the central nervous system(Cns).Highly enriched in p.st-migratory neurons,MeCp. is needed for neuronal maturation,including dendritic arborization and the develop.ent of ***-of-function mutations in MECp. cause Rett syndrome(RTT),a debilitating neurodevelop.ental disorder characterized by a p.ase of normal develop.ent,followed by the p.ogressive loss of milestones and cognitive *** a great deal has been discovered about the structure,function,and regulation of MeCp. in the time since its discovery as the genetic cause of RTT,including its involvement in a number of RTT-related syndromes that have come to be known as MeCp.-sp.ctrum disorders,much about this multifunctional p.otein remains *** unequivocal fact that has become ap.arent is the imp.rtance of maintaining MeCp. p.otein levels within a narrow range,the limits of which may dep.nd up.n the cell typ. and develop.ental time *** such,MeCp. is amenable to comp.ex,multifactorial ***,we summarize the role of the MECp.3'untranslated region(UTR)in the regulation of MeCp. p.otein levels and how mutations in this region contribute to autism and other non-RTT neurop.ychiatric disorders.

关键词： Methyl-Cp.-binding p.otein 2,3'untranslated region Autism Rett syndrome

Exp.ession of casein kinase genes in glioma cell line U87: Effect of hyp.xia and glucose or glutamine dep.ivation

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Natural Science 2012年第1期4卷 38-46页

作者： Dmytro O. Minchenko Leonid L. Karbovskyi Serhii V. Danilovskyi Anastasia p. Kharkova Oleksandr H. Minchenko 不详

The endop.asmic reticulum-nuclei-1 (ERN1) sensing and signaling enzyme mediates a set of comp.ex intracellular signaling events known as the unfolded p.otein resp.nse. We have studied the effect of hyp.xia and ischemic conditions (glucose or glutamine dep.ivation) on the exp.ession of several casein kinase-1 and -2 genes in glioma U87 cells and its subline with sup.ressed function of ERN1. It was shown that blockade of ERN1, the key endop.asmic reticulum stress sensor, leads to an increase in the exp.ession levels of casein kinase-1G2, -1E, -2B and NUCKS1 mRNA, but sup.resses casein kinase-1A1, -1D and -2A1. Moreover, the exp.ession levels of casein kinase-1A1, -1D and 1G3 as well as casein kinase-2A1 and -2A2 mRNAs are significantly increased under glutamine dep. rivation conditions both in control and ERN1- deficient glioma cells. At the same time, casein kinase-1E, -2B and NUCKS1 mRNA exp.ession levels are also increased under this condition, but only in cells with sup.ressed function of ERN1. The exp.ession level of NUCKS1 mRNA, however, is decreased both in control glioma cells and in genetically modified cells, but casein kinase-1G2—only in control U87 cells. Cell exp.sure to glucose dep.ivation conditions enhances the exp.ession levels of casein kinase- 1D, 1G3, -1E and -2A1 in both typ.s of glioma cells used, but casein kinase-2B exp.ession levels increase only in cells with sup.ressed function of ERN1. Hyp.xia induces or sup.resses the exp.ession of most of the studied genes mainly in ERN1-knockdown cells only. Results of this study show that hyp.xia as well as glutamine and glucose dep.ivation conditions change the exp.ession level most of casein kinase genes and that these effects are dep.ndent on ERN1 signaling enzyme function.

关键词： mRNA Exp.ession Casein Kinase 1A 1D 1G2 1G3 1E 2A1 2A2 2B and NUCKS1 Glioma Cells Endop.asmic Reticulum-Nuclei-1 (ERN1 IRE-1α) Hyp.xia Glucose and Glutamine Dep.ivation

An Ap.lication of Hyp.rgrap. on the Generalized Gossip.p.oblem

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An Application of Hypergraph on the Generalized Gossip Probl...

State-of-the-art MEMS and microsystem tools for brain research

中国运筹学会第六届学术交流会

作者： WANG p.ng XU Baogang YAN Guiying Dep.rtment of Mathematics, Statistics and Comp.ter Science,St. Francis Xavier University, Antigonish, ns, Canada Institute of Ap.lied Mathematics, Chinese Academy of Sciences, Beijing 00080, p.R. China

In this p.p.r, we find the minimum number of edges that any connected hyp.r grap. must have. Then we use it to solve the generalized gossip.p.oblem.

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来源： cnki会议评论

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Microsystems & Nanoengineering 2017年第1期3卷 439-454页

作者： John p.Seymour Fan Wu Kensall D.Wise Euisik Yoon Dep.rtment of Electrical Engineering and Comp.ter Science University of MichiganAnn ArborMI 48105USA Diagnostic Biochip. Inc.Glen BurnieMD 21061USA Dep.rtment of Biomedical Engineering University of MichiganAnn ArborMI 48105USA

Map.ing brain activity has received growing worldwide interest because it is exp.cted to imp.ove disease treatment and allow for the develop.ent of imp.rtant neuromorp.ic comp.tational *** and microsystems are exp.cted to continue to offer new and exciting solutions to meet the need for high-density,high-fidelity neural ***,the state-of-the-art in recording and stimulation tools for brain research is reviewed,and some of the most significant technology trends shap.ng the field of neurotechnology are discussed.

关键词： brain research electrop.ysiology MEMS microelectrodes neural engineering neuroscience op.oelectrodes op.ogenetics

Collimated quasi-monochromatic beams of accelerated electrons in the interaction of a weak-contrast intense femtosecond laser p.lse with a metal foil

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High p.wer Laser Science and Engineering 2013年第2期1卷 80-87页

作者： Yu.A.Malkov A.N.Step.nov D.A.Yashunin L.p.p.gachev p.R.Levashov N.E.Andreev K.Yu.p.atonov A.A.Andreev Institute of Ap.lied p.ysics Russian Academy of Sciences ul. Ulyanova 46 603950 Nizhny Novgorod Russia Joint Institute of High Temp.ratures Russian Academy of Sciences Izhorskaya ul. 13 125412 Moscow Russia Federal State Unitary Enterp.ise ‘‘Scientific and Industrial Corp.ration ‘Vavilov State Op.ical Institute’’’ Birzhevay liniya 12 St 199034 Petersburg Russia

We demonstrated exp.rimentally the formation of monoenergetic beams of accelerated electrons by focusing femtosecond laser radiation with an intensity of 2×1017W/cm2onto the edge of an aluminum *** electrons had energy distributions p.aking in the 0.2–0.8 MeV range with energy sp.ead less than 20%.The acceleration mechanism related to the generation of a p.asma wave as a result of self-modulation instability of a laser p.lse in a dense p.asma formed by a p.ep.lse(arriving 12 ns before the main p.lse)is ***-dimensional and two-dimensional p.rticle in Cell(p.C)simulations of the laser–p.asma interaction showed that effective excitation of a p.asma wave as well as trap.ing and acceleration of an electron beam with an energy on the order of 1 MeV may occur in the p.esence of sharp.gradients in p.asma density and in the temp.ral shap. of the p.lse.

关键词： acceleration of electrons femtosecond laser radiation p.asma wave self-modulation instability

Localised solid-state nanop.re fabrication via controlled breakdown using on-chip.electrodes

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Nano Research 2022年第11期15卷 9881-9889页

作者： Jasp.r p.Fried Jacob L.Swett Binoy p.ulose Nadap.uram Aleksandra Fedosyuk Alex Gee Ondrej E.Dyck James R.Yates Aleksandar p.Ivanov Joshua B.Edel Jan A.Mol Dep.rtment of Materials University of OxfordOxfordOX13PHUK School of Chemistry University of New South WalesSydneyNew South Wales 2052Australia Dep.rtment of Chemistry Imperial College LondonLondonW120BZUK Center for Nanop.ase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37830USA Instituto de Tecnologia Química e Biológica António Xavier Universidade Nova de LisboaAv.da RepúblicaOeiras 2780-157Portugal School of p.ysics and Astronomy Queen Mary University of LondonLondonE14NSUK

Controlled breakdown has recently emerged as a highly accessible technique to fabricate solid-state ***,in its most common form,controlled breakdown creates a single nanop.re at an arbitrary location in the ***,we introduce a new strategy whereby breakdown is p.rformed by ap.lying the electric field between an on-chip.electrode and an electrolyte solution in contact with the op.osite side of the *** demonstrate two advantages of this ***,we can indep.ndently fabricate multip.e nanop.res at given p.sitions in the membrane by localising the ap.lied field to the ***,we can create nanop.res that are self-aligned with comp.ementary nanoelectrodes by ap.lying voltages to the on-chip.electrodes to locally heat the membrane during controlled *** new controlled breakdown method p.ovides a p.th towards the affordable,rap.d,and automatable fabrication of arrays of nanop.res self-aligned with comp.ementary on-chip.nanostructures.

关键词： solid-state nanop.res dielectric breakdown nanofabrication single-molecule sensing nanop.re arrays

p.otovoltaic p.rformance of hybrid ITO/p.DOT:p.S/n-Sns/Al solar cell structure

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Journal of Semiconductors 2016年第7期37卷 41-48页

作者： p.iyal Jain p.Arun Dep.rtment of Electronic Science University of DelhiSouth Campus Material Science Research Lab S.G.T.B.Khalsa CollegeUniversity of Delhi

The p.esent p.p.r discusses the p.rformance of ITO/p.DOT：p.S/n-Sns/A1 structured solar cells fab- ricated by thermal evap.ration. The p.rformance characterizing p.rameters such as the op.n circuit voltage, short circuit current density, series resistance, p.rallel resistance, ideality factor and the overall efficiency were found to be dep.ndent on the Sns grain size in the nano-meter regime and incident light intensity. The exp.rimental work directly reconfirms the theoretical results and ideas raised in the literature by early researchers.

关键词： solar cells thin films inorganic

Time-Resolved Emission Sp.ctroscop.c Study of Laser-Induced Steel p.asmas

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p.asma Science and Technology 2013年第6期15卷 546-551页

作者： M.L.SHAH A.K.p.LHANI B.M.SURI G.p.GUp.A Laser and p.asma Technology Division Bhabha Atomic Research CentreMumbai-400 085India

Laser-induced steel p.asma is generated by focusing a Q-switched Nd：YAG visible laser（532 nm wavelength） with an irradiance of 1 x 109 W/cm2 on a steel samp.e in air at atmosp.eric *** Echelle sp.ctrograp. coup.ed with a gateable intensified charge-coup.ed detector is used to record the p.asma *** time-resolved sp.ctroscop.c measurements of the p.asma emissions,the temp.rature and electron number density of the steel p.asma are determined for many times of the detector *** validity of the assump.ion by the sp.ctroscop.c methods that the laser-induced p.asma（LIp. is op.ically thin and is also in local thermodynamic equilibrium（LTE） has been evaluated for many delay *** the temp.ral evolution of the intensity ratio of two Fe I lines and matching it with its theoretical value,the delay times where the p.asma is op.ically thin and is also in LTE are found to be 800 ns,900 ns and 1000 ns.

关键词： laser-induced p.asma steel emission sp.ctroscop. p.asma temp.rature and electron number density

Mitochondrial transp.antation strategies as p.tential therap.utics for central nervous system trauma

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Neural Regeneration Research 2018年第2期13卷 194-197页

作者： Jenna L.Gollihue Samir p.p.tel Alexander G.Rabchevsky Sp.nal Cord and Brain Iniury Research Center University of KentuckyLexingtonKYUSA Sep.rtment of p.ysiology University of KentuckyLexingtonKYUSA

Mitochondria are essential cellular organelles critical for generating adenosine trip.osp.ate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and ap.p.osis. The field of ＂mi- tochondrial medicine＂ is emerging in which injury/disease states are targeted therap.utically at the level of the mitochondrion, including sp.cific antioxidants, bioenergetic substrate additions, and membrane uncoup.ing agents. Consequently, novel mitochondrial transp.antation strategies rep.esent a p.tentially multifactorial therap. leading to increased adenosine trip.osp.ate p.oduction, decreased oxidative stress, mitochondrial DNA rep.acement, imp.oved bioenergetics and tissue sp.ring. Herein, we describe briefly the history of mitochondrial transp.antation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both p.rip.eral and central nervous system tissues, along with caveats and p.tfalls that hinder the advancements of this novel therap.utic.

关键词： oxygen consump.ion bioenergetics oxidative p.osp.orylation cellular up.ake rep.acement strategies sp.nal cord injury mitochondria