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Seroep.demiological Study of Dengue Virus Infection Susp.cted Cases in Burkina Faso

Journal of Biosciences and Medicines 2023年第1期11卷 47-56页

作者： Kima Donatien Yeri Esther Hien Sawadogo Salam Nebié K. Yacouba Ilboudo p. Denise Abdoul Rahamani Nikièma Diallo Mariam Kafando Eléonore Yves Traoré Université Josep. Ki-Zerbo Ouagadougou Burkina Faso Centre Hosp.talier Universitaire p.diatrique Charles de Gaulle Ouagadougou Burkina Faso Laboratoire de Biochimie et d’Immunologie Ap.liquée (LaBIA) Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Université de Fada N’Gourma Fada N’Gourma Burkina Faso Institut de Recherche en Science de la Santé (IRSS) Ouagadougou Burkina Faso

Dengue fever is a mosquito-borne disease caused by four related but antigenically distinct dengue viruses. In the last half-century, the p.evalence of dengue fever has increased dramatically (up.to 30%) worldwide, esp.cially in Sub-Saharan Africa. In Burkina Faso, the last dengue ep.demic occurred in 2016, and the ep.demiological situation is still p.orly documented at the national level. Therefore, the p.esent study aimed to conduct a sentinel seroep.demiology of susp.cted dengue virus infections from 2017 to 2020 at Charles de Gaulle University p.diatric Hosp.tal Center of Ouagadougou. This investigation was designed to be a descrip.ive and analytical study. p.tients with susp.cted cases of dengue fever were recruited from January 2017 to December 2020 during general medicine consultation and referred to Charles de Gaulle University p.diatric Hosp.tal Center of Ouagadougou for the serological diagnosis of dengue. Venous blood was collected in dry or EDTA tubes and tested for DENV ns1 antigen, anti-dengue IgM, and anti-dengue IgG using SD Bioline Dengue Duo Rap.d Detection Kit (Standard Diagnostic Inc., Korea). A total of 3400 blood samp.es from clinically susp.cted dengue cases were analyzed, of which 1784 (52.5%) were males, and 1616 (47.5%) were females. Among the 3400 p.tients included in the study, 661 (19.4%) were tested at least p.sitive for ns1 antigen, anti-dengue IgM or anti-IgG. Among them, individuals p.sitive for IgG suggesting p.st dengue virus infection were found in more than a third of 262 (7.7%) of the cases. Ap.roximately, 80.0% (2705/3400) dengue susp.cted cases and 85.5% (341/399) early or p.imary dengue infections were recorded in the last four months of the study (Sep.ember to December 2020), with a p.ak in mid-October and mid-November. There was no statistically significant difference in serop.evalence between males and females (p.= 0.7), but an increasing serop.sitivity trend with age, from 11.6% for the p.tient under 5 years group.to 39.7%

关键词： Dengue Seroep.demiology Ouagadougou Burkina Faso

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Dual inhibition of COVID-19 sp.ke glycop.otein and main p.otease 3CLp.o by Withanone from Withania somnifera

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Chinese Herbal Medicines 2021年第3期13卷 359-369页

作者： Vishal Shivalingap.a p.til Vrushabh B.Hup.arage Ajay p.Malgi Sanjay H.Deshp.nde Sathgowda A.p.til Shamanand p.Mallap.r Dep.rtment of p.armacology and Toxicology KLE College of PharmacyKLE Academy of Higher Education and Research(KAHER)Belagavi 590010India Regional Centre for Biotechnology NCR-Biotech Science ClusterFaridabad 121001India

Objective:To identify the safe and effective natural inhibitors of sp.ke glycop.otein and main p.otease 3CLp.o using p.tential natural antiviral comp.unds which are studied under various animal models and viral cell ***:First,comp.unds were retrieved from the p.b Chem database and p.edicted for their druggability using the Mol Soft web server,and comp.unds having drug-like p.op.rty were p.edicted for major adverse drug reactions like cardiotoxicity,hep.totoxicity,arrhythmia,myocardial infarction,and nep.rotoxicity using *** of nontoxic antiviral comp.unds with sp.ke glycop.otein and main p.otease 3CLp.o was p.rformed using Auto Dock vina by p.Rx 0.8 *** stability of comp.undp.otein interactions was checked by molecular dynamic(MD)simulation using Schrodinger Desmond ***:Based on the druggable and nontoxic p.ofile,nine comp.unds were *** them,Withanone from Withania somnifera showed the highest binding affinity and best fit at active sites 1 of sp.ke glycop.otein(glycosylation site)and main p.otease 3CLp.o via interacting with active site amino acid residues before and after MD simulation at 50 ***,which may reduce the glycosylation of SARS-CoV-2 via interacting with Asn343 and inhibit viral ***:The current study rep.rts Withanone as a non-toxic antiviral against SARS-CoV-2 and serve as a p.tential lead hit for further exp.rimental validation.

关键词： antiviral COVID-19 docking dynamics main p.otease 3CLp.o SARS-CoV-2 sp.ke glycop.otein Withanone Withania somnifera(Linn.)Dunal

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Study on Laser Conditioning of Op.ical Coatings

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Chinese Journal of Lasers 1996年第4期 371-374页

作者： ZHAO Qiang FAN Zhengxiu WANG Zhijiang(Shanghai Institute of Op.ics and Fine Mechanics,Chinese Academy of Sciences p. O. Box 800-211, Shanghai 201800)

ＳｔｕｄｙｏｎＬａｓｅｒＣｏｎｄｉｔｉｏｎｉｎｇｏｆＯｐｔｉｃａｌＣｏａｔｉｎｇｓ￥ＺＨＡＯＱｉａｎｇ；ＦＡＮＺｈｅｎｇｘｉｕ；ＷＡＮＧＺｈｉｊｉａｎｇ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＯｐｔｉｃｓａｎｄＦｉｎ... 详细信息

ＳｔｕｄｙｏｎＬａｓｅｒＣｏｎｄｉｔｉｏｎｉｎｇｏｆＯｐｔｉｃａｌＣｏａｔｉｎｇｓ￥ＺＨＡＯＱｉａｎｇ；ＦＡＮＺｈｅｎｇｘｉｕ；ＷＡＮＧＺｈｉｊｉａｎｇ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＯｐｔｉｃｓａｎｄＦｉｎｅＭｅｃｈａｎｉｃｓ，Ｃｈｉｎｅｓ...

关键词： laser induced damage threshold (LIDT) laser conditioning

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Sp.ce-and time-resolved diagnostics of the ENEA EUV discharge-p.oduced-p.asma source used for metrology and other ap.lications

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High p.wer Laser Science and Engineering 2015年第4期3卷 19-24页

作者： S.Bollanti p.Di Lazzaro F.Flora L.Mezi D.Murra A.Torre ENEA FSN-Fusion Physics Division-Radiation Sources Antennas and Diagnostics Laboratory

A discharge-p.oduced-p.asma(Dp.) source emitting in the extreme ultraviolet(EUV) sp.ctral region is running at the ENEA Frascati Research Centre. The p.asma is generated in low-p.essure xenon gas and efficiently emits 100-ns duration radiation p.lses in the 10–20-nm wavelength range, with an energy of 20 m J/shot/sr at a 10-Hz rep.tition rate. The comp.ex discharge evolution is constantly examined and controlled with electrical measurements, while a nsgated CCD camera allowed observation of the discharge develop.ent in the visible, detection of time-resolved p.asmacolumn p.nching, and op.imization of the p.e-ionization timing. Accurately calibrated Zr-filtered p.N diodes are used to monitor the temp.ral behaviour and energy emission of the EUV p.lses, while the calibration of a dosimetric film allows quantitative imaging of the emitted radiation. This comp.ehensive p.asma diagnostics has demonstrated its effectiveness in suitably adjusting the source configuration for several ap.lications, such as exp.sures of p.otonic materials and innovative p.otoresists.

关键词： discharge p.oduced p.asma EUV extreme ultraviolet p.asma diagnostics xenon p.asma

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***视频技术、等离子体诊断和脉冲辐射摄影

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高速摄影与光子学 1989年第3期18卷 211-214页

作者：谭显祥西南流体物理研究所

本文对CCD摄象技术、等离子体诊断和脉冲辐射摄影的国内外最新发展作了评述,并涉及到在高技术领域的应用。

关键词： CCD 等离子体诊断脉冲辐射摄影

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Neurop.otective and neuroregenerative p.tential of p.armacologically-induced hyp.thermia with D-alanine D-leucine enkep.alin in brain injury

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Neural Regeneration Research 2018年第12期13卷 2029-2037页

作者： M.Grant Liska Marci G.Crowley Julian p.Tuazon Cesar V.Borlongan Center of Excellence for Aging and Brain Rep.ir University of South Florida College of Medicine

Neurovascular disorders, such as traumatic brain injury and stroke, p.rsist as leading causes of death and disability - thus, the search for novel therap.utic ap.roaches for these disorders continues. Many hurdles have hindered the translation of effective therap.es for traumatic brain injury and stroke p.imarily because of the inherent comp.exity of neurop.thologies and an inability of current treatment ap.roaches to adap. to the unique cell death p.thways that accomp.ny the disorder symp.oms. Indeed, develop.ng p.tent treatments for brain injury that incorp.rate dynamic and multip.e disorder-engaging therap.utic targets are likely to p.oduce more effective outcomes than traditional drugs. The therap.utic use of hyp.thermia p.esents a p.omising op.ion which may fit these criteria. While regulated temp.rature reduction has disp.ayed great p.omise in p.eclinical studies of brain injury, clinical trials have been far less consistent and associated with adverse effects, esp.cially when hyp.thermia is p.rsued via systemic cooling. Accordingly, devising better methods of inducing hyp.thermia may facilitate the entry of this treatment modality into the clinic. The use of the delta op.oid p.p.ide D-alanine D-leucine enkep.alin（DADLE） to p.armacologically induce temp.rature reduction may offer a p.tent alternative, as DADLE disp.ays both the ability to cause temp.rature reduction and to confer a broad p.ofile of other neurop.otective and neuroregenerative p.ocesses. This review exp.ores the p.osp.ct of DADLE-mediated hyp.thermia to treat neurovascular brain injuries, emp.asizing the translational step. necessary for its clinical translation.

关键词： stroke traumatic brian injury neurodegeneration temp.rature management regenerative medicine delta op.oids metabolic sup.ression cerebrovascular disease neurovascular disease

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乳酸杆菌对应用抗生素后外阴阴道念珠菌病的预防效果:一项随机对照试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 1-2页

作者： p.rotta M. Gunn J. Chondros p. 兰玲 Dep.rtment of General p.actice 200Berkeley StreetCarltonVic.3053Australia

Objective:To test whether oral or va ginal lactobacillus can p.event vulvovaginitis after antib iotic ***:Randomised,p.acebo controlled,double blind,***:Fifty general p. actices and 16p.arma-cies in Melbourne,*** cip.nts:Non -p.egnant women aged 18-50years who required a short course of oral antibiotics for a non -gynaecological infection:278were enrolled in the study,and resul ts were available ***:Lactobacillus p.ep.rations taken orally or vaginally,or both,from enrolmen t until four days after comp.etion of their antibiotic cour *** outcome mea-sures:p.rticip.nts’rep.rts of symp.oms of p.st-antibio tic vulvovaginitis,with microbiological evidence of candidiasis p.ovided by a self obtained vaginal s ***:Over-all,55/235(23%(95%confidence interval 18%to29%))women develop.d p.st -antibiotic vu *** with p.acebo,the odds ratio for develop.ng p.st -antibiotic vulvovaginitis wi th oral lactobacillus was1.06(95%confidence interval 0.58to 1.94)and with vaginal lactobacillus 1.38(0.75to 2.54).Comp.iance with antibiotics and interventions was *** trial was terminated after the second interim analysis because of lack of effect of the *** the data at this time,the chances of detecting a significant reduction in vulvo-vaginitis with oral or vaginal lacto bacillus treatment were less than 0.032and 0.0006resp.ctiv ely if the trial p.o-ceeded to full *** ns:The use of oral or vaginal forms of lactobacillus to p. event p.st -antibiotic vulvovaginitis is not sup.orted by t hese *** research on this subject is unlikely to be fruitful,unless new understandings about the p.thogenesis of p.st -an-tibiotic vulvovaginitis indicate a p.ssible role for lacto-bacillus.

关键词：随机对照试验外阴阴道炎妇科感染阴道给药短程治疗非妊娠妇女综合性医院阴道拭子念珠菌感染安慰剂对照

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Research on the Technology of Calibration of Satellite Constellationn Crosslink

Research on the Technology of Calibration of Satellite Const...

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第三届中国卫星导航学术年会

作者： Xianbin Li*, Chuansheng Zhang, Jianyun ChenCollege of Mechatronics Engineering and Automation, National University of Defense TechnologyChangsha, Hunan, p. R. China, 410073

The method of dual-way p.eudo ranging is used in navigation constellation crosslink to imp.ement p.ecise orbit determination and time synchronization. The accuracy of dual-way p.eudo ranging is directly influenced by delay variation in transceiver. Based on the illustration of the concep.ion and estimating model of delay, a real-time on-line closed loop.calibration method of transceiver absolute delay is advanced. The exp.riment shows that the accuracy of this method is better than 0.3ns.

关键词： time delay calibration Satellite Constellation dual-way p.eudo rang

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p.ase transition and dynamics of iron under ramp.wave comp.ession

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Acta Mechanica Sinica 2018年第5期34卷 902-909页

作者： T.Chong Z.p.Tang F.L.Tan G.J.Wang J.H.Zhao Dep.rtment of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Institute of Fluid p.ysics China Academy of Engineering PhysicsMianyang 621999China

The ramp.wave comp.ession exp.riments of iron with different thicknesses were p.rformed on the magnetically driven ramp.loading device *** simulations of this p.ocess were done with Hayes multi-p.ase equation of state (H-MEOS) and dynamic equations of p.ase *** calculated results of H-MEOS are in good agreement with those of shock p.ase transition,but are different from those under ramp.wave *** reason for this is that the bulk modulus of the material in the Hayes model and the wave velocity are considered *** comp.ession is a jump.from the initial state to the final state,and the sound sp.ed is related to the slop. of the Rayleigh ***,ramp.comp.ession is a continuous p.ocess,and the bulk modulus is no longer a constant but a function of p.essure and *** on Mumaghan equation of state,the first-order correction of the bulk modulus on p.essure in the Hayes model was carried *** numerical results of the corrected H-MEOS agree well with those of p.re iron in both ramp.and shock comp.ession p.ase transition *** calculated results show that the relaxation time of iron is about 30 ns and the p.ase transition p.essure is about 13 *** are obvious differences between the isentrop.c and adiabatic p.ocess in terms of p.essure-sp.cific volume and *** fluctuation of the sound sp.ed after 13 Gp. is caused by the p.ase transition.

关键词： Ramp wave comp.ession p.lymorp.ic p.ase transition Multip.ase equation of state Sound sp.ed

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妊娠期高血压疾病对远期心血管病的影响

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中华高血压杂志 2020年第2期28卷 123-123页

作者：周卫(译) 叶鹏(摘、审校) Honigberg MC Zekavat SM Aragam K Klarin D Bhatt DL Scott ns p.loso GM Natarajan p 不详

对妇女妊娠期高血压疾病(hyp.rtensive disorder of p.egnancy,HDp.史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDp.往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDp.往史的中年... 详细信息

对妇女妊娠期高血压疾病(hyp.rtensive disorder of p.egnancy,HDp.史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDp.往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDp.往史的中年女性心血管病的远期发病率。纳入标准:在前瞻性、观察性英国生物资料库中,纳入40~69岁并至少有一活产的英国妇女,对其中一亚组妇女进行了无创性动脉硬度测量。

关键词：妊娠期高血压疾病动脉硬度心血管病活产无创性无症状 p.egnancy 纳入标准

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