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Petroleum 2017年第1期3卷 3-9页

作者： ken brown Steve Whittaker Malcolm Wilson Wayuta Srisang Heidi Smithson Paitoon Tontiwachwuthikul Clean Energy Technologies Research Institute(CETRI) University of Regina3737 Wascana ParkwayReginaSK S4S 0A2Canada

*** The Weyburn oil field occurs within a larger trend of similar oil accumulations in Mississippian-aged *** history of discovery of these oil accumulations resulted in the fields being given several different *** Weyburn field and the immediately-adjacent Midale field are effectively part of a larger oil pool with OOIP(original oil in place)reserves of over 2 billion *** is certainly a large conventional oil pool for Canada even if not large by world *** pools are found in truncated stratigraphic traps and occur at about 1450e1550 m depth making them ideal for CO_(2) storage[1].

关键词： Canada Storage CCS

New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima ken Sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

Exploring the novel role of oligodendrocyte precursor cells in phagocytosis:beyond myelinogenesis

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Neural Regeneration Research 2025年第2期20卷 473-474页

作者： Gen Hamanaka ken Arai Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA

Roles of oligodendrocyte precursor cells in the central nervous system:Oligodendrocyte precursor cells(OPCs)have long been recognized for their critical role as precursors to oligodendrocytes,the primary myelin-producing *** precursors,OPCs mature and differentiate into oligodendrocytes,which contribute significantly to the formation of myelin sheaths around *** myelination,which is critical for the conduction of salutatory nerve impulses in the cerebral white matter,underscores the classical role of oligodendrocytes in central nervous system(CNS)***,because oligodendrocytes are differentiated cells that cannot proliferate.

关键词： critical system conduction

Prediction of Crohn's disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort

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World Journal of Gastroenterology 2014年第17期20卷 5008-5016页

作者： Maneesha Bhullar Finlay Macrae Gregor brown Margie Smith ken Sharpe Department of Colorectal Medicine and Genetics 3 CentreThe Royal Melbourne HospitalParkville 3052Australia Department of Molecular Genetics CMR Room 204PathologyThe Royal Melbourne HospitalParkville 3052Australia Department of Statistics University of MelbourneParkville 3050Australia

AIM: To investigate the association between mutations in oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) and the natural history of Crohn’s disease (CD) to identify patients who would benefit fr... 详细信息

关键词： Inflammatory bowel disease, Oligomerisation domain 2/caspase recruitment domains 15, Genotyping, Crohn’ s disease, Natural history

Unwanted and unintended effects of culling: A case for ecologically-based rodent management

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Integrative Zoology 2007年第4期2卷 247-259页

作者： Grant R.SINGLETON Peter R.brown Jens JACOB ken P.APLIN SUDARMAJI International Rice Research Institute ManilaPhilippines CSIRO Sustainable Ecosystems CanberraAustralian Capital TerritoryAustralia Federal Biological Research Centre for Agriculture and Forestry Institute for Nematology and Vertebrate ResearchMünsterGermany Indonesian Institute for Rice Research Central Research Institute for Food CropsSubangWest JavaIndonesia

In this study, the ecological effects of culling programs are considered in the context of rodent pest *** the escalation of rodent problems globally, over the past quarter of a century there have not been many newdevelopments in culling programs directed at managing these populations. There is a strong reliance on broad scaleuse of chemical rodenticides or other lethal methods of control. The ecological consequences of culling programsbased on chemical rodenticides and bounty systems are considered. Although rodents cause tremendous economichardship to people on a continental scale, usually less than 10% of species cause substantial impacts. Indeed, manyspecies of rodent provide important “ecological services” and, given that culling programs rarely distinguishbetween rodent species, often the non-pest rodents are at grave risk. Rodent control is conducted with littleappreciation of what proportion of the population would need to be culled for a significant reduction in economicdamage. In Indonesian rice fields, once rodent densities are high then a reduction in yield loss from 30% to 15%would require more than 75% of the population to be culled;a reduction to less than 5% yield loss would requiremore than a 95% cull. The negative ecological consequences of culling can be better managed if the method isspecifically tailored to the species that need to be managed. A greater emphasis on ecologically-based rodentmanagement would assist markedly in reducing the unwanted and unintended effects of culling.

关键词： bounty systems culling ecological effects rodenticides rodents.

Local charge neutrality condition,Fermi level and majority carrier density of a semiconductor with multiple localized multi-level intrinsic/impurity defects

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Journal of Semiconductors 2011年第11期32卷 1-8页

作者： ken K.Chin Department of Physics and Apollo CdTe Solar Energy Research Center New Jersey Institute of Technology Department of Photonic and Information Engineering School of Electronic and Information EngineeringBeihang University

For semiconductors with localized intrinsic/impurity defects, intentionally doped or unintentionally incorporated, that have multiple transition energy levels among charge states, the general formulation of the local charge neutrality condition is given for the determination of the Fermi level and the majority carrier density. A graphical method is used to illustrate the solution of the problem. Relations among the transition energy levels of the multi-level defect are derived using the graphical method. Numerical examples are given for p-doping of the CdTe thin film used in solar panels and semi-insulating Si to illustrate the relevance and importance of the issues discussed in this work.

关键词： multi-level defects defect complex intrinsic impurity semiconductor Fermi level majority carrier density

Approximate graphical method of solving Fermi level and majority carrier density of semiconductors with multiple donors and multiple acceptors

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Journal of Semiconductors 2011年第6期32卷 1-6页

作者： ken K.Chin Department of Physics and Apollo CdTe Solar Energy Research Center New Jersey Institute of Technology

We present a generic approximate graphical method for determining the equilibrium Fermi level and majority carrier density of a semiconductor with multiple donors and multiple acceptors compensating each other. Simple and easy-to-follow procedures of the graphical method are *** graphically plotting two wrapping step functions facing each other,one for the positive hole-ionized donor and one for the negative electron-ionized acceptor,we have the crossing point that renders the Fermi level and majority carrier *** the graphical method,new equations are derived,such as the carrier compensation proportional to N;/N;,not the widely quoted N;-N;.Visual insight is offered to view not only the result of graphic determination of Fermi level and majority carrier density but also the dominant and critical pair of donors and acceptors in *** graphical method presented in this work will help to guide the design,adjustment,and improvement of the multiply doped *** of this approximate graphical method with previous work on compensation,and with some experimental results,is *** work in the field is proposed.

关键词： doping compensation Fermi level carrier density graphical method ionization

The Structure and Mechanical Properties of Cr4Mo4V Steel Treated by PIII Carbonitriding

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稀有金属材料与工程 2012年第S1期41卷 176-179页

作者： ken Yukimura Harbin Institute of Technology Harbin 150001China

The composition and structure of PIII(plasma immersion ion implantation)carbonitrided Cr4Mo4V steel were analyzed using X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD),optical microscopy(OM)and *** results indicate that the nitride and carbide are dispersion phase precipitation and except formation of compound other implantation atoms dissolve into martensite *** total concentration of carbon and nitrogen is about 30 at%near the surface,and still keeps at about 20 at%even at the depth of 8μ*** effect of treatment temperature,implantation time and ratio of N2 to CH4 on the hardness and wear resistance of carbonitrided layer are *** is found that the hardness of Cr4Mo4V steel increases after *** highest hardness of samples is 22.3 GPa,which is about 1.8 times than initial *** dry-wear resistance of the samples is also improved after treatment,and the sample with higher hardness shows the better wear resistance.

关键词： Cr4Mo4V steel PBII carbonitriding hardness wear resistance

Role of STAT3 in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第33期14卷 5110-5114页

作者： ken Sugimoto Experimental Pathology Massachusetts General Hospital Harvard Medical SchoolBoston MA 02114 United States

Signal transducers and activators of transcription 3 (STAT3) play an important role in various autoimmune disorders including inflammatory bowel disease (IBD). Recent studies have revealed that STAT3 activation plays distinctly different roles between innate immune responses and acquired immune responses in colitis. STAT3-mediated activation of acquired immune re-sponses plays a pathogenic role in colitis by enhancing the survival of pathogenic T cells. In contrast, STAT3-mediated activation of innate responses contributes to the suppression of colitis. This review will summarize the current understanding of the roles of STAT3 in IBD and the potential of targeting STAT3 for the treatment of IBD, emphasizing recent observations.

关键词： Inflammatory bowel disease STAT3 Inflammation Innate immunity Acquired immunity

Analysis of the stress wave and rarefaction wave produced by hypervelocity impact of sphere onto thin plate

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Defence Technology（防务技术） 2020年第5期16卷 969-979页

作者： ken Wen Xiao-wei Chen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute of Systems Engineering China Academy of Engineering PhysicsMianyangSichuan621999China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China

Shock wave is emitted into the plate and sphere when a sphere hypervelocity impacts onto a thin *** fragmentation and phase change of the material caused by the propagation and unloading of shock wave could result in the formation of debris cloud *** models are deduced based on one-dimensional shock wave theory and the geometry of sphere,which uses elliptic equations(corresponding to ellipsoid equations in physical space)to describe the propagation of shock wave and the rarefaction ***“Effective thickness”is defined as the critical plate thickness that ensures the rarefaction wave overtake the shock wave at the back of the ***“Effective thickness”is directly related to the form of the debris *** relation of the“Effective thickness”and the“Optimum thickness”is also *** impacts of Al spheres onto Al plates are simulated within SPH to verify the propagation models and associated *** results show that the wave fronts predicted by the propagation models are closer to the simulation result at higher impact *** curvatures of the wave fronts decrease with the increase of impact *** predicted“Effective thickness”is consistent with the simulation *** analysis about the shock wave propagation and unloading in this paper can provide a new sight and inspiration for the quantitative study of hypervelocity impact and space debris protection.

关键词： Hypervelocity impact Debris cloud Shock wave Rarefaction wave Effective thickness of plate