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Chinese Science Bulletin 2005年第24期50卷 2821-2826页

作者： HE Xiaoxiao WANG kemin TAN Weihong chen Jiyun DUAN Jinghua YUAN Yin LIN Xia State Key Laboratory of Chemo/biosensing and Chemometrics Engineering Center for Biomedicine Institute of Life Science and Biological Technology Hunan University Engineering Research Center for Bio-Nanotechnology of Hunan Province Changsha 410082 China

The routine method for preparation of silica core-shell nanoparticles (NPs) is to carry out nucleation and shell coating through the hydrolysis of silane in water in oil (W/O) microemulsion to form three-dimensional netted silica shell. We found that electrostatic interaction of the core ma- terials with shell materials would determine whether the stable core-shell silica NPs formed or not. The traditional important factors such as molecular weight of core materials or the thickness of the shell have no obvious relationship with it. And the stability of the core-shell silica NPs can be im- proved after changing the electric charge polarity by regu- lating the experiment condition of relevant materials if some core materials cannot be doped inside to form the stable core-shell silica NPs based on the traditional method, which provided experimental and theoretic foundation for prepara- tion and application of the core-shell silica NPs.

关键词：硅纳米粒子静电相互作用稳定性微乳液法

Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 315-323页

作者： Weixia Li Ruokun Li Xiangtian Zhao Xiaozhu Lin Yixing Yu Jing Zhang kemin chen Weimin Chai Fuhua Yan Department of Radiology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Department of Nuclear Medicine Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary hepatic *** study was designed to investigate the value of computed tomography(CT)spectral imaging in differentiating HCC from hepatic hemangioma(HH)and focal nodular hyperplasia(FNH).Methods:This was a retrospective study of 51 patients who underwent spectral multiple-phase CT at 40–140 keV during the arterial phase(AP)and portal venous phase(PP).Slopes of the spectral curves,iodine density,water density derived from iodine-and water-based material decomposition images,iodine uptake ratio(IUR),normalized iodine concentration,and the ratio of iodine concentration in liver lesions between AP and PP were measured or ***:As energy level decreased,the CT values of HCC(n=31),HH(n=17),and FNH(n=7)increased in both AP and *** were significant differences in IUR in the AP,IUR in the PP,normalized iodine concentration in the AP,slope in the AP,and slope in the PP among HCC,HH,and *** CT values in AP,IUR in the AP and PP,normalized iodine concentration in the AP,slope in the AP and PP had high sensitivity and specificity in differentiating HH and HCC from *** CT spectral data had higher sensitivity and specificity than conventional qualitative CT image analysis during the combined ***:Mean CT values at low energy(40–90 keV)and quantitative analysis of CT spectral data(IUR in the AP)could be helpful in the differentiation of HCC,HH,and FNH.

关键词： Hepatocellular carcinoma Hepatic hemangioma Focal nodular hyperplasia Computed tomography spectral imaging Spectral curve

Localized production of LECT2 by orthotopic histiocytes during inflammation

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Journal of Genetics and Genomics 2024年第12期51卷 1517-1520页

作者： Zhenhan Huang Xiaojun Yang Xun Qin kemin chen Wei Liu Jin Xu Jianchao Li Wenqing Zhang Zhibin Huang The Innovation Centre of Ministry of Education for Development and Diseases School of Medicine South China University of Technology Greater Bay Biomedical Innocenter Shenzhen Bay Laboratory

Leukocyte cell-derived chemotaxin 2 (LECT2), initially identified as a multifunctional protein secreted by hepatocytes and involved in diverse hepatic pathophysiological processes (Yamagoe et al.,1998; Xie et al., 2022), is also a prominent amyloid fibril protein in both renal and hepatic amyloidosis (Mann et al., 2022). Recently,LECT2 has been implicated in immune processes across various pathologies, including hepatocellular carcinoma (HCC), nonalcoholic fatty liver disease (NAFLD), sepsis, atherosclerosis, arthritis, and allergic diseases (Zhu et al., 2023).

关键词： al. inflammation LECT2

Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

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Journal of Genetics and Genomics 2024年第3期51卷 359-362页

作者： Ao Zhang Jingao Lu Shachuan Feng Huapeng Yu Tao Yu Shizheng Zhao kemin chen Zhibin Huang Jin Xu Jianan Y.Qu Zilong Wen Division of Life Science Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Immunology and Microbiology School of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomedical Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518067China

Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue *** integrity of their functions heavily relies on the generation of a proper number of mature macrophages and neutrophils through embryonic and adult *** mammalian adult myelopoiesis,oligopotent common myeloid progenitors(CMPs)are known to be the earliest myeloid progenitors,which give rise to granulocyte-macrophage progenitors(GMPs),subsequently differentiate into unipotent neutrophil and macrophage precursors,and finally,mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny of embryonic myelopoiesis and the mechanism underlying the formation of macrophages and neutrophils remainless understood.

关键词： fish macrophage homeostasis

Structural changes in the gray matter of unmedicated patients with obsessive-compulsive disorder: a voxel-based morphometric study

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Neuroscience Bulletin 2013年第5期29卷 642-648页

作者： Ling Tan Qing Fan Chao You Jijun Wang Zhao Dong Xuemei Wang kemin chen Zeping Xiao Kaida Jiang Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine School of Pharmacy Shanghai University of Traditional Chinese Medicine

The aim of the current study was to use whole brain voxel-based morphometry（VBM）to assess the gray matter（GM）changes in unmedicated patients with obsessive-compulsive disorder（OCD）compared with normal *** compared the GM volumes in28 patients with 22 matched healthy controls using a1.5T ***-dimensional T1-weighted magnetic resonance images were obtained from all *** was performed to detect GM volume differences between the two *** detected increased regional GM volumes in the bilateral middle temporal gyri,bilateral middle occipital gyri,bilateral globus pallidus,right inferior parietal gyrus,left superior parietal gyrus,right parahippocampus,right supramarginal gyrus,right medial superior frontal gyrus,and left inferior frontal opercular cortex in the OCD patients relative to controls（P〈0.001,uncorrected,cluster size〉100 voxels）.No decreased GM volume was found in the OCD group compared with normal *** findings suggest that structural changes in the GM are not limited to fronto-striato-thalamic circuits in the pathogenesis of ***-parietal cortex may also play an important role.

关键词： obsessive-compulsive disorder magnetic resonance imaging voxel-based morphometry gray matter

基于功能磁共振的织物触压舒适度脑感知研究进展

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纺织学报 2017年第10期38卷 146-152页

作者：苑洁于伟东陈克敏东华大学纺织学院上海201620 东华大学纺织面料技术教育部重点实验室上海201620 上海交通大学医学院附属瑞金医院上海200025

针对织物接触人体皮肤所产生的压、挤、摩擦等作用在人体中的综合表征问题,通过对比国内外织物接触压力舒适性评价方法的优劣,并结合现代先进医学影像技术功能磁共振成像(f MRI)技术,从时空分辨率和织物感知神经环路2个方面,证明了f MR... 详细信息

针对织物接触人体皮肤所产生的压、挤、摩擦等作用在人体中的综合表征问题,通过对比国内外织物接触压力舒适性评价方法的优劣,并结合现代先进医学影像技术功能磁共振成像(f MRI)技术,从时空分辨率和织物感知神经环路2个方面,证明了f MRI大脑皮层评价对皮肤触觉真实感知可视化表达的唯一性。结合国内外相关案例,指出与舒适性有关的脑区可能位于对侧次级感觉皮层脑区,而不舒适感可能是在杏仁核区域。在可行性问题上,通过合理控制环境、人体因素、刺激时间以及引入呼气末二氧化碳回归量可将实验可信度由0.4以下成功提高至0.82。结果证明f MRI将成为纺织材料与工程领域中认知解答穿着中的接触舒适性的客观表征与机理认知的新的实践性方法。

关键词：触觉织物接触压力舒适度大脑感知功能磁共振成像

原发性高血压肾脏血流的多层螺旋CT灌注研究

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临床放射学杂志 2007年第9期26卷 891-894页

作者：王晓琰陈克敏第二军医大学附属东方肝胆外科医院放射科上海200438 上海交通大学附属瑞金医院放射科

目的利用多层螺旋CT(MSCT)灌注扫描研究原发性高血压病肾脏血流变化,探讨其在诊断高血压病早期肾损害的价值。资料与方法将原发性高血压病患者分为两组:无早期肾损害组和早期肾损害组。应用MSCT灌注扫描检查,测量血流量(BF)、血容量(BV... 详细信息

目的利用多层螺旋CT(MSCT)灌注扫描研究原发性高血压病肾脏血流变化,探讨其在诊断高血压病早期肾损害的价值。资料与方法将原发性高血压病患者分为两组:无早期肾损害组和早期肾损害组。应用MSCT灌注扫描检查,测量血流量(BF)、血容量(BV)和平均通过时间(MTT)等,并与核医学肾脏有效血浆流量(ERPF)进行比较。结果高血压组整肾、皮质和髓质的BF值均低于对照组,其中高血压有早期肾损害组下降明显,3组间差异均有统计学意义。高血压病组整肾BV下降,与正常组比较,高血压有早期肾损害组差异有统计学意义(P0.05)。高血压病组MTT延长,与正常组比较差异无统计学意义。高血压病组整肾BF与ERPF线性相关。结论MSCT可对原发性高血压病患者组织血流变化进行动态观察,早期诊断和预测高血压病肾脏损害。

关键词：原发性高血压体层摄影术,X线计算机肾灌注图

基于MicroStation Ⅴ8的立体采编系统开发与实现

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测绘信息与工程 2006年第2期31卷 17-19页

作者：王密陈克明陈少勤楼燕敏武汉大学测绘遥感信息工程国家重点实验室武汉市珞喻路129号430079 浙江省基础地理信息中心浙江省第二测绘院杭州市保俶北路83号310012

在VC环境下进行MicroStation的二次开发,实现了一套基于MicroStationⅤ8平台的全数字摄影测量立体采编系统。该系统在核线立体模型建立之后,利用摄影测量基本原理解算三维坐标,直接通过鼠标进行立体切准和量测,实现了面向地物要素的立... 详细信息

在VC环境下进行MicroStation的二次开发,实现了一套基于MicroStationⅤ8平台的全数字摄影测量立体采编系统。该系统在核线立体模型建立之后,利用摄影测量基本原理解算三维坐标,直接通过鼠标进行立体切准和量测,实现了面向地物要素的立体采集和立体编辑。

关键词： MicroStation VBA 二次开发语言数字摄影测量立体采编

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盐酸小檗碱对毒蕈碱型受体的作用

药学学报 1999年第4期34卷 260-263页

作者：王文雅陈克敏关永源中国人民解放军广州医学高等专科学校药理教研室中山医科大学药理教研室

目的：研究盐酸小檗碱对乙酰胆碱系统的影响。方法：采用离体血管环、离体支气管螺旋体及放射配基受体结合实验等方法。结果：较低浓度的盐酸小檗碱（Ｂｅｒ）对乙酰胆碱的舒张反应有浓度依赖性的增强作用；而较高浓度的Ｂｅｒ可浓度... 详细信息

目的：研究盐酸小檗碱对乙酰胆碱系统的影响。方法：采用离体血管环、离体支气管螺旋体及放射配基受体结合实验等方法。结果：较低浓度的盐酸小檗碱（Ｂｅｒ）对乙酰胆碱的舒张反应有浓度依赖性的增强作用；而较高浓度的Ｂｅｒ可浓度依赖性地直接舒张带内皮的动脉环，此作用在去内皮或阻断Ｍ受体后被完全抑制。在豚鼠离体气管条上，Ｂｅｒ可引起浓度依赖性的收缩反应，而阿托品可阻断这种作用。放射配基受体结合实验显示盐酸小檗碱可特异性与大鼠脑组织的毒蕈碱受体结合，Ｋｉ值为１６μｍｏｌ·Ｌ－１。结论：盐酸小檗碱可激动毒蕈碱受体，从而引起血管的内皮依赖性的舒张反应及支气管的收缩。

关键词：盐酸小檗碱毒蕈碱受体乙酰胆碱

MDCT在鉴别胰腺实性型浆液性囊腺瘤与富血供神经内分泌肿瘤中的价值

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中国医学计算机成像杂志 2022年第1期28卷 50-55页

作者：王晴柔陈克敏朱兰陈楠柴维敏上海交通大学医学院附属瑞金医院放射科

目的:探讨多排CT(MDCT)在鉴别胰腺实性型浆液性囊腺瘤(sSCA)与富血供神经内分泌肿瘤(pNET)中的价值。方法:回顾性分析2014年1月至2020年2月经上海交通大学医学院附属瑞金医院手术病理证实为胰腺sSCA(13例)及pNET(26例)的临床、上腹部CT... 详细信息

目的:探讨多排CT(MDCT)在鉴别胰腺实性型浆液性囊腺瘤(sSCA)与富血供神经内分泌肿瘤(pNET)中的价值。方法:回顾性分析2014年1月至2020年2月经上海交通大学医学院附属瑞金医院手术病理证实为胰腺sSCA(13例)及pNET(26例)的临床、上腹部CT资料。采用χ2检验比较2组患者定性参数(性别、病灶部位、形态等),采用两独立样本t检验比较2组患者定量参数(病灶大小、平扫CT值、动脉期CT值等),对其中差异有统计学意义的定量参数绘制ROC曲线并比较曲线下面积(AUC)以评价其诊断效能。结果:sSCA(12/13)相较于pNET(13/26)平扫多呈相对低密度改变,sSCA平扫、门脉期CT值[(29.4±3.7)HU、(107.3±13.1)HU)]低于pNET[(43.6±6.5)HU、(123.4±18.4)HU],而动脉期、门脉期强化率[(4.1±1.3)×100%、(2.8±0.8)×100%]均高于pNET[(2.9±0.9)×100%、(1.9±0.5)×100%],差异均有统计学意义(P<0.05)。ROC曲线显示平扫CT值所对应AUC(0.959)高于增强动脉期强化率(0.781)、门脉期CT值(0.750)、门脉期强化率(0.831),差异有统计学意义(P<0.05),平扫CT值≤36.8 HU诊断sSCA的灵敏度、特异度分别为100%、92.3%。结论:胰腺sSCA与富血供pNET的CT表现常易混淆,平扫CT值对两者鉴别诊断具有较大价值。

关键词：胰腺肿瘤实性型浆液性囊腺瘤计算机体层成像