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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan fan Tao Zhang Xin Ding Yushuo Gu Qing Li Wei Jiang kelong fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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Nanomaterials for refining tumor microenvironment and enhancing therapy in head and neck squamous cell carcinoma: a review

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Oncology and Translational Medicine 2024年第4期10卷 151-161页

作者： Kaifeng Zheng Ruibiao Song Ruifeng Li Mengli Liu Yunpeng Ba Wei Jiang kelong fan Department of Rhinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Application Center for Precision Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhouHenanChina CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules(CAS)CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijingChina Zhongyuan Nanozyme Laboratory ZhengzhouHenanChina

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal solid tumor with a high mortality rate. Conventional cancertreatments, including surgery, radiotherapy, and chemotherapy, primarily target cancer cell eradication. However, uncontrolled proliferation and metabolic activities of these cells result in abnormalities in nutrient levels, hypoxia, and immunosuppression within the tumor microenvironment (TME). These factors constrain the efficacy of traditional treatments by promoting drug resistance, recurrence, and metastasis. Nanomaterials (NMs), such as nanozymes, can exhibit enzymatic activity similar to that of natural enzymes and offer a promising avenuefor the direct modification of the TME through catalytic oxidation-reduction processes. Moreover, they can serve as sensitizers or drug deliverycarriers, enhancing the efficacy of traditional treatment methods. Recently, NMs have garnered significant attention from oncologists. Thisreview begins with an overview of the composition and unique characteristics of the TME. Subsequently, we comprehensively exploredthe application of NMs in the treatment of HNSCC. Finally, we discuss the potential prospects and challenges associated with usingNMs in biomedical research.

关键词： Nanomaterials Tumor microenvironment Antitumor therapy Tumor diagnosis Head and neck squamous cell carcinoma

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纳米酶:结合天然酶和人工催化的力量

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中国科学院院刊 2024年第5期39卷 809-820页

作者：杜鹏高利增焦健范克龙阎锡蕴中国科学院科技战略咨询研究院北京100190 中国科学院生物物理研究所中国科学院纳米酶工程实验室北京100101 中原纳米酶实验室郑州451163 郑州大学基础医学院纳米酶医学研究中心郑州450001

纳米酶代表了一类新型人工酶和生物催化剂,打破了无机与有机生命的界限。它既有纳米材料的理化特性,也有独特的类酶催化活性。同时,这些理化特性有可能会调控催化活性,使得纳米酶跟天然酶、传统的模拟酶和化学催化剂区别开来。纳米酶有... 详细信息

纳米酶代表了一类新型人工酶和生物催化剂,打破了无机与有机生命的界限。它既有纳米材料的理化特性,也有独特的类酶催化活性。同时,这些理化特性有可能会调控催化活性,使得纳米酶跟天然酶、传统的模拟酶和化学催化剂区别开来。纳米酶有比较好的稳定性、耐高温、低温、耐酸碱、活性可调且多功能,目前受到了广泛关注,在生物医药、环境治理、绿色农业、新能源等领域展现出巨大的应用前景,并初步形成了相应的学科框架。为了更好地推动纳米酶的发展,拓展对纳米酶的认识,文章回顾了纳米酶发现,分析凝练了纳米酶的学科特点及其结构,综述了纳米酶的应用,并展望了未来的发展趋势。

关键词：纳米酶新材料天然酶催化人工酶交叉学科

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The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

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Nanozyme:A promising tool from clinical diagnosis and environmental monitoring to wastewater treatment

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Particuology 2022年第12期71卷 90-107页

作者： Chaoyi Hong Xiangqin Meng Jiuyang He kelong fan Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Future Technology University of Chinese Academy of SciencesBeijing 101408China Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450052China

Natural enzymes,owing to their outstanding catalytic efficiency and substrate specificity,have been used in a variety of applications including clinical diagnosis,environmental monitoring and wastewater ***,they face inevitable problems such as relatively high cost and lack of stability,dramatically hindering their practical applications in the ***,a class of nanomaterial that possesses intrinsic enzyme-like properties,nanozyme,has emerged exhibiting numerous advantages over its natural counterpart and has been used as a viable enzyme *** the past decade there are many reviews on *** previous discussions tend to view nanozyme as a type of nanomaterial rather than an ***,it is the enzyme-like activity of nanozymes that provides foundation for their application and nanozymes with the same enzymatic activity usually have some regularity in ***,in this review,we attempt to classify nanozymes by their enzyme-like activity to explain the application principle and relevant cases of nanozymes in clinical diagnosis,environmental monitoring and wastewater treatment,expecting to promote deeper thinking of nanozymes as enzyme mimics and provide useful guidance for future research.

关键词： Nanozyme Enzymatic activity Clinical diagnosis Environmental monitoring Wastewater treatment

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Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting

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Science China(Life Sciences) 2022年第2期65卷 328-340页

作者： Bing Jiang Xiaohua Jia Tianjiao Ji Meng Zhou Jiuyang He Kun Wang Jie Tian Xiyun Yan kelong fan Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Imaging of Chinese Academy of Sciences Institute of AutomationChinese Academy of SciencesBeijing 100190China CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100191China

Engineered nanocarriers have been widely developed for tumor ***,the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major ***,by using tailor-functionalized human H-ferritin(HFn),we developed a triple-modality nanoprobe IRdye800-M-HFn and achieved the early imaging of tumor cells before the formation of solid tumor ***,we developed an HFn-doxorubicin(Dox)drug delivery system by loading Dox into the HFn protein cage and achieved early-stage tumor *** intravenous injection of HFn nanoprobes enabled the imaging of tumor cells as early as two days after tumor implantation,and the triple-modality imaging techniques,namely,near-infrared fluorescence molecular imaging(NIR-FMI),magnetic resonance imaging(MRI),and photoacoustic imaging(PAI),ensured the accuracy of *** exploration indicated that HFn could specifically penetrate into pre-solid tumor sites by tumor-associated inflammation-mediated blood vessel leakage,followed by effective accumulation in tumor cells by the specific targeting property of HFn to transferrin receptor ***,the HFn-Dox drug delivery system delivered Dox into the tumor pre-formation site and effectively killed tumor cells at early ***800-M-HFn nanoprobes and HFn-Dox provide promising strategies for early-stage tumor diagnosis and constructive implications for early-stage tumor treatment.

关键词： ferritin nanocage early theranostics tumor-associated inflammation multimodality tumor imaging drug delivery

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Nanozymes: created by learning from nature

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Science China(Life Sciences) 2020年第8期63卷 1183-1200页

作者： Ruofei Zhang kelong fan Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Joint Laboratory of Nanozymes in Zhengzhou University Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Nanozymes,a type of nanomaterials with enzyme-like activity,have shown great potential to replace natural enzymes in many fields such as biochemical detection,environmental management and disease ***,the catalytic efficiency and substrate specificity of nanozymes still need *** further optimize the enzymatic properties of nanozymes,recent studies have introduced the structural characteristics of natural enzymes into the rational design of nanozymes,either by employing small molecules to mimic the cofactors of natural enzymes to boost nanozymes’catalytic potential,or by simulating the active center of natural enzymes to construct the nanostructure of *** review introduces the commonly used bio-inspired strategies to create nanozymes,aiming at clarifying the current progress and *** and challenges focusing on the research of bio-inspired nanozymes are outlined to provide ideas for the de novo design of ideal nanozymes.

关键词： bio-inspired nanozyme enzyme-like activity bio-mimic active center cofactors single-atom catalysis

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Nanozymes: an emerging field bridging nanotechnology and enzymology

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Science China(Life Sciences) 2019年第11期62卷 1543-1546页

作者： Xiangqin Meng kelong fan Xiyun Yan School of Future Technology University of Chinese Academy of SciencesBeijing 101408China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Joint Laboratory of Nanozymes in Zhengzhou University Academy of Medical SciencesZhengzhou University40 Daxue RoadZhengzhou 450052China

Nanozyme,a class of nanomaterials with intrinsic enzymelike properties,is a new concept which has been included in the Encyclopedia of China and the textbook of enzyme *** the first evidence published in 2007(Gao et al.,2007),great progress has been achieved in the study of nanozyme from new concept,new material to its new application,and it becomes an emerging field bridging nanotechnology and biology(Gao and Yan,2016).

关键词： bridging field intrinsic

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Corrigendum to“Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics”[***.6(2021)2676-2687/452]

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生物活性材料(英文) 2023年第5期23卷 524-525页

作者： Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang kelong fan Chaoming Xie Xiong Lu Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031SichuanChina National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhenGuangdong518055China College of Life Science and Biotechnology Mianyang Teachers’CollegeMianyang621006China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing100101China Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China

The authors regret 详细信息

The authors regret

关键词： Figure catalyzed correction

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Questions about horse the blood brain barrier receptor 1 spleen ferritin crossing via mouse transferrin

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Protein & Cell 2017年第11期8卷 788-790页

作者： kelong fan Meng Zhou Xiyun Yan Key Laboratory of Protein and Peptide Pharmaceuticals CAS-University of Tokyo Joint Laboratory of Structural Virology and Immunology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Ferritin, an iron storage protein naturally occurring in the body, has emerged as a promising nanocarrier thanks to its unique architecture, excellent biocompatibility, and ability to self-assemble/disassemble （fan et al., 2013）. More specifically, the finding that human H-ferritin intrinsically targets tumor cells via binding to its receptor transferrin receptor 1 （TfR1）（Li et al., 2010; fan et al., 2012; Liang et al., 2014; Zhao et al., 2016） inspired research into using ferritins for tumor target therapy.

关键词： Questions horse the blood brain barrier receptor 1 spleen ferritin crossing via mouse transferrin

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