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In Situ Mineralization of Biomass-Derived Hydrogels Boosts Capacitive Electrochemical Energy Storage in Free-Standing 3D Carbon Aerogels

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Energy & Environmental Materials 2024年第2期7卷 359-371页

作者： Anj.li Achazhiyath Edathil Babak Rezaei Kristoffer Almdal Stephan Sylνest keller National Centre for Nano Fabrication and Characterization DTU NanolabTechnical University of Denmark2800LyngbyDenmark DTU Chemistry Technical University of Denmark2800LyngbyDenmark

Here,a novel fabrication method for making free-standing 3D hierarchical porous carbon aerogels from molecularly engineered biomass-derived hydrogels is *** situ formed flower-like CaCO_(3)molecularly embedded within the hydrogel network regulated the pore structure during in situ mineralization assisted one-step activation graphitization(iMAG),while the intrinsic structural integrity of the carbon aerogels was *** homogenously distributed minerals simultaneously acted as a hard template,activating agent,and graphitization *** decomposition of the homogenously distributed CaCO_(3)during iMAG followed by the etching of residual CaO through a mild acid washing endowed a robust carbon aerogel with high porosity and excellent electrochemical *** 0.5 mA cm^(-2),the gravimetric capacitance increased from 0.01 F g^(-1)without mineralization to 322 F g^(-1)with iMAG,which exceeds values reported for any other free-standing or powder-based biomass-derived carbon *** outstanding cycling stability of~104%after 1000 cycles in 1 M HClO4 was *** assembled symmetric supercapacitor device delivered a high specific capacitance of 376 F g^(-1)and a high energy density of 26 W h kg^(-1)at a power density of 4000 W kg^(-1),with excellent cycling performance(98.5%retention after 2000 cycles).In combination with the proposed 3D printed mold-assisted solution casting(3DMASC),iMAG allows for the generation of free-standing carbon aerogel architectures with arbitrary ***,the novel method introduces flexibility in constructing free-standing carbon aerogels from any ionically cross-linkable biopolymer while maintaining the ability to tailor the design,dimensions,and pore size distribution for specific energy storage applications.

关键词： biomass carbon aerogel sustainable energy materials free-standing supercapacitors

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The emerging role of tranexamic acid and its principal target,plasminogen,in skeletal health

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2869-2884页

作者： Weixin Xie Antonia Donat Shan j.ang Anke Baranowsky j.hannes keller Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-EppendorfHamburg 20246Germany

The worldwide burden of skeletal diseases such as osteoporosis,degenerative j.int disease and impaired fracture healing is steadily *** acid(TXA),a plasminogen inhibitor and anti-fibrinolytic agent,is used to reduce bleeding with high effectiveness and safety in maj.r surgical *** its widespread clinical application,the effects of TXA beyond anti-fibrinolysis have been noticed and prompted renewed interest in its *** clinical trials have characterized the effects of TXA on reducing postoperative infection rates and regulating immune responses in patients undergoing ***,several animal studies suggest potential therapeutic effects of TXA on skeletal diseases such as osteoporosis and fracture *** a direct effect of TXA on the differentiation and function of bone cells in vitro was shown,few mechanisms of action have been ***,we summarize recent findings of the effects of TXA on skeletal diseases and discuss the underlying plasminogen-dependent and-independent mechanisms related to bone metabolism and the immune *** furthermore discuss potential novel indications for TXA application as a treatment strategy for skeletal diseases.

关键词： Tranexamic acid Osteoporosis Osteoarthritis Fracture healing Bone metabolism Inflammation Plasminogen Fibrinolysis

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Untangling the biotic stress in the late Maastrichtian Deccan-benchmark interval of Bidart(France)

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j.urnal of Palaeogeography 2024年第2期13卷 181-198页

作者： Subham Patra Gerta keller Eric Font Thierry Adatte j.hnavi Punekar Indian Institute of Technology Bombay PowaiMumbai 400076India Princeton University PrincetonNJ 08544USA Departamento de Ciencias da Terra Faculdade de Ciencias e TecnologiaUniversidade de Coimbra3000-272 CoimbraPortugal Institute of Earth Sciences University of Lausanne1015 LausanneSwitzerland

The late Maastrichtian witnessed substantial surges in Deccan volcanism,prompting the hypothesis that these voluminous pulses may have instigated repeated episodes of ocean acidification during this *** Cretaceous-Palaeogene(K/Pg)boundary at Bidart(France)is preceded by a~0.5 m thick interval with geochemical and taphonomic vestiges of an ocean acidification event linked with Deccan *** planktic foraminifera census and morphometric data now confirm biotic stress conditions related to acidification in the Deccan benchmark *** absolute abundance data of larger(>150μm)heavily calcified planktic morphogroups show fluctuating populations throughout zone CF1(spanning the final~225 ky),lowest peaks within the Deccan benchmark,and a demographic collapse(>90%)at the K/Pg *** analyzed species are generally reduced in size,with thinner test walls in this~0.5 m interval,indicating the likelihood of calcification stress as a contributor to the overall biotic *** the K/Pg boundary,maximum biotic stress is recorded in all the tested faunal proxies.A preliminary graphic correlation of zone CF1 at Bidart with the auxiliary GSSP at Elles(Tunisia)constrains the Deccan benchmark interval of high biotic stress to the final~58ky of the late Maastrichtian,culminating in the K/Pg mass *** volcanogenic Hg peaks coincident with faunal and taphonomic evidence of ocean acidification strengthen the Deccan-related ocean acidification hypothesis.

关键词： Deccan volcanism K/Pg mass extinction Biotic stress Calcification stress

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Managing type 2 diabetes:targeting a microbial enzyme as a novel treatment option

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Signal Transduction and Targeted Therapy 2024年第1期9卷 3-5页

作者： Anikó keller-Pintér Tamás Korcsmáros Tibor Vellai Department of Biochemistry Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzeged6720Hungary Department of Metabolism Digestion and ReproductionImperial College LondonLondonW120NNUK Quadram Institute Bioscience Norwich Research ParkNorwichNR47UQUK Department of Genetics Eötvös Loránd University(ELTE)Budapest1117Hungary Hungarian Research Network HUN-REN-ELTE Genetics Research Group Budapest1117Hungary

In a recent Science article,Wang and colleagues showed that the dipeptidyl peptidase 4(DPP4)enzyme produced by the gut microbiota can interfere with the effect of host glucagon-like peptide-1(GLP-1)involved in stimulating insulin secretion,and the specific inhibitor of microbial DPP4(mDPP4),combined with clinical inhibitors of host DPP4 isoenzymes,further promotes blood glucose homeostasis.1 These results point out why certain patients respond inadequately to an antidiabetic medication.

关键词： homeostasis stimulating clinical

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替加色罗:在初级治疗中对便秘型肠易激综合征患者的长期治疗

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 18-19页

作者： Layer P. keller j. Mueller-Lissner S. 李明 Department of Medicine Israelitic Hospital Hamburg University Orchideenstieg 14 DE-22297 Hamburg Germany Dr.

Background: Tegaserod, a prokinetic 5-HT4 receptor agonist, has demonstrated efficacy and tolerability in irritable bowel syndrome (IBS) patients with constipation (IBS- C) in controlled clinical trials. Its use in primary care has not been investigated. Aim: To determine whether tegaserod is effective and well tolerated by primary care IBS- C patients. Methods: Patients received tegaserod 6 mg b.i.d. for 12 weeks and were assessed for response, abdominal pain/discomfort, bloating, stool consistency/frequency and straining at weeks 4 and 12. Previous successful treatment with the withdrawn drug, cisapride, was noted. A 9- month study extension was offered to patients completing 12 weeks of tegaserod treatment. Results: 212 patients entered the 12- week treatment period; 166 completed as planned. Response rates were 64.2% at week 4 and 70.3% at week 12. After 12weeks, abdominal pain/discomfort and bloating were reduced from baseline (p< 0.0001; mean change - 1.02 and - 0.91 points, respectively), stool frequency increased (0.78- 0.97 stools/day) and stool consistency improved (2.45- 3.42; lumpy stools became softer). Tegaserod was well tolerated; the most common adverse events were headache (13.2% ) and diarrhea (9.4% ). One hundred and twenty patients entered the 9- month extension study, 85 completed and tegaserod continued to be well tolerated. Conclusions: In ambulatory primary care IBS- C patients, tegaserod is an effective and well- tolerated long- term treatment.

关键词：替加色罗西沙比利腹胀症状临床对照试验肛门下坠感受体激动剂周和改变值色胺其在

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Wheat zinc finger protein TaZF interacts with both the powdery mildew AvrPm2 protein and the corresponding wheat Pm2a immune receptor

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Plant Communications 2024年第5期5卷 25-41页

作者： Beatrice Manser Helen Zbinden Gerhard Herren j.el Steger j.natan Isaksson Stephanie Braunlich Thomas Wicker Beat keller Department of Plant and Microbial Biology University of ZurichZollikerstrasse 1078008 ZurichSwitzerland Agroscope Route de Duillier 501260 NyonSwitzerland BIOREBA AG Christoph Merian-Ring 74153 ReinachSwitzerland

Plant defense responses to pathogens are induced after direct or indirect perception of effector proteins or their activity on host *** fungal–plant interactions,relatively little is known about whether,in addi-tion to avirulence effectors and immune receptors,other proteins contribute to specific *** nucleotide-binding leucine-rich repeat(NLR)immune receptor Pm2a in wheat recognizes the fungal pow-dery mildew effector *** found that the predicted wheat zincfinger TaZF interacts with both the fungal avirulence protein AvrPm2 and the wheat NLR *** further demonstrated that the virulent AvrPm2-H2 variant does not interact with *** silencing in wheat resulted in a reduction but not a loss of Pm2a-mediated powdery mildew *** studies showed that the leucine-rich repeat domain of Pm2a is the mediator of the interaction with *** recruits both Pm2a and AvrPm2 from the cytosol to the nucleus,resulting in nuclear localization of Pm2a,TaZF,and AvrPm2 in *** propose that TaZF acts as a facilitator of Pm2a-dependent AvrPm2 effector *** highlight the importance of identifying effector host targets for characterization of NLR-mediated effector recognition.

关键词： plant immunity plant-fungal interactions pathogen effectors nucleotide-binding leucine-rich repeat immune receptor NLR wheat powdery mildew

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Extreme Antarctic Cold of Late Winter 2023

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Advances in Atmospheric Sciences 2024年第10期41卷 1873-1880页

作者： Anastasia j.TOMANEK David E.MIKOLAj.ZYK Matthew A.LAZZARA Stefano DI BATTISTA Minghu DING Mariana FONTOLAN LITELL David H.BROMWICH Taylor P.NORTON Linda M.keller Lee j.WELHOUSE Antarctic Meteorological Research and Data Center Space Science and Engineering CenterUniversity of Wisconsin-Madison Department of Physical Sciences School of Engineering Science and MathematicsMadison Area Technical College Meteogiornale State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Byrd Polar and Climate Research Center The Ohio State University Department of Geography The Ohio State University

Extreme cold temperatures were observed in j.ly and August 2023, coinciding with the WINFLY(winter fly-in)period of mid to late August into September 2023, meaning aircraft operations into Mc Murdo Station and Phoenix Airfield were adversely impacted. Specifically, with temperatures below-50℃, safe flight operation was not possible because of the risk of failing hydraulics and fuel turning to gel onboard the aircraft. The cold temperatures were measured across a broad area of the Antarctic, from East Antarctica toward the Ross Ice Shelf, and stretching across West Antarctica to the Antarctic Peninsula. A review of automatic weather station measurements and staffed station observations revealed a series of sites recording new record low temperatures. Four separate cold phases were identified, each a few days in duration and occurring from mid-j.ly to the end of August 2023. A brief analysis of 500-hPa geopotential height anomalies shows how the mid-tropospheric atmospheric environment evolves in relation to these extreme cold temperatures. The monthly 500-hPa geopotential height anomalies show strong negative anomalies in August. Examination of composite geopotential height anomalies during each of the four cold phases suggests various factors leading to cold temperatures, including both southerly off-content flow and calm atmospheric conditions. Understanding the atmospheric environment that leads to such extreme cold temperatures can improve prediction of such events and benefit Antarctic operations and the study of Antarctic meteorology and climatology.

关键词： Antarctica extreme cold temperature automatic weather station networks

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Microbial electricity-driven anaerobic phenol degradation in bioelectrochemical systems

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Environmental Science and Ecotechnology 2024年第1期17卷 40-47页

作者： Shixiang Dai Falk Harnisch Micj.l Chávez Morej.n Nina Sophie keller Benj.min Korth Carsten Vogt Department of Environmental Microbiology Helmholtz Centre for Environmental Research GmbH-UFZLeipzigGermany Department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research GmbH-UFZLeipzigGermany

Microbial electrochemical technologies have been extensively employed for phenol ***,previous research has yielded inconsistent results,leaving uncertainties regarding the feasibility of phenol degradation under strictly anaerobic conditions using anodes as sole terminal electron *** this study,we employed high-performance liquid chromatography and gas chromatography-mass spectrometry to investigate the anaerobic phenol degradation *** findings provide robust evidence for the purely anaerobic degradation of phenol,as we identified benzoic acid,4-hydroxybenzoic acid,glutaric acid,and other metabolites of this ***,no typical intermediates of the aerobic phenol degradation pathway were ***-chamber reactors(t0.4 V ***)exhibited a phenol removal rate of 3.5±0.2 mg L^(-1) d^(-1),while two-chamber reactors showed 3.6±0.1 and 2.6±0.9 mg L^(-1) d^(-1) at anode potentials of t0.4 and t 0.2 V,*** results also suggest that the reactor configuration certainly influenced the microbial community,presumably leading to different ratios of phenol consumers and microorganisms feeding on degradation products.

关键词： Microbial electroremediation Geobacter Extracellular electron transfer Anaerobic phenol degradation Microbial syntrophy

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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura j.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan j.ang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge j.lian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David j.Beech Frank Timo Beil Michael Amling j.hannes keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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活动策划中的包容性包容和无障碍的聚会

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中国会展 2024年第10期 42-47页

作者： Maura keller 不详

倾听与会者的需求可以为所有人营造最包容的氛围。活动策划的包容性是关键。策划者不仅要注意他们所选择的环境——选择一个让每个人都感到舒适的场地——而且他们还关注规划和执行过程中的包容性和可达性,确保与会者的体验反映出这些... 详细信息

倾听与会者的需求可以为所有人营造最包容的氛围。活动策划的包容性是关键。策划者不仅要注意他们所选择的环境——选择一个让每个人都感到舒适的场地——而且他们还关注规划和执行过程中的包容性和可达性,确保与会者的体验反映出这些倡议。

关键词：活动策划无障碍可达性策划者包容倾听氛围

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