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Efficacy of a Diabetes Specific Nutritional Supplement (DSNS) on Glycemic response in Prediabetic Adults: A Two-Armed, Open-Labelled randomized Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： Deepti Khanna kejal joshi r.ddy Hema S. Gopalan Jaladhi Bhatt Jayanti Gupta Simran Sethi Parth joshi Manoj Pareek Department of r&D Hindustan Unilever Limited Gurugram India Mumbai India Cliantha research Ahmedabad India

It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose response (ABGr) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGr of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose response Incremental Area under Curve Lifestyle Counselling

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Efficacy of a Diabetes Specific Nutrition Supplement on Glycemic, Anthropometric, Dietary and Gut Health Markers in Adults with Type 2 Diabetes: An rCT

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Food and Nutrition Sciences 2024年第8期15卷 846-867页

作者： Deepti Khanna Hema S. Gopalan Kuzhandaivelu Abirami Vasudevan Sudha rajagopal Gayatri kejal joshi-r.ddy Jaladhi Bhatt raman Ganesh Jeevan Karthikeyan Parkavi Vadivel Deepika Manoj Pareek ranjit Mohan Anjana Viswanathan Mohan r&D Department Hindustan Unilever Limited Gurugram India Department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India Department of Diabetology Dr. Mohans Diabetes Specialities Centre Chennai India

With increasing incidence of diabetes, use of diabetes specific nutrition supplements (DSNS) is common for better management of the disease. To study effect of 12-week DSNS supplementation on glycemic markers, anthropometry, lipid profile, SCFAs, and gut microbiome in individuals with diabetes. Markers studied were glycemic [Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excursions (MAGE), Time in/above range (TIr/TAr)], anthropometry [weight, Body Mass Index (BMI), waist circumference (WC)], lipid profile, diet and gut health [plasma short chain fatty acids (SCFAs)]. N = 210 adults were randomized to receive either DSNS with standard care (DSNS + SC;n = 105) or standard care alone (SC alone;n = 105). After 12 weeks, significant differences between DSNS + SC versus SC alone was observed in FBG [−3 ± 6 vs 14 ± 6 mg/dl;p = 0.03], PPG [−35 ± 9 vs −3 ± 9 mg/dl;p = 0.01], weight [−0.6 ± 0.1 vs 0.2 ± 0.1 kg;p = 0.0001], BMI [−0.3 ± 0.1 vs 0.1 ± 0.1 kg/m2;p = 0.0001] and WC [−0.3 ± 0.2 vs 0.2 ± 0.2 cm;p = 0.01]. HbA1C and low-density lipoprotein (LDL) were significantly reduced in DSNS + SC [−0.2 ± 0.9;p = 0.04 and −5 mg/dl;p = 0.03] respectively with no change in control. Continuous Glucose Monitoring (CGM) reported significant differences between DSNS + SC versus SC alone for mean glucose [−12 ± 65 vs 28 ± 93 mg/dl;p r 180 [−9 ± 42 vs 7 ± 45 mg/dl;p = 0.04], TAr 250 [−3 ± 27 vs 9 ± 38 mg/dl;p = 0.05], iAUC [−192 (1.1) vs −48 (1.1) mg/dl;p = 0.03]. MAGE was significantly reduced for both DSNS + SC (−19 ± 67;p reduction being more pronounced for DSNS + SC. DSNS + SC reported a decrease in carbohydrate energy % [−9.4 (−11.3, −7.6) %;p reased dietary fiber [9.5 (7.2, 11.8) g;p rotein energy % [0.9 (0.5, 1.3) %;p rsus SC alone. DSNS + SC reported signi

关键词： Diabetes Specific Nutrition Supplement Standard of Care Diabetes Glycemic Markers HbA1C

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Efficacy of a Diabetes Specific Nutritional Supplement (DSNS) on Glycemic response in Prediabetic Adults: A Two-Armed,Open-Labelled randomized Controlled Study

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Food and Nutrition Sciences（食品与营养科学） 2024年第7期 612页

作者： Deepti Khanna kejal joshi r.ddy Hema S.Gopalan Jaladhi Bhatt Jayanti Gupta Simran Sethi Parth joshi Manoj Pareek

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Hepatopulmonary syndrome: An update

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World Journal of Hepatology 2021年第11期13卷 1699-1706页

作者： kejal D Gandhi Pahnwat Tonya Taweesedt Munish Sharma Salim Surani Department of Internal Medicine Medstar Washington Hospital Center/Georgetown UniversityWashigtonDC 20010United States Department of Medicine Corpus Christi Medical CenterCorpus ChristiTX 78412United States Department of Medicine Texas A&M UniversityBryanTX 78413United States Department of Anesthesiology Mayo ClinicRochesterMN 55905United States

Hepatopulmonary syndrome(HPS)is characterized by defects in oxygenation caused by intra-pulmonary vasodilation occurring because of chronic liver disease,portal hypertension,or congenital portosystemic *** implications of portal hypertension are very well-known,however,awareness of its effect on multiple organs such as the lungs are less *** presence of HPS in chronic liver disease is associated with increased *** therapies available for HPS have not been proven effective and definitive treatment for HPS is mainly liver transplantation(LT).LT improves mortality for patients with HPS *** article provides a review on the definition,clinical presentation,diagnosis,and management of HPS.

关键词： Hepatopulmonary syndrome Chronic liver disease Hypoxemia Intrapulmonary vasodilatation Liver failure

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Toward imaging of alpha-synuclein with PET

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四川生理科学杂志 2023年第9期45卷 1457-1457页

作者： kejal Kantarci Department of radiology Division of Neuroradiology Mayo Clinic Rochester MN USA

Development of radiopharmaceuticals for in vivo positron emission tomography imaging of alpha-synuclein aggregates has the potential to revolutionize Lewy body disease diagnosis and *** in this issue of Cell,Xiang et ... 详细信息

关键词： positron treatment. diagnosis

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role of proning and positive end-expiratory pressure in COVID-19

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World Journal of Critical Care Medicine 2021年第5期10卷 183-193页

作者： kejal D Gandhi Munish Sharma Pahnwat Tonya Taweesedt Salim Surani Department of Medicine Georgetown University/Medstar Washington Hospital CenterWashigtonDC 20010United States Department of Medicine Corpus Christi Medical CenterCorpus ChristiTX 78412United States Department of Medicine Texas A&M UniversityCorpus ChristiTX 78404United States

The novel coronavirus,which was declared a pandemic by the World Health Organization in early 2020 has brought with itself major morbidity and *** has increased hospital occupancy,heralded economic turmoil,and the rapid transmission and community spread have added to the burden of the *** of the patients are admitted to the intensive care unit(ICU)for acute hypoxic respiratory failure often secondary to acute respiratory distress syndrome(ArDS).Based on the limited data available,there have been different opinions about the respiratory mechanics of the ArDS caused by coronavirus disease 2019(COVID-19).Our article provides an insight into COVID-19 pathophysiology and how it differs from typical *** on these differences,our article explains the different approach to ventilation in COVID-19 ArDS compared to typical *** critically analyze the role of positive end-expiratory pressure(PEEP)and proning in the ICU *** the limited data and clinical experience are available,we believe that early proning in COVID-19 patients improves oxygenation and optimal PEEP should be titrated based on individual lung compliance.

关键词： COVID-19 Acute respiratory distress syndrome Positive end-expiratory pressure Proning Ventilation management Acute respiratory distress syndrome Intensive care unit

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Degree of Approximation of Conjugate of Signals (Functions) by Lower Triangular Matrix Operator

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Applied Mathematics 2011年第12期2卷 1448-1452页

作者： Vishnu Narayan Mishra Huzoor H. Khan kejal Khatri Department of Mathematics S. V. National Institute of Technology Department of Mathematics Aligarh Muslim University

In the present paper, an attempt is made to obtain the degree of approximation of conjugate of functions (signals) belonging to the generalized weighted W(LP, ξ(t)), (p ≥ 1)-class, by using lower triangular matrix o... 详细信息

关键词： Conjugate Fourier Series Generalized Weighted W(LP ξ(t))-Class Degree of Approximation and Lower Triangular Matrix Means

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Trigonometric Approximation of Signals (Functions) Belonging to the Lip(ξ(t),r),(r>1)-Class by (E,q) (q>0)-Means of the Conjugate Series of Its Fourier Series

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Advances in Pure Mathematics 2013年第3期3卷 353-358页

作者： Vishnu Narayan Mishra Huzoor H. Khan Idrees A. Khan kejal Khatri Lakshmi N. Mishra Department of Applied Mathematics & Humanities Sardar Vallabhbhai National Institute of Technology Surat India Department of Mathematics Aligarh Muslim University Aligarh India Dr. ram Manohar Lohia Avadh University Faizabad India

Various investigators such as Khan ([1-4]), Khan and ram [5], Chandra [6,7], Leindler [8], Mishra et al. [9], Mishra [10], Mittal et al. [11], Mittal, rhoades and Mishra [12], Mittal and Mishra [13], rhoades et al. [14] have determined the degree of approximation of 2π-periodic signals (functions) belonging to various classes Lipα, Lip(α,r), Lip(ξ(t),r) and W(Lr,ζ(t)) of functions through trigonometric Fourier approximation (TFA) using different summability matrices with monotone rows. recently, Mittal et al. [15], Mishra and Mishra [16], Mishra [17] have obtained the degree of approximation of signals belonging to -class by general summability matrix, which generalizes the results of Leindler [8] and some of the results of Chandra [7] by dropping monotonicity on the elements of the matrix rows (that is, weakening the conditions on the filter, we improve the quality of digital filter). In this paper, a theorem concerning the degree of approximation of the conjugate of a signal (function) f belonging to Lip(ξ(t),r) class by (E,q) summability of conjugate series of its Fourier series has been established which in turn generalizes the results of Chandra [7] and Shukla [18].

关键词： Signals Conjugate Fourier Series Trigonometric Fourier Approximation Degree of Approximation Lip(ξ(t) r)-Class (E q) Summability

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脑膜瘤对AV-1451的摄取研究

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中华核医学与分子影像杂志 2018年第6期38卷 455-455页

作者：唐军 Tyler J.Bruinsma Derek r.Johnson Ping Fang Matthew Senjem Keith A.Josephs Jennifer L.Whitwell Bradley F.Boeve Mukesh K Pandey kejal Kantarci David T.Jones Prashanthi Vemuri Melissa Murray Jonathan Graff-radford Christopher G.Schwarz David S.Knopman ronald C.Petersen Clifford r.Jack Val J.Lowe 上海交通大学医学院附属苏州九龙医院核医学科 Department of radiology Mayo Clinic

目的 AV-1451是;F标记的正电子核素显像剂,;F-AV-1451可与成对螺旋丝状的tau蛋白（PHF-tau）结合,而tau蛋白与阿尔茨海默病的病理机制有关。对650例认知正常的对象进行AV-1451显像的过程中,偶然发现1例脑膜瘤患者的病灶可显著摄取AV-145... 详细信息

目的 AV-1451是;F标记的正电子核素显像剂,;F-AV-1451可与成对螺旋丝状的tau蛋白（PHF-tau）结合,而tau蛋白与阿尔茨海默病的病理机制有关。对650例认知正常的对象进行AV-1451显像的过程中,偶然发现1例脑膜瘤患者的病灶可显著摄取AV-1451。因此,对该650例研究对象进行回顾性分析,以总结其中的脑膜瘤患者病灶对AV-1451的摄取特点。方法经回顾性分析确诊,650例研究对象中有脑膜瘤患者12例,对其PET/CT显像和MrI图像重新读片,并对PET图像进行半定量分析。本底和肿瘤组织的标准摄取值（SUV）采用配对t检验进行统计分析,AV-1451的摄取与CT图像上钙化灶的出现的关系采用确切概率法进行分析。结果 12例脑膜瘤患者中,7例（58%）经视觉分析及计算肿瘤与正常皮质比值（T/N=1.90±0.83）均发现病灶对AV-1451的摄取高于本底。t检验提示本底和肿瘤组织的SUV差异无统计学意义,但在T/N大于1的患者中,其病灶对AV-1451的摄取增高差异有统计学意义（P=0.01）。AV-1451摄取增高与钙化灶的出现明显相关。结论使用AV-1451行PET显像时,应对PET和解剖影像学图像同时读片,以避免将脑膜瘤对AV-1451的摄取误读为PHF-tau蛋白的聚集。

关键词：脑膜瘤 AV-1451显像

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