Role of proning and positive end-expiratory pressure in COVID-19

作     者：Kejal D Gandhi Munish Sharma Pahnwat Tonya Taweesedt Salim Surani 

作者机构：Department of MedicineGeorgetown University/Medstar Washington Hospital CenterWashigtonDC 20010United States Department of MedicineCorpus Christi Medical CenterCorpus ChristiTX 78412United States Department of MedicineTexas A&M UniversityCorpus ChristiTX 78404United States 

出 版 物：《World Journal of Critical Care Medicine》 (世界重症医学杂志)

年 卷 期：2021年第10卷第5期

页      面：183-193页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：COVID-19 Acute respiratory distress syndrome Positive end-expiratory pressure Proning Ventilation management Acute respiratory distress syndrome Intensive care unit 

摘      要：The novel coronavirus,which was declared a pandemic by the World Health Organization in early 2020 has brought with itself major morbidity and *** has increased hospital occupancy,heralded economic turmoil,and the rapid transmission and community spread have added to the burden of the *** of the patients are admitted to the intensive care unit(ICU)for acute hypoxic respiratory failure often secondary to acute respiratory distress syndrome(ARDS).Based on the limited data available,there have been different opinions about the respiratory mechanics of the ARDS caused by coronavirus disease 2019(COVID-19).Our article provides an insight into COVID-19 pathophysiology and how it differs from typical *** on these differences,our article explains the different approach to ventilation in COVID-19 ARDS compared to typical *** critically analyze the role of positive end-expiratory pressure(PEEP)and proning in the ICU *** the limited data and clinical experience are available,we believe that early proning in COVID-19 patients improves oxygenation and optimal PEEP should be titrated based on individual lung compliance.