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Distributed representations of atoms and materials for machine learning

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npj Computational materials 2022年第1期8卷 415-423页

作者： Luis m.Antunes Ricardo Grau-Crespo keith T.Butler Department of Chemistry University of ReadingWhiteknightsReadingRG66DXUK ScimL Scientific Computing DepartmentRutherford Appleton LaboratoryHarwellOX110QXUK

The use of machine learning is becoming increasingly common in computational materials *** build effective models of the chemistry of materials,useful machine-based representations of atoms and their compounds are *** derive distributed representations of compounds from their chemical formulas only,via pooling operations of distributed representations of *** compound representations are evaluated on ten different tasks,such as the prediction of formation energy and band gap,and are found to be competitive with existing benchmarks that make use of structure,and even superior in cases where only composition is ***,we introduce an approach for learning distributed representations of atoms,named SkipAtom,which makes use of the growing information in materials structure databases.

关键词： representations operations competitive

Hereditary diffuse gastric cancer: One family's story

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World Journal of Clinical Cases 2018年第1期6卷 1-5页

作者： Haley m Zylberberg keith Sultan Steven Rubin Donald and Barbara Zucker School of medicine at Hofstra/Northwell Division of Gastroenterology Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Hereditary diffuse gastric cancer(HDGC) is an inherited form of gastric cancer that carries a poor prognosis. most HDGCs are caused by an autosomal dominant genetic mutation in the CDH1 gene, which carries a 70%-80% lifetime risk of gastric cancer. Given its submucosal origin, endoscopic surveillance is an unreliable means of early detection, and prophylactic gastrectomy is recommended for CDH1 positive individuals older than age 20 years. We describe the case of a male with recurrent gastric cancer who was diagnosed with HDGC secondary to the CDH1 mutation, and we also describe the patient's pedigree and outcomes of recommended genetic testing.

关键词： Hereditary diffuse gastric cancer Genetic testing Genetic diseases Gastric cancer Lobular breast cancer Inheritable diseases

Cancer risk in primary sclerosing cholangitis: Epidemiology,prevention, and surveillance strategies

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World Journal of Gastroenterology 2019年第6期25卷 659-671页

作者： Brian m Fung keith D Lindor James H Tabibian UCLA-Olive View Internal medicine Residency Program Olive View-UCLA Medical Center Office of the University Provost Arizona State University Division of Gastroenterology Department of MedicineOlive View-UCLA Medical Center

Primary sclerosing cholangitis(PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra-and/or extrahepatic biliary ducts. While its features and disease course can be variable,most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly,PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma,hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Therefore, robust surveillance strategies are needed, though uncertainty remains regarding how to best do so. In this review, we discuss the epidemiology, prevention, and surveillance of cancers in patients with PSC. Where evidence is limited, we present pragmatic approaches based on currently available data and expert opinion.

关键词： Bile duct diseases Cholangiocarcinoma Gallbladder carcinoma Hepatocellular carcinoma Colorectal cancer Chemoprotection Inflammatory bowel disease

Factors controlling nutrient availability to the developing fetus in ruminants

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Journal of Animal Science and Biotechnology 2015年第2期6卷 205-214页

作者： Kathrin A Dunlap Jacob D Brown Ashley B keith m Carey Satterfield Department of Animal Science Texas A&M University2471 TAMU College Station

Inadequate delivery of nutrients results in intrauterine growth restriction （IUGR）, which is a leading cause of neonatal morbidity and mortality in livestock. In ruminants, inadequate nutrition during pregnancy is often prevalent due to frequent utilization of exensive forage based grazing systems, making them highly susceptible to changes in nutrient quality and availability. Delivery of nutrients to the fetus is dependent on a number of critical factors including placental growth and development, utero-placental blood flow, nutrient availability, and placenta metabolism and transport capacity. Previous findings from our laboratory and others, highlight essential roles for amino acids and their metabolites in supporting normal fetal growth and development, as well as the critical role for amino acid transporters in nutrient delivery to the fetus. The focus of this review will be on the role of materna nutrition on placental form and function as a regulator of fetal development in ruminants.

关键词： Intrauterine growth restriction Nutrient transport Placenta Ruminant

Reduced homotopic interhemispheric connectivity in psychiatric disorders:evidence for both transdiagnostic and disorder specific features

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Psychoradiology 2022年第4期2卷 129-145页

作者： Shuxia Yao keith m.Kendrick The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 611731China

There is considerable interest in the significance of structural and functional connections between the two brain hemispheres in terms of both normal function and in relation to psychiatric *** recent years,many studies have used voxel mirrored homotopic connectivity analysis of resting state data to investigate the importance of connectivity between homotopic regions in the brain hemispheres in a range of neuropsychiatric *** current review summarizes findings fromthese voxel mirrored homotopic connectivity studies in individuals with autism spectrum disorder,addiction,attention deficit hyperactivity disorder,anxiety and depression disorders,and schizophrenia,aswell as disorders such as Alzheimer’s disease,mild cognitive impairment,epilepsy,and ***,other than attention deficit hyperactivity disorder,studies across psychiatric disorders report decreased homotopic resting state functional connectivity in the default mode,attention,salience,sensorimotor,social cognition,visual recognition,primary visual processing,and reward networks,which are often associated with symptom severity and/or illness onset/*** homotopic resting state functional connectivity may therefore represent a transdiagnostic marker for general *** terms of disorder specificity,the extensive decreases in homotopic resting state functional connectivity in autism differ markedly from attention deficit hyperactivity disorder,despite both occurring during early childhood and showing extensive co-morbidity.A pattern of more posterior than anterior regions showing reductions in schizophrenia is also *** forward,more studies are needed to elucidate the functions of these homotopic functional connections in both health and disorder and focusing on associations with general psychopathology,and not only on disorder specific symptoms.

关键词： interhemispheric communication resting state fmRI voxel mirrored homotopic connectivity psychiatric disorders transdiagnostic marker disorder specific marker

Esophageal lichen planus:A case report and review of the literature

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World Journal of Gastroenterology 2013年第14期19卷 2278-2281页

作者： Jennifer A Nielsen Robert m Law keith H Fiman Cory A Roberts Division of Research ProPathDallasTX 75247United States Division of Dermatopathology ProPathDallas TX 75247United States Gastroenterology Consultants Southwest LLP Sugar LandTX 77478United States Division of Gastrointestinal Pathology ProPathDallasTX 75247United States

Esophageal involvement by lichen planus(ELP),previously thought to be quite rare,is a disease much more common in women and frequently the initial manifestation of mucocutaneous lichen planus(LP).Considering that the symptoms of ELP do not present in a predictable manner,ELP is perhaps more under-recognized than *** date,four cases of squamous cell carcinoma in association with ELP have been reported,suggesting that timely and accurate diagnosis of ELP is of importance for appropriate *** this case report,a 69-year-old female presented with dysphagia and *** reported a history of oral LP but had no active oral or skin *** examination revealed severe strictures and web-like areas in the *** examination demonstratedextensive denudation of the squamous epithelium,scattered intraepithelial lymphocytes,rare eosinophils and dyskeratotic *** immunofluorescence showed rare cytoid bodies and was used to exclude other primary immunobullous *** using clinical,endoscopic,and histologic data,a broad list of differential diagnoses can be narrowed,and the accurate diagnosis of ELP can be made,which is essential for proper treatment and subsequent follow-up.

关键词： Esophageal lichen planus Esophagus Immunofluorescence Immunobullous disorders Diagnostic accuracy

Writing and updating technology plans : a guidebook with sample policies on CD-ROm / John m. Cohn, Ann L. Kelsey, and keith michael Fiels.

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Pancreaticopleuralfistula:etiology,treatmentandlong-termfollow-up

1999年

作者： John m. Cohn Ann L. Kelsey and keith michael Fiels.

来源：畅想之星图书光盘版（南... 评论

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 215-219页

作者： keith J Roberts maria Sheridan Gareth morris-Stiff Andrew m Smith Department of Pancreatic Surgery St James University HospitalLeedsUK

BACKGROUND:Pancreaticopleural fistula(PPF) are *** multidisciplinary treatment is required due to nutritional compromise and *** is the first description of long-term follow-up of patients with ***:Eleven patients with PPF treated at a specialist unit were ***,investigation,treatment and outcomes were ***:Pancreatitis was the etiology of the PPF in 9 patients,and in the remaining 2 the PPF developed following distal ***-sectional imaging demonstrated the site of duct disruption in 10 cases,with endoscopic retrograde cholangiopancreatography identifying the final *** of pancreatic exocrine secretion and percutaneous drainage formed the mainstay of *** cases resolved following pancreatic duct stent insertion and three patients required surgical treatment for established *** were no *** all cases that resolved there has been no recurrence of PPF over a median follow-up of 50 months(range 15-62).CONCLUSIONS:PPF is an uncommon event complicating pancreatitis or pancreatectomy;pancreatic duct disruption is the common link.A step-up approach consisting of minimally invasive techniques treats the majority with surgery needed for refractory sepsis.

关键词： pancreatic disease pancreatitis pancreatic pseudocyst

IDeATe @ Hunt Library

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图书馆建设 2017年第2期 40-41页

作者： keith Webster 美国卡内基梅隆大学图书馆

Good evening!Thank you for your invitation!Today I will mainly talk about my perspectives on maker spaces especially on academic *** change is that the real thing is not simply about creating opportunities for students but for librarians to build academic *** the program language I'm talking about is IDeA Te.I will also talk about a few words

关键词：英语阅读理解图书馆