Reduced homotopic interhemispheric connectivity in psychiatric disorders:evidence for both transdiagnostic and disorder specific features
作者机构：The Clinical Hospital of Chengdu Brain Science InstituteMOE Key Laboratory for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 611731China
出 版 物：《Psychoradiology》 (精神影像学（英文）)
年 卷 期：2022年第2卷第4期
页 面：129-145页
基 金：This study was supported by the Key Technological Projects of Guangdong Province(grant number 2018B030335001) UESTC High-end Expert Project Development(grant number Y0301902610100201)
主 题：interhemispheric communication resting state fMRI voxel mirrored homotopic connectivity psychiatric disorders transdiagnostic marker disorder specific marker
摘 要：There is considerable interest in the significance of structural and functional connections between the two brain hemispheres in terms of both normal function and in relation to psychiatric *** recent years,many studies have used voxel mirrored homotopic connectivity analysis of resting state data to investigate the importance of connectivity between homotopic regions in the brain hemispheres in a range of neuropsychiatric *** current review summarizes findings fromthese voxel mirrored homotopic connectivity studies in individuals with autism spectrum disorder,addiction,attention deficit hyperactivity disorder,anxiety and depression disorders,and schizophrenia,aswell as disorders such as Alzheimer’s disease,mild cognitive impairment,epilepsy,and ***,other than attention deficit hyperactivity disorder,studies across psychiatric disorders report decreased homotopic resting state functional connectivity in the default mode,attention,salience,sensorimotor,social cognition,visual recognition,primary visual processing,and reward networks,which are often associated with symptom severity and/or illness onset/*** homotopic resting state functional connectivity may therefore represent a transdiagnostic marker for general *** terms of disorder specificity,the extensive decreases in homotopic resting state functional connectivity in autism differ markedly from attention deficit hyperactivity disorder,despite both occurring during early childhood and showing extensive co-morbidity.A pattern of more posterior than anterior regions showing reductions in schizophrenia is also *** forward,more studies are needed to elucidate the functions of these homotopic functional connections in both health and disorder and focusing on associations with general psychopathology,and not only on disorder specific symptoms.
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