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Reduced homotopic interhemispheric connectivity in psychiatric disorders:evidence for both transdiagnostic and disorder specific features

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Psychoradiology 2022年第4期2卷 129-145页

作者： Shuxia Yao keith m.kendrick The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 611731China

There is considerable interest in the significance of structural and functional connections between the two brain hemispheres in terms of both normal function and in relation to psychiatric *** recent years,many studies have used voxel mirrored homotopic connectivity analysis of resting state data to investigate the importance of connectivity between homotopic regions in the brain hemispheres in a range of neuropsychiatric *** current review summarizes findings fromthese voxel mirrored homotopic connectivity studies in individuals with autism spectrum disorder,addiction,attention deficit hyperactivity disorder,anxiety and depression disorders,and schizophrenia,aswell as disorders such as Alzheimer’s disease,mild cognitive impairment,epilepsy,and ***,other than attention deficit hyperactivity disorder,studies across psychiatric disorders report decreased homotopic resting state functional connectivity in the default mode,attention,salience,sensorimotor,social cognition,visual recognition,primary visual processing,and reward networks,which are often associated with symptom severity and/or illness onset/*** homotopic resting state functional connectivity may therefore represent a transdiagnostic marker for general *** terms of disorder specificity,the extensive decreases in homotopic resting state functional connectivity in autism differ markedly from attention deficit hyperactivity disorder,despite both occurring during early childhood and showing extensive co-morbidity.A pattern of more posterior than anterior regions showing reductions in schizophrenia is also *** forward,more studies are needed to elucidate the functions of these homotopic functional connections in both health and disorder and focusing on associations with general psychopathology,and not only on disorder specific symptoms.

关键词： interhemispheric communication resting state fmRI voxel mirrored homotopic connectivity psychiatric disorders transdiagnostic marker disorder specific marker

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A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments

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Psychoradiology 2021年第1期1卷 3-12页

作者： keith m.kendrick Joerg Daumann Daniel Wagner Philip Koester marc Tittgemeyer Qiang Luo Euphrosyne Gouzoulis-mayfrank Benjamin Becker The Clinical Hospital of Chengdu Brain Science Institute Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduChina Department of Psychiatry and Psychotherapy University of CologneGermany max-Planck Institute for Neurological Research CologneGermany Institute of Science and Technology for Brain-Inspired Intelligence Ministry of Education Key Laboratory of Computational Neuroscience and Brain-Inspired IntelligenceFudan UniversityShanghaiPR China LVR Clinics of Cologne CologneGermany

Background:Amphetamine-type stimulants(ATS)have become a critical public health *** models have indicated a clear neurotoxic potential of *** humans,chronic use has been associated with cogni-tive deficits and structural brain ***,cross-sectional retrospective designs in chronic users cannot truly determine the causal direction of the ***:To prospectively determine effects of occasional ATS use on cognitive functioning and brain ***:In a prospective longitudinal study design,cognitive functioning and brain structure were assessed at baseline and at 12-month follow-up in occasional ATS users(cumulative lifetime usemination of change scores between the initial examination and follow-up revealed declined verbal memory performance and putamen volume in users with high relative to low interim ATS *** the entire sample,interim ATS use,memory decline,and putamen volume reductions were strongly ***:The present findings support the hypothesis that ATS use is associated with deficient dorsal stri-atal morphology that might reflect alterations in dopaminergic *** importantly,these findings strongly suggest that even occasional,low-dose ATS use disrupts striatal integrity and cognitive functioning.

关键词： amphetamines brain volume dorsal striatum mDmA prospective stimulants

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Psychoradiology: a new era for neuropsychiatric imaging

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Psychoradiology 2021年第1期1卷 1-2页

作者： Qiyong Gong keith m.kendrick Lin Lu Huaxi mR Research Center(HmRRC) Department of RadiologyWest China Hospital of Sichuan University ChengduSichuan ProvinceChina Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengduSichuan ProvinceChina Neurotherapy and Social Cognitive and Affective Neuroscience CenterUniversity of Electronic Science and TechnologyChengduSichuan ProvinceChina Institute of mental Health/Peking University Sixth Hospital Peking UniversityChina

We are very pleased to introduce the first issue of Psychoradiology,an open-access journal that publishes original research articles,reviews,case reports,editorials,commentaries,correspondence,and *** journal will publish high-quality and interdisciplinary manuscripts that span the genetic and molecular basis of psychiatric disorders to social and cultural factors that influence the onset,progress,and behavioral symptoms of these illnesses.

关键词： journal correspondence radiology

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催产素对学习和记忆的调节效应:来自动物与人类的研究证据

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心理科学进展 2021年第12期29卷 2195-2208页

作者：周梦晗张源高山 keith m.kendrick 姚树霞电子科技大学生命科学与技术学院/神经信息教育部重点实验室成都611731

作为一种神经肽,催产素对于个体社会认知和情绪加工有着非常重要的调节作用,其中就包括对在人们工作和生活中扮演着关键角色的学习和记忆活动的影响。采用不同模态技术的动物和人类研究一致表明了外源性催产素对于学习和记忆具有重要的... 详细信息

作为一种神经肽,催产素对于个体社会认知和情绪加工有着非常重要的调节作用,其中就包括对在人们工作和生活中扮演着关键角色的学习和记忆活动的影响。采用不同模态技术的动物和人类研究一致表明了外源性催产素对于学习和记忆具有重要的调节作用,这一作用可能是外源性催产素通过与多巴胺奖赏通路、边缘系统等学习和记忆关键脑网络中广泛分布的催产素受体相结合,进而调整其功能状态实现的;但与此同时,催产素对学习和记忆的促进或抑制作用会因实验范式、刺激材料、给药时间、位置和剂量等因素的不同而存在差异。未来需要协同动物和人类研究的各自优势,采用规范化的实验任务设置和给药程序克服当前该领域的研究局限,并积极发掘催产素在干预相关精神疾病患者学习和记忆加工缺陷中的应用潜力。

关键词：催产素学习记忆神经机制

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The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit

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Psychoradiology 2023年第1期3卷 242-253页

作者： Qian Zhuang Lei Qiao Lei Xu Shuxia Yao Shuaiyu Chen Xiaoxiao Zheng Jialin Li meina Fu Keshuang Li Deniz Vatansever Stefania Ferraro keith m.kendrick Benjamin Becker The Center of Psychosomatia medicine Sichuan Provincial Center for Mental HealthSichuan Provincial People's HospitalThe University of Eectronic Science and Technology of ChinaChengduSichuan Province 611731China Center for Cognition and Brain Disorders The Affliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang Province 11121 China School of Psychology Shenzhen UniversityShenzhen 518060China Institute of Brain and Psychological Sciences Sichuan Normal UniversityChengdu610068China Brain Cognition and Brain Disease Institute(BCBDI) Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Psychology and Cognitive Science East China Normal UniversityShanghai 200062China Institute of Science and Technology for Brain-Inspired Itelligence Fudan UniversityShanghai 200433China State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong 99077 China Department of Psychology The University of Hong Kong Hong Kong 990777 China

Background:The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal ***,the pivotal nodes and directed causal regulation within this inhibitory circuit in humans remains ***:The main aim of the present study was to determine the causal information flow and critical nodes in the basal ganglia-thalamocortical inhibitory circuits and also to examine whether these are modulated by biological factors(***)and behavioral ***:Here,we capitalize on the recent progress in robust and biologically plausible directed causal modeling(DCm-PEB)and a large response inhibition dataset(n=250)acquired with concomitant functional magnetic resonance imaging to determine key nodes,their causal regulation and modulation via biological variables(sex)and inhibitory performance in the inhibitory circuit encompassing the right inferior frontal gyrus(rIFG),caudate nucleus(rCau),globus pallidum(rGP),and thalamus(rThal).Results:The entire neural circuit exhibited high intrinsic connectivity and response inhibition critically increased causal projections from the rIFG to both rCau and *** comparison further demonstrated that response inhibition induced an increasing rIFG inflow and increased the causal regulation of this region over the rCau and *** addition,sex and performance influenced the functional architecture of the regulatory circuits such that women displayed increased rThal self-inhibition and decreased rThal to GP modulation,while better inhibitory performance was associated with stronger rThal to rIFG ***,control analyses did not reveal a similar key communication in a left lateralized ***:Together,these findings indicate a pivotal role of the rIFG as input and causal regulator of subcortical response inhibition nodes.

关键词： response inhibition basal ganglia inferior frontal gyrus effective connectivity DCm

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A brain structural connectivity biomarker for autism spectrum disorder diagnosis in early childhood

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Psychoradiology 2023年第1期3卷 171-181页

作者： Xi Jiang Xiao-Jing Shou Zhongbo Zhao Yuzhong Chen Fan-Chao meng Jiao Le Tian-Jia Song Xin-Jie Xu Weitong Guo Xiaoyan Ke Xiao-E Cai Weihua Zhao Juan Kou Ran Huo Ying Liu Hui-Shu Yuan Yan Xing Ji-Sheng Han Song-Ping Han Yun Li Hua Lai Lan Zhang mei-Xiang Jia Jing Liu Xuan Liu keith m.kendrick Rong Zhang The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroinformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731China Neuroscience Research Institute Key Laboratory for NeuroscienceMinistry of Education of ChinaKey Laboratory for NeuroscienceNational Committee of Health and Family Planning of ChinaDepartment of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Cognitive Neuroscience and Leamning Beijing Key Laboratory of Brain Imaging and Connectomicsand IDG/McGovermn Institute for Brain ResearchBeijing Normal UniversityBeijng 100875China Chengdu Women's and Children's Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Child mental Health Research Center Nanjing Brain Hospital Affliated of Nanjing Medical UniversityNanjing 210029China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Wuxi Shenpingxintai medical Technology Co LtdWuxi 214091China mental Health Institute Peking UniversityKey Laboratory of Ministry of HealthThe Ministry of Public HealthBeijing 100191China Shandong Ke Luo Ni Ke(CLINIC)medical Technology Co LtdDezhou 253011China Autism Research Center of Peking University Health Science Center Beiing 100191China Department of Integration of Chinese and Western medicine School of Basic Medical SciencesPeking University100191BeijingChina

Background:Autism spectrum disorder(ASD)is associated with altered brain development,but it is unclear which specific structural changes may serve as potential diagnostic markers,particularly in young children at the age when symptoms become fully ***,such brain markers need to meet the requirements of precision medicine and be accurate in aiding diagnosis at an individual rather than only a group ***:This study aimed to identify and model brain-wide differences in structural connectivity using diffusion tensor imaging(DTI)in young ASD and typically developing(TD)***:A discovery cohort including 93 ASD and 26 TD children and two independent validation cohorts including 12 ASD and 9 TD children from three different cities in China were ***-wide(294 regions)structural connectivity was measured using DTI(fractional anisotropy,FA)together with symptom severity and cognitive development.A connection matrix was constructed for each child for comparisons between ASD and TD *** classification was performed on the discovery dataset and the resulting model was tested on the two independent validation ***:Thirty-three structural connections showed increased FA in ASD compared to TD children and associated with both autistic symptom severity and impaired general cognitive *** majority(29/33)involved the frontal lobe and comprised five different networks with functional relevance to default mode,motor control,social recognition,language and ***,clas-sification achieved very high accuracy of 96.77%in the discovery dataset,and 91.67%and 88.89%in the two independent validation ***:Identified structural connectivity differences primarily involving the frontal cortex can very accurately distinguish novel individual ASD from TD children and may therefore represent a robust early brain biomarker which can address the requirements of precision medicine.

关键词： autism spectrum disorder diffusion tensor imaging fractional anisotropy brain structural connectivity individual diag-nosis early childhood

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A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network

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Chinese Science Bulletin 2014年第13期59卷 1355-1361页

作者： Haixia Long Bing Liu Bing Hou Chao Wang keith m. kendrick Chunshui Yu Tianzi Jiang Brainnetome Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Key Laboratory for NeuroInformation of ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Department of Radiology Tianjin Medical University General Hospital Queensland Brain Institute University of Queensland Brisbane QLD 4072 Australia

The serotonin-transporter-linked polymorphic region(5-HTTLPR)is associated with mood *** association is thought to be due to amygdala hyperresponsiveness to negative emotional stimuli as a result of reduced frontal cortical *** Caucasians,the short form is associated with this effect,but in Han Chinese we recently found that the long form is *** receptors have rich expression in default mode network(DmN)regions and the recent studies have found an association between the short form of the 5-HTTLPR and DmN functional connectivity(FC)in *** present study has investigated whether there may also be anethnic difference in this influence of 5-HTTLPR on the *** recruited 233 young Han Chinese subjects and calculated the resting-state default-network *** study found that the L carriers had decreased FC in the bilateral medial prefrontal cortex,right parahippocampal gyrus,left middle temporal gyrus,and increased FC in left precuneus(Pcu)compared to *** PCC-Pcu FC in L carriers was significantly negatively correlated with the depression *** findings,therefore,suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different forms of the5-HTTLPR and DmN functional connectivity.

关键词：网络表多态性关联种族差异大脑中国汉族消极情绪前额叶皮质

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How does oxytocin help to focus attention on social cues?

How does oxytocin help to focus attention on social cues?

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中国神经科学学会第十二届全国学术会议

作者： keith m.kendrick

One of the most consistent findings on the functional effects of the hypothalamic neuropeptide oxytocin is that it can increase attention to salient social cues. Not only is this important for directing attention towards key social cues such as the eyes, but it also contributes fundamentally to enhanced recognition of individuals and the emotions they express. In humans, intranasal oxytocin treatment can increase both covert and overt attention to positive valence cues and in some cases reduce it towards negative valence ones. Oxytocin can also shift attention away from the self and towards others, in line with its role in promoting the formation of social bonds. These effects of oxytocin in focusing attention on salient social cues are clearly of great potential relevance to its proposed therapeutic use in autism spectrum disorder. Indeed, neuroimaging studies have demonstrated that oxytocin particularly modulates neural responses in the brain salience network including the frontal and insula cortices and the amygdala regions, which are dysfunctional in autism. The insula cortex plays an important role in the processing of both interoceptive and external cues, and switching attention between them. This switching between internal and external cues is impaired in autism and some other affective disorders. We have recently investigated whether oxytocin influences the processing of interoceptive cues（heartbeat detection） and attention switching between them and external social cues（face stimuli）. Our findings revealed that while oxytocin had no effect on interoceptive accuracy or insula activity in the absence of external social cues, when the latter were present interoceptive accuracy decreased, and anterior insula activity and its functional connectivity with the posterior insula was increased. This suggests that a key therapeutic role of oxytocin may be to help switch attention away from interoceptive/self-based cues towards external social/other-based cues via modu

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EmDS 3.0:A modeling framework for coping with complexity in environmental assessment and planning

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Science China(Technological Sciences) 2006年第z1期49卷 63-75页

作者： keith m.Reynolds U.S.Dept.Agriculture Forest ServicePacific Northwest Research Station3200 SW Jefferson WayCorvallisOR 97331USA

The Ecosystem management Decision Support (EmDS) system is an application framework for knowledge-based decision support of ecological assessments at any geographic scale. The system integrates state-of-the-art geographic information system (GIS) as well as knowledge-based reasoning and decision modeling technologies to provide decision support for a substantial portion of the adaptive management process of ecosystem management. EmDS 3.0 is implemented as an Arcmap extension and integrates the logic engine of NetWeaver to perform landscape evaluations, and the decision modeling engine of Criterium DecisionPlus for evaluating management priorities. Key features of the system's evaluation component include abilities to (1) reason about large, abstract, multi-faceted ecosystem management problems, (2) perform useful evaluations with incomplete information, (3) evaluate the influence of missing information, and (4) determine priorities for missing information. A key feature of the planning component is the ability to determine priorities for management activities, taking into account not only ecosystem condition, but also criteria that account for the feasibility and efficacy of potential management actions. Both components include powerful and intuitive diagnostic features that facilitate communicating the explanation of modeling results to a broad audience.

关键词： natural resources, modeling, assessment, analysis, planning, software, ecosystem management.

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CI-WGAN:融合临床指标和WGAN的孤独症个体化脑功能连接网络生成

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数据采集与处理 2024年第4期39卷 813-826页

作者：孙海林严加栋张嵘 kendrick keith 蒋希电子科技大学生命科学与技术学院成都611731 麦吉尔大学蒙特利尔神经研究所蒙特利尔H3A 2B4 北京大学基础医学院神经生物学系北京100191 北京大学神经科学研究所北京100191 神经科学教育部重点实验室北京100191 卫健委神经科学重点实验室北京100191 北京大学医学部孤独症研究中心北京100191

脑功能连接(Functional connectivity,FC)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的FC生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾... 详细信息

脑功能连接(Functional connectivity,FC)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的FC生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾病的特异性信息。而且,ASD作为一种谱系障碍,其临床指标存在显著的个体化差异。因此,仅基于脑影像数据的传统生成模型在生成准确的且能反映个体化临床指标的ASD个体FC的任务上存在挑战。针对上述挑战,提出了个体化临床指标引导的沃瑟斯坦生成对抗网络模型(Clinical-indicator-aware Wasserstein generative adversarial network,CI-WGAN),用于生成孤独症个体化FC网络。该模型引入个体化临床指标引导机制,实现了高精度ASD患者FC网络的生成。基于全世界最大孤独症脑影像公开数据集之一的ABIDE I数据集进行实验,CI-WGAN生成FC与真实FC的峰值信噪比(Peak signal-to-noise ratio,PSNR)、结构相似度(Structural similarity,SSIm)与平均绝对误差(mean absolute error,mAE)分别达到19.037、0.236与0.178,相较于其他FC生成模型分别提升了3%、12%与2%。此外基于生成FC和独立临床验证指标的表征相似度分析(Representational similarity analysis,RSA),CI-WGAN生成的FC相较其他模型生成FC最少提高了0.1倍和3.7倍,证明了CI-WGAN生成的FC包含更多的ASD个体特异性信息。本文提出的CI-WGAN模型实现了高质量个体化FC的生成,为ASD的早期诊断和个性化治疗提供了有力的技术支持。

关键词：孤独症谱系障碍大脑功能连接生成对抗网络临床指标引导机制梯度惩罚机制

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