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Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

World Journal of Gastrointestinal Oncology 2017年第1期9卷 21-29页

作者： keitaro hayashi Naohiko Anzai Department of Pharmacology and Toxicology Dokkyo Medical University School of Medicine Department of Pharmacology Chiba University Graduate School of Medicine

L-type amino acid transporters(LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs(LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1(SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review.

关键词： LAT1 氨基酸 transporter 分子的目标药氨基酸饥饿反应信号 transduction

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CJ Detonation Structure-3D Rectangular Tube Case-

CJ Detonation Structure-3D Rectangular Tube Case-

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第四届亚洲CFD会议

作者： A.Koichi hayashi keitaro ETO Nobuyuki TSUBOI Department of Mechanical Engineering Aoyama Gakuin University Fuchinobe 5-10-1 Sagamihara Kanagawa 229-8558 Japan Department of Mechanical Engineering Aoyama Gakuin University Fuchinobe 5-10-1 Sagamihara Kanagawa 229-8558 Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency Yoshinodai 3-1-1 Sagamihara Kanagawa 229-8510 Japan

＜正＞An unsteady three-dimensional simulations are performed for hydrogen/air CJ detonation in a rectangular tube, where a detailed reaction model is used to reveal its structure. The simulations clearly show detailed three-dimensional detonation modes: a rectangular mode and a diagonal mode. It turns out that the rectangular mode consists of 2 two-dimensional waves and that its cell length is approximately equal to that of the two-dimensional simulations. The diagonal mode is shown to be a three-dimensional diagonal motion of the lines of the triple points completely. The cell length of the diagonal mode is about 3/4 of those obtained in the two-dimensional and other three-dimensional simulations. The detonation front for both rectangular and diagonal modes becomes various and complicated three-dimensional pattern, and the three-dimensional simulations agree well with the results of the experiments reported by many researchers. Furthermore, the formations of unreacted pockets and vortex rings behind the detonation are captured for the diagonal mode.

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