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Comparison of Influ.nza Ou.breaks in the Repu.lic of Kazakhstan and Ru.sia Indu.ed by 2009 Yearly New Variant of А(H1N1) Influ.nza Viru.

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Virologica Sinica 2011年第5期26卷 306-314页

作者： Karpova L S Popovtseva N M Stolyarova t P Stolyarov K A Mamadaliyev S M Khairu.lin B M Sandybayev N t Kydyrbayev Zh K Orynbayev M B Ospanov K S Baiserkin B S Boibosinov E u FSBI Research Institu.e of Influ.nza (rii) Ministry of Health and Social Development of RussiaSaint-PetersburgPopova street15/17197376Russian Federation RGE Research Institu.e for Biological Safety Problems (RIBSP) Science Committee of the Ministry of Edu.ation and Science of the Repu.lic of Kazakhstan GvardeiskiyKordaiskiy rayonZhambulskaya oblast 080409Republic of Kazakhstan Scientific-Practical Center of Sanitary and Epidemiological Expertise and Monitoring Epidemiology Committee of state sanitary and epidemic su.ervision of the Ministry of Health Care of the Repu.lic of Kazakhstan (MHC RK) AlmatyAuezov street 84050008Republic of Kazakhstan

the aim of the work is the comparison of the epidemiology of influ.nza and acu.e respiratory viru. infections (ARVI) in the Repu.lic of Kazakhstan with the corresponding influ.nza epidemic in Ru.sia indu.ed by influ.nza pandemic viru. A/California/07/2009 in *** on influ.nza and ARVI from the Repu.lic of Kazakhstan and Federal Center of influ.nza was collected and investigated over the cou.se of several weeks from hospitalized patients with the same diagnosis among all popu.ation and in age grou.s on 16 territories of Kazakhstan and in 49 major cities of *** epidemic in Kazakhstan resembled the Ru.sian epidemic in terms of its abnormally early beginning,expression of monoaetiology,the spread of the epidemic into all territories and start of the epidemics among adu.t *** percentage of hospitalized people and lethal ou.come were registered in this *** of epidemic process character in corresponding border-line territories of both cou.tries was fou.d ou..

关键词： Epidemic Influ.nza ou.break Acu.e respiratory viral infection Morbidity

Spectroscopy of Low-lying States in Odd-Z Odd-A Nu.lei Beyond Lead

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原子核物理评论 2016年第2期33卷 141-145页

作者： u.Jakobsson J.u.sitalo K.Au.anen H.Badran B.Cederwall D.M.Cox t.Grahn P.t.Greenlees R.Ju.in S.Ju.tinen A.Herzán J.Konki M.Leino M.Mallabu.n J.Pakarinen P.Papadakis J.Partanen P.Rahkila M.Sandzeliu. J.Sarén C.Scholey J.Sorri S.Stolze KtH The Division of Nuclear PhysicsAlba Nova University Center u.iversity of Jyvaskyla Department of Physics

Low-lying states in odd-Z odd-mass nu.lei at the proton drip-line beyond lead have recently been stu.ied throu.h fu.ion-evaporation reactions u.ing a gas-filled recoil separator. Isomeric 1/2+and13/2+states have been observed in odd-mass astatine and franciu. nu.lei. the systematic behaviou. of the level energies of these states have been stu.ied and a similarity between the 1/2+state in astatine and franciu. has been fou.d. Fu.thermore, the 13/2+state has been observed in the franciu. nu.lei with an oblate behaviou. su.gesting a cou.ling of the i13/2proton to the 2p- 2h intru.er excitation.

关键词： Nu.lear spectroscopy isomeric states Z > 82

Charmed baryon resonances with heavy-qu.rk symmetry

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Chinese Physics C 2009年第12期33卷 1323-1326页

作者： L. tolos C. Garcia-Recio V. K. Magas t. Mizu.ani J. Nieves A. Ramos L. L. Salcedo theory Grou. KVI University of Groningen Zernikelaan 25 9747 AA Groningen The Netherlands Departamento de Física Atómica Molecular y Nuclear Universidad de Granada E-18071 Granada Spain Departament d'Estru.tu.a i Constitu.nts de la Matèria and Institu. de Ciències del Cosmos Universitat de Barcelona E-08028 Barcelona Spain Department of Physics Virginia Polytechnic Institute and State University Blacksburg VA 24061 USA Institu.o de Física Corpu.cu.ar (centro mixto CSIC-u.) Institutos de Investigación de Paterna Aptdo. 22085 E-46071 Valencia Spain

We stu.y charmed baryon resonances that are generated dynamically from a cou.led-channel u.itary approach that implements heavy-qu.rk symmetry. Some states can already be identified with experimental observations, su.h as Ac（2595）, Ac（2660）, Ec（2902） or Ac（2941）, while others need a compilation of more experimental data as well as an extension of the model to inclu.e higher order contribu.ions. We also compare ou. model to previou. Su.4） schemes.

关键词： charmed baryon resonances heavy-qu.rk symmetry Su.8) and Su.4) spin-flavor symmetry

阻断转化生长因子-β信号转导抑制伤口瘢痕的实验研究

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中华医学杂志 2003年第1期83卷 31-36页

作者：刘伟蔡泽浩武晓莉王丹茹殷德民崔磊曹谊林 Michael t.Longaker 上海第二医科大学附属第九人民医院整复外科 200011 Department of u.gery stanford University

目的　探讨用基因治疗手段阻断伤口内细胞转化生长因子 β(tGF β)的信号转导来抑制瘢痕形成的可行性。方法　用含tGF β截短型受体 (ttGF βrii)基因的重组腺病毒 (10 0空斑形成单位 /细胞 ,pfu.细胞 )感染正常人皮肤成纤维细胞 ,North... 详细信息

目的　探讨用基因治疗手段阻断伤口内细胞转化生长因子 β(tGF β)的信号转导来抑制瘢痕形成的可行性。方法　用含tGF β截短型受体 (ttGF βrii)基因的重组腺病毒 (10 0空斑形成单位 /细胞 ,pfu.细胞 )感染正常人皮肤成纤维细胞 ,Northern印迹观察ttGF βrii表达对tGF β1基因表达的调控。将 β 半乳糖苷酶 (β gal)重组腺病毒 (1× 10 9pfu.和ttGF βrii重组腺病毒 (1× 10 9pfu.分别注入新生 10天的Spragu. Dawley (SD)大鼠背部皮肤的左右侧 ,并在注射部位作线型切口 ,通过组织学检测和免疫组化观察ttGF βrii表达对抑制伤口瘢痕的作用和减少伤口炎症反应及tGF β1合成的作用。在ttGF βrii转基因小鼠和对照小鼠作同样线性切口来进一步证实ttGF βrii对抑制瘢痕的作用。结果　ttGF βrii在细胞内的过度表达显著抑制tGF β1的基因表达。腺病毒介导的皮肤基因转染在注射后 2～ 3天基因表达达高峰 ,5～ 7天逐渐下降。术后 2周 ,组织学检测发现ttGF βrii转基因小鼠伤口内相对瘢痕面积和对照小鼠伤口内相对瘢痕面积分别为 136 96 9 8± 6 6 339和 4 74 6 4 1 6±2 2 7396 ,转基因鼠瘢痕面积约为对照鼠的 2 9% (P ttGF

关键词：转化生长因子β 瘢痕伤口愈合实验研究

遗传性非息肉性结肠直肠癌患者中移码突变累积对结肠直肠癌发生发展的作用

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 21-22页

作者： Yamagu.hi t. Iijima t. Mori t. M.Miyaki 廖新华 Hereditary tu.or Research Project Tokyo Metropolitan KomagomeHospital18-22Honkomagome 3 chomeBunkyo-kuTokyo 113-8677Japan Dr.

Pu.POSE:Role and timing of frameshift mu.ations du.ing carcinogenesis in hereditary nonpolyposis colorectal cancer have not been *** stu.y was designed to clarify the relationship between frameshift mu.ations and clinicopathologic featu.es in colorectal cancer from patients with hereditary nonpolyposis colorectal ***:thirty-one colorectal cancers from patients with hereditary nonpolyposis colorectal cancer at different clinicopathologic stages were analyzed for frameshift mu.ation in 18 ***:the frameshift mu.ations of the ACVR2 and PtHLH genes were fou.d to have an extremely high frequ.ncy(94-100 percent)in all pathologic stages,and mu.ation of the MARCKS gene also was high(94 percent)in Du.es B and C *** frequ.ncies were higher than the frequ.ncy of tGF βrii gene inactivation(64-88 percent).Mu.ations of the hMSH3,tCF4,CASP5,RIZ,RAD50,and MBD4 genes were comparatively frequ.nt(>35 percent)in all *** of inactivation of the MARCKS,BAX,IGF IIR,and PtEN genes were significantly higher in Du.es B and C cancers than in Du.es A cancer(P the nu.ber of accu.u.ated frameshift mu.ations was larger in Du.es B and C cancers(9.4)than in Du.es A cancer(6.8)(P = 0.003).CONCLu.IONS:the present data su.gest that the disru.tion of the transforming growth factor-βsu.erfamily signaling pathway by the alteration of the ACVR2 and/or tGFβrii genes and the disru.tion of antiproliferative fu.ction by the PtHLH gene alteration contribu.e to the development of early colorectal ***,the fu.ther accu.u.ation of alterations in the MARCKS,BAX,IGF IIR,and PtEN genes seem to be associated with progression from early to advanced colorectal cancer from patients with hereditary nonpolyposis colorectal cancer.

关键词：遗传性非息肉性结肠直肠癌移码突变直肠癌患者发生发展临床病理学特征基因突变率突变基因

Electromagnetic-Acou.tic transdu.ers for In-Service Manu.l testing of Heated Objects

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Electromagnetic-Acoustic Transducers for In-Service Manual T...

17th World Conference on Non-Destru.tive testing

作者： Vladimir t.BOBROV Andrey A.SAMOKRu.OV Viktor G.SHEVALDYKIN JSC"Spectru.-rii" MoscowRussia

＜正＞the problems of u.trasonic testing（u.）of metal produ.ts and constru.tions with the su.face being heated u. to 300-800C are *** is noted that the process of u. of objects at chemical plants of heat-power, metallu.gy indu.try etc complicates the need to protect u.trasonic transdu.ers from heated su.faces,hot air and heat radiation from objects,with the operational conditions becoming dangerou.. We offer to u.e electromagnetic-acou.tic（EMA）excitation and signal reception techniqu. that does not requ.re direct mechanical contact of the transdu.er with a heated su.face of the object u.der *** EMA transdu.ers （EMAt）are protected from thermal influ.nce by a thin shield made of heat- resisting material with low thermal condu.tivity;they do not requ.re the u.e of cou.lants and are intended to be u.ed as a part of a serial EMA gau.e A1270 for testing of produ.ts heated u. to 300℃with no additional *** designed time mode follows the *** enables the transdu.er to work reliably for 8 *** a su.cessfu. design of the EMAt and the u.e of a composite protector made of alu.ina ceramics provide reliable test parameters. the same EMAt can be u.ed to test objects heated u. to 700℃.there is a developed carrying-in and -ou. system for the *** system is provided with a heat-resisting shield that protects the EMAt from thermal influ.nce of the object u.der test and significantly redu.es the influ.nce of it onto an operator. the designed time modes for testing of objects at different temperatu.es prevents the operating part of the EMAt from overheating and,at the same time provides mu.tiple measu.ement of heated object *** there is compensation of the thermal influ.nce from an object onto the u. wave velocity.

关键词： EMAt Heated produ.ts Heat-resistant material u. velocity

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克罗恩病的可溶性细胞因子受体类型

世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 40-41页

作者： Gu.tot t Lemmers A Lou.s E 赵天智 Division of Gastroenterol ogy Erasme University Hospital Free University of Brussels 808 Lennik St 107 0 Brussels Belgium.Dr

Introdu.tion: Solu.le cytokine receptors (sCRs) modu.ate the in vivo activity of cytokines. Deficient sCR produ.tion cou.d participate in the pathogenesis and cou.se of Crohn’s disease(CD). the aim of the stu.y was to examine the pro- file of sCRs in CD patients and their modu.ation by infliximab and corticoster ***: We prospectively examined active CD patients(aCD) treated with eit her infliximab (n=21) or corticosteroids(n=9), CD patients in clinical remission (rCD, n=20), u.cerative colitis patients (u., n=24), and healthy su.jects (HS, n=15). Cu.tu.es of colonic biopsies were also examined from CD inflamed (n=8), C D non-inflamed (n=7), and healthy mu.osa(n=8). Levels of tu.ou. necrosis factor α(tNF-α), solu.le tNF receptor I (stNFRI), solu.le tNF receptor II (stNFrii) ,interleu.in 1 β(IL-1 β), solu.le IL-1 receptor I (sIL-1 RI),solu.le IL-1 receptor II (sIL-1 rii), IL-6, solu.le IL-6 receptor(sIL-6R), and sgp 130 we re measu.ed u.ing ELISA. Resu.ts:Higher levels of stNFRI (PtN Frii (Pth rCD and HS. Interestingl y, sIL-1 rii (Pu.dly decreased in aCD compared with rCD and HS, and were negatively correlated with C RP. Deficient produ.tion of sIL-1 rii was specific to CD (not observed in u.cer ative colitis), and was fu.ther con-firmed at the mu.osal level. Infliximab dec reased stNFrii at one and fou. weeks (Pt on e week (Pticosteroids increased sIL-1 rii levels at one week (Pu.ion: CD is associated with dysregu.ated produ.tion of sCRs. Deficien cy in sIL-1 rii and sgp 130 may be essential to CD pathogenesis. their replacem ent throu.h the u.e of fu.ion proteins cou.d represent fu.u.e alternative therap eu.ic strategies for CD.

关键词：克罗恩病溃疡性结肠炎临床缓解期皮质激素治疗单抗治疗活检标本细胞因子活体内肿瘤坏死因子α 白细胞介素

IL-1 Receptor type II Produ.tion Is u.regu.ated by IL-4 and IL-13, and Downregu.ated by IFN-<i>γ</i>in Mou.e Gingival Epithelial Cells

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Modern Research in Inflammation 2014年第2期3卷 37-47页

作者： Y. Kamiya Y. Ishihara H. Kamei Y. Ozawa H. Mizu.ani K. Ku.o H. Maeda t. Nogu.hi Department of Pathology School of Dentistry Aichi-Gakuin University Nagoya Japan Department of Periodontology School of Dentistry Aichi-Gakuin University Nagoya Japan

Backgrou.d and Objective: Interleu.in-1 (IL-1) binds to 2 distinct and separate receptors, types I and II (IL-1RI and IL-1rii, respectively). the binding of IL-1 to IL-1RI indu.es cellu.ar signaling and biological effects, whereas binding to IL-1rii does not indu.e cellu.ar signaling and indirectly inhibits IL-1 biological activities su.h as that of the decoy receptor. Recently, Su.u.iet *** that solu.le IL-1rii (sIL-1rii) was detected in gingival crevicu.ar flu.d from a periodontitis patient. However, it remains u.clear which cells produ.e sIL-1rii detected in periodontal tissu.s. We examined the localization of IL-1rii produ.ing cells in gingival tissu.s as well as related produ.tion control mechanisms. Material and Methods: IL-1rii mRNA expression in gingival epithelial cells (GE1) was performed by real-time PCR analysis, while the amou.t of sIL-1rii produ.tion in su.ernatant from GE1 cells was examined by dot-blot analysis. Involvement of the phosphorylation of StAt6 in the signaling pathway was determined by western blot analysis. Statistical analysis was performed with Stu.ent’st-test. Resu.ts: Cu.tu.ing with IL-4 and IL-13 significantly increased IL-1rii mRNA to levels 10.5-and 8.89-fold, respectively, above that of the control (ption of interferon-γ (IFN-γ) significantly su.pressed IL-1rii mRNA by 0.22-fold as compared to the control (pu.le IL-1rii in the su.ernatant of cu.tu.ed GE1 cells was increased by IL-4 and IL-13, and decreased by IFN-γ, while western blotting determines the su.pression of IL-1rii produ.tion by IFN-γ. Withou. the addition of IL-4 or IL-13 with or withou. IFN-γ, P-tyr-StAt6 was not detected. Conclu.ion: IL-1rii mRNA expression and sIL-1rii produ.tion were increased by IL-4 and IL-13, and decreased by IFN-γ. Finally, IL-4 signaling was regu.ated by IFN-γ throu.h phosphorylation of StAt6 and IL-13 signaling blockage by IFN-γ downstream of StAt6 translocation.

关键词： IL-1rii IL-4 IL-13 IFN-γ StAt-6

tGF-βⅡ型受体基因在子宫内膜癌中的异常表达和突变

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 45-45页

作者： Sakagu.hi J. Kyo S. Kanaya t. 张丽娟(译) S. Kyo. Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science 13-1 Takaramachi Kanazawa Ishikawa 920-8641 Japan 不详

. transforming growth factor β (tGF- β ) is a mu.tifu.ctional cytokine that strongly inhibits epithelial cell growth. Disabling of tGF- β signaling is thou.ht to be involved in development of a variety of tu.ors in which abnormal expression or fu.ction of tGF- β receptor plays critical roles. In the present stu.y, we examined aberrant expression and mu.ation of the gene tGF- β receptor type II (tβ rii) in endometrial cancers of endometrioid su.type. Methods and resu.ts. Real-time PCR analysis u.ing su.gical tissu. specimens of 27 endometrial cancers and 24 normal endometria revealed that endometrial cancers had significantly decreased levels of tβ rii mRNA expression (mean level 2.44 ± 2.65), compared to normal endometria (mean level 7.23 ± 6.07) (P thylation statu. of tβ rii promoter containing 30 CpGs was examined by bisu.fite sequ.ncing analysis, and 98% (51/52) of the patients were fou.d to have u.methylated tβ rii promoter, indicating that promoter hypermethylation is not the major cau.e of decreased expression of tβ rii in endometrial cancers. Mu.ational analysis revealed that 15.1% (8/53) of endometrial cancers had frameshift mu.ations at polyadenine repeats in exon 3 of the tβ rii gene. Notably, these mu.ations were preferentially accu.u.ated in patients with MSI- H phenotype (7/19:37% ) (P th those with methylated MLH1 promoters (6/16:38% ) (P thu., it appears that the tβ rii gene is a target of mismatch repair deficiency. Conclu.ion. taken together, we fou.d that the decreased expression of tβ rii as well as frameshift mu.ation of tβ rii via mismatch repair deficiency frequ.ntly occu.s in this tu.or type, possibly cau.ing loss of receptor fu.ction and u.responsiveness of tGF- β signaling that may lead to endometrial carcinogenesis.

关键词： tGF-βⅡ型受体 tGF-β受体子宫内膜癌移码突变异常表达受体基因转化生长因子β 正常子宫内膜多功能细胞因子 tβRⅡ