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World Journal of Hepatology 2011年第2期3卷 56-60页

作者： Kiyotaka Fujise keiko tatsuzawa Midori Kono Sadayori Hoshina Akihito Tsubota Minoru Niiya Yoshihisa Namiki Norio Tada Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal MedicineKashiwa HospitalThe Jikei University School of MedicineChiba277-8567Japan Institute of Clinical Medicine and Research The Jikei University School of Medicine Chiba277-8567Japan Department of Laboratory Medicine The Jikei University School of MedicineTokyo 105-8461Japan

There are cases of hepatitis involving occult hepatitis B virus(HBV)infection in which,even though the HB surface antigen(HBsAg)is negative,HBV-DNA is detected by a polymerase chain reaction(PCR).We con-ducted a sequence analysis of the entire HBV region in a case of non-B non-C chronic hepatitis in a 46-yearold female.A diagnosis of non-B non-C chronic hepatitis was *** HBV markers,such as HBs antibody(anti-HBs),anti-HBc,HBeAg and anti-HBe,were negative,HBV-DNA was *** PCR was performed to amplify the precore region of HBV-DNA and all remaining regions by long nested *** analysis of the two obtained bands was conducted by direct *** with the control strains,the ATG(Methionine)start codon in the X region had mut ated to GTG(Valine).It is assumed that a mutation at the start codon in the X region may be the reason why HBV markers are negative in some cases of hepatitis that involve occult HBV infection.

关键词： Hepatitis B virus X region Mutation Non-B non-C chronic hepatitis Occult infection

Direct Correlation among Telomere Length, Cellular Aging, and Rejuvenation Effects of Honey Child Powder

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Journal of Biosciences and Medicines 2024年第7期12卷 55-70页

作者： Naofumi Shiomi keiko Watanabe Yuki Fujiwara Takae Yamasaki Hideto Matsuyama Research Center for Membrane and Film Technology Kobe University Kobe Japan School of Human Sciences Kobe College Nishinomiya Japan Department of Chemical Science and Engineering Kobe University Kobe Japan

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

关键词： Telomere Cellular Aging Telomerase Reverse Transcriptase Gene Rejuvenation Honey Child Powder

Perinatal Morbidity, Mortality, and Neurodevelopmental Outcomes of Neonates with Fetal Growth Restriction

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Open Journal of Obstetrics and Gynecology 2024年第3期14卷 321-333页

作者： Natsuki Tamashiro Shuko Chinen Yoshino Kinjyo Yukiko Chinen Tadatsugu Kinjo keiko Mekaru Department of Obstetrics and Gynecology Graduate School of Medicine University of the Ryukyus Nishihara Japan

Objective: This study aimed to assess perinatal morbidity, mortality rates, and neurodevelopmental outcomes in the management of fetal growth restriction (FGR) at a single tertiary institute. Methods: Among 2465 deliveries between 2013 and 2019, 109 cases of FGR were reviewed retrospectively for causes, indications for pregnancy termination, perinatal death, overall neonatal outcomes, and long-term prognosis. Results: Excluding FGR due to congenital anomalies (n = 17), the mortality rate was 3.3% (3/92). One neonate delivered at 23 weeks developed cerebral palsy (1.1%). Retinopathy of prematurity occurred in four neonates (4.3%). Neurodevelopmental disorders were present in six neonates (6.5%), all of whom were delivered at 32 - 38 weeks. Significantly lower gestational age at delivery, lower birth weight, and higher umbilical artery resistance indices were observed in neonates with neurodevelopmental disorders. Conclusions: Intact survival before 27 weeks of gestation at delivery with FGR is uncommon. Neurodevelopmental disorders may still develop after delivery at 32 - 38 weeks;consideration should be given to the timing of delivery usingfetal ductus venosus Doppler waveforms measurements to reduce neurodevelopmental disorders.

关键词： Fetal Death Fetal Growth Retardation Neurodevelopmental Disorders Perinatal Mortality Umbilical Artery Doppler Velocimetry

Zoonotic human liver flukes, a type 1 biocarcinogen, in freshwater fishes: genetic analysis and confirmation of molluscan vectors and reservoir hosts in Bangladesh

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贫困所致传染病(英文) 2024年第3期13卷 1-16页

作者： Labony Sharmin Shahid Alim Md. Abdul Hasan Muhammad Mehedi Hossain Md. Shahadat Akter Sharmin Paul Joydeep Farjana Thahsin Ali Md. Haydar Alam Mohammad Zahangir Hatta Takeshi Kawada Hayato Mizutani keiko Tsuji Naotoshi Anisuzzaman Department of Parasitology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh Department of Fisheries Technology Faculty of Fisheries Bangladesh Agricultural University Mymensingh Bangladesh Department of Biotechnology School of Life Sciences &amp Biotechnology Adamas University Barasat - Barrackpore Rd Jagannathpur Kolkata West Bengal India Department of Pathology and Parasitology Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh Department of Parasitology and Tropical Medicine Kitasato University School of Medicine-15-Kitasato Minami Sagamihara Kanagawa-0374 Japan Department of Molecular and Cellular Parasitology Kitasato University Graduate School of Medical Sciences-15-Kitasato Minami Sagamihara Kanagawa-0373 Japan

Background Opisthorchiid flukes, particularlyOpisthorchis viverrini,Opisthorchis felineus,Clonorchis sinensis, andMetorchis spp. are the most common fish-borne zoonotic human liver flukes (hLFs). Liver fluke infections are more prevalent in resource-deprived and underprivileged areas. We herein estimated the prevalence of the metacercariae (MC) of major hLFs in common large freshwater fishes (lFWF) marketed for human consumption from some selected areas of Bangladesh along with detection of their molluscan vectors and *** The current status of fish-borne zoonotic hLF infections in lFWF was investigated along with their molluscan vectors and mammalian reservoir hosts in Mymensingh and Kishoreganj in Bangladesh from July 2018–June 2022 using conventional and multiple molecular techniques, such as PCR, PCR-restriction fragment length polymorphism (RFLP), sequencing, and bioinformatic analyses. The infection rate of fishes was analyzed using theZ-test and the loads of MC were compared using the chi-squared (χ2) *** The MC ofC. sinensis,Opisthorchis spp., andMetorchis spp. were detected in 11 species of common and popular lFWF. In lFWF, the estimated prevalence was 18.7% and the mean load was 137.4 ± 149.8 MC per 100 g of fish. The prevalence was the highest (P 0.05) distributed between the head and body of fishes. The infection rate was slightly higher in cultured (19.6%) fishes. The MC ofC. sinensis,O. felineus,O. viverrini, andMetorchis orientalis in fishes were confirmed using PCR, PCR-RFLP and bioinformatics. The cercariae of opisthorchiid (Pleurolophocercus cercariae) flukes were only recovered fromBithynia spp. (3.9%, 42 out of 1089). The ova of hLFs from dogs (4.3%, 5 out of 116) and cats (6.0%, 6 out of 100), and adult flukes (***) from ducks

关键词： Human liver fluke Freshwater fish Molluscan vector Reservoir host Bangladesh

Development and Evaluation of 3D Delivery Animation Software Designed to Improve the Mother’s and Spouse’s Satisfaction with Delivery

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Health 2024年第5期16卷 439-458页

作者： Ayako Sasaki Sachi Chikazawa Nojima Kumiko Tomita Takako Hatakeyama keiko Imoto Yasufumi Imoto Nobutane Faculty of Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan Imoto Ladies Clinic Echizen Japan

Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands.

关键词： Mother Spouse Satisfaction 3D Delivery Animation Software

A Case Report of Kissing Molars Class II

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Open Journal of Stomatology 2024年第5期14卷 249-254页

作者： Toshiyuki Inou Keiichi Uchida keiko Kaneko Anna Fuji Nina Wakimoto Tatsuo Takaya Hiroyuki Kitamura Hiroshi Mori Yuji Kurihara Department of Oral Diagnostics and Comprehensive Dentistry Matsumoto Dental University Hospital Shiojiri Japan Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University Shiojiri Japan

Kissing molars (KMs) is a condition of occlusal molar surfaces in a single follicular space with roots extending in opposite directions. Here, we have reported a case of KMs in a 58-year-old woman. The patient complained of pain in the right mandibular molar region and was diagnosed with KMs consisting of the right mandibular second and third molars. Because of the patient’s pain having subsided at the time of the visit and her unwillingness to undergo tooth extraction, the patient was followed up. KMs is classified into three classes (I-III) and is either true-KMs or pseudo-KMs and presents with or without cystic variants of dental follicles. The presents as true-KMs class II without a cystic variant. With reference to the literature and based on our analysis, the mean age of patients affected by this specific case of KMs is 31.7 years and unilateral KMs is relatively more common (85.7%). Histopathological findings of dentigerous cysts are more often indicated (42.9%). The treatment policy for KMs should therefore be based on the classification of KMs. Importantly, the focus should be on preserving the first and second molars as much as possible. The treatment approach, such as the employment of surgical removal or orthodontics, should be determined by considering the associated factors such as the crowns, tissues, and age of the patient.

关键词： Kissing Molars Mandibular Second Molar Mandibular Third Molar Cone-Beam Computed Tomography

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

Performance Evaluation of Electromagnetic Shield Constructed from Open-Cell Metal Foam Based on Sphere Functions

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Computer Modeling in Engineering & Sciences 2022年第7期132卷 43-53页

作者： Yuya Hanaoka Taku Itoh Kohei Tateyama Susumu Nakata keiko Watanabe Graduate School of Industrial Technology Nihon UniversityNarashinoChiba 275-8575Japan College of Industrial Technology Nihon UniversityNarashinoChiba 275-8575Japan College of Science and Engineering Ritsumeican UniversityKusatsuShiga 525-8577Japan College of Information Science and Engineering Ritsumeican UniversityKusatsuShiga 525-8577Japan

This study evaluates the performance of a model of open-cell metal foams generated by sphere *** this end,an electromagnetic shield constructed from the model was inserted between two horn antennas in an electromagnetic wave propagation *** foam-hole diameter in the electromagnetic shield model was varied as d=2.5 and 5.0 mm,and the frequency of the electromagnetic waves was varied from 3 to 13 *** the numerical experiments of shield effectiveness,the shields with foam holes of both diameters attenuated the electromagnetic waves across the studied frequency *** shield effectiveness was enhanced at low frequencies and in the shield with smaller hole diameter.

关键词： Electromagnetic propagation electromagnetic shielding materials metal foams numerical simulation

添加剂对地质聚合物固化Se(Ⅵ)与Cr(Ⅵ)的作用机制

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硅酸盐学报 2022年第5期50卷 1335-1346页

作者：田全志 SASAKI keiko 中国矿业大学国家煤加工与洁净化工程技术研究中心江苏徐州221116 九州大学地球资源工程系日本福冈819-0395

针对地质聚合物固化Se(Ⅵ)、Cr(Ⅵ)等含氧阴离子效率低的问题,研究了Ca、Mg、Fe(Ⅱ)盐对地质聚合物固化Se(Ⅵ)、Cr(Ⅵ)的作用机制。结果表明:无添加剂作用的地质聚合物固化体Se或Cr浸出量可高达60%以上,CaO或Fe(Ⅱ)盐对Se或Cr浸出有一... 详细信息

针对地质聚合物固化Se(Ⅵ)、Cr(Ⅵ)等含氧阴离子效率低的问题,研究了Ca、Mg、Fe(Ⅱ)盐对地质聚合物固化Se(Ⅵ)、Cr(Ⅵ)的作用机制。结果表明:无添加剂作用的地质聚合物固化体Se或Cr浸出量可高达60%以上,CaO或Fe(Ⅱ)盐对Se或Cr浸出有一定的抑制作用,但浸出量仍高达40%以上,效果均有限,而Mg O作用下Se或Cr浸出量可降至10%以下。LCF分析结果显示Cr(Ⅵ)与Se(Ⅵ)在地质聚合物三维网状结构中均以静电力的结合方式存在。此外,Mg O或CaO的水化过程可促使Fe(Ⅱ)还原性的释放,约15%的Cr(Ⅵ)可被还原为Cr(Ⅲ);而针对Se(Ⅵ),Ca与Se(Ⅵ)可发生键合作用,Fe(Ⅱ)并没有起到还原性的作用;Mg O、CaO、Fe(Ⅱ)盐对固化体中Se(Ⅵ)或Cr(Ⅵ)的浸出起着一定的协同效应。此外,Mg O、CaO、Fe(Ⅱ)盐作用的地质聚合物固化体强度均满足工业填埋最低要求。

关键词：地质聚合物固化浸出添加剂

Effect of hydrogen peroxide on selective flotation of chalcocite and enargite

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International Journal of Mining Science and Technology 2023年第6期33卷 703-716页

作者： Gde Pandhe Wisnu Suyantara Daniyarov Berdakh Hajime Miki Tsuyoshi Hirajima keiko Sasaki Daishi Ochi Yuji Aoki Department of Earth Resources Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan Kyushu University Institute for Asian and Oceanian Studies Kyushu UniversityFukuoka 819-0395Japan Graduate School of Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan Uzbekistan-Japan Innovation Center of Youth Tashkent 100095Uzbekistan Sumitomo Metal Mining Co. Ltd.Tokyo 105-8716Japan Sumitomo Metal Mining Co. Ltd.Ehime 792-0002Japan

Enargite is typically associated with *** to the similarity in the flotation behaviors of these minerals,both minerals are reported to concentrate in the conventional flotation ***,inorganic arsenic in enargite can decrease the copper concentrate quality and increase the operating cost of processing this *** these minerals is important for cleaner copper production to avoid these *** this context,this study investigated the effect of hydrogen peroxide(H_(2)O_(2))treatment on the flotation behavior of chalcocite and *** tests of pure and mixed minerals indicated that H_(2)O_(2)treatment reduced the floatability of chalcocite and enargite by forming sulfate and copper hydroxide on their *** the detrimental effect of the H_(2)O_(2)treatment,there was a narrow window of H_(2)O_(2)concentration for separating both minerals,in which enargite floated and chalcocite was *** selective flotation behavior was caused by the rapid adsorption of potassium amyl xanthate(KAX)and lower surface oxidation of enargite compared with that of chalcocite.

关键词： Enargite Chalcocite Hydrogen peroxide Potassium amyl xanthate Selective flotation