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Non-thermal plasma treatment of Radix aconiti wastewater generated by traditional Chinese medicine processing

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Journal of Environmental Sciences 2016年第6期28卷 99-108页

作者： Yiyong Wen Jianping Yi Shen Zhao Song Jiang Yuming Chi kefu liu Institute for Electric Light Sources Fudan University Shanghai 200433 China Institute of Tong Ren Tang Beijing 100079 China Department of Electrical Engineering University of Shanghai for Science and Technology Shanghai 200093 China

The wastewater effluent from Radix aconiti processing, an important step in the production processes of traditional Chinese medicine（TCM）, is a type of toxic wastewater and difficult to treat. Plasma oxidation methods have emerged as feasible techniques for effective decomposition of toxic organic pollutants. This study examined the performance of a plasma reactor operated in a dielectric barrier discharge（DBD） to degrade the effluent from R. aconiti processing. The effects of treatment time, discharge voltage, initial pH value and the feeding gas for the reactor on the degradation of this TCM wastewater were investigated. A bacterium bioluminescence assay was adopted in this study to test the toxicity of the TCM wastewater after non-thermal plasma treatment. The degradation ratio of the main toxic component was 87.77% after 60 min treatment with oxygen used as feed gas and it was 99.59% when the initial p H value was 8.0. High discharge voltage and alkaline solution environment were beneficial for improving the degradation ratio. The treatment process was found to be capable of reducing the toxicity of the wastewater to a low level or even render it non-toxic. These experimental results suggested that the DBD plasma method may be a competitive technology for primary decomposition of biologically undegradable toxic organic pollutants in TCM wastewater.

关键词： Traditional Chinese medicine(TCM) wastewater Plasma Advanced oxidation processes(AOPs) Acute toxicity Aconitum alkaloid removal

基于杏仁核亚区CBF的阈下抑郁和首发重度抑郁症的危险因素分析

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中国实用神经疾病杂志 2025年第1期28卷 7-12页

作者：张宁宁王云徐成刘可夫南京医科大学姑苏学院南京医科大学附属苏州医院苏州市立医院江苏苏州215002 复旦大学附属中山医院青浦分院上海201799

目的探讨阈下抑郁(StD)和重度抑郁症(MDD)杏仁核各亚区脑血流量(CBF)变化,分析StD和MDD的危险因素。方法招募49例StD患者(StD组)、58例未经治疗的首发MDD患者(MDD组)和55例健康被试者(HC组),比较3组杏仁核(Amy)及其3个亚区[基底外侧核(... 详细信息

目的探讨阈下抑郁(StD)和重度抑郁症(MDD)杏仁核各亚区脑血流量(CBF)变化,分析StD和MDD的危险因素。方法招募49例StD患者(StD组)、58例未经治疗的首发MDD患者(MDD组)和55例健康被试者(HC组),比较3组杏仁核(Amy)及其3个亚区[基底外侧核(LB)、中央内侧核(CM)、浅表核(SF)]CBF和外周血清炎性因子(IL-1β、IL-4、IL-6和TNF-α)水平,采用多分类Logistic回归分析评估StD和MDD的危险因素。结果3组被试者IL-1β和TNF-α水平、RAmy、RLB、RCM和LCM亚区的CBF存在统计学差异(P<0.05)。Logistic回归分析表明,RLB、RCM和LCM亚区的CBF变化是HC发展为StD的风险指标(P<0.05),TNF-α水平、RAmy和RCM亚区的CBF变化是HC发展为MDD的风险指标(P<0.05),RAmy、RLB和LCM亚区的CBF变化是StD进展为MDD的风险指标(P<0.05)。结论无抑郁状态下与阈下抑郁状态下发生重度抑郁症的高危因素存在差异,抑郁症的发生可能是一个涉及多个杏仁核亚区的动态变化过程,将有提高抑郁症检出率及监测其发生、发展的成效。

关键词：阈下抑郁亚临床抑郁轻微抑郁重度抑郁症杏仁核亚区基底外侧杏仁核中央内侧杏仁核浅表杏仁核脑血流灌注危险因素

Impedance matching for repetitive high voltage all-solid-state Marx generator and excimer DBD UV sources

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Plasma Science and Technology 2017年第6期19卷 10-19页

作者： Yonggang WANG Liqing TONG kefu liu Institute of Electrical Light Source Fudan University Shanghai 200433 People＇s Republic of China

The purpose of impedance matching for a Marx generator and DBD lamp is to limit the output current of the Marx generator,provide a large discharge current at ignition,and obtain fast voltage rising/falling edges and large *** this paper,different impedance matching circuits（series inductor,parallel capacitor,and series inductor combined with parallel capacitor） are *** demonstrates that a series inductor could limit the Marx ***,the discharge current is also limited.A parallel capacitor could provide a large discharge current,but the Marx current is also enlarged.A series inductor combined with a parallel capacitor takes full advantage of the inductor and capacitor,and avoids their ***,it is a good *** results match the theoretical analysis well and show that both the series inductor and parallel capacitor improve the performance of the ***,the series inductor combined with the parallel capacitor has the best *** with driving the DBD lamp with a Marx generator direcdy,an increase of 97.3%in radiant power and an increase of 59.3%in system efficiency are achieved using this matching circuit.

关键词： impedance matching circuit all-solid-state Marx generator DBD lamp

Influence of electrical parameters on H2O2 generation in DBD non-thermal reactor with water mist

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Plasma Science and Technology 2017年第6期19卷 26-32页

作者： Di XU Zehua XIAO Chunjing HAO Jian QIU kefu liu Institute of Light Sources and Illuminating Engineering Fudan University Shanghai 200433 People＇s Republic of China

A dielectric barrier discharge（DBD） reactor is introduced to generate H2O2 by non-thermal plasma with a mixture of oxygen and water mist produced by an ultrasonic *** results of our experiment show that the energy yield and concentration of the generated H2O2 in the pulsed discharge are much higher than that in AC discharge,due to its high energy efficiency and low heating ***-sized liquid droplets produced by an ultrasonic atomizer in water mist have large specific surface area,which greatly reduces mass transfer resistance between hydroxyl radicals and water liquids,leading to higher energy yield and H2O2 concentration than in our previous *** influence of applied voltage,discharge frequency,and environmental temperature on the generated H2O2 is discussed in detail from the viewpoint of the DBD *** H2O2 concentration of 30 mg l^-1,with the energy yield of 2 gkW^-1h^-1 is obtained by pulsed discharge in our research.

关键词： hydrogen peroxide dielectric barrier discharge pulsed discharge non-thermal plasma electrical parameters

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固态Marx发生器研究进展

高电压技术 2015年第6期41卷 1781-1787页

作者：刘克富复旦大学信息学院上海200433

为推动固态Marx发生器技术的研究和发展,介绍了近年来国内外学术界对固态Marx发生器技术的研究现状,重点分析了固态Marx发生器涉及的隔离充电技术、陡化技术以及负载能力等关键技术问题,并展望了其未来发展的趋势。固态Marx发生器的固... 详细信息

为推动固态Marx发生器技术的研究和发展,介绍了近年来国内外学术界对固态Marx发生器技术的研究现状,重点分析了固态Marx发生器涉及的隔离充电技术、陡化技术以及负载能力等关键技术问题,并展望了其未来发展的趋势。固态Marx发生器的固态开关采用独立触发方式,每个开关可分别控制开通和关断,具有多参数特制、高频化、寿命长3方面的突出技术优势。通过采用隔离充电方式,可以实现低压充电电源和高压脉冲输出之间的电气隔离;通过陡化技术,可以实现数十ns脉冲上升沿输出;结合特定设计,固态Marx发生器可适用于驱动电阻、电容、电感以及它们的组合型非线性负载,在一定范围内调制出需要的电压、电流波形,具有较大的灵活性。伴随着半导体开关器件以及电力电子技术水平的发展,固态Marx发生器将向小型化、集成化和模块化方向发展,满足脉冲功率技术未来不断提高的应用需求。

关键词： Marx发生器气体开关固态开关电压叠加脉冲调制电力电子多电平

Characterization of an Electromagnetic Vibration Isolator

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Journal of Electromagnetic Analysis and Applications 2011年第12期3卷 519-528页

作者： Naibiao Zhou kefu liu Department of Mechanical Engineering Lakehead University

A novel vibration isolator is constructed by connecting a mechanical spring in parallel with a magnetic spring in order to achieve the property of high-static-low-dynamic stiffness (HSLDS). The HSLDS property of the isolator can be tuned off-line or on-line. This study focuses on the characterization of the isolator using a finite element based package. Firstly using the single physics solver, the stiffness behaviours of the mechanical and magnetic springs are determined, respectively. Then using the weakly coupled multi-physics method, the stiffness behaviours of the passive isolator and the semi-active isolator are investigated, respectively. With the found stiffness models, a nonlinear differential equation governing the dynamics of the isolator is solved using the time-dependent solver. The displacement transmissibility ratios of the isolator are obtained. The study confirms that the isolation region of the isolator can be widened through off-line or on-line tuning.

关键词： High-Static-Low-Dynamic Stiffness Spring Semi-Active Vibration Isolator Magnetic Spring Coupling of Structural Mechanics and Magnetics

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两间隙毛细管等离子体发生器出口参数研究

高电压技术 2006年第6期32卷 72-74,112页

作者：夏胜国刘克富华中科技大学电气与电子工程学院武汉430074

消融放电毛细管等离子体发生器产生的等离子体射流具有高密和相对低温的特性,在许多科学研究和工业应用领域都具有潜在的应用前景。为此,利用数值模拟的方法考察了在1 kJ放电能量水平下两间隙毛细管的长度和半径、主放电电容器组的电容... 详细信息

消融放电毛细管等离子体发生器产生的等离子体射流具有高密和相对低温的特性,在许多科学研究和工业应用领域都具有潜在的应用前景。为此,利用数值模拟的方法考察了在1 kJ放电能量水平下两间隙毛细管的长度和半径、主放电电容器组的电容和起始充电电压等放电参数对毛细管出口参数的影响。研究表明,各放电参数的改变都能引起出口处的质量密度、压强的大幅度改变,而出口温度和出口速度相对保持稳定。其中,主放电电容器组充电电压、电容值增大、毛细管半径变小时,所有的出口参数都相应增大;而毛细管长度增大时,密度和压强随之增大,温度和速度反而减小。

关键词：消融放电等离子体发生器等离子体射流数值模拟出口参数

The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment

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Neuroscience Bulletin 2024年第8期40卷 1076-1092页

作者： Zongyao Ren Haiyan Tang Wendiao Zhang Minghui Guo Jingjie Cui Hua Wang Bin Xie Jing Yu Yonghao Chen Ming Zhang Cong Han Tianyao Chu Qiuman Liang Shunan Zhao Yingjie Huang Xuelian He kefu liu Chunyu liu Chao Chen Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life Sciencesand Department of PsychiatryThe Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center on Mental Disorders The Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410011China Furong Laboratory Changsha 410000China Department of Psychiatry SUNY Upstate Medical UniversitySyracuseNY 13210USA Precision Medical Center Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430014China Department of Medical Genetics Hunan Children's HospitalChangsha 410007China

Intellectual disability(ID)is a condition characterized by cognitive impairment and difficulties in adaptive *** our research,we identified two de novo mutations(c.955C>T and c.732C>A)at the KDM2A locus in individuals with varying degrees of *** addition,by using the Gene4Denovo database,we discovered five additional cases of de novo mutations in *** mutations we identified significantly decreased the expression of the KDM2A *** investigate the role of KDM2A in neural development,we used both 2D neural stem cell models and 3D cerebral *** findings demonstrated that the reduced expression of KDM2A impairs the proliferation of neural progenitor cells(NPCs),increases apoptosis,induces premature neuronal differentiation,and affects synapse *** ChIP-Seq analysis,we found that KDM2A exhibited binding to the transcription start site regions of genes involved in *** addition,the knockdown of KDM2A hindered H3K36me2 binding to the downstream regulatory elements of *** integrating ChIP-Seq and RNA-Seq data,we made a significant discovery of the core genes'remarkable enrichment in the MAPK signaling ***,this enrichment was specifically linked to the p38 MAPK ***,disease enrichment analysis linked the differentially-expressed genes identified from RNA-Seq of NPCs and cerebral organoids to neurodevelopmental disorders such as ID,autism spectrum disorder,and ***,our findings suggest that KDM2A plays a crucial role in regulating the H3K36me2 modification of downstream genes,thereby modulating the MAPK signaling pathway and potentially impacting early brain development.

关键词： Intellectual disability KDM2A Neurodevelopmental disorder Cerebral organoids

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基于感应变压器原理的多路开关同步触发技术

强激光与粒子束 2012年第7期24卷 1549-1554页

作者：雷宇邱剑刘克富复旦大学电光源研究所上海200433

为满足直线变压器驱动源(LTD)中大规模开关同步触发的技术需求,提出了一种采用逆LTD结构、基于感应变压器原理的多路LTD开关同步触发技术(LTD-trigger)。它的工作原理类似若干个串联工作的脉冲变压器,即初级输入一个高压快脉冲,通过脉... 详细信息

为满足直线变压器驱动源(LTD)中大规模开关同步触发的技术需求,提出了一种采用逆LTD结构、基于感应变压器原理的多路LTD开关同步触发技术(LTD-trigger)。它的工作原理类似若干个串联工作的脉冲变压器,即初级输入一个高压快脉冲,通过脉冲变压器的感应耦合后在次级输出多路的同步触发脉冲,且能够与LTD中的气体开关形成很好的对应关系。与传统的触发技术相比,LTD-trigger的同轴结构有效地减小了触发脉冲的延时与抖动,并且通过合理设计,能够满足LTD模块对于同步触发的要求。分析了LTD-trigger的工作原理,建立了电路模型和仿真模型,通过仿真结果和一些故障模式分析,结合已开展的初步实验结果,验证了同步触发技术的可行性。

关键词：直线变压器驱动源同步触发感应变压器同轴结构故障模式