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Treatment of hepatitis C in children and adolescents:how far have we reached?

World Journal of Pediatrics 2023年第2期19卷 107-119页

作者： Vybhav Venkatesh keerthivasan seetharaman Neha Anushree Department of Gastroenterology and Hepatobiliary Sciences IMS and SUM HospitalSOA UniversityBhubaneswarIndia Department of Pediatrics Sri Manakula Vinayagar Medical College and HospitalPuducherryIndia Department of Pediatrics Command Hospital-Southern CommandPune411040India

Background Hepatitis C virus(HCV)infection is a global public health problem and also generates a significant case load in children and *** the introduction of directly acting antivirals(DAA),the treatment and care of HCV-infected patients have progressed *** available treatment options in children are limited,and this review aims to provide an overview of treatment of HCV infection in children and adolescents with the current available DAA *** sources This comprehensive review was undertaken after searching the PubMed/Medline and Embase databases for the available up-to-date literature on pediatric HCV infection and treatment using hepatitis C virus infection/HCV,directly acting antivirals/DAA,natural history,treatment,pediatrics,children,and adolescents as *** Combination therapies with highly effective DAA regimes,such as sofosbuvir/ledipasvir,sofosbuvir/velpatasvir,glecaprevir/pibrentasvir,sofosbuvir/daclatasvir,sofosbuvir/ribavirin and others,are available for use in *** of the DAA regimens have either received or are pending to receive regulatory approval by different medical/drug agencies for use in children and ***-genotypic regimens are also available in children and adolescents,and these regimens can be used while skipping genotype *** The literature on different DAA regimens for use in children shows that these regimens have higher cure rates with minimal side effects and shorter duration of therapy.

关键词： Children Directly acting antivirals Hepatitis C

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