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Effects of tissue-cultured mountain ginseng （Panax ginseng CA Meyer） extract on male patients with erectile dysfunction

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Asian Journal of Andrology 2009年第3期11卷 356-361页

作者： Tae-Hwan Kim Seung Hyun Jeon Eun-joo Hahn kee-Yoeup Paek Jong Kwan Park Nae Young Youn Hyung-Lae Lee Department of Urology School of Medicine Kyung Hee University Seoul 134-727 Korea Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-711 Korea Department of Urology Chonbuk National University Medical School Jeonju 561-712 Korea Infertility Clinic Sanbornjeil Women＇s Hospital Kunpo 435-042 Korea

Korean ginseng and mountain ginseng （Panax ginseng CA Meyer） are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract （TMGE） on male patients with erectile dysfunction （ED）. A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, and the other group took 1 000 mg of placebo twice a day. The effects of the TMGE and the placebo were analyzed using the Korean version of the International Index of Erectile Function （IIEF） questionnaire. A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE （P 〈 0.05）, whereas no significant improvement was observed in the placebo group （P 〉 0.05）. Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group （P 〈 0.05）. Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improving erectile function in male patients.

关键词： erectile dysfunction Panax ginseng tissue-cultured mountain ginseng extract

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Comparison of the Bright Band Characteristics Measured by Micro Rain Radar (MRR) at a Mountain and a Coastal Site in South Korea

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Advances in Atmospheric Sciences 2009年第2期26卷 211-221页

作者： joo-Wan CHA Ki-Ho chang Seong Soo YUM Young-Jean CHOI Department of Atmospheric Sciences Yonsei University Global Environment System Research Laboratory NIMR/KMA

Data from a long term measurement of Micro Rain Radar （MRR） at a mountain site （Daegwallyeong, DG, one year period of 2005） and a coastal site （Haenam, HN, three years 2004-2006） in South Korea were analyzed to compare the MRR measured bright band characteristics of stratiform precipitation at the two sites. On average, the bright band was somewhat thicker and the sharpness （average gradient of reflectivity above and below the reflectivity peak） was slightly weaker at DG, compared to those values at HN. The peak reflectivity itself was twice as strong and the relative location of the peak reflectivity within the bright band was higher at HN than at DG. Importantly, the variability of these values was much larger at HN than at DG. The key parameter to cause these differences is suggested to be the difference of the snow particle densities at the two sites, which is related to the degree of riming. Therefore, it is speculated that the cloud microphysical processes at HN may have varied significantly from un-rimed snow growth, producing low density snow particles, to the riming of higher density particles, while snow particle growth at DG was more consistently affected by the riming process, and therefore high density snow particles. Forced uplifting of cloudy air over the mountain area around DG might have resulted in an orographic supercooling effect that led to the enhanced riming of supercooled cloud drops.

关键词： Micro Rain Radar bright band thickness and sharpness cloud microphysical processes local characteristics

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Silver-palladium alloy deposited by DC magnetron sputtering method as lubricant for high temperature application

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中国有色金属学会会刊：英文版 2009年第4期19卷 1001-1004页

作者： Jung-Dae KWON Sung-Hun LEE Koo-Hyun LEE Jong-joo RHA kee-Seok NAM Sang-Hoon CHOI Dong-Min LEE Dong-Il KIM Materials Processing Division Korea Institute of Materials Science Technology Research & Development Institute Korea Plant Service and Engineering

The silver-palladium(Ag-Pd) alloy coating as a solid lubricant was investigated for its application to the high temperature stud bolts used in nuclear power plants.A hex bolt sample was prepared in the following steps:1) bolt surface treatment using alumina grit blasting for cleaning and increasing the surface area;2) nickel(Ni) film coating as a glue layer on the surface of the bolt;and 3) Ag-Pd alloy coating on the Ni *** films were deposited by using a direct current(DC) magnetron sputtering *** thickness and composition of the Ag-Pd alloy film have effect on the friction coefficient,which was determined using axial force measurement.A 500 nm-thick Ag-Pd(80-20,molar ratio) alloy film has the lowest friction coefficient of 0.109.A cyclic test was conducted to evaluate the durability of bolts coated with either the Ag-Pd(80-20) alloy film or N-5000 *** a cycle,the bolts were inserted into a block using a torque wrench,which was followed by heating and *** only one cycle,it was not possible to remove the bolts coated with the N-5000 oil from the ***,the bolts coated with the Ag-Pd(80-20) alloy could be easily removed up until 15 cycles.

关键词：银钯合金直流电高温润滑剂沉积磁控溅射法固体润滑涂层高温螺栓

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Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

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World Journal of Gastroenterology 2009年第46期15卷 5799-5804页

作者： Byung joo Kim Kyu joo Park Hyung Woo Kim Seok Choi Jae Yeoul Jun In Youb chang Ju-Hong Jeon Insuk So Seon Jeong Kim School of Korean Medicine Pusan National University Department of Surgery College of MedicineSeoul National University Department of Physiology College of MedicineChosun University Department of Anatomy College of MedicineChosun University Center for Bio-Artif icial Muscle and Department of Physiology College of MedicineSeoul National University Center for Bio-Artifi cial Muscle and Depart-ment of Biomedical Engineering Hanyang University

AIM： To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 （TRPM7） in the human gastrointestinal （GI） tract. METHODS： Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajat （ICCs）. RESULTS： The human GI tract generated slow electrical waves and had ICCs which functioned as pacemak er cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB （2-aminoethoxydiphenyl borate） and La3＋, TRPM7 channel blockers, inhibited the slowwaves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION： These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the gen- eration of the slow waves.

关键词： Electrophysiology Interstitial cells of Cajal TRPM cation channels Transient receptor potential melastatin-type 7 protein Human Gastrointestinal tract

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Porcine vesical acellular matrix graft of tunica albuginea for penile reconstruction

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Asian Journal of Andrology 2006年第5期8卷 543-548页

作者： Kwan-joong joo Byung-Soo Kim Jeong-Ho Han chang-Ju Kim Chil-HunKwon Heung-JaePark Department of Urology Kangbuk Samsung HospitalSungkyunkwan University School of Medicine108 Pyung-DongJongro-KuSeoul 110-746Korea Department of Chemical Engineering Hanyang University College of Engineering 17 Hangdang-DongSeongdong-KuSeoul 133-791Korea Department of Pathology Samsung Medical CenterSungkyunkwan University School of Medicine50 Ilwon-DongGangnam-KuSeoul 135-710Korea Department of Physiology Kyung Hee University College of Medicine1 Hoegi-DongDongdaemun-Ku Seoul 130-701Korea

Aim： To characterize the feasibility of the surgical replacement of the penile tunica albuginea （TA） and to evaluate the value of a porcine bladder acellular matrix （BAM） graft. Methods： Acellular matrices were constructed from pigs＇ bladders by cell lysis, and then examined by scanning electron microscopy （SEM）. Expression levels of the mRNA of the vascular endothelial growth factor （VEGF） receptor, fibroblast growth factor （FGF）-1 receptor, neuregulin, and brain-derived neurotrophic factor （BDNF） in the acellular matrix and submucosa of the pigs＇ bladders were determined through the reverse transcription-polymerase chain reaction （PCR）. A 5 mm× 5 mm square was excised from the penile TA of nine rabbits. The defective TA was then covered in porcine BAM. Equal numbers of animals were sacrificed and histochemically examined at 2, 4 and 6 months after implantation. Results： SEM of the BAM showed collagen fibers with many pores. VEGF receptor, FGF-1 receptor and neuregulin mRNA were expressed in the porcine BAM; BDNF mRNA was not detected. Two months after implantation, the graft sites exhibited excellent healing without contracture, and the fusion between the graft and the neighboring normal TA appeared to be well established. There were no significant histological differences between the implanted tunica and the normal control tunica at 6 months after implantation. Conclusion： The porcine BAM graft resulted in a structure which was sufficiently like that of the normal TA. This implantation might be considered applicable to the reconstruction of the TA in conditions such as trauma or Peyronie＇s disease.

关键词： tissue engineering extracellular matrix penis reconstructive surgical procedure graft survival

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Antimicrobial effect of alexidine and chlorhexidine against Enterococcus faecalis infection

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International Journal of Oral Science 2013年第1期5卷 26-31页

作者： Hyun-Shik Kim Seok Woo chang Seung-Ho Baek Seung Hyun Han Yoon Lee Qiang Zhu kee-Yeon Kum Department of Conservative Dentistry Dental Research Institute and BK21 ProgramSeoul National University Dental HospitalSeoul National University School of Dentistry Department of Conservative Dentistry School of DentistryKyung Hee University Department of Oral Microbiology and Immunology Dental Research Institute and BK21 ProgramSeoul National University Dental HospitalSeoul National University School of Dentistry Department of Dentistry Wonju College of Medicine Yonsei University Division of Endodontology School of Dental MedicineUniversity of Connecticut Health Center

A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than *** aim of this study was to compare the antimicrobial activity of 1%alexidine with that of 2%chlorhexidine using Enterococcus faecalis-infected dentin *** bovine dentin blocks were prepared and randomly divided into six groups of 10 *** was inoculated on 60 dentin blocks using the Luppens apparatus for 24 h and then the dentin blocks were soaked in 2%chlorhexidine or 1%alexidine solutions for 5 and 10 min,*** saline was used as a *** antimicrobial efficacy was assessed by counting the number of bacteria adhering to the dentin surface and observing the degradation of bacterial shape or membrane rupture under a scanning electron *** fewer bacteria were observed in the 2%chlorhexidine-or 1%alexidine-soaked groups than in the control group(P0.05).Ruptured or antiseptic-attached bacteria were more frequently observed in the 10-min-soaked chlorhexidine and alexidine groups than in the 5-min-soaked chlorhexidine and alexidine *** conclusion,10-min soaking with 1%alexidine or 2%chlorhexidine can be effective against *** infection.

关键词： alexidine antibacterial effect chlorhexidine Enterococcus faecalis Luppens apparatus root canal soaking scanning electron microscope

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Septic shock due to Granulicatella adiacens after endoscopic ultrasound-guided biopsy of a splenic mass:A case report

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World Journal of Gastroenterology 2021年第8期27卷 751-759页

作者： Seo-Yeon Cho Eunae Cho chang-Hwan Park Hee-joon Kim joo-Yeon Koo Division of Gastroenterology Department of Internal MedicineChonnam National University HospitalGwangju 61469South Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Endoscopic ultrasound-guided fine needle aspiration or biopsy(EUS-FNA or FNB)has become a popular method for diagnosing various lesions of the gastrointestinal tract and surrounding tissue due to the accuracy and *** the best of our knowledge,no case report of severe infection after EUS-FNB of a solid lesion in the spleen has been ***,we report a rare case of septic shock after EUS-FNB of a splenic *** SUMMARY A 45-year-old male patient presented to the outpatient clinic due to an incidentally detected splenic mass.A definitive diagnosis could not be established based on the abdominal magnetic resonance *** of the spleen showed a 6 cm-sized,relatively well-demarcated,heterogeneous mass,and EUS-FNB with a 22G needle was *** days after the procedure patient developed septic shock and a splenic abscess was *** culture revealed growth of Granulicatella *** the treatment with antibiotics the patient underwent surgical resection,and the pathological examination showed diffuse large B-cell *** patient received chemotherapy and he is in complete *** Infection of a splenic mass after EUS-FNB is a rare complication and prophylactic antibiotics might be considered.

关键词： Endoscopic ultrasound Endoscopic ultrasound-guided fine needle biopsy Splenic neoplasms Lymphoma Septic shock Case report

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Adventitious Roots and Secondary Metabolism

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生物工程学报 2008年第5期24卷 711-716页

作者： Hosakatte Niranjana Murthy Eun joo Hahn kee Yoeup Paek Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-763 South Korea Department of Botany Karnatak University Dharwad 580003 India

Plants are a rich source of valuable secondary metabolites and in the recent years plant cell, tissue and organ cultures have been developed as an important alternative sources for the production of these compounds. Adventitious roots have been successfully induced in many plant species and cultured for the production of high value secondary metabolites of pharmaceutical, nutraceutical and industrial importance. Adoption of elicitation methods have shown improved synthesis of secondary metabolites in adventitious root cultures. Development of large-scale culture methods using bioreactors has opened up feasibilities of production of secondary metabolites at the industrial levels. In the present review we summarize the progress made in recent past in the area of adventitious root cultures for the production of secondary metabolites.

关键词：次生代谢植物细胞基因

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An effective method to reduce residual lithium compounds on Ni-rich Li[Ni0.6Co0.2Mn0.2]O2 active material using a phosphoric acid derived Li3PO4 nanolayer

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Nano Research 2015年第5期8卷 1464-1479页

作者： chang-Heum Jo Dae-Hyun Cho Hyung-joo Noh Hithshi Yashiro Yang-Kook Sun Seung Taek Myung Department of Nano Engineering Sejong University 98 Gunja-dong Gwangjin-gu Seou1143-747 Republic of Korea Department of Chemical Engineering Iwate University Morioka Iwate 020-8551 Japan Department of Energy Engineering Hanyang University Seongdong-gu Seou1133-791 Republic of Korea

The Ni-rich Li[Ni0.6Co0.2Mn0.2]O2 surface has been modified with H3PO4. After coating at 80 ℃, the products were heated further at a moderate temperature of 500 ℃ in air, when the added H3PO4 transformed to Li3PO4 after reacting with residual LiOH and Li2CO3 on the surface. A thin and uniform smooth nanolayer （〈 10 nm） was observed on the surface of Li[Ni0.6Co0.2Mn0.2]O2 as confirmed by transmission electron microscopy （TEM）. Time-of-flight secondary ion mass spectroscopic （ToF-SIMS） data exhibit the presence of LIP＋, LiPO-, and Li2PO2＋ fragments, indicating the formation of the Li3PO4 coating layer on the surface of the Li[Ni0.6Co0.2Mn0.2]O2. As a result, the amounts of residual lithium compounds, such as LiOH and Li2CO3, are significantly reduced. As a consequence, the LigPO4-coated Li[Ni0.6Co0.2Mn0.2]O2 exhibits noticeable improvement in capacity retention and rate capability due to the reduction of residual LiOH and Li2CO3. Further investigation of the extensively cycled electrodes by X-ray diffraction （XRD）, TEM, and ToF-SIMS demonstrated that the LiBPO4 coating layers have multi-functions： Absorption of water in the electrolyte that lowers the HF level, HF scavenging, and protection of the active materials from deleterious side reactions with the electrolyte during extensive cycling, enabling high capacity retention over 1,000 cycles.

关键词： Li3PO4 coating positive electrode lithium batteries

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Recurrent massive bleeding due to dissecting intramural hematoma of the esophagus: Treatment with therapeutic angiography

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World Journal of Gastroenterology 2009年第41期15卷 5232-5235页

作者： Jaejun Shim Jae Young Jang Young Hwangbo Seok Ho Dong joo Hyeong Oh Hyo Jong Kim Byung-Ho Kim Young Woon chang Rin chang Department of Internal Medicine Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoongu Seoul 130-702 South Korea Department of Diagnostic Radiology Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoon-gu Seoul 130-702 South Korea

Spontaneous or traumatic intramural bleeding of the esophagus, which is often associated with overlying mucosal dissection, constitutes a rare spectrum of esophageal injury called dissecting intramural hematoma of the esophagus (DIHE). Chest pain, swallowing diffi culty, and minor hematemesis are common, which resolve spontaneously in most cases. This case report describes a patient with spontaneous DIHE with recurrent massive bleeding which required critical management and highlights a potential role for therapeutic angiography as an alternative to surgery.

关键词： Esophagus Intramural hematoma Therapeutic angiography

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