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Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

world Journal of Gastrointestinal Endoscopy 2024年第6期16卷 335-342页

作者： ke.ne.h w chow Matthew T Bell Nicholas Cumpian Maryanne Amour Ryan h hsu Viktor E Eysselein neetika Srivastava Michael w Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUND Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in November *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** we evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(P=0.77),40.0%established post-AI(P=0.44),and 39.5%late post-AI(P=0.77).There were no significant differences in polyp detection rate(PDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic PDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy Adenoma detection rate Screening Colorectal adenoma

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Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase

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Journal of Genetics and Genomics 2024年第4期51卷 458-461页

作者： Xi Yang Changkun Pan Meitong Ye Jinshuo Liang haoyang Cheng Qing Liang Shu huang Jianshu wang hoi Yee chow haihuai he Cancer Center and State key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China National Clinical Research Center for Geriatrics and State key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The assembly of neurons into complex circuits relies upon appropriate axonal navigation to distant *** considerable progress has been made toward understanding the regulation of the guidance and branching of axon extension,the molecular and cellular mechanisms underlying the coordination of the motility of the axon tip,axon growth,and branching remain largely unknown(Sudhof,2017).The Drosophila mushroom body(MB),the major site for associative learning and memory,is a powerful model system to investigate complex axon *** MB is a bilaterally symmetric central brain structure,mainly composed of kenyon cells,MB output neurons,and dopaminergic neurons(Li et al.,2020).Among the seven neuronal subtypes of~2000 kenyon cells,Y,a/β,and a/β'subtypes extend axons in a fascicle and bifurcate to produce two sister branches,one projecting into the dorsal lobe and the other into the medial lobe.

关键词： branching medial axon

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Synthesis,Structures,and Chiroptical Properties of NBN-Doped helicenes with Boron Atoms in the Inner Rims

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Precision Chemistry 2024年第1期2卷 28-39页

作者： weiwen Zhuang Yujian Liu Ziqi Deng Yu Guo Philip C.Y.chow David Lee Phillips wei Jiang Zhaohui wang Junzhi Liu State key Laboratory of Synthetic Chemistry HKU-CAS Joint Laboratory on New Materials and Department of ChemistryThe University of Hong KongPokfulamHong KongChina key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Department of Mechanical Engineering The University of Hong KongPokfulamHong KongChina

The precise synthesis of helicenes with topologically defined length and specific heteroatomic perturbation in the screw-like conjugated skeletons plays an emerging role in the manipulation of chiral ***,selective,and programmable routes to helicenes or heterohelicenes are highly desirable yet challenging for structure-chiroptical property relationship ***,we report the synthesis and characterization of NBN-doped helicenes with boron atoms in the inner rims,enabled by the highly regioselective one-pot borylation of rationally designed precursors with,namely,fold-in or pan-out *** incorporation of nonbonded boron and nitrogen atoms resulted in narrow-band emission and improved optical properties for the single-stranded carbon *** addition,numbers and arrangement modes of fused six-membered rings have distinct effects on configurational stability and chiroptical properties,revealing that BN-[6]h with strong circular dichroism is a promising candidate for chiral *** combination of experimental and theoretical studies on these helical structures might provide insights into the design of helically chiral small-molecule-based sensors or emitters.

关键词： Nitrogen-boron helicenes Borylation Chiroptical properties Narrow-band emission

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SIGneT-RING MUCINOUS ADENOCARCINOMA OF ThE PANCREAS

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Chinese Medical Sciences Journal 1994年第3期9卷 176-178页

作者： w.h.chow LouisT.C.chow DepartmentofAnatomicalandCellularPathology PrinceofWalesHospitalShatinHongKong Consulatantphysician DepartmentofMedicineGranthamHospitalAberdeenHongKong.

An 88-year-old man presented symptoms and signs of ascending cholangitis and died 20 days after the onset of illness. Postmortem examination revealed a mucinous tumor arising from the head of the pancreas, encasing the common bile duct and invading the liver with multiple hepatic metastasis. The tumor showed a unique and uniform histological apperarance, consisting of signet-ring neoplastic cells floating in mucin pools. The rapid clinical course and widespread hepatic metastasis of this patient suggest that this pure, signet-ring variant of mucinous adenocarcinoma of the pancreas might have a poorer prognosis.

关键词： signet-ring carcinoma mucinous adenocarcinoma pancreas

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Enabling Inverter-based Resource Stability Control in Power Systems with high Renewable Penetration

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 1248-1250页

作者： Joe h.chow Rensselaer Polytechnic Institute TroyNY 12180-3590USA

This rapid communication provides the author’s viewpoints on the need to develop grid stability functions for inverter-based resources,in particular,controls to enhance system *** discussion will be focused on transi... 详细信息

关键词： Frequency regulation inverter control time scales transient stability

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Doubly periodic patterns of modulated hydrodynamic waves:exact solutions of the Davey-Stewartson system

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Acta Mechanica Sinica 2011年第5期27卷 620-626页

作者： J.-h. Li S.-Y. Lou K.-w. chow Department of Mechanical Engineering University of Hong Kong Pokfulam Road Hong Kong China Department of Physics Shanghai Jiao Tong University200030 Shanghai China

Exact doubly periodic standing wave patterns of the Davey-Stewartson （DS） equations are derived in terms of rational expressions of elliptic *** fluid mechanics,DS equations govern the evolution of weakly nonlinear,free surface wave packets when long wavelength modulations in two mutually perpendicular,horizontal directions are *** functions with two different moduli （periods） are necessary in the two *** relation between the moduli and the wave numbers constitutes the dispersion relation of such *** the long wave limit,localized pulses are recovered.

关键词： Free surface waves · Periodic patterns · DaveyStewartson equations

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All-Optical wavelength Conversion with Amplitude Equalization and Pulse Shaping

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光学学报 2003年第S1期23卷 491-492页

作者： C.w.chow C.S.wong h.K.Tsang Department of Electronic Engineering The Chinese University of Hong Kong Shatin Hong Kong ChinaDepartment of Electronic Engineering The Chinese University of Hong Kong Shatin Hong Kong ChinaDepartment of Electronic Engineering The Chinese University of Hong Kong Shatin Hong Kong China

A dual-wavelength-injection-locked (DwIL) Fabry-Perot (FP) laser is used as an all-optical wavelength converter and regenerator. Regenerated pulses have narrower pulse-width of 37ps. Power penalty and extinction-ratio... 详细信息

关键词： EDFA on in as of mode FP All-Optical wavelength Conversion with Amplitude Equalization and Pulse Shaping with dBm

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Pulse Generation by Mode-Beating in a Dual-wavelength Injection-Locked Laser

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光学学报 2003年第S1期23卷 -页

Generating of repetition-rate tunable optical pulses is achieved by mode-beating within a Cw-operated Fabry-Perot laser. The repetition-rate was tunable from 6Ghz to 32Ghz and may be synchronized by a low frequency (5... 详细信息

关键词： mode on as by Pulse Generation by Mode-Beating in a Dual-wavelength Injection-Locked Laser FP in

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Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-hui Zhang Fei-Fei Zhang Zhi-Ling Zhang ke-Fei Fang wen-Xing Sun Na Kong Min wu hai-Ou Liu Yan Liu Zhi Li Qing-Qing Cai Yang wang Quan-wei wei Peng-Cheng Lin Yan Lin wei Xu Cong-Jian Xu Yi-Yuan Yuan Shi-Min Zhao The Obstetrics&Gynecology hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSh)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSh promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSh,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSh

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Online Pattern Recognition and Data Correction of PMU Data Under GPS Spoofing Attack

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1240-1249页

作者： Ancheng Xue Feiyang Xu Jingsong Xu Joe h.chow Shuang Leng Tianshu Bi State key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China State Grid Ningxia Yinchuan Electric Power Company Yinchuan 750001China the Department of Electrical Computerand Systems EngineeringRensselaer Polytechnic Institute(RPI)TroyNY 12180USA

Smart grids are increasingly dependent on data with the rapid development of communication and *** one of the important data sources of smart grids,phasor measurement unit(PMU)is facing the high risk from *** with cyber attacks,global position system(GPS)spoofing attacks(GSAs)are easier to implement because they can be exploited by portable devices,without the need to access the physical ***,this paper proposes a novel method for pattern recognition of GSA and an additional function of the proposed method is the data correction to the phase angle difference(PAD)***,this paper analyzes the effect of GSA on PMU measurement and gives two common patterns of GSA,i.e.,the step attack and the ramp ***,the method of estimating the PAD deviation across a transmission line introduced by GSA is proposed,which does not require the line *** obtaining the estimated PAD deviations,the pattern of GSA can be recognized by hypothesis tests and correlation coefficients according to the statistical characteristics of the estimated PAD ***,with the case studies,the effectiveness of the proposed method is demonstrated,and the success rate of the pattern recognition and the online performance of the proposed method are analyzed.

关键词： global position system(GPS) GPS spoofing attack(GSA),phasor measurement,pattern recognition,data correction,line parameter

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