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A near-complete assembly of the Houttuynia cordata genome provides insights into the regulatory mechanism of flavonoid biosynthesis in Yuxingcao

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Plant Communications 2024年第10期5卷 180-199页

作者： Zhengting Yang Fayin He Yingxiao Mai Sixian fan Yin An Kun li Fengqi Wu Ming Tang hui Yu Jian-Xiang liu Rui Xia key Laboratory of State Forestry Administration on Biodiversity Conservation in Karst Mountainous Areas of Southwestern China School of Life SciencesGuizhou Normal UniversityGuiyangGuizhou 550025China State key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510640China lishui Innovation Center for life and Health Zhejiang UniversityHangzhou 310027China

Houttuynia cordata,also known as Yuxingcao in Chinese,is a perennial herb in the Saururaceae *** is highly regarded for its medicinal properties,particularly in treating respiratory infections and inflammatory conditions,as well as boosting the human immune ***,a lack of genomic information has hindered research on the functional genomics and potential improvements of *** this study,we present a near-complete assembly of *** genome and investigate the biosynthetic pathway of flavonoids,specifically quercetin,using genomics,transcriptomics,and metabolomics *** genome of *** diverged from that of Saururus chinensis around 33.4 million years ago;it consists of 2.24 Gb with 76 chromosomes(4n=76)and has undergone three whole-genome duplication(WGD)*** WGDs played a crucial role in shaping the *** genome and influencing the gene families associated with its medicinal *** metabolomics and transcriptomics analyses,we identified key genes involved in the b-oxidation process for biosynthesis of houttuynin,one of the volatile oils responsible for the plant’s fishy *** addition,using the reference genome,we identified genes involved in flavonoid biosynthesis,particularly quercetin metabolism,in *** discovery has important implications for understanding the regulatory mechanisms that underlie production of active pharmaceutical ingredients in traditional Chinese ***,the high-quality genome assembly of *** serves as a valuable resource for future functional genomics research and provides a solid foundation for genetic improvement of *** for the benefit of human health.

关键词： Houttuynia cordata flavonoid biosynthesis genome assembly houttuynin quercetin whole-genome duplication

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Prediction of suitable water content in granulation of sintering mixture based on litster's model

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Journal of Iron and Steel Research International 2024年第3期31卷 552-560页

作者： fang-lei Dai Xiao-hui fan Xiao-xian Huang Xu-ling Chen Min Gan Zhi-yun Ji Zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Suitable water content plays a decisive role in the granulation of sintering ***,a method was proposed to predict the suitable water content for effective granulation on the basis of litster's granulation *** granulation effectiveness of a sintering mixture was predicted by the model,with the allowance error of±10%.The effects of the water absorption properties,particle size composition and content of adhesive particles on the suitable water content were *** results showed that the allowable error of prediction was within±0.5%compared to the experimentally determined suitable water *** an increase in adhesive powder content of mixtures with higher water absorption,the suitable water content increased to achieve similar granulation ***,as the amount of concentrates increased,the suitable water content first increased and then remained *** influence of the water absorption characteristics of the adhesive particles on the suitable water content was less than that of their particle size composition in the mixture.

关键词： Adhesive particle Sintering mixture Granulation effectiveness Suitable water content

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Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain:A prospective,multicenter randomized trial

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Journal of Integrative Medicine 2024年第1期22卷 39-45页

作者： Jun-yan He Xiao-yu Tu Zi-fei Yin hui Mu Ming-jun Luo Xing-yu Chen Wei-bin Cai Xue Zhao Can Peng fan-fu fang Can Lü Bai li School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Physiotherapy the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Training PLA 458 HospitalGuangzhou 510602Guangdong ProvinceChina No.3 Ward of Acupuncture Rehabilitation Department Guangdong Second Traditional Chinese Medicine HospitalGuangzhou 510095Guangdong ProvinceChina

Background As one of the most common musculoskeletal ailments,chronic nonspecific low-back pain(CNLBP)causes persistent disability and substantial medical *** evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is *** guidelines indicate a reduced role for medicines in the management of *** The present study investigates the short-term effects of cupping and scraping therapy using a medicated balm,compared to nonsteroidal anti-inflammatory drug(NSAID)with a capsaicin plaster,in the treatment of ***,setting,participants and interventions We designed a prospective multicenter randomized clinical trial enrolling patients from January 1,2022 to December 31,2022.A total of 156 patients with CNLBP were randomized into two parallel *** sodium-sustained release tablets were administered orally to participants in the control group for one week while a capsaicin plaster was applied *** in the test group were treated with cupping and scraping using a medical device and medicated *** outcome measures Primary outcome was pain recorded using the visual analogue scale(VAS).Two secondary outcomes were recorded using the Japanese Orthopedic Association low-back pain scale(JOA)and the traditional Chinese medicine(TCM)syndrome integral scale(TCMS)as assessment *** Between baseline and postintervention,all changes in outcome metric scales were statistically significant(Plinear regression analysis,the participants’pain(VAS score)was related to their marital status,age,smoking habits and body mass *** adverse r

关键词： Chronic nonspecific low-back pain Traditional Chinese medicine Cupping and scraping therapy

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Thermodynamic simulation of stepwise precipitation of NH_4VO_(3)and NaHCO_(3)from carbonating Na_(3)VO_(4)solution

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Transactions of Nonferrous Metals Society of China 2024年第10期34卷 3386-3399页

作者： fan-cheng MENG yong-chao WANG Xin CHAI Ya-hui liU li-na WANG De-sheng CHEN National Engineering Research Center for Green Recycling of Strategic Metal Resources Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 101408China

Thermodynamic simulation was conducted to design a new process of stepwise precipitating NH_4VO_(3)and NaHCO_(3)from regulating the CO_(2)carbonation of Na_(3)VO_(4)***,a new V(V)speciation model for the aqueous solution containing vanadate and carbonate is established by using the Bromley-Zemaitis activity coefficient ***,thermodynamic equilibrium calculations are conducted to clarify the behavior of vanadium,carbon,sodium,and impurity species in atmospheric or high-pressure *** ensure the purity and recovery of vanadium products,Na_(3)VO_(4)solution is initially carbonated to the pH of 9.3-9.4,followed by precipitating NH_4VO_(3)by adding(NH_4)_(2)CO_(3).After vanadium precipitation,the solution is deeply carbonated to the final pH of 7.3-7.5 to precipitate NaHCO_(3),and the remaining solution is recycled to dissolve Na_(3)VO_(4)***,verification experiments demonstrate that 99.1%of vanadium and 91.4%of sodium in the solution are recovered in the form of NH_4VO_(3)and NaHCO_(3),respectively.

关键词： thermodynamics sodium orthovanadate speciation model carbonation vanadium precipitation sodium bicarbonate

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结核病免疫治疗年度进展2023

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中华结核和呼吸杂志 2024年第4期47卷 371-375页

作者：柯荟范琳同济大学附属上海市肺科医院结核科上海市感染性疾病(结核病)医学临床研究中心上海市结核(肺)重点实验室上海200433

结核病作为一种慢性感染性疾病,与免疫调控及免疫效应密切相关。免疫治疗作为结核病综合治疗的重要手段之一,可改善结核病的疗效、控制结核病的传播。2022年10月至2023年9月,国内外进行了多项关于结核病的免疫治疗研究,对耐多药、广泛... 详细信息

结核病作为一种慢性感染性疾病,与免疫调控及免疫效应密切相关。免疫治疗作为结核病综合治疗的重要手段之一,可改善结核病的疗效、控制结核病的传播。2022年10月至2023年9月,国内外进行了多项关于结核病的免疫治疗研究,对耐多药、广泛耐药结核的治疗提供了新的可能。宿主靶向治疗及治疗性疫苗的研究是结核病辅助治疗探索的新方向。

关键词：慢性感染性疾病免疫治疗广泛耐药结核治疗性疫苗耐多药结核病靶向治疗免疫调控

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Study on the clogging mechanism of punching screen in sand control by the punching structure parameters

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Petroleum Science 2024年第1期21卷 609-620页

作者： Fu-Cheng Deng Fu-lin Gui Bai-Tao fan Lei Wen Sheng-Hong Chen Ning Gong Yun-Chen Xiao Zhi-hui Xu Yangtze University Jingzhou434023HubeiChina CNOOC Research Institute Ltd. Beijing100028China CNOOC Ener Tech-Drilling&Production Co. Tianjin300457China Tianjin Branch of CNOOC Ltd. Tianjin300459China

As an independent sand control unit or a common protective shell of a high-quality screen,the punching screen is the outermost sand retaining unit of the sand control pipe which is used in geothermal well or oil and gas ***,most screens only consider the influence of the internal sand retaining medium parameters in the sand control performance design while ignoring the influence of the plugging of the punching screen on the overall sand retaining performance of the *** explore the clogging mechanism of the punching screen,this paper established the clogging mechanism calculation model of a single punching screen sand control unit by using the computational fluid mechanics-discrete element method(CFD-DEM)combined *** to the combined motion of particles and fluids,the influence of the internal flow state on particle motion and accumulation was *** results showed that(1)the clogging process of the punching sand control unit is divided into three stages:initial clogging,aggravation of clogging and stability of *** the initial stage of blockage,coarse particles form a loose bridge structure,and blockage often occurs preferentially at the streamline gathering place below chamfering inside the sand control *** the stage of blockage intensification,the particle mass develops into a relatively complete sand bridge,which develops from both ends of the opening to the center of the *** the stable plugging stage,the sand deposits show a“fan shape”and form a“V-shaped”gully inside the punching slot element.(2)Under a certain reservoir particle-size distribution,The slit length and opening height have a large influence on the permeability and blockage rate,while the slit width size has little influence on the permeability and blockage *** microscopic clogging mechanism and its law of the punching screen prevention unit are proposed in this study,which has some field guidance significance for the design of punching screen

关键词： Punching screen Plugging CFD-DEM Size parameter Sand control

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Traditional Chinese Medicine in the treatment of recurrent respiratory tract infections in children: an overview of systematic reviews and Meta-analyses

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Journal of Traditional Chinese Medicine 2024年第5期44卷 871-884页

作者： DENG Yasheng HAN Siyin XI Lanhua HUANG hui liANG Tianwei ZHENG Yiqing fan Yanping liN Jiang School of Basic Medical Sciences Guangxi University of Chinese Medicine School of Basic Medical Sciences Guangxi University of Chinese MedicineGuangxi Key Laboratory of Marine Drugs Department of Pharmacy Hainan Traditional Chinese Medicine Hospital

OBJECTIVE: To evaluate and summarise the evidence from published Meta-analyses/systematic reviews(MAs/SRs) of Traditional Chinese Medicine(TCM) in the treatment of recurrent respiratory tract infections(RRTIs) and to provide a scientific basis for the clinical treatment of RRTIs with TCM. METHODS: Studies were retrieved from Chinese and English databases including the China National Knowledge Infrastructure, Wanfang database, China Science and Technology Journal Database, SinoM ed, PubM ed, Web of Science, the Cochrane library and EMbase from their establishment date to March 2023. Involved studies were screened, extracted, and evaluated for quality by two researchers independently. The a measurement tool to assess systematic reviews(AMSTAR) 2 scale was used for methodological quality evaluation, as well as the preferred reporting items for systematic reviews and Meta-analyses(PRISMA) 2020 statement for report quality evaluation, the risk of bias in systematic reviews(ROBIS) tool for risk of bias, and the grading of recommendations, assessment, development and evaluation(GRADE) quality assessment tool for evidence quality. RESULTS: Twenty MAs/SRs studies were included, including analyses of 274 original studies involving 38 335 patients with RRTIs. The AMSTAR 2 scale evaluation results showed that 19 studies were of very low quality and one of moderate quality. The ROBIS evaluation results showed that 11 MAs/SRs were at high risk and nine at low risk of bias. The PRISMA 2020 report quality showed the included studies had scores between 23.5 and 35.5, among them one with high quality, 17 with moderate quality and two with low quality. The GRADE system results showed that among 126 outcome indicators, only 17 had moderate quality of evidence, 27 had low quality, 82 had very low quality, and none had high quality. CONCLUSIONS: The MAs/SRs methodological quality of using TCM for treatment RRTIs is generally poor, the quality of reports as well as of evidence is generall

关键词： Meta-analysis child medicine, Chinese traditional randomized controlled trial respiratory tract infections systematic review

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Reproducibility study of intravoxel incoherent motion and apparent diffusion coefficient parameters in normal pancreas

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2031-2039页

作者： Xiang liu Yi-Feng Wang Xiao-hui Qi Zhi-Lei Zhang Jiang-Yang Pan Xue-li fan Yu Du Ying-Min Zhai Qi Wang Department of CT and MRI The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND The consistency of pancreatic apparent diffusion coefficient(ADC)values and intravoxel incoherent motion(IVIM)parameter values across different magnetic resonance imaging(MRI)devices significantly impacts the patient’s diagnosis and *** To explore consistency in image quality,ADC values,and IVIM parameter values among different MRI devices in pancreatic *** This retrospective study was approved by the local ethics committee,and informed consent was obtained from all *** total,22 healthy volunteers(10 males and 12 females)aged 24-61 years(mean,28.9±2.3 years)underwent pancreatic diffusion-weighted imaging using 3.0T MRI equipment from three *** independent observers subjectively scored image quality and measured the pancreas’s overall ADC values and signal-to-noise ratios(SNRs).Subsequently,regions of interest(ROIs)were delineated for the IVIM parameters(true diffusion coefficient,pseudo-diffusion coefficient,and perfusion fraction)using post-processing *** ROIs were on the head,body,and tail of the *** subjective image ratings were assessed using the kappa consistency *** correlation coefficients(ICCs)and mixed linear models were used to evaluate each device’s quantitative parameter ***,a pairwise analysis of IVIM parameter values across each device was performed using Bland-Altman *** The Kappa value for the subjective ratings of the different observers was 0.776(P0.05),and the ICCs for the ADC values from different devices were 0.870,0.707,and 0.808,respectively(P<0.05).Notably,only a few statistically significant inter-device agreements were observed for different IVIM parameters,and among t

关键词： Intravoxel incoherent motion Pancreas Image quality Consistency test

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CrN supported by carbon nanosheets as efficient catalysts toward oxygen reduction reaction and Zn-air batteries

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Rare Metals 2024年第10期43卷 4973-4981页

作者： Ya-Ting Zhang fan Zhang Zhe Lu Jun-Ming Luo Su-Yang Feng Qi Wang hui Chen Hao-Ming Wu Zheng-Pei Miao Bin Chi Neng Yu Cheng-Hang You Jing li Xin-Long Tian School of Chemistry and Chemical Engineering School of Marine Science and EngineeringHainan Provincial Key Lab of Fine ChemistryHainan University State Power Investment Group Hainan Electric Power Co.Ltd. key Laboratory of Fuel Cell Technology of Guangdong Province Shenzhen Automotive Research Institute Beijing Institute of Technology State key Laboratory of Nuclear Resources and Environment East China University of Technology

Exploring non-precious efficient oxygen reduction reaction （ORR） catalysts is of great significance to fuel cells and Zn-air batteries （ZABs）.CrN is a theoretically promising ORR catalyst,but its potential needs to be unlocked by proper supports that provide high conductivity and high exposure of active *** this work,we introduce a novel synthesis of carbon nanosheets-supported CrN nanoparticles （CrN/C） by annealing the mixture of CrCl3,1,10-phenanthroline and melamine via a two-step *** prepared CrN/C materials show good ORR activity and stability in acidic and alkaline *** optimal CrN/C material has an ORR half-wave potential of 0.73 and 0.72 V （*** hydrogen electrode） in acidic and alkaline media,*** it retains 82% and 78% of ORR current density in acidic and alkaline media after durability tests,***,the optimal CrN/C material-based self-breathing ZABs deliver a maximum power density of 168 mW·cm-2,which is one of the highest among transition metal nitrides-based ZABs It is found that the ORR activity of CrN/C materials is highly related to the Cr–N valence *** work highlights the good potential of CrN as robust ORR catalyst and verifies its promising application in ZABs.

关键词： Carbon nanosheets CrN Fuel cells Oxygen reduction reaction Zn-air batteries

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Vibronic effect study of ^(1)A_(2) state of H_(2)O and D_(2)O

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Chinese Physics B 2024年第5期33卷 395-399页

作者：张倍源王礼涵朱剑辉徐卫青马子茹赵小利吴勇朱林繁 Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China Department of Physics Yantai UniversityYantai 264005China Institute of Applied Physics and Computational Mathematics Beijing 100088China School of Physics and Information Technology Shaanxi Normal UniversityXi'an 710119China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100084China

The generalized oscillator strengths of the dipole-forbidden excitations of the ^(1)A_(2) of H_(2)O and D_(2)O were calculated with the time dependent density functional theory,by taking into account the vibronic *** is found that the vibronic effect converts the dipole-forbidden excitation of the ^(1)A_(2) into a dipole-allowed one,which enhances the intensities of the corresponding generalized oscillator strength in the small squared momentum transfer *** present investigation shows that the vibronic effect of H_(2)O is slightly stronger than that of D_(2)O,which exhibits a clear isotopic effect.

关键词： water heavy water generalized oscillator strength vibronic effect isotope effect

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