A near-complete assembly of the Houttuynia cordata genome provides insights into the regulatory mechanism of flavonoid biosynthesis in Yuxingcao
作者机构：Key Laboratory of State Forestry Administration on Biodiversity Conservation in Karst Mountainous Areas of Southwestern ChinaSchool of Life SciencesGuizhou Normal UniversityGuiyangGuizhou 550025China State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510640China Lishui Innovation Center for Life and HealthZhejiang UniversityHangzhou 310027China
出 版 物：《Plant Communications》 (植物通讯（英文）)
年 卷 期：2024年第5卷第10期
页 面：180-199页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：funded by the National Natural Science Foundation of China,China(grant number 32360074) the Guizhou Provincial Natural Science Foundation of Department of Education,China(077) The Karst Mountain Ecological Security Engineering Research Center,China(KY007) the Joint Fund of the National Natural Science Foundation of China and the Karst Science Research Center of Guizhou Province,China(U1812401)
主 题：Houttuynia cordata flavonoid biosynthesis genome assembly houttuynin quercetin whole-genome duplication
摘 要：Houttuynia cordata,also known as Yuxingcao in Chinese,is a perennial herb in the Saururaceae *** is highly regarded for its medicinal properties,particularly in treating respiratory infections and inflammatory conditions,as well as boosting the human immune ***,a lack of genomic information has hindered research on the functional genomics and potential improvements of *** this study,we present a near-complete assembly of *** genome and investigate the biosynthetic pathway of flavonoids,specifically quercetin,using genomics,transcriptomics,and metabolomics *** genome of *** diverged from that of Saururus chinensis around 33.4 million years ago;it consists of 2.24 Gb with 76 chromosomes(4n=76)and has undergone three whole-genome duplication(WGD)*** WGDs played a crucial role in shaping the *** genome and influencing the gene families associated with its medicinal *** metabolomics and transcriptomics analyses,we identified key genes involved in the b-oxidation process for biosynthesis of houttuynin,one of the volatile oils responsible for the plant’s fishy *** addition,using the reference genome,we identified genes involved in flavonoid biosynthesis,particularly quercetin metabolism,in *** discovery has important implications for understanding the regulatory mechanisms that underlie production of active pharmaceutical ingredients in traditional Chinese ***,the high-quality genome assembly of *** serves as a valuable resource for future functional genomics research and provides a solid foundation for genetic improvement of *** for the benefit of human health.
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