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Metal-Organic Framework Nanozyme Enabling Dual-Functional Photo-lnduced Charge Transfer and Biomimetic Precipitation for Advanced Organic Photoelectrochemical Transistor Bioanalysis

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Chinese Journal of Chemistry 2024年第17期42卷 1999-2004页

作者： ke-Xin Xu cheng Yuan Hao Lou Feng-Zao chen Ling Zhang Guangxu chen De-Man Han w.i-w.i Zhao state key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210023China School of Pharmaceutical and Chemical Engineering Taizhou UniversityTaizhouJjiangsu 318000China School of Environment and Energy State Key Laboratory of Luminescent Materials and DevicesGuangdong Provincial Key Laboratory of Atmospheric Environment and Pollution ControlSouth China University of TechnologyGuangzhouGuangdong 510006China

we report herein the first observation of MoF nanozyme enabling dual-functional photo-induced charge transfer and biomimetic precipitation for advanced organic photoelectrochemical transistor(OPECT)***,Fe/Co-MiL-88,serving simultaneously as the semiconductor and nanozyme,was explored as a dual-functional gating module in *** light llumination,it could accelerate the charge transfer of the photogate to produce enhanced photo-induced ***,its catalytic property could efficiently produce biomimetic precipitation to block the nanopores in Fe/Co-MiL-88 and thus alter the device characteristics.

关键词： Metal-organic frameworks Nanozymes Organic transistor Photoelectrochemical Biosensing Electrodes

TransCell:in Silico Characterization of Genomic Landscape and Cellular Responses by Deep Transfer Learning

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 157-170页

作者： Shan-Ju Yeh Shreya Paithankar Ruoqiao chen Jing Xing Mengying Sun ke Liu Jiayu Zhou Bin chen Department of Pediatrics and Human Development Michigan State UniversityGrand RapidsMI 49503USA Department of Pharmacology and Toxicology Michigan State UniversityGrand RapidsMI 49503USA Department of Computer Science and Engineering Michigan State UniversityEast LansingMI 48824USA

Gene expression profiling of new or modified cell lines becomes routine today;however,obtaining comprehensive molecular characterization and cellular responses for a variety of cell lines,including those derived from underrepresented groups,is not trivial when resources are *** gene expression to predict other measurements has been actively explored;however,systematic investigation of its predictive power in various measurements has not been well ***,we evaluated commonly used machine learning methods and presented TransCell,a two-step deep transfer learning framework that utilized the knowledge derived from pan-cancer tumor samples to predict molecular features and *** these models,TransCell had the best performance in predicting metabolite,gene effect score(or genetic dependency),and drug sensitivity,and had comparable performance in predicting mutation,copy number variation,and protein ***,TransCell improved the performance by over 50%in drug sensitivity prediction and achieved a correlation of 0.7 in gene effect score ***,predicted drug sensitivities revealed potential repurposing candidates for new 100 pediatric cancer cell lines,and predicted gene effect scores reflected BRAF resistance in melanoma cell ***,we investigated the predictive power of gene expression in six molecular measurement types and developed a web portal(http://***/transcell/)that enables the prediction of 352,000 genomic and cellular response features solely from gene expression profiles.

关键词： Genomics Transcriptomics Cancer dependency Drug repurposing Transfer learning

Characteristics of the microbial communities regulate soil multi-functionality under different cover crop amendments in Ultisol

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Journal of integrative Agriculture 2024年第6期23卷 2099-2111页

作者： Guilong Li Xiaofen chen wenjing Qin Jingrui chen ke Leng Luyuan Sun Ming Liu Meng wu Jianbo Fan Changxu Xu Jia Liu Soil and Fertilizer&Resources and Environment institute Jiangxi Academy of Agricultural SciencesNanchang 330200China key Laboratory of Acidified Soil Amelioration and Utilization Ministry of Agriculture and Rural AffairsNanchang 330200China Ecological Experimental Station of Red Soil Chinese Academy of SciencesYingtan 335211China

The use of cover crops is a promising strategy for influencing the soil microbial consortium,w.ich is essential for the delivery of multiple soil functions(i.e.,soil multifunctionality).Nonetheless,relatively little is known about the role of the soil microbial consortium in mediating soil multifunctionality under different cover crop amendments in dryland ***,we assessed the multifunctionality of soils subjected to four cover crop amendments(control,non-amended treatment;RD,radish monoculture;HV,hairy vetch monoculture;and RDHV,radish-hairy vetch mixture),and we investigated the contributions of soil microbial richness,network complexity,and ecological clusters to soil *** results demonstrated that cover crops whose chemical composition differed from that of the main plant crop promoted higher multifunctionality,and the radish-hairy vetch mixture rendered the highest *** obtained evidence that changes in soil microbial richness and network complexity triggered by the cover crops were associated with higher soil ***,specialized microbes in a key ecological cluster(ecological cluster 2)of the soil microbial network were particularly important for maintaining soil *** results highlight the importance of cover crop-induced variations in functionally important taxa for promoting the soil multifunctionality of dryland Ultisols.

关键词： cover crops soil multifunctionality microbial richness network complexity ecological cluster

C-terminal frameshift mutations generate viable knockout mutants with developmental defects for three essential protein kinases

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aBiOTECH 2024年第2期5卷 219-224页

作者： Yun Zhang Miao-Miao Cui Run-Nan ke Yue-Dan chen Kabin Xie National key Laboratory of Crop Genetic improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Hubei key Laboratory of Plant Pathology Huazhong Agricultural UniversityWuhan 430070China

Loss-of-function mutants are fundamental resources for gene function ***,it is difficult to generate viable and heritable knockout mutants for essential ***,we show that targeted editing of the C-terminal sequence of the embryo lethal gene MiTOGEN-ACTiVATED PROTEiN KiNASES 1(OsMPK1)results in weak *** C-terminal-edited osmpk1 mutants displayed severe developmental defects and altered disease resistance but generated tens of viable seeds that inherited the *** the same C-terminal editing approach,we also obtained viable mutants for a wallassociated protein kinase(Os07g0493200)and a leucine-rich repeat receptor-like protein kinase(Os01g0239700),w.ile the null mutations of these genes were *** data suggest that protein kinase activity could be reduced by introducing frameshift mutations adjacent to the C-terminus,w.ich could generate valuable resources for gene function studies and tune protein kinase activity for signaling pathway engineering.

关键词： CRiSPR/Cas9 Lethal mutant Protein kinases Genome editing C-terminus

Two sandwich-type uranyl-containing polytungstates catalyze aerobic synthesis of benzimidazoles

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Rare Metals 2024年第3期43卷 1316-1322页

作者： Yu-Feng Liu Qi-Long Hu Xue-Jiao chen ke Li Pei Luo Guo-Ping Yang School of Chemistry and Material Science Jiangxi Province Key Laboratory of Synthetic ChemistryJiangxi Key Laboratory for Mass Spectrometry and InstrumentationEast China University of TechnologyNanchang330013China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Diversified synthetic strategies are extremely important for the structural diversity of uranium-containing polyoxometalates(U-POMs)and their functional ***,two sandwich-type U-POMs were reported,w.ich are Na_(5.6)K_(6.4)[(UO_(2))(H_(2)O)(Tew_(9)O_(33))]_(2)·21H_(2)O(UTew_(9))and Na_(8.9)K_(2.7)H_(1.19)[K_(0.79)(UO_(2))_(2.21)(Pw_(9)O_(34))_(2)]·12H_(2)O(UPw_9)using in-situ strategy and lacunary precursor strategy,***_9 shows a typical keggin-typeopen or half-sandwich configuration.

关键词： configuration expansion sandwich

A case of herpesviral corneal endotheliitis presenting with corneal endothelial defect

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international Journal of Ophthalmology(English edition) 2024年第7期17卷 1375-1378页

作者： Yan-Xia chen Han Deng Xiao-Yun ke Min Fu Department of Ophthalmology Women and Children’s HospitalSchool of MedicineXiamen UniversityXiamen 361003Fujian ProvinceChina Department of Ophthamology Zhujiang HosptialSouthern Medical UniversityGuangzhou 510280Guangdong ProvinceChina

Dear Editor,Corneal endotheliitis,first reported in 1982 as an autoimmune disorder by Khodadoust and Attarzadeh[1],is now recognized to be frequently induced by viral infections,including varicella zoster virus(VZV),cytomegalovirus(CMV)and herpes simplex virus(HSV),that can cause inflammatory and immune-related injuries or direct damages to corneal endothelial cells[2-3].in cases with this type of endotheliitis of viral origin,manifestations may include conjunctival ciliary congestion or mixed congestion,corneal subepithelial bulla,localized corneal edema,keratic precipitates(KP)characteristic to the edema area,puckered posterior elastic lamina,mild anterior chamber reaction,intraocular pressure(iOP)elevation in presence of inflammation in trabecular meshwork,and endothelial decompensation[3-4].Accurate diagnosis of viral corneal endotheliitis is challenging due to its complex presentation,leading to a high misdiagnosis *** the best of our knowledge,there was no previous report of viral corneal endotheliitis presenting with corneal endothelial defects in the English literature.

关键词： corneal injuries herpes

Linearized waveform inversion for vertical transversely isotropic elastic media:Methodology and multi-parameter crosstalk analysis

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Petroleum Science 2024年第1期21卷 252-271页

作者： ke chen Lu Liu Li-Nan Xu Fei Hu Yuan Yang Jia-Hui Zuo Le-Le Zhang Yang Zhao National key Laboratory of Petroleum Resources and Engineering Unconventional Petroleum Research InstituteChina University of Petroleum(Beijing)Beijing102249China Aramco Beijing Research Center Aramco AsiaBeijing100102China University of Lausanne LausanneCH-1015Switzerland Bureau of Geophysical Prospecting China National Petroleum CorporationZhuozhou 072750HebeiChina

Seismic migration and inversion are closely related techniques to portray subsurface images and identify hydrocarbon *** migration aims at obtaining structural images of subsurface geologic *** specifically,seismic migration estimates the reflectivity function(stacked average reflectivity or pre-stack angle-dependent reflectivity)from seismic reflection *** the other hand,seismic inversion quantitatively estimates the intrinsic rock properties of subsurface *** seismic inversion methods are applicable to detect hydrocarbon reservoirs that may exhibit lateral variations in the inverted *** there exist many differences,pre-stack seismic migration is similar with the first iteration of the general linearized seismic ***,seismic migration and inversion techniques assume an acoustic or isotropic elastic *** reservoirs such as shale and tight sand formation have notable anisotropic *** present a linearized waveform inversion(Lwi)scheme for weakly anisotropic elastic media with vertical transversely isotropic(VTi)*** is based on two-way anisotropic elastic wave equation and simultaneously inverts for the localized perturbations(ΔVp_(0)/Vp_(0)/Vs_(0)/Vs_(0)/,Δ∈,Δδ)from the long-wavelength reference *** proposed VTi-elastic Lwi is an iterative method that requires a forward and an adjoint operator acting on vectors in each *** derive the forward Born approximation operator by perturbation theory and adjoint operator via adjoint-state *** inversion has improved the quality of the images and reduces the multi-parameter crosstalk comparing with the adjoint-based *** have observed that the multi-parameter crosstalk problem is more prominent in the inversion images for Thomsen anisotropy ***,the Thomsen parameter is the most difficult to *** also analyze the multi-parameter crosstalk using scattering radiation patte

关键词： Elastic Anisotropy Least-squares imaging waveform inversion Computational geophysics

Rh(Ⅱ)-catalyzed intermolecular carboamination of pyridines via double Csp^(2)-H bond activations

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Science China Chemistry 2024年第1期67卷 374-382页

作者： Zhongfeng Luo Jingxing Jiang Lifang Zou Xiaoyu Zhou Junshan Liu Zhuofeng ke Fengjuan chen Huanfeng Jiang w.i Zeng key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China School of Materials Science and Engineering PCFM LabSun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial key Laboratory of Chinese Medicine Pharmaceutics School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China

we disclose the development of the Rh-catalyzed amine-directed remote 5,6-carboamination protocol of pyridines via dual Csp^(2)-H functionalizations.A variety of readily available 2-aminopyridines and 1,2,3-triazoles are allowed for coupling cyclization to access polyfunctionalized *** studies including DFT calculations unveil that relay carbenoidelectrophilic addition to pyridines and the sequential pyridyl Csp^(2)-H amination are involved in this *** postsynthetic utility of this methodology is showcased by versatile and site-selective modification of azaindoles.

关键词： Rh-catalysis azaindoles pyridyl Csp^(2)-H bond carboamination coupling-cyclization

interface engineering strategy via electron-defect trimethyl borate additive toward 4.7 V ultrahigh-nickel LiNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)battery

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Journal of Energy Chemistry 2024年第5期92卷 639-647页

作者： Yilin Zhang Yuqing chen Qiu He Jinlong ke w.i wang Jian-Fang wu Peng Gao Yanhua Li Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangsha 410082HunanChina College of Materials Science and Engineering Sichuan UniversityChengdu 610065SichuanChina School of Materials Science and Engineering Hunan Institute of TechnologyHengyang 421002HunanChina

The Li metal battery with ultrahigh-nickel cathode(LiNi_(x)M_(1-x)O_(2),M=Mn,Co,and x≥0.9)under high-voltage is regarded as one of the most promising approaches to fulfill the ambitious target of 400 wh/***,the practical application is impeded by the instability of electrode/electrolyte interface and Ni-rich cathode *** we proposed an electron-defect electrolyte additive trimethyl borate(TMB)w.ich is paired with the commercial carbonate electrolyte to construct highly conductive fluorine-and boron-rich cathode electrolyte interface(CEi)on LiNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)(NCM90)surface and solid electrolyte interphase(SEi)on lithium metal *** modified CEi effectively mitigates the structural transformation from layered to disordered rock-salt phase,and consequently alleviate the dissolution of transition metal ions(TMs)and its“cross-talk”effect,w.ile the enhanced SEi enables stable lithium plating/striping and thus demonstrated good compatibility between electrolyte and lithium metal *** a result,the common electrolyte with 1 wt%TMB enables 4.7 V NCM90/Li cell cycle stably over 100 cycles with 70%capacity *** work highlights the significance of the electron-defect boron compounds for designing desirable interfacial chemistries to achieve high performance NCM90/Li battery under high voltage operation.

关键词： NCM90 batteries Electrolyte additive Trimethyl borate