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Reduction of atrial fibrillation in remotely monitored pacemaker patients： results from a Chinese multicentre registry

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Chinese Medical Journal 2013年第22期126卷 4216-4221页

作者： CHEN ke-ping DAI yan HUA Wei yanG Jie-fu LI Kang LIANG Zhao-guang SHEN Fa-rong CHEN Si-lin SUyan-gang DING yan-sheng ZHANG Shu Chinese Acad Med Sci Fuwai Hosp Clin EP Lab Beijing 100037 Peoples R China Chinese Acad Med Sci Fuwai Hosp Arrhythm Ctr Beijing 100037 Peoples R China Peking Union Med Coll Beijing 100037 Peoples R China Beijing Hosp Dept Cardiol Beijing 100730 Peoples R China Capital Med Univ Xuan Wu Hosp Dept Cardiol Beijing 100053 Peoples R China Harbin Med Univ Affiliated Hosp 1 Dept Cardiol Harbin 150001 Heilongjiang Peoples R China Zhejiang Hosp Dept Cardiol Hangzhou 310013 Zhejiang Peoples R China Guangdong Gen Hosp Dept Cardiol Guangzhou 510100 Guangdong Peoples R China Fudan Univ Zhongshan Hosp Dept Cardiol Shanghai 200032 Peoples R China Peking Univ Hosp 1 Dept Cardiol Beijing 100034 Peoples R China

Background Many recipients of implantable cardiac electronic devices have atrial fibrillation （AF） occurrences after device implantation, even if there is no previous history of AF, and some of the episodes are asymptomatic. The purpose of this study was to evaluate trends in AF burden following early AF detection in patients treated with pacemakers equipped with automatic, daily Home Monitoring function. Methods Between February 2009 and December 2010, the registry recruited 701 pacemaker patients （628 dual-chamber, 73 biventricular devices） at 97 clinical centers in China. Daily Home Monitoring data transmissions were analyzed to screen for the AF burden. In-office follow-ups were scheduled for 3 and 6 months after implantation. Upon first AF （i.e., mode-switch） detection in a patient, screening olAF burden by Home Monitoring was extended for the next 180 days. Results At least one episode of AF was observed in 22.9% of patients with dual-chamber pacemakers and in 28.8% of patients with biventricular pacemakers. The first AF detection in a patient occurred, on average, about 2 months before scheduled follow-up visits. In both pacemaker groups, mean AF burden decreased significantly （P〈0.05） over 180 days following first AF detection： from 12.0% to 2.5% in dual-chamber and from 12.2% to 0.5% in biventricular pacemaker recipients. The number of patients with an AF burden 〉10% per month was significantly reduced over 6 months of implantation in both dual chamber （38 patients in the first month vs. 21 patients in month 6, P〈0.05） and biventricular （7 patients in the first month vs. 0 patient in months 4-6, P〈0.05） pacemaker recipients. Conclusions Automatic, daily Home Monitoring of patients treated with cardiac pacemakers allows early detection of AF, and there is a gradual and significant decrease in AF burden.

关键词： home monitoring atrialfibrillation burden pacemaker cardiac resynchronization device

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改性硅藻土对水中DDTs的吸附机理

地球科学（中国地质大学学报） 2012年第3期37卷 621-626页

作者：谭凌智祁士华张家泉张小辉柯艳萍于佳陈静严春杰生物地质与环境地质教育部重点实验室中国地质大学环境学院湖北武汉430074 长江流域水环境监测中心湖北武汉430010 中国地质大学教育部纳米矿物材料及应用工程研究中心湖北武汉430074

采用阳离子表面活性剂(十六烷基三甲基溴化铵)对硅藻土进行改性,并以优选的改性方案为基础,研究了该有机硅藻土对水中有机氯农药DDTs(p,p-DDT、p,p-DDE和p,p-DDD)的吸附过程及增强机理.结果表明,十六烷基三甲基溴化铵能有效改变... 详细信息

采用阳离子表面活性剂(十六烷基三甲基溴化铵)对硅藻土进行改性,并以优选的改性方案为基础,研究了该有机硅藻土对水中有机氯农药DDTs(p,p-DDT、p,p-DDE和p,p-DDD)的吸附过程及增强机理.结果表明,十六烷基三甲基溴化铵能有效改变硅藻土的Zeta电位、比表面积和表面疏水性质,从而提高硅藻土吸附有机氯农药的能力.改性硅藻土对水中3种有机氯农药的吸附能力依次为:p,p-DDT>p,p-DDE>p,p-DDD.基于模型的准确性(R2值)考虑,Redlich-Peterson方程能更好地用于拟合DDTs在改性硅藻土上的等温吸附曲线.

关键词：硅藻土有机改性吸附有机氯农药

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一种双氧水氧化二硫醚合成硫代芳基砜的方法

韶关学院学报 2017年第3期38卷 67-71页

作者：李术艳柯炎平漳州职业技术学院食品与生物工程系福建漳州363000 农产品深加工及安全福建省高校应用技术工程中心福建漳州363000 华南农业大学材料与能源学院广东广州510642

以二芳基二硫醚(ArSSAr)为原料,以廉价环保的双氧水(H_2O_2)为氧化剂,在碘单质(I2)促进下,以乙醇或二甲亚砜(DMSO)为溶剂,60℃下简便合成了S-芳基硫代芳基砜并通过核磁共振氢谱1H NMR和红外IR对产物结构进行确证.该方法具有反应条件温... 详细信息

以二芳基二硫醚(ArSSAr)为原料,以廉价环保的双氧水(H_2O_2)为氧化剂,在碘单质(I2)促进下,以乙醇或二甲亚砜(DMSO)为溶剂,60℃下简便合成了S-芳基硫代芳基砜并通过核磁共振氢谱1H NMR和红外IR对产物结构进行确证.该方法具有反应条件温和、原料易得和操作简单等优点.

关键词：二芳基二硫醚双氧水 S-芳基硫代芳基砜氧化

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-ping Guo yan-Mei Lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(Pker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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神农架大九湖大气中的多环芳烃

环境科学 2017年第5期38卷 1760-1768页

作者：金梦云邢新丽柯艳萍郑煌胡天鹏孙焰丁洋李绘张泽洲祁士华中国地质大学(武汉)环境学院生物地质与环境地质国家重点实验室武汉430074

为了研究神农架大九湖大气中多环芳烃(polycyclic aromatic hydrocarbons,PAHs)的质量浓度、来源及健康风险,用聚氨基甲酸酯泡沫被动采样器对大九湖大气中的PAHs进行了季节性监测.结果表明,大气中ΣPAHs的质量浓度为6.94~184.23 ng·m^(... 详细信息

为了研究神农架大九湖大气中多环芳烃(polycyclic aromatic hydrocarbons,PAHs)的质量浓度、来源及健康风险,用聚氨基甲酸酯泡沫被动采样器对大九湖大气中的PAHs进行了季节性监测.结果表明,大气中ΣPAHs的质量浓度为6.94~184.23 ng·m^(-3),平均值为30.36 ng·m^(-3),主要成分为菲(Phe)、萘(Nap)、芘(Pyr)、荧蒽(Fla)、芴(Flu)和蒽(Ant)等低环数化合物.与其他地区相比,大九湖大气中的PAHs处于较低污染水平.鹿场附近、大九湖泥炭区和大九湖管理局PAHs污染较严重.秋冬季污染较严重,春夏季污染较轻.特征化合物含量比值法和后向轨迹聚类分析法解析结果表明,大九湖大气中的PAHs污染主要来自煤和生物质的燃烧,兼有机动车尾气排放和石油源,既有当地排放又有来自湖北、河南和湖南等地的近源传输和少数西北方向的远源传输.健康风险评价结果表明,总毒性当量质量浓度(ΣBaPeq)年平均值为0.208 ng·m^(-3),低于我国环境空气质量标准(GB 3095-2012)中规定的BaP年平均质量浓度限值(1 ng·m^(-3)),说明大九湖大气中PAHs的健康风险较小.

关键词：大九湖大气多环芳烃 PUF 长距离迁移后向轨迹分析健康风险评价

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin yan You Zheng Gong yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

以学科建设为中心发展图书情报档案教育——纪念南开大学图书馆学系建系20周年

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四川图书馆学报 2004年第2期 2-7页

作者：柯平闫慧南开大学国际商学院图书馆学系天津300071

介绍了南开大学图书馆学系20年的发展,总结了该系在学科建设和图书情报档案教育等方面的成就与经验。

关键词：学科建设图书馆学教育情报学教育档案学教育南开大学图书馆学系

四川绵竹—阿坝剖面土壤中多环芳烃含量和来源及其生态风险

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安全与环境工程 2013年第4期20卷 79-83页

作者：柯艳萍祁士华陈静许峰邢新丽张小辉中国地质大学环境学院武汉430074 中国地质大学生物地质与环境地质国家重点实验室武汉430074

利用气相色谱与质谱联用仪(GC-MS)对四川绵竹—阿坝剖面土壤中16种优控多环芳烃(PAHs)的含量及其来源进行了研究,并分析了土壤中PAHs的生态毒性风险。结果表明:研究区冬季和夏季土壤中∑16PAHs的含量变化范围分别为32.78～1131.57ng/g和... 详细信息

利用气相色谱与质谱联用仪(GC-MS)对四川绵竹—阿坝剖面土壤中16种优控多环芳烃(PAHs)的含量及其来源进行了研究,并分析了土壤中PAHs的生态毒性风险。结果表明:研究区冬季和夏季土壤中∑16PAHs的含量变化范围分别为32.78～1131.57ng/g和64.5～461.29ng/g,整体表现为冬季含量高于夏季,且与高程不存在相关性;冬季和夏季土壤中PAHs均主要来源于木材、煤的燃烧,部分采样点受石油燃烧污染;将土壤中多环芳烃苯并[a]芘的毒性当量(Bapeq)与荷兰目标值(32.96ng/g)进行比较,结果显示夏季PAHs基本无潜在生态毒性风险,而冬季高度脆弱地区存在一定的潜在生态毒性风险。

关键词：多环芳烃(PAHs) 土壤含量来源生态毒性风险四川绵竹-阿坝

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li yan-yan Qiu Xue-ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report