检索结果-南通市图书馆

Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique

National Science review 2023年第4期10卷 19-21页

作者： Yanan Cao Lingling chen Hua chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai cheng Li ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-nong Ye Li Yu fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang ruijin Hospital Shanghai Jiao Tong University College of Life Science and Technology Guangxi University Beijing Institute of Genomics Chinese Academy of Sciences Children's Hospital of Chongqing Medical university Wuxi School of Medicine Jiangnan University School of Biology and Biological Engineering South China University of Technology department of physics School of ScienceTianjin University School of pharmaceutical Sciences Wuhan University Institute of Botany Chinese Academy of Sciences Institut pasteur of shanghai Chinese Academy of Sciences Institute of Biophysics Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences School of Life Sciences Sun Yat-sen University Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Faculty of Medicine and Health Sciences University College Sedaya International School of Medicine South China University of Technology department of Medical Genetics Capital Institute of Pediatrics School of Life Science and Technology Harbin Institute of Technology department of Biochemistry Abdul Wali Khan University Xiangya Hospital Central South University department of Computer Science City University of Hong Kong College of Life Science and Technology Foshan University South china Sea Institute of Oceanology Chinese Academy of Sciences College of Ecology Lanzhou University School of Life Sciences and Technology Tongji University School of Life Sciences Peking University Kunming Institute of Zoology Chinese Academy of Sciences College of Animal Science South China Agricultural University Institute of Neuroscience Chinese Academy of Sciences School of Life Sciences East China Normal University Nanjing university of Aeronautics and Astronautics Wenzhou Institute University of Chinese Academy of Sciences Institute of Systems Biomedicine Shanghai Jiao Tong University Tongji Medical College Huazhong University of Science and Technology School of Life Sciences Xiamen University Division of Life Science and department of

recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic’ that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19.

关键词： SArS-COV-2 OrIGIN

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对一例罕见头状地霉肺炎的治疗和体会

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药学服务与研究 2018年第2期18卷 96-100,116页

作者：李平卜书红陈峰刘瑛刘芳何慧敏祁红上海交通大学医学院药理与化学生物学系上海200025 上海交通大学医学院附属新华医院药学部上海200092 上海交通大学医学院附属新华医院检验科上海200092 上海交通大学医学院附属新华医院老年医学科上海200092

目的:介绍一例罕见的头状地霉肺炎的治疗方法以及药学服务经验。方法和结果:临床药师参与一例高龄头状地霉肺炎病人的治疗过程。通过查阅文献制定了氟康唑联合氟胞嘧啶的治疗方案,该病人对治疗反应较好,但治疗1个月仍不足以根除病菌,复... 详细信息

目的:介绍一例罕见的头状地霉肺炎的治疗方法以及药学服务经验。方法和结果:临床药师参与一例高龄头状地霉肺炎病人的治疗过程。通过查阅文献制定了氟康唑联合氟胞嘧啶的治疗方案,该病人对治疗反应较好,但治疗1个月仍不足以根除病菌,复发后再次合用氟康唑和氟胞嘧啶治疗2个月可彻底治愈。作者保留了菌种,6个月后通过体外联合药敏试验进行了验证。结论:氟胞嘧啶与氟康唑联合治疗头状地霉肺炎方案具有效性、安全性和经济性。体外联合药敏试验亦验证了该方案的有效性。

关键词：头状地霉肺炎氟康唑氟胞嘧啶微生物敏感性试验临床药师

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肺癌适应性治疗中国专家共识

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循证医学 2024年第4期24卷 193-200页

作者：吴一龙陆舜程颖周清张嘉涛潘燚汪斌超韩宝惠陈海泉周清华王绿化陈明王洁周彩存刘晓晴马智勇黄诚宋启斌莫树锦钟文昭朱正飞宋勇陈蓉蓉陈克终刘基巍杨帆胡晓桦胡毅杨懿岳东升王群赵军范江陈椿孟庆威闫小龙董晓荣朱波邢力刚李兆澄李子明褚倩陈元林根段建春田攀文范云刘安文刘慧刘哲峰杨农汪步海张同梅信涛刘思阳王志杰马锐于起涛林劼涂海燕姚煜赵明芳王慧娟张海波蔡尚立张绪超李慧杜瀛瀛吴芳严令华崔久嵬王燕邬麟周建娅汪笑男黄媚娟冯卫能周进李力中国抗癌协会肺癌专业委员会广东省临床试验协会/中国胸部肿瘤研究协作组广东省肺癌研究所南方医科大学附属广东省人民医院(广东省医学科学院)广州510080 上海交通大学医学院附属胸科医院上海200030 吉林省肿瘤医院长春130021 复旦大学附属肿瘤医院上海200032 四川大学华西医院成都610041 中国医学科学院肿瘤医院深圳医院广东深圳518116 中山大学肿瘤防治中心广州510060 中国医学科学院肿瘤医院北京100021 同济大学附属上海市肺科医院上海200433 解放军总医院第五医学中心北京100039 郑州大学附属肿瘤医院/河南省肿瘤医院郑州450003 福建省肿瘤医院福州350011 武汉大学人民医院肿瘤中心武汉430060 香港中文大学医学院中国香港东部战区总医院南京210002 北京吉因加科技有限公司北京102206 北京大学人民医院北京100044 大连医科大学附属第一医院辽宁大连116011 广西医科大学第一附属医院南宁530020 解放军总医院北京100071 成都市第三人民医院/西南交通大学医学院成都610031 天津医科大学肿瘤医院天津300060 复旦大学附属中山医院上海200032 北京大学肿瘤医院北京100142 上海交通大学附属上海市第一人民医院上海200025 福建医科大学附属协和医院福州350001 哈尔滨医科大学附属肿瘤医院哈尔滨150081 空军军医大学唐都医院西安710038 华中科技大学同济医学院附属协和医院武汉430022 陆军军医大学第二附属医院-新桥医院重庆400037 山东省肿瘤医院济南250117 华中科技大学同济医学院附属同济医院武汉430030 中国医学科学院肿瘤医院山西医院太原030013 中国科学院大学附属肿瘤医院/浙江省肿瘤医院杭州310022 南昌大学附属第二医院南昌330006 湖南省第二人民医院长沙410035 南京大学医学院附属苏北人民医院江苏扬州225001 首都医科大学附属北京胸科医院北京101149 哈尔滨医科大学附属第二医院哈尔滨150001 暨南大学附属第一医院广州510630 辽宁省肿瘤医院沈阳110042 广西医科大学附属肿瘤医院南宁530012 昆明医科大学第二附属医院昆明650101 西安交通大学第一附属医院西安710061 中国医科大学附属第一医院沈阳110001 广东省中医院广州510120 广州燃石医学检验所有限公司广州510300 安徽医科大学第一附属医院合肥230022 中南大学湘雅二医院长沙410011 上海桐树生物科技有限公司上海200444 吉林大学白求恩第一医院长春130021 湖南省肿瘤医院长沙410013 浙江大学医学院附属第一医院杭州310031 南京世和基因生物技术股份有限公司南京210032 佛山市第一人民医院广东佛山528000 四川省肿瘤医院成都610042 陆军军医大学大坪医院重庆400042 不详

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第21届中国肺癌高峰论坛”于2024年3月2日在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物... 详细信息

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第21届中国肺癌高峰论坛”于2024年3月2日在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物对适应性治疗的指导价值等角度展开探讨并达成了专家共识。

关键词：肺癌适应性治疗共识

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非离子型对比剂对冠状动脉造影患者肾功能的影响

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上海交通大学学报（医学版） 2010年第10期30卷 1270-1274页

作者：叶颖方唯一仇兴标陈晖施鸿毓宋洁任诗佳上海交通大学附属胸科医院心内科上海200030 浙江台州市第一人民医院心内科台州318020

目的观察患者使用非离子型对比剂进行冠状动脉造影检查前后肾功能的变化。方法收集2009年9月—2010年2月在上海交通大学附属胸科医院心内科使用非离子型对比剂行冠状动脉造影检查的556例(男性342例,女性214例)患者的资料。分别比较造影... 详细信息

目的观察患者使用非离子型对比剂进行冠状动脉造影检查前后肾功能的变化。方法收集2009年9月—2010年2月在上海交通大学附属胸科医院心内科使用非离子型对比剂行冠状动脉造影检查的556例(男性342例,女性214例)患者的资料。分别比较造影前后血液和尿液肾功能指标的变化,如果血清肌酐(Scr)绝对值水平升高>44.2μmol/L或者较基础水平升高>25%,则定义为发生了对比剂肾病(CIN)。对CIN患者作进一步分析,筛选反映CIN的敏感指标。结果血液肾功能常规检查显示,除胱抑素C(Cys C)以外,造影术前后患者的Scr、尿素氮(BUN)、尿酸(UA)和视黄醇结合蛋白(rBp)浓度比较差异均有统计学意义(pppr)值均在正常范围,造影术前后比较差异无统计学意义(p>0.05);而造影术前后肾小球滤过率(eGFr)差异均有统计学意义[男性(118.88±38.03)***-1.1.73 m-2vs(88.14±28.18)***-1.1.73 m-2,女性(107.69±38.65)***-1.1.73 m-2vs(77.40±30.71)***-1.1.73 m-2](pp<0.01)。Logistic多元回归分析显示,与CIN发病相关的因素包括高血压、糖尿病、慢性肾功能不全和对比剂用量。结论 CIN患者在冠状动脉造影前后肾功能的变化均与注射非离子型对比剂有关;α1-MG是发生CIN的早期敏感指标。

关键词：对比剂对比剂肾病冠心病冠状动脉造影

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弥漫大B细胞淋巴瘤中C-MYC、BCL-2和BCL-6基因异常与临床病理意义

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临床与实验病理学杂志 2021年第11期37卷 1322-1327页

作者：常玉清方建晨冯蔚鹰陈海仁丁祺冯砺锦葛荣上海市静安区市北医院病理科上海200435 上海交通大学附属仁济医院病理科上海200127 浙江省宁波市临床病理诊断中心宁波315021 上海同济大学附属第十人民院病理科上海200032

目的探讨弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)中C-MYC、BCL-2、BCL-6基因异常和蛋白表达及其临床意义。方法收集205例DLBCL标本及临床资料,采用免疫组化EnVision法和FISH法检测DLBCL中C-MYC、BCL-2和BCL-6蛋白表达和基因易位情况,分析其与DLBCL临床病理特征的关系。结果205例DLBCL中男性106例,女性99例,中位年龄60岁,C-MYC/BCL-2双表达44.4%(91/205)。按照Hans分型分类,GCB型占37.1%,non-GCB占62.9%;C-MYC、BCL-2和BCL-6基因易位阳性率分别为9.3%、8.8%、30.1%。C-MYC与BCL-2基因异位在双表达组较高,与Hans分型、性别、年龄等无关;BLC-6基因易位在各组间差异均无统计学意义。双重打击淋巴瘤2例,三重打击淋巴瘤3例,占2.44%(5/205)。171例患者获得随访,34例失访,随访8~107个月,死亡48例,病死率为28.1%;患者生存时间与Hans分型及年龄有关,而C-MYC与BCL-2双表达组与双重打击及三重打击组总预后比普通组差。结论C-MYC/BCL-2双表达对基因易位有提示作用,明确诊断可依靠免疫组化和FISH检测;C-MYC、BCL-2及BCL-6基因易位可作为DLBCL患者预后的指标。

关键词：弥漫大B细胞淋巴瘤 B细胞基因异常 C-MYC BCL-2 BCL-6

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Corticosteroid therapy in ulcerative colitis:Clinical response and predictors

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World Journal of Gastroenterology 2015年第10期21卷 3005-3012页

作者： Jin Li Fan Wang Hong-Jie Zhang Jian-Qiu Sheng Wen-Feng Yan Min-Xing Ma ru-ying Fan fang Gu Chuan-Feng Li Da-Fan chen ping Zheng Yu-pei Gu Qian Cao Hong Yang Jia-Ming Qian pin-Jin Hu Bing Xia department of Gastroenterology Zhongnan Hospital of Wuhan University Hubei Clinical Center and key Lab of Intestinal and Colorectal Diseases department of Gastroenterology First Affiliated Hospital of Nanjing Medical University department of Gastroenterology Military General Hospital of Beijing PLA department of Gastroenterology Third Affiliated Hospital of Peking University department of Gastroenterology First Affiliated Hospital of Shanghai Jiaotong University department of Gastroenterology Ruijin HospitalShanghai Jiaotong University department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University department of Gastroenterology Peking Union Medical College Hospital department of Gastroenterology Sixed Affiliated Hospital of Zhongshan University

aiM:To evaluate clinical response to initial corticosteroid(CS) treatment in Chinese ulcerative colitis patients(UC) and identify predictors of clinical ***:Four hundred and twenty-three UC patients who were initially treated with oral or intravenous CS from 2007 to 2011 were retrospectively reviewed at eight inflammatory bowel disease centers in china,and 101 consecutive cases with one-year follow-up were analyzed further for clinical response and ***-term outcomes within one month were classified as primary response and primary *** outcomes within one year were classified as prolonged CS response,CS dependence and secondary *** refractoriness included primary and secondary *** analyses were performed to identify predictors associated with clinical ***:Within one month,95.0%and 5.0%of the cases were classified into primary response andnon-response,*** one year,41.6%of cases were assessed as prolonged CS response,while49.5%as CS dependence and 4.0%as secondary *** rate of CS refractoriness was 8.9%,while the cumulative rate of surgery was 6.9%within one *** multivariate analysis of all the variables,tenesmus was found to be a negative predictor of CS dependence(Or=0.336;95%CI:0.147-0.768;p=0.013)and weight loss as a predictor of CS refractoriness(Or=5.662;95%CI:1.111-28.857;p=0.040).After one-month treatment,sustained high Sutherland score(≥6)also predicted CS dependence(Or=2.347;95%CI:0.935-5.890;p=0.014).CONCLUSION:Tenesmus was a negative predictor of CS dependence,while weight loss and sustained high Sutherland score were strongly associated with poor CS response.

关键词： Clinical response predictor Corticosteroid Ulcerat

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C／EBpα对糖尿病肾病足细胞保护作用的研究

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中华肾脏病杂志 2018年第5期34卷 355-360页

作者：周芳芳张沥文刘剑应霁刘韵子仲芳王伟铭陈楠上海交通大学医学院肾脏病研究所上海交通大学医学院附属瑞金医院肾脏科 200025 美国纽约州西奈山伊坎医学院肾脏科

目的构建足细胞C／EBpα条件性敲除小鼠，进一步构建糖尿病肾病模型，研究C／EBpα敲除后对糖尿病肾病足细胞的影响及机制。方法将C／EBpαlwp/loxp与podocin—cre小鼠进行杂交，得到F1代杂合子后继续繁殖直至得到纯合子小鼠（C／EBpα... 详细信息

目的构建足细胞C／EBpα条件性敲除小鼠，进一步构建糖尿病肾病模型，研究C／EBpα敲除后对糖尿病肾病足细胞的影响及机制。方法将C／EBpαlwp/loxp与podocin—cre小鼠进行杂交，得到F1代杂合子后继续繁殖直至得到纯合子小鼠（C／EBpαf/f）。分别通过常规喂养或45％高脂饮食喂养25周，并用低剂量链脲佐菌素（STZ，100mg／kg）处理小鼠后构建糖尿病肾病模型，检测小鼠血尿生化指标以及观察各组肾脏组织形态学改变，并检测。肾组织纤维化、氧化应激调控因子和线粒体功能相关蛋白的表达。结果成功构建足细胞C／EBpα特异性敲除小鼠，并在此基础上成功构建2型糖尿病肾病模型。8月龄的C／EBpaf/f小鼠。肾脏无明显组织形态学异常，但糖尿病。肾病的C／EBpαf/f小鼠具有明显的肾脏损伤、炎症和氧化应激反应。与野生型糖尿病肾病小鼠相比，糖尿病肾病C／EBpαf/f小鼠Nephrin和E—cadherin表达极度降低（均p〈0．01），Fibronectin显著升高（p〈0．01），Nrf2显著升高（p〈0．05），keapl降低（p〈0．05），且磷酸化AMpK水平降低（p〈0．05），线粒体功能相关基因pgc-1α也显著降低（p〈0．05）。结论足细胞C／EBpα基因敲除通过促进纤维化并抑制pgc—1α介导的线粒体抗氧化功能加重糖尿病肾病。

关键词：糖尿病肾病足细胞小鼠,基因敲除 CCAAT增强子结合蛋白

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Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)

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Military Medical research 2022年第4期9卷 389-403页

作者： Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut kenan Cetin Afsaneh Alikhassi rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-ramos pelin Seher Oztekin Ava Kwong Cedric W.pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-rong chen Xing chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao run-fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-ying Liao Hong Luo Zheng-ren Liu Jing-Hua Lu Bin Luo Xiao-peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-ran Xu Wen-Bo Zhou Gao-Song Wu department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China department of pathology University of Chicago Pritzker School of MedicineChicagoIL60637USA department of Surgical Oncology and Breast Surgery Oncology CenterFaculty of MedicineMansoura UniversityMansoura35516Egypt department of Breast Surgery Beijing University of Chinese MedicineBeijing100700China department of Infectious Diseases and Tropical Medicine Faculty of MedicineMashhad University of Medical SciencesMashhad***Iran Breast department KK Women’s and Children’s Hospital100 Bukit Timah RoadSingapore229899Singapore department of Surgery Department of Public HealthDepartment of BiostatisticsBioinformatics and Medical InformaticsInonu University Faculty of Medicine44280MalatyaTurkey department of General Surgery Faculty of MedicineÇanakkale Onsekiz Mart University17020ÇanakkaleTurkey department of radiology Cancer InstituteImam Khomeini HospitalTehran University of Medical SciencesTehran***Iran department of Surgery College of Medicine and Medical SciencesArabian Gulf University-BahrainManama26671Bahrain department of radiology International Faculty of MedicineIstanbul Medipol University34810IstanbulTurkey department of General Surgery Faculty of MedicineSakarya University54050SakaryaTurkey department of Surgery HiU Clinic170Gwongwang-roPaldal-guSuwon16488Korea department of radiology Faculty of MedicineAtaturk University25240ErzurumTurkey Academic Support and Education Center Hırkai Serif DistrictKececi Cesmesi StrDoktorlar BuildingB/734091IstanbulTurkey department of General and Digestive Surgery Hospital General CastellonAvda Benicassim S/N12812004CastellónSpain radiology department Ankara Training and Research Hospital305018AnkaraTurkey department of Surgery The University of Hong KongChina The university of Hong Kong-Shenzhen Hospital Shenzhen518053China university of Miami Health System and Miller School of Medicine 1475 NW 12th AvenueM

Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using pubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the *** of evidence were determined using the American College of physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and *** approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.

关键词： Granulomatous mastitis Granulomatous lobular mastitis Idiopathic granulomatous mastitis Diagnosis Treatment

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Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng ying-Hui Jin Tong-Zu Liu fang-Ming chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang Yin-Huai Wang Yu-Jie Wang Zhi-ping Wang Zhong Wang Qiang Wei Min-Hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan Wang 无 department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China department of Urology Qinghai University Affiliated HospitalXi’ning810012China department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China department of Urology

Benign prostatic hyperplasia (BpH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUpKp) is one of the foremost surgical procedures for the treatment of BpH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUpKp for BpH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUpKp in the treatment of BpH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUpKp for BpH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUpKp in the treatment of BpH included indications and contraindications for TUpKp, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia recommendation Treatment Guideline

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一例X连锁点状软骨发育不全2型患儿的临床及突变分析

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中华医学遗传学杂志 2018年第4期35卷 527-530页

作者：常国营周云芳殷蕾顾龙君应大明陈惠金王秀敏王剑上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科 200127 上海交通大学医学院附属上海儿童医学中心罕见病诊治中心 200127 上海交通大学医学院附属上海儿童医学中心医学遗传科分子诊断实验室 200127

目的分析1例重度矮小合并畸形患儿的临床特点及基因变异，探讨其遗传学病因。方法对患儿进行病史采集和辅助检查，提取患儿及其部分家系成员的外周血基因组DNA，用Agilent SureSelect方法构建测序文库，在Illumina平台上进行高通量测序... 详细信息

目的分析1例重度矮小合并畸形患儿的临床特点及基因变异，探讨其遗传学病因。方法对患儿进行病史采集和辅助检查，提取患儿及其部分家系成员的外周血基因组DNA，用Agilent SureSelect方法构建测序文库，在Illumina平台上进行高通量测序，并用Sanger测序法进行验证。结果患儿，女，6岁10个月，表现为非匀称性身材矮小、特殊面容、四肢及脊柱畸形，左眼弱视，右眼白内障，呼吸道频发感染，尿频等，实验室检查提示总25-羟维生素D缺乏，其母亲、姨妈、弟弟亦表现为身材矮小。基因检测显示患儿EBp基因存在C．184C〉T（***62Trp）杂合突变，其母亲携带同样的突变，父亲和弟弟则未发现该突变。结论EBp基因C．184C〉T（***62Trp）杂合突变可能是该家系的发病原因。

关键词：身材矮小点状软骨发育不全 X-连锁 EBp基因突变

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