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Study on Thermosensitive Micellization of Dextran-g-PNIPAAm in Aqueous Solutions

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Chinese Chemical Letters 2006年第6期17卷 837-840页

作者： Dan ZHAO Li Qun WANG ke hua tu Song Wei TAN Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027

The thermosensitive micellization of dextran-g-PNIPAAm in aqueous solutions has been investigated by fluorescence spectroscopy, dynamic light scattering and transmission electron microscope. The formed polymeric micelles showed different diameters of about 20 nm or 100 nm, when the solution temperature was below or above the phase transition temperature.

关键词： Amphiphiles micelles poly(N-isopropylacrylamide) thermosensitive copolymers.

A GENERAL APPROACH TO DETERMINING THE EVOLUTION OF MOLECULAR WEIGHT DISTRIBUTION CURVES OF LINEAR POLYMERS UNDERGOING CHAIN SCISSION

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Chinese Journal of Polymer Science 2013年第7期31卷 1056-1060页

作者： Zhuo-li Lin Jun Luo Zheng-jian Chen ke-hua tu 王利群王衍伟 MOE key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University Department of Polymer Science and Engineering College of ChemistryChemical Engineering and Materials ScienceSoochow University

A numerical method is developed to compute the development of molecular weight distribution （MWD） curves of linear polymers undergoing chain scission. The method can be applied to complex chain scission kinetics and for arbitrarily complex initial MWD curves. Our method is based on the method of lines （MoL）. Different from the existing numerical scheme, we propose the use of logarithmically spaced points. This development ensures the accuracy of the computed MWD curves at low molecular weights, and it does not require a very fine discretization to produce an accurate result.

关键词： Polymer degradation Reaction kinetics Molecular weight distribution Modeling.

Temperature-pH Sensitive IPN Hydrogels Composed of Silk Sericin and Poly(N-isopropylacrylamide)

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Chinese Chemical Letters 2006年第3期17卷 403-406页

作者： Wen WU Wen Jing LI Li Qun WANG ke hua tu Wei Lin SUN Deparment of Polymer Science and Engineering Zhejiang University Hangzhou 310027 Ningbo Institute of Technology Zhejiang University Ningbo 315100

Interpenetrating polymer network （IPN） composed of silk sericin （SS） and poly（N-isopropylacrylamide）（PNIPAAm） was prepared. The morphology of the IPNs, in which the SS phase was stained with ammonium cuprate, was examined with TEM and a relative homogeneous distribution of the two polymers was exhibited. The swelling behavior of the IPN hydrogels showed both temperature and pH dependences.

关键词： Silk sericin poly(N-isopropylacrylamide) interpenetrating polymer network.

Ibuprofen induced drug loaded polymeric micelles

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Chinese Chemical Letters 2011年第9期22卷 1123-1126页

作者： Song Wei Tan Hong Jun Wang ke hua tu Hong Liang Jiang Li Qun Wang MOE key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 China

Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly （N-isopropylacrylalaide）. Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly （N-isopropylacrylamide） and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found thai the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.

关键词： Micellc Thernlo-sensilive Drug Hydrogen-bonding Poly (N-isopropylacryhlmide)

A MONTE CARLO SIMULATION StuDY OF THE EFFECT OF CHAIN LENGTH ON THE HYDROLYSIS OF POLY(LACTIC ACID)

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Chinese Journal of Polymer Science 2013年第11期31卷 1554-1562页

作者： Zhuo-li Lin Jun Luo Zheng-jian Chen Jun Yi Hong-liang Jiang ke-hua tu 王利群 MOE key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

The intrinsic relationship between molecular chain length and the probability of chain reaction during poly（lactic acid）（PLA） hydrolysis was investigated by Monte Carlo simulation. The chain reaction rate was calculated by introducing a power function of different molecular chain lengths. The hydrolysis of both amorphous and extended-chain crystal PLA was selected as the model system. It is found that, the chain reaction probability was proportional to the chain length with a power of 0.4 for amorphous PLA and 0.7-1 for extended-chain crystal PLA, respectively. These results indicate that PLA with longer chain length usually exhibits larger reaction rate than that with shorter length. Comparing the hydrolysis of the two kinds of PLA, the competition between longer and shorter chains in the different condensed structures is different.

关键词： Monte Carlo Simulation Chain length Poly(lactic acid) Hydrolysis Molecular weight distribution.

三层同轴电喷-去模板法制备核壳纳米颗粒用于蛋白质药物输送

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高分子学报 2014年第9期24卷 1238-1243页

作者：曹丽华王红军涂克华蒋宏亮王利群浙江大学高分子科学与工程学系高分子合成与功能构造教育部重点实验室杭州310027

分别以聚乙二醇(PEG)、聚(丙交酯-乙交酯)(PLGA)和牛血清白蛋白(BSA)为冠、壳和核层材料,采用三层同轴电喷技术制备得到微米颗粒.激光共聚焦显微镜(LSCM)显示,该方法制备得到的微米颗粒呈现核-壳-冠结构.通过脱去该微米颗粒的PEG冠层(模... 详细信息

分别以聚乙二醇(PEG)、聚(丙交酯-乙交酯)(PLGA)和牛血清白蛋白(BSA)为冠、壳和核层材料,采用三层同轴电喷技术制备得到微米颗粒.激光共聚焦显微镜(LSCM)显示,该方法制备得到的微米颗粒呈现核-壳-冠结构.通过脱去该微米颗粒的PEG冠层(模板),得到包载有BSA的纳米颗粒.研究发现,随着壳层PLGA溶液进样速度的减慢,去模板后纳米颗粒的粒径从约146 nm减小到68 ***在纳米颗粒中的包埋率可高达78.3%,并且其释放没有显著的药物暴释现象.圆二色谱结果表明,同轴电喷过程对BSA二级结构影响很小.因此,利用三层同轴电喷-去模板法可制备得到粒径可调控的蛋白质纳米载体系统,并且该过程中蛋白质的结构基本维持不变.

关键词：同轴电喷纳米颗粒核壳结构蛋白质药物输送

载血红蛋白纳米胶束的制备及蛋白封装行为研究

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高分子学报 2015年第5期25卷 535-541页

作者：孙芬芬林辉涂克华王红军王利群浙江大学高分子科学与工程学系杭州310027 浙江大学医学院附属邵逸夫医院杭州310016 浙江大学教育部高分子合成与功能构造重点实验室杭州310027

通过原子转移自由基聚合(ATRP)制备了两亲性嵌段共聚物聚乙二醇-聚甲基丙烯酸缩水甘油酯PEG-b-P(GMA)45,利用1-(3-氨基丙基)咪唑(API)与GMA上的环氧基发生开环反应,合成了聚乙二醇-聚(咪唑丙基-1-胺-甲基丙烯酸羟丙酯)PEG-P(GMA-API)45... 详细信息

通过原子转移自由基聚合(ATRP)制备了两亲性嵌段共聚物聚乙二醇-聚甲基丙烯酸缩水甘油酯PEG-b-P(GMA)45,利用1-(3-氨基丙基)咪唑(API)与GMA上的环氧基发生开环反应,合成了聚乙二醇-聚(咪唑丙基-1-胺-甲基丙烯酸羟丙酯)PEG-P(GMA-API)45.研究表明,该聚合物可以直接在水中自组装形成均匀的球形纳米胶束,粒径约为40 nm.由于咪唑基的p H响应性,胶束表面在p H从4增大到9的范围内均带正电荷,p H 7.4时共聚物可以与血红蛋白产生较强的静电作用和氢键作用,达到包载血红蛋白的目的.同时还研究了聚合物对不同比例血红蛋白的包封率,当聚合物与血红蛋白的质量比为1∶1时包封率最高,为32.4wt%.UV-Vis显示包封后的血红蛋白在不同气体结合状态的特征吸收峰与自由血红蛋白差别不大,表明载血红蛋白纳米胶束具有良好的气体运输能力,PEG-P(GMA-API)45纳米胶束将有可能用于新型的人工氧载体.

关键词： ATRP 纳米胶束咪唑血红蛋白人工氧载体

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利用酸敏感超支化聚缩醛制备聚乳酸多孔微球

高分子学报 2014年第6期24卷 802-807页

作者：陈蕊罗军卢毅於麟涂克华蒋宏亮王利群浙江大学高分子科学与工程学系教育部高分子合成与功能构造重点实验室杭州310027

通过缩醛转移聚合合成了一种具有酸敏感特性的超支化聚缩醛(HBPAs),对该聚合物降解行为的研究表明,该聚合物具有很强的酸敏感特性,在pH为5.0时,短时间内可发生迅速的降解,而在pH为7.4时,该聚合物基本不发生降解.利用该聚合物的酸敏感特... 详细信息

通过缩醛转移聚合合成了一种具有酸敏感特性的超支化聚缩醛(HBPAs),对该聚合物降解行为的研究表明,该聚合物具有很强的酸敏感特性,在pH为5.0时,短时间内可发生迅速的降解,而在pH为7.4时,该聚合物基本不发生降解.利用该聚合物的酸敏感特性,其在弱酸性条件下降解速率远远超过PLA的降解速率,制备了多孔PLA微球.进一步研究发现,通过调控超支化聚缩醛(HBPAs)与PLA的投料比,可以线性调控PLA多孔微球的孔径尺寸,并拟合得到了线性方程.DSC结果以及对微球降解过程的观察表明,在共混微球内部,HBPAs与PLA会发生一定的相分离,使得在酸降解的过程中,更有利于微球内部的HBPAs组分发生降解.

关键词：超支化聚缩醛酸敏感致孔剂多孔微球

Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng Sheng-ke tu Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report