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SRT1720, a SIRT1 Activator, Aggravates Bleomycin-Induced Lung Injury in Mice

Food and Nutrition Sciences 2012年第2期3卷 157-163页

作者： Shingo Imanishi Ryuji Hayashi Tomomi Ichikawa Kensuke Suzuki Masakiyo Sasahara Takashi Kondo Hirofumi Ogawa kazuyuki Tobe Department of Pathology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan Department of Radiological Sciences Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan. First Department of Internal Medicine Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan

Diagnosis and management of interstitial lung diseases (ILDs), caused by lung epithelial injury followed by apoptosis, are often challenging. It has been controversial whether the SIRT1 protein, a principal modulator of longevity due to caloric restriction, ameliorates or aggravates ILD in animal models. Here we examined the effect of SRT1720, a syn- thetic activator of SIRT1, on bleomycin-induced lung injury in a mouse model and apoptosis in cultured epithelial cells. Oral intubation of SRT1720 over a period of 15 days caused body weight loss and a high mortality rate among bleomy- cin-treated mice. Histological examinations showed that the SRT1720 load increased fibrosis in the bleomycin-treated lung. An analysis of bronchoalveolar lavage fluid revealed remarkably increased numbers of inflammatory cells in the SRT1720-treated group. Moreover, the apoptosis of A549 lung cancer cells, caused by X-ray irradiation and an anti-Fas activating antibody, was promoted by SRT1720. These results indicate that SRT1720 not only aggravates bleomy- cin-induced ILD, but stimulates the apoptosis of physically and biologically stimulated A549 cells. While SIRT1 acti- vators are considered promising for the treatment of conditions such as diabetes mellitus, fatty liver, and chronic ob- structive pulmonary diseases, an excess of food containing SIRT1 activators may be harmful depending on the disease state, especially in the case of acute inflammation.

关键词： Interstitial Lung Diseases (ILDs) Lung Injury SIRT1 Bleomycin X-Ray Irradiation Oxidative Stress

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螺旋桨鳍状导流帽的研究和发展

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江苏船舶 1989年第3期6卷 14-20页

作者： kazuyuki Ouchi 任淑丽日本三井OGK Lines公司技术部研究开发室镇江船厂

PBCF(螺旋桨鳍状导流帽)改变了螺旋桨毂后的水流,从而分散和减弱桨毂涡,达到增加螺旋桨效率的目的。试验结果表明:敞水推进器试验获益3％到7 ％;7米自航模试验大约获益2％;44979总吨位的 Mercury Ace号汽车运输船大约获益4％。这些数据... 详细信息

PBCF(螺旋桨鳍状导流帽)改变了螺旋桨毂后的水流,从而分散和减弱桨毂涡,达到增加螺旋桨效率的目的。试验结果表明:敞水推进器试验获益3％到7 ％;7米自航模试验大约获益2％;44979总吨位的 Mercury Ace号汽车运输船大约获益4％。这些数据表明,PBCF结构简单并具有良好的节能效果。

关键词：螺旋桨节能推进装置导流帽发展

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Reliability Verification and Practical Effectiveness Evaluation of the Nursing Administration Analysis Formulae Based on PSYCHOMS^(■)

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Health 2014年第21期6卷 3013-3021页

作者： Misao Miyagawa Kaori Katou Yuko Yasuhara kazuyuki Matsumoto Motoyuki Suzuki Takako Takebayashi Tetsuya Tanioka Rozzano Locsin Department of Nursing Faculty of Health and WelfareTokushima Bunri UniversityTokushimaJapan The Major in Nursing School of Health Sciences The University of TokushimaTokushimaJapan Institute of Health Biosciences The University of Tokushima Graduate SchoolTokushimaJapan Faculty of Engineering The University of TokushimaTokushimaJapan Faculty of information Science and Technology Osaka Institute of TechnologyOsakaJapan Umibenomori Hospital KochiJapan

In psychiatric hospitals, the ratios between patients versus physician and patients versus nurse are low as compared to those in general hospitals. Furthermore, usages of electronic medical records are also low so that nurse administrators are limited in their ability to compile, analyze, and generate patient care staffing information for their administrative use. Psychiatric nurse administrators anticipate the development of a nursing administration analysis system that could perform personnel data simulation, manage information on nursing staff, and manage ward/ practice operations. Responding to this situation, the authors developed a nursing administration analysis system utilizing formulae from the Psychiatric Outcome Management System, PSYCHOMS®to aid nurse administrators. Such formulae are awaiting patent approval. The purpose of this study was to examine the validity of the formulae and the Structured Query Language (SQL) statement, and its practical effectiveness of analyzing data. The study findings showed that two kinds of computation expressions—a classification and extraction were able to display required information desired by nurse administrators. Moreover, significant information critical to assigning staff was validated to ensure high quality of nursing care according to the function and characteristic of the hospital ward.

关键词： Analysis Formulae Nursing Administration Analysis Psychiatric Hospital PSYCHOMS^(■)

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Characteristics of Gamma-Ray Irradiated Pentacene Organic Thin Film Field Effect Transistors

Characteristics of Gamma-Ray Irradiated Pentacene Organic Th...

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The 1st International Congress on Advanced Materials 2011

作者： HIROAKI YANO LI CAI TOSHIO hirao ZONGFAN DUAN YUTARO TAKAYANAGI HIROKUNI OHUCHI HIDEHARU UEKI TAKESHI OHSHIMA YASUSHIRO NISHIOKA Department of Precision Machinery College of Science and TechnologyNihon University Japan Atomic Energy Agency

P-channel pentacene field effect transistors with a Si/SiO 2 /pentacene/Au structure were fabricated, and were gamma-ray irradiated with a Co 60 source. The changes of the drain current I D vs. source/drain voltage V SD (I D - V SD ) characteristics were measured after every 200 Gy in silicon (Gy Si ) irradiations up to the total dose of 1200 Gy Si . The drain current I D continuously decreased to less than 10 % of that before irradiation after 1200 Gy Si irradiation. The threshold voltage V th continuously decreased up to 800 Gy Si , started to saturate above 800 Gy Si, and recovered above 1000 Gy Si . The mobility μ continued to decrease up to 1200 Gy Si . Those behaviors were explained by accumulation of positive trapped charge within the gate insulator SiO 2 near the interface, continuous increase of interface traps near the interface between the SiO 2 and pentacene, and build up of electrons in the channel regions. These behaviors were discussed in comparisons with previously reported results on ultraviolet (UV) light irradiation experiments on similarly structured pentacene-based transistors.

关键词： Co60 gamma-ray radiation damage pentacene SiO2 OTFT UV-light

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日本企业的R&D合作及其对国家创新系统改革的政策启示

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科学学研究 2006年第4期24卷 481-487页

作者：元桥一之姜波东京大学先端科学技术研究中心日本经济产业研究所

日本技术创新体系以大企业的自付主义为特征,但是随着技术创新相关国际竞争的激化以及研发内容的复杂化、高级化,推进研发外部合作的动向日益广泛。在这种研发网络的形成中,研发型中小企业的产学研合作,起着非常重要的作用。本文利用《... 详细信息

日本技术创新体系以大企业的自付主义为特征,但是随着技术创新相关国际竞争的激化以及研发内容的复杂化、高级化,推进研发外部合作的动向日益广泛。在这种研发网络的形成中,研发型中小企业的产学研合作,起着非常重要的作用。本文利用《研发外部合作实情调查》中的有关数据,对研发型中小企业的产学研合作进行了定量的分析。

关键词：研发型中小企业风险企业产学研合作日本技术创新体系

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轮缘润滑与踏面黏着功能一体化的改进型车轮摩擦块

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国外铁道机车与动车 2022年第5期 9-12页

作者： [日]kazuyuki HANDA 刘志荣(译) 张静(校) 不详

文章介绍了一种集轮缘润滑和踏面黏着改善功能于一体的车轮摩擦块的研制。设计出一种结构,用踏面清洗装置将增黏摩擦材料垂向施加于踏面,将含有MoS_(2)(二硫化钼)的固体润滑剂垂向施加于轮缘。将所开发的摩擦块用于高速列车进行了约20... 详细信息

文章介绍了一种集轮缘润滑和踏面黏着改善功能于一体的车轮摩擦块的研制。设计出一种结构,用踏面清洗装置将增黏摩擦材料垂向施加于踏面,将含有MoS_(2)(二硫化钼)的固体润滑剂垂向施加于轮缘。将所开发的摩擦块用于高速列车进行了约20万km的运行试验。轮缘的平均磨耗率比未安装所开发摩擦块的车辆降低约40%。

关键词：轮缘磨耗固体润滑剂黏着整体成型润滑

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施用有机物对水稻田甲烷排放的影响

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土壤学进展 1992年第6期20卷 25-29页

作者： kazuyuki Yagi 杜道灯

在水稻整个生育期内,利用密闭箱法测定了日本四个不同地点稻田的甲烷排放量。观察结果表明甲烷通量季节性变化较大。甲烷排放与水稻田土壤氧化还原电位降低密切相关,排水落干和追施化肥能显著降低甲烷排放。甲烷排放量明显与土壤类型有... 详细信息

在水稻整个生育期内,利用密闭箱法测定了日本四个不同地点稻田的甲烷排放量。观察结果表明甲烷通量季节性变化较大。甲烷排放与水稻田土壤氧化还原电位降低密切相关,排水落干和追施化肥能显著降低甲烷排放。甲烷排放量明显与土壤类型有关,泥炭土稻田排放最高(在耕作期内甲烷排放量为44.8克/米~2),其次是潜育化土稻田(为8.0～27.0),浅暗色土稻田,甲烷排放量极低(为0.6～12.6)。以6～9吨/公顷的水稻秸杆施入稻田,甲烷排放量增加了1.8～3.5倍。施用堆肥甲烷排放量有少量增长。每个小区中甲烷的年排放量与淹水前采集的水田土壤易矿化碳(RMC)含量呈正相关,RMC是影响淹水土壤甲烷排放的主要因素之一。

关键词：稻田甲烷施肥有机肥料

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Towards a natural classification and backbone tree for Lophiostomataceae,Floricolaceae,and Amorosiaceae ***.

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Fungal Diversity 2015年第5期74卷 199-266页

作者： Kasun M.Thambugala Kevin D.Hyde Kazuaki Tanaka Qing Tian Dhanushka N.Wanasinghe Hiran A.Ariyawansa Subashini C.Jayasiri Saranyaphat Boonmee Erio Camporesi Akira Hashimoto kazuyuki Hirayama RenéK.Schumacher Itthayakorn Promputtha Zuo-Yi Liu Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Center of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-cho HirosakiAomori 036-8561Japan The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand A.M.B.Gruppo Micologico Forlivese BAntonio Cicognani Via Roma 18ForlìItaly A.M.B.Circolo Micologico BGiovanni Carini C.P.314 BresciaItaly Hölderlinsraße 25 15517 Fürstenwalde/SpreeGermany

The genera Lophiostoma,Misturatosphaeria and several other allied taxa in Lophiostomataceae are *** of these taxa,including their history,morphology,and family placement,based on molecular phylogeny,are *** or representative specimens of Lophiostoma and Misturatosphaeria were examined and fresh specimens were obtained from Germany,Italy,Japan and Thailand.A multi-gene phylogenetic analysis of the lophiostomataceous genera Floricola,Lophiostoma,Misturatosphaeria and related taxa is *** genera including Lophiostoma,Lophiohelichrysum,Dimorphiopsis,Platystomum and Vaginatispora,plus eleven newly introduced genera Biappendiculispora,Alpestrisphaeria,Capulatispora,Coelodictyosporium,Guttulispora,Lophiopoacea,Neotrematosphaeria,Paucispora,Pseudolophiostoma,Pseudoplatystomum and Sigarispora are accepted in Lophiostomataceae based on morphology and *** caulium,Lophiostoma arundinis and Lophiostoma caudatum are accommodated in *** winteri and Lophiostoma fuckelii are placed in the genera Lophiopoacea and Vaginatispora *** Curreya species and Misturatosphaeria claviformis are transferred to a new genus,*** other Misturatosphaeria species except Misturatosphaeria aurantiinotata and *** are separated in the new genera Asymmetrispora,Aurantiascoma,Magnibotryascoma,Pseudoaurantiascoma and Pseudomisturatosphaeria based on their morphological and phylogenetic *** new genus,Ramusculicola is introduced for a new collection from *** seven new genera are accommodated in a new family Floricolaceae,together with Floricola and *** massarina-like species clustered as a sister clade to Amorosia littoralis and are accommodated in a new genus Angustimassarina.A new family Amorosiaceae is proposed to accommodate the genera Amorosia and *** putatively named species Decaisnella formosa and Thyridaria macrostomoides form a s

关键词： Dothideomycetes Floricola Lophiostoma Misturatosphaeria Multi-gene phylogeny new species new genus Pleosporales taxonomy

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Intragastric surgery using laparoscopy and oral endoscopy for gastric submucosal tumors

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World Journal of Gastrointestinal Endoscopy 2015年第1期7卷 53-58页

作者： Nobumi Tagaya Teppei Tatsuoka Yawara Kubota Masayuki Takegami Nana Sugamata kazuyuki Saito Takashi Okuyama Yoshitake Sugamata Masatoshi Oya Department of Surgery Dokkyo Medical University Koshigaya HospitalSaitama 343-8555Japan

We review the techniques and outcomes of the intragastric resection for gastric submucosal tumors(GSTs) using laparoscope and oral endoscope. In the literature, the mean operation time, intraoperative blood loss, pathological size of the tumor and postoperative hospital stay were 134 min, minimal, 31 mm and 6.4 d, respectively. There were no particular perioperative complications during the follow-up period(mean: 121.3 mo). Intragastric surgery using laparoscopy and oral endoscopy can be considerably beneficial for patients with GSTs locating in the upper third of the stomach between 2-5 cm in diameter and < 8 cm2 in crosssectional area and located in the upper third of the stomach.

关键词： Laparoscopic surgery Intragastric resection Gastric submucosal tumor Oral endoscopy

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日本地方政府预算研究与启示

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中南财经政法大学学报 2007年第6期 91-95页

作者：东晓石田和之武汉大学政治与公共管理学院湖北武汉430072 日本国立德岛大学综合科学部

日本以地方财政计划作为地方政府预算的中心环节,并将地方税返还制度列入该计划,以保障和调整地方财源,满足地方公共支出需要。针对目前出现的地方财力不足,以及中央财政对地方财政补充不足的现实状况,日本正在进行三位一体的地方分权... 详细信息

日本以地方财政计划作为地方政府预算的中心环节,并将地方税返还制度列入该计划,以保障和调整地方财源,满足地方公共支出需要。针对目前出现的地方财力不足,以及中央财政对地方财政补充不足的现实状况,日本正在进行三位一体的地方分权改革与财政体制改革。日本地方政府预算制度与改革的经验与教训对于切实推进中国的分税制改革,发挥地方政府财政计划功能、改革政府财政架构、建立公开透明的政府财政预算体系以及制定科学的地方财政保证方法等方面有着重要的启示作用。

关键词：日本地方政府预算财政分权

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